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| 1 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 2 | Analysis of the Fungal Community in Apple Replanted Soil Around Bohai Gulf显示文摘Apple replant disease(ARD) is a frequently occurring plant disease in replanted orchards around Bohai Gulf, which causes growth inhibition and even death of plants. The aim of this study was to investigate the etiology of ARD around Bohai Gulf. In this study, the primary growth inhibition of apple seedlings was evaluated in ten replanted soils, sampled around Bohai Gulf. A fungal clone library was used to identify changes in the structure and composition of the soil fungal community. The results revealed that the Simpson diversity indices of Laizhou and Pulandian orchards were higher than others, presenting severe ARD. Ascomycota dominated around Bohai Gulf at the phyla level. Fusarium and Saccharomyces were abundant in all replanted soils. In addition, correlations between the relative abundance of fungal genera in soils and the severity of ARD were analyzed. The results showed that Fusarium was correlated positively with the severity of ARD, but Mortierella was negatively correlated. Furthermore, the quantitative PCR of Fusarium oxysporum, which was regarded as a factor of ARD, was performed. Overall, this study demonstrated that ARD was strongly associated with an unbalanced microbial ecosystem with more pathogenic fungi, while Fusarium in the apple replanted soil was the key factor for ARD around Bohai Gulf. | WANG Gongshuai YIN Chengmiao PAN Fengbing WANG Xiaobao XIANG Li WANG Yanfang WANG Jinzheng TIAN Changping CHEN Jie MAO Zhiquan | 2018 | Horticultural Plant Journal2018，4，5： | 21 |
| 3 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 4 | Classification of hypersurfaces with constant Laguerre eigenvalues in R^n显示文摘Let x:M → Rn be an umbilical free hypersurface with non-zero principal curvatures.Then x is associated with a Laguerre metric g,a Laguerre tensor L,a Laguerre form C,and a Laguerre second fundamental form B,which are invariants of x under Laguerre transformation group.An eigenvalue of Laguerre tensor L of x is called a Laguerre eigenvalue of x.In this paper,we classify all oriented hypersurfaces with constant Laguerre eigenvalues and vanishing Laguerre form. | LI TongZhu LI HaiZhong WANG ChangPing | 2011 | Science China Mathematics2011，54，6： | 10 |
| 5 | ^(14)C measurement of forest soils in Dinghushan Biosphere Reserve显示文摘Organic carbon in forest soils of Qingyunsi and Wukesong profiles can be divided into fast and slow components. Δ14C values of these profiles decrease with increasing of depth. The Δ14C values in 30—40 cm depth interval of Wukesong profile are decreasing sharply until a very low value,showing that a strong geological environment change occurred about 1 560 years ago. The 14C apparent ages of Wukesong profile show that the coniferous and broad-leaf mixed forests around Wukesong profile have been developing since 425 a BP, which is consistent with historical documents. The penetrating depths of 'bomb 14C' in Qingyunsi and Wukesong profiles are 10 and 20 cm, respectively. | SHEN Chengde , LIU Dongsheng (LIU Tungsheng) , PENG Shaolin, SUN Yanmin , JIANG Mantao , Yl Weixi , XING Changping , GAO Quanzhou , LI Zhi’an and ZHOU Guoyi Guangzhou Institute of Geochemisry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology, Chinese Academy of Sciences , Beijing 100029, China South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650, China | 1999 | Chinese Science Bulletin1999，44，3： | 7 |
| 6 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 7 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 8 | Water permeability in MXene membranes: Process matters显示文摘Recent studies have shown impressive transport behaviors of water and ions within lamellar MXene membranes,which endows great promise in developing advanced separation application based high performance MXene membranes.However,most of the researches focused on modification of MXene nanoflakes and optimizing interlayer distance,leaving the impact of membrane fabrication process marginal.In this work,we studied the water flux of membranes made by vacuum filtration using delaminated MXene nanoflakes as the building-blocks.Our results show that the water permeability is extremely sensitive to the process,especially at the drying process,loading and deposit rate of nanoflakes(the feeding concentration).We find that the voids from less ordered stack rather than in-plane defects and interlayer galleries contribute to the large water permeability.The voids can be effectively avoided via deposition of MXene nanoflakes at a slow rate.Manipulating the stack of MXene nanoflakes during vacuum filtration and drying are critical for development of MXene membranes with desired performance for water permeation. | Hang Zhou Yuwei Wang Fuqiang Wang Hao Deng Yongchen Song Changping Li Zheng Ling | 2020 | Chinese Chemical Letters2020，31，6： | 3 |
| 9 | Subgrid-scale model based on the vorticity gradient tensor for rotating turbulent flows显示文摘A new subgrid-scale(SGS)stress model is proposed for rotating turbulent flows,and the new model is based on the traceless symmetric part of the square of the velocity gradient tensor and the symmetric part of the vorticity gradient tensor(or the so-called vorticity strain rate tensor).The new subgrid-scale stress model is taken into account the effect of the vortex motions in turbulence,which is reflected on the anti-symmetric part of the velocity gradient tensor.In addition,the eddy viscosity of the new model reproduces the proper scaling as O(y^3)near the wall.Then,the new SGS model is applied in large-eddy simulation of the spanwise rotating turbulent channel flow.Different simulating cases are selected to test the new model.The results demonstrate that the present model can well predict the mean velocity profiles,the turbulence intensities,and the rotating turbulence structures.In addition,it needs no a second filter,and is convenient to be used in the engineering rotational flows. | Han Qi Xinliang Li Changping Yu | 2020 | Acta Mechanica Sinica2020，36，3： | 3 |
| 10 | Polyploidy events shaped the expansion of transcription factors in Cucurbitaceae and exploitation of genes for tendril development显示文摘Cucurbitaceae is one of the most important plant families distributed worldwide.Transcription factors(TFs)regulate plant growth at the transcription level.Here,we performed a systematic analysis of 42641 TFs from 63 families in 14 Cucurbitaceae and 10 non-cucurbit species.Whole-genome duplication(WGD)was the dominant event type in almost all Cucurbitaceae plants.The TF families were divided into 1210 orthogroups(OGs),of which,112 were unique to Cucurbitaceae.Although the loss of several gene families was detected in Cucurbitaceae,the gene families expanded in five species that experienced a WGD event comparing with grape.Our findings revealed that the recent WGD events that had occurred in Cucurbitaceae played important roles in the expansion of most TF families.The functional enrichment analysis of the genes that significantly expanded or contracted uncovered five gene families,AUX/IAA,NAC,NBS,HB,and NF-YB.Finally,we conducted a comprehensive analysis of the TCP gene family and identified 16 tendril-related(TEN)genes in 11 Cucurbitaceae species.Interestingly,the characteristic sequence changed from CNNFYFP to CNNFYLP in the TEN gene(Bhi06M000087)of Benincasa hispida.Furthermore,we identified a new characteristic sequence,YNN,which could be used for TEN gene exploitation in Cucurbitaceae.In conclusion,this study will serve as a reference for studying the relationship between gene family evolution and genome duplication.Moreover,it will provide rich genetic resources for functional Cucurbitaceae studies in the future. | Yu Zhang Yingchao Zhang Bing Li Xiao Tan Changping Zhu Tong Wu Shuyan Feng Qihang Yang Shaoqin Shen Tong Yu Zhuo Liu Xiaoming Song | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 11 | Composite control of linear/ adaptive variable structure control显示文摘 | Gu Wenjin Zhang Yifei Li Changping | 2001 | Chinese Journal of Astronautics2001，14，1： | 1 |
| 12 | Composite control of linear/adaptive variable structure control显示文摘 | Gu Wenjin Zhang Yifei Li Changping | 2001 | Chinese Journal of Astronautics2001，14，1： | 1 |
| 13 | Composite Control of Linear /Adaptive Variable Structure Control 显示文摘 | Gu Wenjin Zhang Yifei Li Changping | 2001 | Chinese Journal of Astronautics2001，14，1： | 1 |
| 14 | Composite Control of Linear /Adaptive Variable Structure Control 显示文摘 | Gu Wenjin Zhang Yifei Li Changping | 2001 | Chinese Journal of Astronautics2001，14，1： | 1 |
| 15 | Desulfu-rization by Oxidation Combined with Extraction Using AcidicRoom-Temperature Ionic Liquids 显示文摘 | Chi Yansheng Li Changping Jiao Qingzhu | 2011 | Green Chem2011，13，5： | 1 |
| 16 | Composite Control of Linear/Adaptive Variable Structure Control 显示文摘 | Gu Wenjin Zhang Yifei Li Changping | 2001 | Chinese Journal of Astronautics2001，14，1： | 1 |
| 17 | Classification of hypersurfaces with parallel Laguerre second fundamental form in R n显示文摘 | Tongzhu Li Haizhong Li Changping Wang | 2009 | Differential Geometry and its Applications2009，，2： | 1 |
| 18 | Laguerre geometry of hypersurfaces in $$\mathbb{R}^{n}$$显示文摘 | Tongzhu Li Changping Wang | 2007 | manuscripta mathematica2007，，1： | 1 |
| 19 | Composite control of linear/adaptive variable structure control显示文摘 | ZHANG YIFEI LI CHANGPING | 2001 | 航空学报(英文版)2001，，1： | 1 |
| 20 | Protoraphis Simonsen, a newly recorded marine epizoic diatom genus for China显示文摘Epizoic diatoms on marine copepods are common in nature and may have a special ecological relationship with their hosts.However,this special ecological group is not well known,and it has only rarely been studied in the China seas.To address this knowledge gap,the species diversity and classification of epizoic diatoms on planktonic copepods were studied with samples collected from the East China Sea.In the present study,a marine araphid diatom genus Protoraphis and its type species,Pr.hustedtiana,were observed and identified by light and electron microscopy,thus representing the first record of this genus and its type species in China.This genus is characterized by a median sternum strongly bent to opposite sides and terminate in two transapical grooves at the valve ends.Protoraphis hustedtiana was found to be epizoic on the posterior body appendages and segments of the marine calanoid copepod Candacia bradyi.An internal view shows a complex,ear-shaped process that is close to the apical slit field.The ecological habitats and geographical distributions of Protoraphis were also discussed,and,together with complementary morphological studies,our results have increased the number of records for marine epizoic diatoms to three genera with three species in China,including Pseudohimantidium and Pseudofalcula. | Lang Li Changping Chen Lin Sun Jiawei Zhang Junrong Liang Yahui Gao | 2020 | Acta Oceanologica Sinica2020，39，4： | 1 |
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