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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Decomposition processes in Al-Zn-Mg alloys显示文摘 | Loftier H Kovace I Lendvai J | 1992 | J Mater Sci1992，27，7： | 1 |
| 4 | Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo显示文摘 | LENDVAI B STERN EA CHEN B et ol | 2000 | Nature2000，404，6780： | 1 |
| 5 | Biodistribution of ^68Ga-labelled Phosphodiester, Phosphorothioate, and 2'-O-methyl Phosphodiester Oligonueleotides in Normal Rats显示文摘 | LENDVAI G VELIKYAN I BERGSTROM M | 2005 | EurJ Pharm Sci2005，26，： | 1 |
| 6 | Possible modification of cast structure by continuous casting technology in AlFeSi alloys,Part Ⅲ:mermetallic phases显示文摘 | Griger A Stefaniay S Lendvai A | | 0，，10： | 1 |
| 7 | Cigarette peak coal temperature measurements 显示文摘 | LASZLO T S LENDVAY A T | 1974 | Beitr Tabakforsch1974，7，： | 1 |
| 8 | Precipitation and strengthening in aluminium alloys 显示文摘 | | 1996 | Materials Science Forum1996，，： | 1 |
| 9 | A vinca alkaloid enhances morphological dynamics of dendritic spins of neocortical layer 2/3 pyramidal cells 显示文摘 | Lendvai B Zelles T Rozsa B | 2003 | Brain Res Bull2003，59，4： | 1 |
| 10 | 显示文摘 | Zs Kovács A Castellero A L Lendvai G J | 2004 | Materials Science and Engineering2004，，： | 1 |
| 11 | A vinca alkaloid enhances morphological dynamics of dendritic spines of neocortical layer 2/3 pyramidal cells显示文摘 | Balazs Lendvai Tibor Zelles Balazs Rozsa E.Sylvester Vizi | 2002 | Brain Research Bulletin2002，，4： | 1 |
| 12 | Micro RNA profile before and after antiviral therapy in liver transplant recipients for hepatitis C virus cirrhosis显示文摘 | Fanni Gelley Gergely Zadori Balazs Nemes Matteo Fassan Gabor Lendvai Eniko Sarvary Attila Doros Zsuzsanna Gerlei Peter Nagy Zsuzsa Schaff Andras Kiss | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 13 | Precipitation and strengthening in aluminium alloys 显示文摘 | | 1996 | Materials Science Forum1996，，： | 1 |
| 14 | Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes显示文摘 | Lendvay T S Morris D K Sah J | 1996 | Genetics1996，144，： | 1 |
| 15 | Corrosion - protection properties of water - borne paint coatings as studied by electrochemical impedance spectroscopy and gravimetry显示文摘 | GABRIELLA LENDVAY -GYORIK TAMaS PAJKOSSY BELA LENGYEL | 2006 | Progress in Organic Coatings2006，56，4： | 1 |
| 16 | TeleRobotic fundamentals of laparoscopic surgery (FLS) : effects of time delay-pilot study 显示文摘 | Lum M J Rosen J Lendvay TS | 2008 | Conf Proc IEEE Eng Med Biol Soc2008，2008，： | 1 |
| 17 | The effect of Cu on mechanical and precipitation properties of AlZn-Mg alloys显示文摘 | Chinh N Q Lendvai J Ping D H | 2004 | Journals of Alloys and Compounds2004，378，： | 1 |
| 18 | Mechanical properties of AIZnMg alloys 显示文摘 | KOVACS I LENDVAI J UNGAR T GROMA G LAKNER J | 1980 | Acta Metallurgica1980，28，12： | 1 |
| 19 | Biodistribution of 68Ga-labelled phosphodiester,phosphorothioate,and 2'-O-methyl phosphodiester oligonucleotides in normal rats显示文摘 | Lendvai G Velikyan I Bergstrom M | | 0，，： | 1 |
| 20 | The tuberous sclerosis complex and its highly variable manifestations显示文摘 | Lendvay T S Marshall F F | 2003 | J Urol2003，169，5： | 1 |
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