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| 1 | Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer显示文摘Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of France.Methods The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was included.Nutritional status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and BC.Results In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies. | Vittoria Balzano Véronique Dardaine Giraud Carine Sauger Carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg | 2020 | Journal of Nutritional Oncology2020，5，4： | 2 |
| 2 | The capsanthin-capsorubin synthase gene: a candidate gene for the y locus controlling the red fruit colour in pepper显示文摘 | Véronique Lefebvre Marcel Kuntz Bilal Camara Alain Palloix | 1998 | Plant Molecular Biology1998，，5： | 2 |
| 3 | Potent inhibition of the master chondrogenic factor Sox9 gene by inteleukin-1 and t umor necrosis factor alpha显示文摘 | Murakami S Lefebvre V de Crombrugge B | 2000 | Biol Chem2000，275，5： | 1 |
| 4 | Parallel ex- pression of SOX9 and Col2a1 in cells undergoing ehon- drogenesis显示文摘 | Zhao Q Eberspaeeher H Lefebvre V | 1997 | Dev Dyn1997，209，4： | 1 |
| 5 | Evaluation of genetic distances between pepper inbred lines for cultivar protection purposes:comparison of AFLP,RAPD and Phenotypic data显示文摘 | Lefebvre V Goffinet B Chauvet J C | 2001 | Theoretical and Applied Genetics2001，，05： | 1 |
| 6 | Electron accelera- tion by a wake field forced by an intense ultrashort laser pulse 显示文摘 | MALKA V FRITZLER S LEFEBVRE E | 2002 | Science2002，298，5598： | 1 |
| 7 | Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis显示文摘 | Zhao Q Eberspaecher H Lefebvre V | 1997 | Dev Dyn1997，209，： | 1 |
| 8 | Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells显示文摘Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 cells.Recently,the roles of Sox(SRY-related high-mobility-group(HMG)-box)family members in various immune responses have been investigated.However,the roles of Sox12,a member of the SoxC group,in Th2 cell differentiation and allergic airway inflammation,remain unknown.We showed that Sox12 mRNA was significantly increased during Th2 cell differentiation.In vivo,HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12−/−mice compared with those in control Sox12+/−mice.In vitro,Sox12−/−CD4^(+)T cells that were cultured under Th2 conditions had increased production of Th2 cytokines and GATA3 protein compared with those of control Sox12+/−CD4^(+)T cells.Importantly,forced expression of Sox12 decreased the protein levels of GATA3 in CD4^(+)T cells under Th2 conditions without affecting mRNA expression.Furthermore,Sox12 induced degradation of GATA3 through the proteasome pathway in CD4^(+)T cells.Consistently,Sox12 enhanced ubiquitination of GATA3,which was mediated by the E3 ligase Fbw7.Finally,we found that Fbw7 knockdown partly abrogated Sox12-mediated GATA3 suppression in CD4^(+)T cells.Taken together,these results suggest that Sox12 suppresses Th2 cell differentiation by accelerating Fbw7-mediated GATA3 degradation,and attenuates HDM-induced allergic inflammation. | Ken-Ichi Suehiro Akira Suto Kensuke Suga Hiroki Furuya Arifumi Iwata Taro Iwamoto Shigeru Tanaka Takahiro Kageyama Kotaro Suzuki Koichi Hirose Véronique Lefebvre Hiroshi Nakajima | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 9 | Preliminary experimental investigation of the pressure evolution in detonation cells显示文摘 | Hanana M Lefebvre M H Tiggelen P J V | 2000 | Experimental Thermal and Fluid Science2000，21，： | 1 |
| 10 | A new long form of SOX5 (L -SOXS), SOX6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type Ⅱ collagen gene显示文摘 | Lefebvre V Li P de Crombrugghe B | 1998 | EMBO J1998，17，： | 1 |
| 11 | Transcriptional control of chonfrocyte fate and differentiation显示文摘 | Lefebvre V Smits P | | 0，，03： | 1 |
| 12 | Disease resistance gene analogs as candidates for QTLs involved in pepper-pathogen interactions 显示文摘 | Flieger S P Lefebvre V Caranta C | 1999 | G enome1999，42，： | 1 |
| 13 | Electron accelera- tion by a wake field forced by an intense ultrashort laser pulse 显示文摘 | MALKA V FRITZLER S LEFEBVRE E | 2002 | Science2002，298，5598： | 1 |
| 14 | Sox5 and Sox6 are required for notochord extraeellular matrix sheath formation,notochord cell survival and development of the nucleus pulposus of intervertebral discs显示文摘 | Smits P Lefebvre V | 2003 | Development2003，130，6： | 1 |
| 15 | Parallel expression of Sox9 and Col2al in cells undergoing chondrogenesis 显示文摘 | ZHAO Q EBERsPAEcHER H LEFEBVRE V | 1997 | Dev Dyn1997，209，4： | 1 |
| 16 | Transient and har- monic eddy currents: lift-off point of intersection 显示文摘 | Mandache C Lefebvre J H V | 2006 | NDT&E International2006，39，7： | 1 |
| 17 | Phosphorylation of SOX9 by cyclic AMP- dependent protein kinase A enhances SOX9' s ability to transactivate a Col2al chondrocyte-specific enhancer 显示文摘 | HUANG W ZHOU X LEFEBVRE V | 2000 | Mol Cell Bio12000，20，11： | 1 |
| 18 | The capsanthin- gene: a candidate gene for the y locus fruit color in pepper显示文摘 | Lefebvre V Kuntz capsorubin synthase controlling the red Biology 1998 36: M Camara B et ol | 1998 | Plant Molecular1998，，： | 1 |
| 19 | Characterization of brevicin 27, a bacteriocin synthetized by LactobaciHus brevis SB27显示文摘 | Benoit V Mathis R Lefebvre G | 1994 | Curr Microbiol1994，28，1： | 1 |
| 20 | Toward understanding the functions of the two highly related SOX5 and SOX6 genes显示文摘 | Lefebvre V | 2002 | J Bone Miner Metab2002，20，： | 1 |
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