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| 1 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 2 | Mechanisms of Traditional Chinese Medicine Bushenantai granules(补肾安胎颗粒) in promoting angiogenesis at the maternal-fetal interface of recurrent spontaneous abortion mice显示文摘OBJECTIVE:To assess the effects of Bushenantai(BSAT)granule(补肾安胎颗粒)on angiogenesis-related factors[E2,P,and vascular endothelial growth factor(VEGF)]at the maternal-fetal interface of recurrent spontaneous abortion(RSA)mice,and to evaluate the role of BSAT in promoting angiogenesis at the maternal-fetal interface by influencing the expression of sex hormones,and VEGF.METHODS:A mouse model with normal pregnancy and another with Clark’s classic RSA were established.The RSA mice were randomly assigned to six groups:normal,model,progesterone,high-doseBSAT granule(BSAT-H),medium-dose-BSAT granule(BSAT-M),and low-dose-BSAT granule(BSAT-L)(n=10 for each group).The embryo loss rate and the histopathological changes in the decidual tissues were measured.Serum levels of estrogen(E2),progesterone(P),and VEGF were detected by enzyme-linked immunosorbent assay.The m RNA and protein expressions of estradiol receptor(ER),progesterone receptor(PR),VEGF,and vascular endothelial growth factor receptor 2(VEGFR2)in the decidual tissues were identified by immunohistochemistry,Western blotting,and quantitative reverse transcription polymerase chain reaction.RESULTS:The embryo loss rate in all groups that received BSAT treatment was reduced,while the number of blood vessels at decidual tissues was increased.The serum levels of E2,P and VEGF were elevated,and the m RNA and protein expressions of ER,PR,VEGF,and VEGFR2 in the decidual tissues were enhanced.CONCLUSION:BSAT can improve angiogenesis at the maternal-fetal interface and reduce the embryo loss rate,which may be associated with its ability to increase the serum levels of estrogen,progesterone,and VEGF,in addition to up-regulation of m RNA and protein expression of ER,PR,VEGF,and VEGFR2 in the decidual tissues. | LI Yuanqi LI Weili YU Xinhui WU Hua WANG Yuanzhong JIN Ya HAO Lele LIU Mingmin SONG Xiaoge | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 3 | Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy显示文摘Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment. | Wenjun Zhu Qian Chen Qiutong Jin Yu Chao Lele Sun Xiao Han Jun Xu Longlong Tian Jinglei Zhang Teng Liu Zhuang Liu | 2021 | Nano Research2021，14，1： | 3 |
| 4 | Angel: a new large-scale machine learning system显示文摘Machine Learning(ML) techniques now are ubiquitous tools to extract structural information from data collections. With the increasing volume of data, large-scale ML applications require an efficient implementation to accelerate the performance. Existing systems parallelize algorithms through either data parallelism or model parallelism. But data parallelism cannot obtain good statistical efficiency due to the conflicting updates to parameters while the performance is damaged by global barriers in model parallel methods. In this paper, we propose a new system, named Angel, to facilitate the development of large-scale ML applications in production environment. By allowing concurrent updates to model across different groups and scheduling the updates in each group, Angel can achieve a good balance between hardware efficiency and statistical efficiency. Besides, Angel reduces the network latency by overlapping the parameter pulling and update computing and also utilizes the sparseness of data to avoid the pulling of unnecessary parameters. We also enhance the usability of Angel by providing a set of efficient tools to integrate with application pipelines and provisioning efficient fault tolerance mechanisms. We conduct extensive experiments to demonstrate the superiority of Angel. | Jie Jiang Lele Yu Jiawei Jiang Yuhong Liu Bin Cui | 2018 | National Science Review2018，5，2： | 3 |
| 5 | Small molecular glasses based on multiposition encapsulated phenyl benzimidazole iridium(iii) complexes:Toward efficient solution-processable host-free electrophosphorescent diodes显示文摘 | XU Hui YU Donghui LIU Lele | 2010 | Journal of Physical Chemistry B2010，114，1： | 1 |
| 6 | Rhizopus chinensis lipase: gene cloning, expression in Pichia pastoris and properties显示文摘 | YU Xiaowei WANG Lele XU Yah | 2009 | Journal of Molecular Catalysis B: Enzymatic2009，57，14： | 1 |
| 7 | A reversible Br2/Br-redox couple in the aqueous phase as a high-performance catholyte for alkali-ion batteries显示文摘 | Zhao Yu Ding Yu Song Jie Peng Lele Goodenough John B Yu Guihua | 2014 | Energy&Environmental Science2014，7，6： | 1 |
| 8 | A Novel Magnetic Carbon Based Catalyst Synthesized from Reed Straw and Electric Furnace Dust for Biodiesel Production显示文摘In the era of serious greenhouse gas emission and energy shortage,it is necessary to use solid waste to prepare new renewable materials.In this work,the potential application of reed straw and electric furnace dust was explored.Firstly,magnetic carbon carrier(EFD&C)was prepared by high temperature calcination,and then magnetic carbon catalyst(SM@EFD&C)was prepared by activation of sodium methoxide.The catalyst was used to prepare biodiesel by transesterification reaction to test its activity and stability.Reed biochar,EFD&C and SM@EFD&C were detected by Diffraction of X-rays(XRD),Fourier transform infrared(FT-IR),Inductively coupled plasma(ICP),Scanning electron microscope(SEM),Transmission electron microscope(TEM),Brunauer-Emmett-Teller(BET),Vibrating sample magnetometer(VSM),Temperature programmed desorption of CO_(2)(CO_(2)-TPD)and Thermogravimetric analysis(TG-DTG).The results showed that SM@EFD&C catalyst had some characteristics including porous structure,easy adsorption and better magnetism.Under the reaction conditions of 65℃for 2 h with 6 wt%catalyst and methanol/oil molar ratio of 15:1,the biodiesel yields from reed biochar and EFD&C were only 4.88 wt%and 0.03 wt%,respectively,while the yield from SM@EFD&C catalyst reached 93.14 wt%(89.84 wt%after 7 cycles)under the same conditions,which proved that it had good catalytic activity and stability when used in biodiesel production.This study is of great significance of carbon dioxide emission reduction and environmental protection. | Fuping Wang Lele Kang Rui Ji Tianji Liu Qing Yu Di Gao Xiaoman Wang Yitong Wang Jie Yang | 2022 | Journal of Renewable Materials2022，10，8： | 1 |
| 9 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 10 | Preparation of immobilized glucose oxidase and its application in improving breadmaking quality of commercial wheat flour显示文摘 | Lele Tang Ruijin Yang Xiao Hua Chaohua Yu Wenbin Zhang Wei Zhao | 2014 | Food Chemistry2014，，： | 1 |
| 11 | Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy显示文摘As a promising modality for cancer therapy, photodynamic therapy(PDT) still acquired limited success in clinical nowadays due to the extremely serious hypoxia and immunosuppression tumor microenvironment. To ameliorate such a situation, we rationally designed and prepared cascade two-stage re-oxygenation and immune re-sensitization BSA-MHI148@SRF nanoparticles via hydrophilic and hydrophobic self-assembly strategy by using near-infrared photodynamic dye MHI148 chemically modified bovine serum albumin(BSA-MHI148) and multi-kinase inhibitor Sorafenib(SRF) as a novel tumor oxygen and immune microenvironment regulation drug. Benefiting from the accumulation of SRF in tumors, BSA-MHI148@SRF nanoparticles dramatically enhanced the PDT efficacy by promoting cascade two-stage tumor re-oxygenation mechanisms:(i) SRF decreased tumor oxygen consumption via inhibiting mitochondria respiratory.(ii) SRF increased the oxygen supply via inducing tumor vessel normalization. Meanwhile, the immunosuppression micro-environment was also obviously reversed by two-stage immune re-sensitization as follows:(i) Enhanced immunogenic cell death(ICD) production amplified by BSA-MHI148@SRF induced reactive oxygen species(ROS) generation enhanced T cell infiltration and improve its tumor cell killing ability.(ii) BSA-MHI148@SRF amplified tumor vessel normalization by VEGF inhibition also obviously reversed the tumor immune-suppression microenvironment. Finally, the growth of solid tumors was significantly depressed by such well-designed BSAMHI148@SRF nanoparticles, which could be potential for clinical cancer therapy. | Zaigang Zhou Jiashe Chen Yu Liu Chunjuan Zheng Wenjuan Luo Lele Chen Shen Zhou Zhiming Li Jianliang Shen | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 0 |
| 12 | Metal oxide ion gated transistors based sensors显示文摘Metal oxide ion-gated transistors(MOIGTs)have garnered significant attention within the sensing domain due to their potential for achieving heightened sensitivity while consuming minimal energy across diverse scenarios.By harnessing the advantageous combination of metal oxides'high carrier mobility and facile surface customization,coupled with the potent signal amplification capabilities of ion-gated transistors,MOIGTs offer a promising avenue for discerning biomolecules,overseeing chemical reactions,p H levels,as well as facilitating gas or light determination.Over the past few decades,the MOIGT field has made remarkable strides in refining device physics,enhancing material properties,showcasing robust sensing capabilities,and broadening its application spectrum.These advancements have simultaneously unveiled new challenges and opportunities,necessitating interdisciplinary expertise to fully unlock the commercial potential of MOIGTs.In this comprehensive review,we offer a snapshot of this swiftly evolving technology,delve into its current applications,and provide insightful recommendations for future directions in the coming decade. | LI Yang YAO Yu WANG LeLe WANG LiWei PANG YunCong LUO ZhongZhong ARUNPRABAHARAN Subramanian LIU ShuJuan ZHAO Qiang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 13 | Author correction to“Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy”[Acta Pharm Sin B(2022)4204-4223]显示文摘The authors regret that there are errors in the article Fig.8A and Fig.S22A due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.Although it does not affect the conclusion,these are obvious errors.The authors have now modified as below.The original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.The authors apologize for any inconvenience caused to the journal and readers. | Zaigang Zhou Jiashe Chen Yu Liu Chunjuan Zheng Wenjuan Luo Lele Chen Shen Zhou Zhiming Li Jianliang Shen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 14 | Prelithiation strategies for silicon-based anode in high energy density lithium-ion battery显示文摘Green energy storage devices play vital roles in reducing fossil fuel emissions and achieving carbon neutrality by 2050.Growing markets for portable electronics and electric vehicles create tremendous demand for advanced lithium-ion batteries(LIBs)with high power and energy density,and novel electrode material with high capacity and energy density is one of the keys to next-generation LIBs.Silicon-based materials,with high specific capacity,abundant natural resources,high-level safety and environmental friendliness,are quite promising alternative anode materials.However,significant volume expansion and redundant side reactions with electrolytes lead to active lithium loss and decreased coulombic efficiency(CE)of silicon-based material,which hinders the commercial application of silicon-based anode.Prelithiation,preembedding extra lithium ions in the electrodes,is a promising approach to replenish the lithium loss during cycling.Recent progress on prelithiation strategies for silicon-based anode,including electrochemical method,chemical method,direct contact method,and active material method,and their practical potentials are reviewed and prospected here.The development of advanced Si-based material and prelithiation technologies is expected to provide promising approaches for the large-scale application of silicon-based materials. | Tianqi Jia Geng Zhong Yao Lv Nanrui Li Yanru Liu Xiaoliang Yu Jinshuo Zou Zhen Chen Lele Peng Feiyu Kang Yidan Cao | 2023 | Green Energy & Environment2023，8，5： | 0 |
| 15 | VG,encoding a thylakoid formation protein,regulates the formation of variegated leaves in tomato显示文摘Leaf-color mutations have been studied extensively in plants.However,to better understand the complex mechanisms underlying the formation of leaf color,it is essential to continue discover novel genes involved in the process of leaf color development.In this study,we identified a variegated-leaf(vg)mutant in tomato that exhibited defective phenotypes in thylakoids and photosynthesis.To clone the vg locus,an F2population was constructed from the cross between the vg mutant(Solanum lycopersicum)and the wild tomato LA1589(S.pimpinellifolium).Using the map-based cloning approach,the vg locus was mapped on chromosome 7 and narrowed down to a 128 kb region that contained 21 open reading frames(ORFs).The expression levels of ORF9,ORF10,and ORF13 were significantly lower in vg than in the wild-type plants,while the ORF11 transcript level was elevated in vg.We then mutagenized ORF9,ORF10,and ORF13 by the CRISPR/Cas9 system in the wild-type tomato background and found that only the ORF10 mutation reproduced the phenotype of variegated leaves,indicating that ORF10 represents VG and its down-regulated expression was responsible for the variegated leaf phenotype.ORF10 encodes a thylakoid formation protein and its mutant lines showed reduced levels of chlorophyll synthesis and photosynthesis.Taken together,these results suggest that VG is necessary for chloroplast development,chlorophyll synthesis,and photosynthesis in tomato. | Jianwen Song Lijie Guo Lele Shang Wenqian Wang Chuying Yu Zhibiao Ye Junhong Zhang | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
| 16 | Static strength and crashworthiness analysis of a train cowcatcher at a running speed of 160 km/h显示文摘The cowcatcher is one of the unique devices at the front end of the train, which can remove obstacles on the track by crashing before the vehicle body to ensure the safety of the train. When a collision accident happens, the cowcatcher serves as the first energy-absorbing structure to dissipate and guide the collision energy. The design of the existing cowcatcher of multiple units generally focuses on the good ability to remove obstacles, while the secondary function, the crashworthiness of orderly deformation under collision, still needs further research. In this study, a finite element model of structural static load and collision analysis was established under standard EN 15227, with the cowcatcher for 160 km/h train as the prototype. Then the solution and simulation process was accomplished under the environment of ANSYS and LS-DYNA. The analysis results showed that the structural static strength of the current cowcatcher met the requirements of the standard EN 15227, and the longitudinal stiffness was evenly distributed. When removing the obstacles with low mass, the impact force was small and the structure would not produce obvious deformation;when removing the obstacles with large mass, the impact force was large and the shear fracture might occur at the connection of the cowcatcher. | Yanzhao Guo Lele Zhang Weiyuan Dou Yu Zhu Haifeng Zhang | 2023 | High-Speed Railway2023，1，4： | 0 |
| 17 | Chondroitin Polymerizing Factor (CHPF) promotes cell proliferation and tumor growth in human osteosarcoma by inhibiting SKP2's ubiquitination while activating the AKT pathway显示文摘Osteosarcoma is a common malignant tumor occurring in children and young adults. Chondroitin sulfate (CS) participates in cell adhesion, cell division, and the formation of neural networks in the body, the biosynthesis of which requires the participation of glycosyltransferases. CHPF, a glycosyltransferase, plays a role in the extension of CS. Recently, CHPF's biological roles and functional importance in human diseases including malignant tumors have been widely discussed. However, whether CHPF is involved in osteosarcoma development and growth has not been revealed. The present work aimed to investigate the expression levels, functional significance and molecular mechanism of CHPF in osteosarcoma progression. Our results revealed that CHPF is strongly expressed in osteosarcoma tissues and cells. Furthermore, CHPF serves as a tumor promoter in the development and progression of osteosarcoma through enhancing cell proliferation and migration while suppressing apoptosis. Exploration of the mechanism by which CHPF promotes osteosarcoma indicated that CHPF promotes osteosarcoma through counteracting SKP2's ubiquitination and activating the Akt signaling pathway. For the first time, we clarified the roles of CHPF in osteosarcoma, and our results suggested that CHPF might be a novel therapeutic target in the treatment strategies for osteosarcoma. | Yi Shen Jun Li Dan Peng Lele Liao Xia Chen Weiye Zhong Zicheng Liu Chao Yu Yuanliang Sun | 2023 | Genes & Diseases2023，10，5： | 0 |
| 18 | Genome Wide Characterization of CBL-CIPK Family Genes and Their Responsive Expression in Rosa chinensis显示文摘Calcium(Ca^(2+))plays a pivotal role in various signal transduction pathways.Calcineurin B-like proteins(CBLs)are a unique group of Ca^(2+)sensors that decode Ca^(2+)signals by activating the plant specific protein kinase known as the CBL-interacting protein kinase(CIPK).In plants,the CBL-CIPK signaling network regulates multiple signals in response to different extracellular cues including abiotic stress.However,the genome wide annotation and expression patterns of CBLs and CIPKs in woody cutting flower plants are still unclear.In this study,a total number of 7 CBLs(RcCBLs)and 17 CIPKs(RcCIPKs)genes,divided into four and five subfamilies,respectively,were identified from the rose genome.All RcCBLs possess a classic elongation factor-hand(EF-hand)domain,while all RcCIPKs possess both the classic kinase and NAF domains.Most RcCBLs were predicted to be plasma membrane localized,whereas most RcCIPKs were predicted to be cytoplasmic localized.Synteny analysis showed that one RcCBL gene pair and five RcCIPK gene pairs have gone through whole genome duplication events.Promoter cis-element prediction assays indicated that RcCBLs and RcCIPKs could function in different abiotic stress responses in rose plants.Further quantitative real-time PCR analysis demonstrated that RcCBLs and RcCIPKs were expressed in different organs with overlapped but distinct patterns in response to various abiotic stresses.The findings in this work will provide fundamental information and gene resources for further functional research on RcCBLs and RcCIPKs. | Lunzeng Huang Hongsheng Gao Ning Jiang Yunhong Xu Zijian Gong Lele Chen Shijie Xue Xiaoyan Li Ruichao Liu Bei Li Hongxia Zhang Chunyan Yu Xiaotong Guo | 2023 | Phyton-International Journal of Experimental Botany2023，92，2： | 0 |
| 19 | An AND-Gate DNA Nanodevice for Dual Protein-Mediated,Tumor-Specific Imaging显示文摘Sensitive and specific imaging of tumor-associated biomarkers offers an effective way for cancer diagnosis.However,most of the reported imaging probes are limited to the targeting of a single biomarker,which may impair imaging precision.Here,we report an aptamer-based,AND-gate DNA nanodevice that relies on the sequential processing of two tumor-associated proteins to produce a specific fluorescent signal for precise tumor imaging.The DNA nanodevice integrates an AS1411 aptamer to bind cell surface nucleolin for tumor targeting and a DNA sensor to respond to intracellular apurinic/apyrimidinic endonuclease 1 for activatable imaging.We evaluated the performance of the system in both living cells and a tumor-bearing mouse model,and demonstrated its capability in tumor cell-specific imaging.We anticipate that this strategy will accelerate the design of multivariate protein-stimulated probes for tumor diagnosis. | Zetan Fan Fangzhi Yu Mingming Yu Lele Li | 2023 | Chinese Journal of Chemistry2023，41，12： | 0 |
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