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| 1 | Circulating extracellular RNAs,myocardial remodeling,and heart failure in patients with acute coronary syndrome显示文摘Background:Given high on-treatment mortality in heart failure(HF),identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues.Circulating extracellular RNAs(ex-RNAs)regulate important biological processes and are emerging as biomarkers of disease,but less is known about their role in the acute setting,particularly in the setting of HF.Methods:We examined the ex-RNA profiles of 296 acute coronary syndrome(ACS)survivors enrolled in the Transitions,Risks,and Actions in Coronary Events Center for Outcomes Research and Education Cohort.We measured 374 ex-RNAs selected a priori,based on previous findings from a large population study.We employed a two-step,mechanism-driven approach to identify ex-RNAs associated with echocardiographic phenotypes(left ventricular[LV]ejection fraction,LV mass,LV end-diastolic volume,left atrial[LA]dimension,and LA volume index)then tested relations of these ex-RNAs with prevalent HF(N=31,10.5%).We performed further bioinformatics analysis of microRNA(miRNAs)predicted targets’genes ontology categories and molecular pathways.Results:We identified 44 ex-RNAs associated with at least one echocardiographic phenotype associated with HF.Of these 44 exRNAs,miR-29-3p,miR-584-5p,and miR-1247-5p were also associated with prevalent HF.The three microRNAs were implicated in the regulation p53 and transforming growth factor-βsignaling pathways and predicted to be involved in cardiac fibrosis and cell death;miRNA predicted targets were enriched in gene ontology categories including several involving the extracellular matrix and cellular differentiation.Conclusions:Among ACS survivors,we observed that miR-29-3p,miR-584-5p,and miR-1247-5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF.Relevance for Patients:miR-29c-3p,miR-584-5p,and miR-1247-5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. | Khanh-Van Tran Kahraman Tanriverdi Gerard P.Aurigemma Darleen Lessard Mayank Sardana Matthew Parker Amir Shaikh Matthew Gottbrecht Zachary Milstone Selim Tanriverdi Olga Vitseva John F.Keaney Catarina I.Kiefe David D.McManus Jane E.Freedman | 2019 | Journal of Clinical & Translational Research2019，5，1： | 7 |
| 2 | The worcester venous thromboembolism study显示文摘 | Frederick A. Spencer Cathy Emery Darleen Lessard Frederick Anderson Sri Emani Jayashri Aragam Richard C. Becker Robert J. Goldberg | 2006 | Journal of General Internal Medicine2006，，7： | 2 |
| 3 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 4 | Thirty-Year Trends (1975 to 2005) in the Magnitude of, Management of, and Hospital Death Rates Associated With Cardiogenic Shock in Patients With Acute Myocardial Infarction: A Population-Based Perspective显示文摘 | Robert J. Goldberg Frederick A. Spencer Joel M. Gore Darleen Lessard Jorge Yarzebski | 2009 | Circulation2009，，9： | 2 |
| 5 | Multiaxial fatigue behaviour of unidirectional plies based on uniaxial fatigue experiments: Part I: Modelling显示文摘 | Shokrieh M M Lessard L B | 1997 | International Journal of Fatigue1997，19，3： | 1 |
| 6 | Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，6937： | 1 |
| 7 | Expression of NF-кB in prostate cancer lymph node metastases显示文摘 | Ismail Ha Lessard L Mes-Masson AM | 2004 | Prostate2004，58，3： | 1 |
| 8 | Progressive fatigue damage modeling of composite materials, part Ⅰ: modeling显示文摘 | Shokrieh M M Lessard L B | 2000 | Journal of Composite Materials2000，34，： | 1 |
| 9 | Cryopreservation alters the levels of the bull sperm surface protein P25b显示文摘 | Parent S Leclerc P | 2000 | J Androl2000，21，5： | 1 |
| 10 | Bmi-1 determines the proliferative capacity of normal and leukemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，： | 1 |
| 11 | Palliation of recurrent Ewing sarcoma of the pelvis with cryoablation and somatosensory-evoked potentials显示文摘 | Lessard AM Gilchrist J Schaefer L | 2009 | J Pediatr Hematol Oncol2009，31，： | 1 |
| 12 | Progressive fatigue damage modeling of composite materials, part Ⅱ: material characterization and model verification 显示文摘 | Shokrich M M Lessard L B | 2000 | Journal of Composite Materials2000，34，： | 1 |
| 13 | Sorption of organic matter from four phytoplankton species to montmorillonite, chlorite, and kaolinite in seawater 显示文摘 | Satterberg J Arnarson T S Lessard E J | 2003 | Marine Chemistry2003，81，： | 1 |
| 14 | An essential switch in sub- unit composition of a chromatin remodeling complex during neural development 显示文摘 | Lessard J Wu JI Ranish JA | 2007 | Neuron2007，55，2： | 1 |
| 15 | Variability estimation of urban wastewater biodegradable fractions by respirometry显示文摘 | Fabienne Lagarde Marie-Hélène Tusseau-Vuillemin Paul Lessard Alain Héduit Fran?ois Dutrop Jean-Marie Mouchel | 2005 | Water Research2005，，19： | 1 |
| 16 | Android forensics: Simplifying cell phone examinations 显示文摘 | Jeff Lessard Gary Kessler | 2011 | Small Scale Device Forensics Journal2011，，： | 1 |
| 17 | Regulation of dendritic development by neuron-specific chromatin remodeling complexes显示文摘 | Wu JI Lessard J Olave IA | 2007 | Neuron2007，56，： | 1 |
| 18 | Immune response of postpar turn dairy cows fed flaxseed显示文摘 | Lessard M Gagnon N Petit H V | 2003 | Journal of Dairy Science2003，86，8： | 1 |
| 19 | Chronic activation ofwild type epidermal growth factor receptor and loss of Cd-kn2a cause mouse glioblastoma fomiation显示文摘 | Acquaviva J Jun HJ Lessard J | 2011 | Cancer Res2011，71，23： | 1 |
| 20 | Thirty - year ( 1975 to 2005) trends in the incidence rates, clinical features,treatment practices,and short- term outcomes of patients <55 years of age hospitalized with an initial acute myocardial infarction显示文摘 | McManus DD Piacentine SM Lessard D | 2011 | Am J Cardiol2011，108，4： | 1 |
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