|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice显示文摘AIM: To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis (SBP) in clinical practice. METHODS: All SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear (PMN) cell count was > 250 cells/mm3, and empirically treated with cefotaxime. RESULTS: Thirty-eight SBP episodes occurred in 32 cirrhotics (22 men/10 women; mean age: 58.6 ± 11.2 years). Prevalence of SBP, in our population, was 17%. Ascitic fluid culture was positive in nine (24%) cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage (44%) similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime. CONCLUSION: In clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment andevaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with antibiotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated. | Stefania Angeloni Cinzia Leboffe Antonella Parente Mario Venditti Alessandra Giordano Manuela Merli Oliviero Riggio | 2008 | World Journal of Gastroenterology2008，14，17： | 42 |
| 2 | Accuracy of the automated cell counters for management of spontaneous bacterial peritonitis显示文摘AIM: To evaluate the accuracy of automated blood cell counters for ascitic polymorphonuclear (PMN) determination for: (1) diagnosis, (2) efficacy of the ongoing antibiotic therapy, and (3) resolution of spontaneous bacterial peritonitis (SBP). METHODS: One hundred and twelve ascitic fluid samples were collected from 52 consecutive cirrhotic patients, 16 of them with SBP. The agreement between the manual and the automated method for PMN count was assessed. The sensitivity/specificity and the positive/negative predictive value of the automated blood cell counter were also calculated by considering the manual method as the 'gold standard' . RESULTS: The mean ± SD of the difference between manual and automated measurements was 7.8 ± 58 cells/mm3, while the limits of agreement were +124 cells/mm3 [95% confidence interval (CI): +145 to +103] and -108 cells/mm3 (95% CI: -87 to -129). The automated cell counter had a sensitivity of 100% and a specificity of 97.7% in diagnosing SBP, and a sensitivity of 91% and a specificity of 100% for the efficacy of the ongoing antibiotic therapy. The two methods showed a complete agreement for the resolution of infection. CONCLUSION: Automated cell counters not only have a good diagnostic accuracy, but are also very effective in monitoring the antibiotic treatment in patients with SBP. Because of their quicker performance, they should replace the manual counting for PMN determination in the ascitic fluid of patients with SBP. | Oliviero Riggio Stefania Angeloni Antonella Parente Cinzia Leboffe Giorgio Pinto Teresa Aronne Manuela Merli | 2008 | World Journal of Gastroenterology2008，14，37： | 6 |
| 3 | Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘 | Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 4 | Occult vitamin D deficiency in postmenopausal US women with acute hip fracture显示文摘 | LeBoff M Kohlmeier L Hurwitz S | 1999 | JAMA1999，281，16： | 1 |
| 5 | Retinoic acid receptors:from molecular mechanisms to cancer therapy显示文摘 | di Masi A Leboffe L De Marinis E | 2015 | Mol Aspects Med2015，41，： | 1 |
| 6 | Clinician’s guide toprevention and treatment of osteoporosis 显示文摘 | Cosman F de Beur SJ Leboff MS | 2014 | Osteoporosis Int2014，，： | 1 |
| 7 | Dual-energy X-ray absorptiometry of the forearm:reproducibility and correlation with single-photon absorptiometry显示文摘 | Leboff MS Fuleihan GE Angell JE | 1992 | Journal of Bone & Mineral Research1992，7，7： | 1 |
| 8 | Clinician's guide to prevention and treatment of osteoporosis显示文摘 | Cosman F De Beur SJ Leboff MS | 2014 | Osteoporos Int2014，25，10： | 1 |
| 9 | Ac- tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies 显示文摘 | Ferrucci A Leboffe L Agamennone M | 2015 | Amino Acids2015，47，1： | 1 |
| 10 | AGA technical review on os- teoporosis in gastrointestinal diseases 显示文摘 | Bernstein CN Leslie WD Leboff MS | 2003 | Gastroenterology2003，124，4： | 1 |
| 11 | Physiological roles of ovotransferrin显示文摘 | Francesco G Leboffe L Giuseppina P | 2012 | Biochimica et Biophysica Acta(BBA)-General Subjects2012，1820，3： | 1 |
| 12 | Homocysteine levels and risk of hip fracture in postmenopausal women显示文摘 | Leboff MS Narweker R LaCroix A | 2009 | J Clin Endocrinol Metab2009，94，： | 1 |
| 13 | Underestimated fracture probability in patients with unilateral hip osteoarthritis as calculated by FRAX显示文摘 | Setty N Leboff MS Thornhill TS | | 0，，： | 1 |
| 14 | Clinician's guide to prevention and treatment of osteoporosis 显示文摘 | Cosman F de Beur SJ LeBoff MS | 2014 | Osteoporos lnt2014，25，： | 1 |
| 15 | Occult vita min D defficiency in postmenopausal US women with acute hip fracture 显示文摘 | LeBoff MS Kohlmeier L Hurwitz S | 1999 | JAMA1999，281，： | 1 |
| 16 | Clinician’s Guide to Prevention and Treatment of Osteoporosis显示文摘 | F. Cosman S. J. Beur M. S. LeBoff E. M. Lewiecki B. Tanner S. Randall R. Lindsay | 2014 | Osteoporosis International2014，，： | 1 |
| 17 | FRAX facts显示文摘 | Watts NB Ettinger B LeBoff MS | 2009 | J Bone Miner Res2009，24，6： | 1 |
| 18 | Clinician's guide to prevention and treatment of osteoporosis 显示文摘 | Cosman F de Beur SJ LeBoff MS | 2014 | Osteoporos Int2014，25，： | 1 |
| 19 | Physiological roles of ovotransferrin 显示文摘 | Francesco Giansanti Loris Leboffe Giuseppina Pitari | 2012 | Biochimica et Biophysica Acta2012，1820，： | 1 |
| 20 | Drug insight: Existing and emerging therapies for osteoporosis 显示文摘 | MULDER J E KOLATKAR N S LEBOFF M S | 2006 | Nat ClinPract Endocrinol Metab2006，2，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员