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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Microbial Biofilms显示文摘 | J W Costerton Z Lewandowski D E Caldwell D R Korber H M Lappin-Scott | 1995 | Annual Review of Microbiology1995，，： | 2 |
| 4 | Ionic liquids as elec?trolytes显示文摘 | Galinski M Lewandowski A Stepniak 1 | 2006 | Electrochimica Acta2006，51，： | 1 |
| 5 | Miscanthus:european experience with a novel energy crop显示文摘 | LEWANDOWSKI I CLIFTON-BROWN J C SCURLOCK J M O | 2000 | Biomass &Biocnergy2000，19，4： | 1 |
| 6 | Orexins/Hypocretins modulate the activity of NPY-positive and negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors显示文摘 | Palus K Chrobok L Lewandowski M H | 2015 | Neuroscience2015，300，15： | 1 |
| 7 | Fracture characteristics of an Al-Si-Mg model composite system显示文摘 | MANOHARAN M HUNT W H | 1993 | Materials Science & Engineering A: Structural Materials: Properties Microstructure and Processing1993，172，12： | 1 |
| 8 | The development and current status of perennial rhizomatous grasses as energy crops in the US and Europe显示文摘 | Lewandowski I Scurlock J M O Lindvall E | 2003 | Biomass and Bioenergy2003，25，4： | 1 |
| 9 | Supercapacitor based on activated carbon and polyethylene oxide-KOH-H2O polymer electrolytè显示文摘 | Lewandowski A Zajder M Frackowiak E | 2001 | Electrochimica Acta2001，46，18： | 1 |
| 10 | 显示文摘 | Galinski M Lewandowski A Stepniak I | 2006 | Electrochim Acta2006，51，26： | 1 |
| 11 | Primary breast lym-phoma-a review of the literature and report of three cases显示文摘 | Joks M Mysliwiec K Lewandowski K | 2011 | Arch Med Sci2011，7，1： | 1 |
| 12 | Practical and theoretical limits for electrochemical double-layer capacitors 显示文摘 | Lewandowski A Galinski M | 2007 | Journal of Power Sources2007，173，2： | 1 |
| 13 | Enhancing anti-tumor efficacy of doxorubicin by non-covalent conjugation to gold nanopartieles-in vitro studies on feline fibmsarcoma cell lines 显示文摘 | WOJCIK M LEWANDOWSKI W KROL M | 2015 | PLoS One2015，10，01： | 1 |
| 14 | Practical and theoretical limits for electrochemical double-layer capacitors 显示文摘 | LEWANDOWSKI A GAL1NSKI M | 2007 | J Power Sources2007，173，2： | 1 |
| 15 | Miscanthus: European experience with a novel energy crop显示文摘 | Lewandowski I Clifton Brown J C Scurlock J M O | 2000 | Biomass and Bioenergy2000，19，4： | 1 |
| 16 | Strength and ductile-phase toughening in the two-phase Nb/Nb5Si3 alloys 显示文摘 | Mendiratta M G Lewandowski J J Dimiduk D M | 1991 | Metallurgical Transactions A1991，22，： | 1 |
| 17 | Simvastatln reduces sympathetic activity in patients with hypertension and hypercholesterolemia显示文摘 | Lewandowski J Siski M Bidiuk J et a1 | 2010 | Hypertens Res2010，33，11： | 1 |
| 18 | Super capacitor based on activated carbon and polyethyleneoxide-KOH-H2O polymer electrolyte 显示文摘 | LEWANDOWSKI A ZAJDER M | 2001 | Electrochimica Acta2001，46，： | 1 |
| 19 | A tobacco mosaic virus-hybrid expresses and loses an added gene显示文摘 | LEWANDOWSKI D J HILF M E | 1989 | Virology1989，172，： | 1 |
| 20 | Epidemiology of ARDS显示文摘 | Lewandowski K Lewandowski M | 2006 | Minerva Anestesiol2006，72，6： | 1 |
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