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| 1 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 2 | Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 after liver transplant显示文摘 | Surakit Pungpapong Bashar Aqel Michael Leise K. Tuesday Werner Jennifer L. Murphy Tanisha M. Henry Kristen Ryland Amy E. Chervenak Kymberly D. Watt Hugo E. Vargas Andrew P. Keaveny | 2015 | Hepatology2015，，6： | 2 |
| 3 | Advanced lithium batteries for implantable medical devices:mechanistic study of SVO cathode synthesis显示文摘 | Takeuchi K J Leising R A Palazzo M J | 2003 | Journal of Power Sources2003，119，121： | 1 |
| 4 | The costs and benefits of sulphur reduction measures:Sulphur scrubbers versus marine gas oil显示文摘 | Jiang Liping Kronbak Jacob Christensen Leise Pil | 2014 | Transportation Research Part D:Transport and Environment2014，28，： | 1 |
| 5 | Photogeneration and recombination processes of neutral and charged excitations in films of a ladder-type poly (para- phenylene)显示文摘 | WOHLGENANNT M GRAUPNER W LEISING G | 1999 | Physical Review B1999，60，8： | 1 |
| 6 | Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy显示文摘 | Thomas J. Borody Eloise F. Warren Sharyn Leis Rosa Surace Ori Ashman | 2003 | Journal of Clinical Gastroenterology2003，，1： | 1 |
| 7 | Abuse Testing of Lithium-Ion Batteries Characterization of the Overcharge Reaction of LiCoO2-Graphite Cells显示文摘 | Leising R A Palazzo M J Takeuchi E S | 2001 | J Electrochem Soc2001，148，8： | 1 |
| 8 | Sensory environments,larval abilities and local self-recruitment显示文摘 | Kingsford M J Leis JM Shanks A | | 0，，： | 1 |
| 9 | Bone-resorbing activity of thyroid hormones is related to prostaglandin production in cultured neonatal mouse calvaria显示文摘 | Klaushofer K Hoffmann O Gleispach H Leis HJ Czerwenka E Koller K Peterlik M | | 0，，： | 1 |
| 10 | Application of two different ICP-hydride techniques to the determination of arsenic显示文摘 | J. A. C. Broekaert F. Leis | 1980 | Fresenius’ Zeitschrift für Analytische Chemie1980，，1： | 1 |
| 11 | Bending modified J–Q theory and crack-tip constraint quantification显示文摘 | Xian-Kui Zhu Brian N. Leis | 2006 | International Journal of Fracture (-)2006，，1： | 1 |
| 12 | Batteries, 1997 to 2002 显示文摘 | Brodd R J Bullock K R Leising R A | 2004 | J Electrochem Soc2004，151，3： | 1 |
| 13 | Blue electroluminescence with ladder-type poly(para-phenylene) and para-hexaphenyl显示文摘 | Leising G Tasch S Meghdadi F | 1996 | Synthetic Metals1996，81，23： | 1 |
| 14 | Batteries, 1977 to 2002 显示文摘 | BRODD R J BULLOCK K R LEISING R A | 2004 | Journal of the Electrochemical Society2004，151，3： | 1 |
| 15 | Glial S100B is elevated in serum across the spectrum of West Nile virus infection显示文摘 | Leis AA Stokic DS Petzold A | | 0，，06： | 1 |
| 16 | Biological and physical attenuation of endocrine disruptors and pharmaceuticals: Implications for water reuse显示文摘 | Snyder S A Leising J Westerhoff P | 2004 | Ground Water Monitoring and Remediation2004，24，2： | 1 |
| 17 | Drug-induced liver injury显示文摘 | Leise MD Poterucha JJ Talwalkar JA | 2014 | Mayo Clin Proc2014，89，1： | 1 |
| 18 | Solid-state characterization of reduced silver vanadium oxide from the Li/SVO discharge reaction 显示文摘 | Leising R A Thiebolt W C Takeuchi E S | 1994 | Inorganic Chemistry1994，33，25： | 1 |
| 19 | Palazzo, amy e marsehilok, esther sans takeuehi显示文摘 | TAKEUCHI K J LEISING R A MARCUS J | 2003 | Journal of Power Sources2003，，： | 1 |
| 20 | Influence of xrays and quinacrine (atebrine) or chloroquine (resochine) -alone or in combination--on growth and melanin formation of Harding-Passey melanoma cells in monolayer cuhur 显示文摘 | Biller H Schachtschabel DO Leising HB | 1982 | Strahlentherapie1982，158，： | 1 |
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