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| 1 | Non-uniform distribution of gas-solid flow through six parallel cyclones in a CFB system: An experimental study显示文摘In large-scale circulating fluidized bed (CFB) boilers, it is common to use multiple cyclones in parallel for the capture of solids, assuming that gas-solid flow to be the same in the cyclones. This article presents a study investigating gas-solid flow through six parallel cyclones in a CFB cold test rig. The six cyclones were located asymmetrically on the left and right walls of the riser. Solid volume fraction and particle velocity profiles at the riser outlets and in the horizontal ducts were measured using a fiber optical probe. Cyclone pressure drop and solid circulating rate were measured for each individual cyclone. Measurements showed good agreement as to the non-uniform distribution of the gas-solid flow, which occurred mainly across the three cyclones on one side: the middle cyclones on both sides had higher particle velocities. Conversely, the solid volume fractions, solid fluxes and solid circulating rates of the middle cyclones were lower than those of the other four cyclones. The apparent reason for the flow non-uniformity among the cyclones is the significant flow non-uniformity at the riser outlets. Under typical operating conditions, the solid volume fractions at the riser outlets had a deviation of up to 26% whereas the solid circulating rates at the stand pipes, 7%. These results are consistent with most other studies in the literature. | Xinglong Zhou Leming Cheng Qinhui Wang Zhongyang Luo Kefa Cen | 2012 | Particuology2012，10，2： | 31 |
| 2 | Characterizing and annotating the genome using RNA-seq data显示文摘Bioinformatics methods for various RNA-seq data analyses are in fast evolution with the improvement of sequencing technologies. However, many challenges still exist in how to efficiently process the RNA-seq data to obtain accurate and comprehensive results. Here we reviewed the strategies for improving diverse transcriptomic studies and the annotation of genetic variants based on RNA-seq data. Mapping RNA-seq reads to the genome and transcriptome represent two distinct methods for quantifying the expression of genes/transcripts. Besides the known genes annotated in current databases, many novel genes/transcripts(especially those long noncoding RNAs) still can be identified on the reference genome using RNA-seq. Moreover, owing to the incompleteness of current reference genomes, some novel genes are missing from them. Genome-guided and de novo transcriptome reconstruction are two effective and complementary strategies for identifying those novel genes/transcripts on or beyond the reference genome. In addition, integrating the genes of distinct databases to conduct transcriptomics and genetics studies can improve the results of corresponding analyses. | Geng Chen Tieliu Shi Leming Shi | 2017 | Science China(Life Sciences)2017，60，2： | 22 |
| 3 | Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine显示文摘Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at present.The technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the data.The prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work alike.Bioinformatics is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized medicine.We review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers. | HONG HuiXiao ZHANG WenQian SHEN Jie SU ZhenQiang NING BaiTang HAN Tao PERKINS Roger SHI LeMing TONG WeiDa | 2013 | Science China(Life Sciences)2013，56，2： | 7 |
| 4 | A comprehensive CFD combustion model for supercritical CFB boilers显示文摘A combustion model of a large-scale supercritical circulati ng fluidized bed (CFB) boiler was developed for comprehensive computational-fluid-dynamics analysis. The model incorporates gas-solid hydrodynamics, coal combustion, heat transfer on heat exchange surfaces in the furnace, and heat transfer between fumace and working medium in the heat transfer tubes. In simulating the dense and dilute phases in the fumace, the gas-solid hydrodynamics is based on the Euler-Euler model and energy-minimization multiscale drag model. Coal combustion entails evaporation, devolatilization, char combustion, gas homoge neous reaction, and pollutant emission. The coefficient ofheat transfer between gas-solid and the waterwall is estimated using the cluster renewal model, and for radiation, the discrete ordinate model is used. Moreover, thermohydraulic processes in the membrane wall are also in eluded in the heat transfer process. The model was successfully applied in simulations of a 350-MW supercritical CFB boiler. Detailed distributions of solids concentration, oxygen, heat flux, and working medium temperature in the boiler furnace are presented. | Linjie Xu Leming Cheng JieqiangJi Qinhui Wang Mengxiang Fang | 2019 | Particuology2019，17，2： | 5 |
| 5 | mRNA enrichment protocols determine the quantification characteristics of external RNA spike-in controls in RNA-Seq studies显示文摘RNA-Seq promises to be used in clinical settings as a gene-expression profiling tool;however,questions about its variability and biases remain and need to be addressed.Thus,RNA controls with known concentrations and sequence identities originally developed by the External RNA Control Consortium(ERCC) for microarray and qPCR platforms have recently been proposed for RNA-Seq platforms,but only with a limited number of samples.In this study,we report our analysis of RNA-Seq data from 92 ERCC controls spiked in a diverse collection of 447 RNA samples from eight ongoing studies involving five species(human,rat,mouse,chicken,and Schistosoma japonicum) and two mRNA enrichment protocols,i.e.,poly(A) and RiboZero.The entire collection of datasets consisted of 15650143175 short sequence reads,131603796(i.e.,0.84%) of which were mapped to the 92 ERCC references.The overall ERCC mapping ratio of 0.84% is close to the expected value of 1.0% when assuming a 2.0% mRNA fraction in total RNA,but showed a difference of 2.8-fold across studies and 4.3-fold among samples from the same study with one tissue type.This level of fluctuation may prevent the ERCC controls from being used for cross-sample normalization in RNA-Seq.Furthermore,we observed striking biases of quantification between poly(A) and RiboZero which are transcript-specific.For example,ERCC-00116 showed a 7.3-fold under-enrichment in poly(A) compared to RiboZero.Extra care is needed in integrative analysis of multiple datasets and technical artifacts of protocol differences should not be taken as true biological findings. | QING Tao YU Ying DU TingTing SHI LeMing | 2013 | Science China(Life Sciences)2013，56，2： | 4 |
| 6 | Predictions of NOx/N2O emissions from an ultra-supercritical CFB boiler using a 2-D comprehensive CFD combustion model显示文摘NOx and N2O emissions from an ultra-supercritical circulating fluidized bed(CFB)boiler were predicted using a two dimensional(2-D)comprehensive computational fluid dynamics(CFD)combustion model.This model was developed from a three dimensional model for a supercritical CFB boiler previously constructed by our group.Based on an analysis of the NOx and N2O conversion processes in a CFB boiler,the primary formation and destruction reactions were introduced into the 2-D model and coupled.The resulting model was validated using data from the Baima 600 MW supercritical CFB boiler,and then applied to a 660 MW ultra-supercritical CFB boiler.The effects of excess air,the secondary air(SA)to(primary air(PA)plus SA)ratio and the SA injection height on NOx and N2O emissions were investigated.The results show that a higher excess air volume increases both NOx and N2O emissions,while increasing the SA/(PA+SA)ratio somewhat reduces both the NOx and N2O concentrations.On the basis of the results of this work,optimal locations for SA injection ports so as to lower NOx and N2O emissions are recommended. | Jieqiang Ji Leming Cheng Yangjun Wei Junfeng Wang Xinyu Gao Mengxiang Fang Qinhui Wang | 2020 | Particuology2020，18，2： | 4 |
| 7 | Studies on abacavir-induced hypersensitivity reaction:a successful example of translation of pharmacogenetics to personalized medicine显示文摘Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy. | GUO YongLi SHI LeMing HONG HuiXiao SU ZhenQiang FUSCOE James NING BaiTang | 2013 | Science China(Life Sciences)2013，56，2： | 3 |
| 8 | Anti-wear beam effects on gas-solid hydrodynamics in a circulating fluidized bed显示文摘Anti-wear beams installed on water walls of circulating fluidized bed(CFB) boilers are one of the most effective ways to protect against water-wall erosion.Beam effects from,for example,beam size and superficial gas velocity were investigated on gas-solid hydrodynamics in a CFB test rig using CFD simulations and experimental methods.The downward flow of the wall layer solids is observed to be disrupted by the beam but is then restored some distance further downstream.When falling solids from the wall layer hit the anti-wear beam,the velocity of the falling solids decreases rapidly.A fraction of the solids accumulates on the beam.Below the beams,the falling solids have reduced velocities but upward-moving solids were observed on the wall.The effect of the beam increases with width and superficial gas velocity.Wear occurs mainly above the beam and its variation with width is different above to below the beam.There is an optimum width that,when combined with beam height,results in less erosion. | Yunfei Xia Leming Cheng Chunjiang Yu Linjie Xu Qinhui Wang Mengxiang Fang | 2015 | Particuology2015，13，2： | 3 |
| 9 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 10 | Thin-layer chromatography of mycotoxins and comparison with other chromatographic methods显示文摘 | Leming Lin Jun Zhang Ping Wang Yuesong Wang Jiping Chen | 1998 | Journal of Chromatography A1998，，1： | 3 |
| 11 | The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability:A mini-review显示文摘Oral administration has been widely regarded as the most conve nient,quick and safe approach compared to other routes of drug delivery.However,oral absorption of drugs is often limited due to rigorous environments and complex obstacles in gastrointestinal tract.Having received considerable attention,biomacromolecules have been applied for oral drug delivery to improve the bioavailability,which could be attributed to its stability and unique bioactivities,including intestinal adhesion,opening of epithelial tight junctions,inhibiting cell efflux and regulating relative protein expression.Specifically,enhancing intestinal permeability has been regarded as a promising strategy for improving bioavailability of oral drug delivery.In this review,a series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated.In addition,recent advances in biomacromolecules based oral delivery and related future directions are mentioned and predicted in this review article. | Min Sun Hankun Hu Leming Sun Zhen Fan | 2020 | Chinese Chemical Letters2020，31，7： | 3 |
| 12 | Papillary fistulotomy vs conventional cannulation for endoscopic biliary access:A prospective randomized trial显示文摘AIM To compare the cannulation success, biochemical profile, and complications of the papillary fistulotomy technique vs catheter and guidewire standard access.METHODS From July 2010 to May 2017, patients were prospectively randomized into two groups: Cannulation with a catheter and guidewire(Group Ⅰ) and papillary fistulotomy(Group Ⅱ). Amylase, lipase and C-reactive protein at T0, as well as 12 h and 24 h after endoscopic retrograde cholangiopancreatography, and complications(pancreatitis, bleeding, perforation) were recorded.RESULTS We included 102 patients(66 females and 36 males, mean age 59.11 ± 18.7 years). Group Ⅰ and Group Ⅱ had 51 patients each. The successful cannulation rates were 76.5% and 100%, respectively(P = 0.0002). Twelve patients(23.5%) in Group Ⅰ had a difficult cannulation and underwent fistulotomy, which led to successful secondary biliary access(Failure Group). The complication rate was 13.7%(2 perforations and 5 mild pancreatitis) vs 2.0%(1 patient with perforation and pancreatitis) in Groups Ⅰ and Ⅱ, respectively(P = 0.0597). CONCLUSION Papillary fistulotomy was more effective than guidewire cannulation, and it was associated with a lower profile of amylase and lipase. Complications were similar in both groups. | Carlos Kiyoshi Furuya Paulo Sakai Fabio Ramalho Tavares Marinho Jose Pinhata Otoch Spencer Cheng Lívia Lemes Prudencio Eduardo Guimaraes Hourneaux de Moura Everson Luiz de Almeida Artifon | 2018 | World Journal of Gastroenterology2018，24，16： | 2 |
| 13 | Preparation and characterization of amorphous silica nanowires from natural chrysotile显示文摘 | Kun Liu Qiming Feng Yanxia Yang Guofan Zhang Leming Ou Yiping Lu | 2007 | Journal of Non-Crystalline Solids2007，，16： | 2 |
| 14 | Study on washability of microcrystal graphite using float-sink tests显示文摘This article presented an experimental research on washability of microcrystal graphite using float-sink tests.Chemical and X-ray analyses showed that graphite,semi-graphite,meta-anthracite,and anthracite existed together in this microcrystal graphite sample;and the intergrowth relationship between microcrystal graphite and gangues was very complicated based on optical mineralogy research.The results of float-sink tests revealed that:for the-25+0.5 mm size fraction,about 68%(by weight)of microcrystal graphite was obtained at the density of 2.0 g/cm^3.and the float product met the standard of commercial grade W65;for the-0.5 mm size fraction,58%(by weight)of microcrystal graphite was floated at the density of 2.0 g/cm^3,which met the standard of commercial grade W70.It can be concluded that microcrystal graphite may be upgraded by dense media separation(DMS)providing a float product using as the raw materials of casting or refractories. | Li Hongqiang Feng Qiming Ou Leming Long Sisi Cui Mengmeng Weng Xiaoqing | 2013 | International Journal of Mining Science and Technology2013，23，6： | 2 |
| 15 | Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications显示文摘Peptide self-assembled nanomaterials have attracted more and more attention due to their wide applications such as drug delive ry,cell imaging,and real-time drug monitoring.However,the application of the peptide is still limited by its inherent optical properties.Here we proposed and prepared a series of fluorescent tripeptide nanoparticles(TPNPs)through π-π stacking and zinc coordination.The experimental results show that the nanoparticles(TPNPs1)formed by the self-assembly of the tripeptide tryptophan-tryptophan-tryptophan have the highest fluorescence intensity,uniform and appropriate size,and low cytotoxicity.Furthermore,there was fluorescence resonance between TPNPs1 and doxorubicin,which has been successfully applied for real-time cell imaging and drug release monitoring. | Dongjie Fu Dingchang Liu Lianbing Zhang Leming Sun | 2020 | Chinese Chemical Letters2020，31，12： | 2 |
| 16 | Schwann cellss for spinal cord repair显示文摘 | Oudega M Moon LD de Almeida Leme RJ | | 0，，06： | 1 |
| 17 | A parallel iterative procedure applicable to the approximate solution of second order partial differential equations by mixed finite dement methods显示文摘 | DOUGLAS J J PAES- LEME P J ROBERTS J E WANG J | 1993 | Numer Math1993，65，： | 1 |
| 18 | Use of small doses of furosemide in chronic kidney disease patients with residual re- nal function undergoing hemodialysis 显示文摘 | Lemes H P Araujo S Nascimento D | 2011 | Clin Exp Nephrol2011，15，4： | 1 |
| 19 | First report of porcine teschovirus(PTV),porcine sapelovirus(PSV)and enterovirus G(EV-G)in pig herds of Brazil显示文摘 | DONIN D G DE ARRUDA LEME R ALFIERI A F | 2014 | Trop Anim Health Prod2014，46，3： | 1 |
| 20 | Expansion of Cylindrical Probes in Cohesive Soils显示文摘 | Baguelin F Jezequel J F Lemee E | 1972 | Journal of the Soil Mechanics and Foundations Division ASCE1972，98，： | 1 |
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