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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Simulating microbiologi- cally influenced corrosion by depositing extracellular biopoly- mers on mild steel surfaces 显示文摘 | Roe F L Lewandowski Z Funk T | 1996 | Corrosion Science1996，52，： | 1 |
| 4 | The ennoblement of stainless steel by manganic oxide biofouling显示文摘 | DICKINSON W H CACCAVO F LEWANDOWSKI Z | | 0，，08： | 1 |
| 5 | In vivo cellular imag- ing pinpoints the role of reactive oxygen species in the early steps of adult hematopoietie reeonstitution显示文摘 | Lewandowski D Barroca V Duconge F | 2010 | Blood2010，115，3： | 1 |
| 6 | Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis)显示文摘 | Lewandowsky F Lutz W | 1922 | Arch Dermatol Syph Bed1922，141，： | 1 |
| 7 | Prevention of vascular dysfunction after preeclampsia: a potential long-term outcome measure and an emerging goal for treatment显示文摘 | Lazdam M Davis E F Lewandowski A J | 2012 | J Pregnancy2012，2012，70： | 1 |
| 8 | Development and characterization of a nonprimate animal model of methanol-induced neurotoxicity 显示文摘 | EELLS J T SALZMAN M M LEWANDOWSKI M F | 1996 | J Engng and Appl Sci1996，1306，： | 1 |
| 9 | Development andcharacterization of flame-retardant fibers from isotactic polypro-pylene melt-compounded with melamine-formaldehyde micro-capsules显示文摘 | Salaiin F Lewandowski M Vroman I | 2011 | Polym Degrad Stab2011，96，1： | 1 |
| 10 | A two-site kinetic model simulating apparent deactivation during photocatalytic oxidation of aromatics on titanium dioxide (TiO2)显示文摘 | Lewandowski M Ollis D F 2003a | 2003 | Applied Catalysis B:Environmental2003，43，： | 1 |
| 11 | Extension of a two-site transient kinetic model of TiO2 deactivation during photocatalytic oxidation of aromatics:concentration variations and catalyst regeneration studies显示文摘 | Lewandowski M Ollis D F 2003b | 2003 | Applied Catalysis B:Environmental2003，45，： | 1 |
| 12 | A two-site kinetic model simulating apparent deactivation during photocatalytic oxidation of aromatics on titanium dioxide (TiO2) 显示文摘 | Lewandowski M Ollis D F | 2003 | Applied Catalysis B2003，43，4： | 1 |
| 13 | Extension of a two-site transient kinetic model of TiO2deactivation during photoeatalytic oxidation of aromatics : concentration variations and catalyst regeneration studies显示文摘 | Lewandowski M Ollis D F | 2003 | Applied Catalysis B2003，45，3： | 1 |
| 14 | Halide acid pretreatment of photocatalysts for oxidation of aromatic air contaminants:rate enhancenment,rate inhibition,and a thermodynamic rationale显示文摘 | Lewandowski M Ollis D F | 2003 | Journal of Catalysis2003，217，1： | 1 |
| 15 | Identification of a novel peptide that interferes with the chemical regulation of connexin43 显示文摘 | Shibayama J Lewandowski R Kieken F | 2006 | Circ Res2006，98，11： | 1 |
| 16 | A two-site kinetic model simulating apparent deactivation during photocatalytic oxidation of aromatics on titanium dioxide (TiO2) 显示文摘 | Lewandowski M Ollis D F | 2003 | Applied Catalysis B:Environmental2003，，43： | 1 |
| 17 | In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution显示文摘 | Lewandowski D Barroca V Ducongé F | 2010 | Blood2010，115，： | 1 |
| 18 | Comparative responses to water stress in stay-green,rapid- and slow senescing genotypes of the biomasscrop显示文摘 | Clifton-Brown J C Lewandowski I Bangerth F | 2002 | Miscanthus New Phytologist2002，154，： | 1 |
| 19 | Effects of biofilm structuies on oxygen distribution and mass transport显示文摘 | Beer D Stoodley P Roe F Lewandowski Z | 1994 | Biotechnol Bioeng1994，43，： | 1 |
| 20 | Combinatorial 'library on bead' approach to polymeric materials with vastly enhanced chiral recognition显示文摘 | Murer P Lewandowski K Svec F | 1998 | Chem Commun1998，，： | 1 |
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