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| 1 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 2 | Thirty - year ( 1975 to 2005) trends in the incidence rates, clinical features,treatment practices,and short- term outcomes of patients <55 years of age hospitalized with an initial acute myocardial infarction显示文摘 | McManus DD Piacentine SM Lessard D | 2011 | Am J Cardiol2011，108，4： | 1 |
| 3 | Differential symptoms of acute myocardial infarction in patients with kidney disease: a community-wide perspective 显示文摘 | Sosnov J Lessard D Goldberg R J | 2006 | Am J Kidney Dis2006，47，3： | 1 |
| 4 | Ten-year trends in the incidence,treatment,and outcome of Q-wave myocardial infarction显示文摘 | DAUERMAN H L LESSARD D YARZEBSKI J | 2000 | Am J Cradiol2000，86，7： | 1 |
| 5 | Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study显示文摘 | Spencer FA Gore JM Lessard D | 2008 | Arch Intern Med2008，168，4： | 1 |
| 6 | Understanding and managing risks in large engineering projects 显示文摘 | Miller R Lessard D | 2001 | Int J of Project Mana2001，19，8： | 1 |
| 7 | Long - term survival after heart failure : a contemporary population - based per- spective显示文摘 | GOLDBERG R J CIAMPA J LESSARD D | 2007 | Arch Intern Med2007，167，5： | 1 |
| 8 | Understanding and managing risks in large engineering projects显示文摘 | Miller R Lessard D | 2001 | International Journal of Project Management2001，19，8： | 1 |
| 9 | Two-decade-long trends(1975-1997)in the incidence,hospitalization,and long-term death rates associated with complete heart block complicating acute myocardial infarction:a community-wide perspective显示文摘 | Spencer FA Jabbour S Lessard D | 2003 | Am Heart J2003，145，3： | 1 |
| 10 | Bleeding complications in patients with anemia and acute myocardial infarction显示文摘 | Dauerman HL Lessard D Yarzebski J | 2005 | Am J Cardiol2005，96，10： | 1 |
| 11 | Thermosensitivity of aqueous solutions of poly(N,N-diethylacrylamide)显示文摘 | Idziak I Avoce D Lessard D | 1999 | Macromolecules1999，32，： | 1 |
| 12 | Isolated calf deep vein thrombosis in the community setting: the Worcester Venous Thromboembolism study显示文摘 | Spencer FA Kroll A Lessard D | 2012 | J Thromb Thrombolysis2012，33，3： | 1 |
| 13 | Nuclear factors interact with a soybean beta-conglycinin enhancer显示文摘 | Alien R D Bernier F Lessard P A | 1989 | Plant Cell1989，1，： | 1 |
| 14 | Recent and death rates from atrial fibrillation complicating initial acute myocardial infarction: A community-wide perspective显示文摘 | GOLDBERG R J YARZEBSKI J trends in the incidence rates of LESSARD D | 2002 | Am Heart J2002，143，3： | 1 |
| 15 | Decade-long trends and factors associated with time to hospital presentation in patients with acute myocardial infarction:the Worcester Heart Attack study显示文摘 | Goldberg RJ Yarzebski J Lessard D | 2000 | Arch Intern Med2000，160，21： | 1 |
| 16 | Decade-long trends and factors associated with time to hospital presentation in patients with acute myocardial infarction:the Worcester Heart Attack study显示文摘 | Goldberg RJ Yarzebski J Lessard D | 2000 | Arch Intern Med2000，160，21： | 1 |
| 17 | The impact of COPD on management and outcomes of patients hospitalized with acute myocardial infarction: a 10-year retrospective observational study显示文摘 | Stefan M S Bannuru R R Lessard D | 2012 | Chest2012，141，6： | 1 |
| 18 | Trends in Prehospital Delay in Patients With Acute Myocardial Infarction(from the Worcester Heart Attack Study)显示文摘 | Saczynski JS Yarzebski J Lessard D | 2008 | Am J Cardiol2008，102，12： | 1 |
| 19 | Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity显示文摘 | Lessard S J Rivas D A Stephenson E J | 2011 | Am J Physiol Regul Integr Comp Physiol2011，300，1： | 1 |
| 20 | Thirty year (1975 to 2005) trends in the incidence rates,clinical features, treatment practices, and short-term outcomes of patients <55 years of age hospitalized with an initial a cute myocardial infarction显示文摘 | McManus DD Piacentine SM Lessard D | 2011 | Am J Cardiol2011，108，4： | 1 |
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