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| 1 | Nutritional support teams increase percutaneous endoscopic gastrostomy uptake in motor neuron disease显示文摘AIM:To examine factors influencing percutaneous endoscopic gastrostomy(PEG) uptake and outcomes in motor neuron disease(MND) in a tertiary care centre.METHODS:Case notes from all patients with a confirmed diagnosis of MND who had attended the clinic at the Repatriation General Hospital between January 2007 and January 2011 and who had since died,were audited.Data were extracted for demographics(age and gender),disease characteristics(date of onset,bulbar or peripheral predominance,complications),date and nature of discussion of gastrostomy insertion,nutritional status [weight measurements,body mass index(BMI)],date of gastrostomy insertion and subsequent progress(duration of survival) and quality of life(QoL) [Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised(ALSFRS-R)].In addition,the type of clinician initiating the discussion regarding gastrostomy was recorded as Nutritional Support Team(involved in providing nutrition input viz Gastroenterologist,Speech Pathologist,Dietitian) and other(involved in non-nutritional aspects of patient care).Factors affecting placement and outcomes including length of survival,change in weight and QoL were determined.RESULTS:Case records were available for all 86 patients(49 men,mean age at diagnosis 66.4 years).Thirty-eight patients had bulbar symptoms and 48 had peripheral disease as their presenting feature.Sixty-six patients reported dysphagia.Thirty-one patients had undergone gastrostomy insertion.The major indications for PEG placement were dysphagia and weight loss.Nine patients required immediate full feeding,whereas 17 patients initially used the gastrostomy to supplement oral intake,4 for medication administration and 1 for hydration.Initially the PEG regime met 73% ± 31% of the estimated total energy requirements,increasing to 87% ± 32% prior to death.There was stabilization of weight in patients undergoing gastrostomy [BMI at 3 mo(22.6 ± 2.2 kg/m 2) and 6 mo(22.5 ± 2.0 kg/m 2) after PEG placement compared to weight at the time of the procedure(22.5 ± 3.0 kg/m 2)].However,weight loss recurred in the terminal stages of the illness.There was a strong trend for longer survival from diagnosis among MND in PEG recipients with limb onset presentation compared to similar patients who did not undergo the procedure(P = 0.063).Initial discussions regarding PEG insertion occurred earlier after diagnosis when seen by nutrition support team(NST) clinicians compared to other clinicians.(5.4 ± 7.0 mo vs 11.9 ± 13.4 mo,P = 0.028).There was a significant increase in PEG uptake(56% vs 24%,P = 0.011) if PEG discussions were initiated by the NST staff compared to other clinicians.There was no change in the ALSFRS-R score in patients who underwent PEG(pre 34.1 ± 8.6 vs post 34.8 ± 7.4),although in non-PEG recipients there was a nonsignificant fall in this score(33.7 ± 7.9 vs 31.6 ± 8.8).Four patients died within one month of the procedure,4 developed bacterial site infection requiring antibiotics and 1 required endoscopic therapy for gastric bleeding.Less serious complications attributed to the procedure included persistent gastrostomy site discomfort,poor appetite,altered bowel function and bloating.CONCLUSION:Initial discussion with NST clinicians increases PEG uptake in MND.Gastrostomy stabilizes patient weight but weight loss recurs with advancing disease. | Lin Zhang Leanne Sanders Robert JL Fraser | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 2 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 6 |
| 3 | 氧化硅去除微囊藻毒素显示文摘考察了氧化硅对微囊藻毒素—LR (Microcystin LR ,MLR)和—LA (Microcystin LA ,MLA)的等温吸附行为 ,并通过微观结构分析和红外吸收光谱对其机理进行了研究。结果表明 :氧化硅对MLR和MLA有着良好的吸附作用 ,吸附率随氧化硅含量的增加而提高 ;同等条件下 ,氧化硅对分子质量较低的MLA具有明显的吸附倾向性 ;氧化硅的吸附能力不仅依赖于其突出的微观结构 ,分布于表面上的大量化学“活性”基团———“自由振动”羟基在吸附过程中同样发挥着相当重要的作用。 | 赵亮 Gayle Newcombe Leanne Britcher | 2004 | 中国给水排水2004，20，2： | 6 |
| 4 | ICU小组长交接班基本信息文档设计:一项小组研究显示文摘背景:尽管对有系统结构的交接班文档(用于引导有效交接班)的需求在不断增加,针对ICU交接班的交班指导工具却是有限的。目的 :此项研究的目的在于帮助ICU小组长收集患者的主要病情项目,更有效地进行班次之间的交接。方法 :研究设在澳洲的一个有21张床位的危重病房内/外科ICU。参加人员为参与交接班的高资历护士。参与小组采用名义群体法(Nominal Group Technique,NGT)选择并且排序需要收集患者主要病情资料的重要性。接班的护士从前一班护士组长的交班内容中选择哪些项目应该包含在基本病情资料中。选择结果以出现频率和百分率作总结。结果 :参与研究的三个小组由17位高资历护士组成。参与人员一致同意ISBAR(识别-基本情况-背景-检查分柝-建议)是指导临床交接班的一项有效的应用工具。经筛选应该包含在基本资料组成的项目(至少65%同意)包括识别(姓名、年龄、ICU住院天数)、基本情况(诊断、手术名称)、现状背景(主要病症)、主要病症的治疗措施、建议(下一班对患者的治疗和观察计划及跟进措施)。总的来说,检查项目中选出的67项中有30项(45%)被认为应该包含为基本资料的组成部分,具体到对身体特定系统的观察和治疗。其他和ISBAR没有关联的项目,例如ICU收住入院、工作人员和技术能力配置、手术病例等,以及患者病情(感染状态、感染部位、濒死计划)都作为重要考虑因素。其他增加的项目并应包含在交接班的内容仅在与患者病情有关时讨论。结论:研究结果表明,使用专为ICU设计的ISBAR能够帮助ICU小组长有效收集患者病情资料,更有效地进行交接班,并保证患者的安全和治疗计划得以实施。 | Amy J. Spooner Leanne M. Aitken Amanda Corley Wendy Chaboyer | 2018 | 中国护理管理2018，18，2： | 6 |
| 5 | Getting started in research, redefined: five questions for clinically focused physicians in family medicine显示文摘Research is crucial to the development of family medicine around the world.However,family physicians in practice often hesitate to enter into investigative endeavours.Common reasons for such hesitation include limited exposure to the process of conducting research and the belief that research is best conducted by academic scholars.Our intent here is to encourage clinically focused family physicians’involvement in research activities by explaining how they can cultivate inquisitiveness so as to develop questions for exploration.We present an approach to research that focuses on five steps emergent from the day-to-day,habitual practice of family medicine,wherever in the world it is practised.We illustrate this approach by describing a successful practice-based research study.We conclude by inviting all family physicians to consider integrating research into their practice lives so as to expand their professional horizons and help educate the next generation of global family physicians. | William Ventres Leanne Whiteside-Mansell | 2019 | Family Medicine and Community Health2019，7，2： | 5 |
| 6 | 四城市初中生吸烟与不健康行为的关系研究显示文摘目的了解北京、杭州、武汉和乌鲁木齐四城市初中生的吸烟情况,并分析其吸烟行为与多种危害健康的行为和心理问题的关系。方法中国疾病预防控制中心(CDC)健康教育所提供四城市所有中学资料,由美国CDC用特殊的抽样软件从中抽取100所学校,采用WHO的全球学校学生健康调查问卷对9015名初中生进行调查。结果参加调查的初中生尝试吸烟率为29.496,过去30d中6.6%的学生使用过烟草。27.0%的吸烟学生在9岁及以前开始吸第1支烟,31.8%的学生从学校教育中学到过拒烟技巧。吸烟组的饮酒、使用毒品、伤害、旷课行为和心理问题发生率均显著高于不吸烟组。结论初中生的尝试吸烟率和吸烟率有上升趋势。吸烟行为的发生与多种不健康行为和心理问题密切相关。 | 田本淳 孟宪鹏 吕书红 钱玲 张巍 张继彬 田向阳 熊光练 严维红 张新卫 Laura Kann Leanne Riley | 2007 | 中华流行病学杂志2007，28，3： | 5 |
| 7 | 重症监护室内患者睡眠的自评和护士评估:一项探索性描述研究显示文摘目的:描述ICU患者的睡眠自评报告,检测患者的睡眠自评报告和床旁护士的睡眠评估报告之间的关系;描述患者建议的促进睡眠的对策。方法:对2014-2015年间连续纳入的能进行交流的成年患者,进行了探索性描述研究。患者睡眠情况采用理查兹-坎贝尔(Richards-Campbell)睡眠问卷(评分范围为0~100 mm;得分越高,表明睡眠质量越好)进行自评,同时护士以5级递进形式记录患者睡眠情况,进行评估。要求患者每日描述辅助或妨碍睡眠的因素。研究已获得伦理委员会批准。进行描述性统计分析[中位数(四分位间距)];用Spearman等级相关分析相关关系,用Kruskal-Wallis检验进行差异检验;P<0.05时,认为差异有显著性。结果:151名受试者纳入研究,年龄为60(46~71)岁,ICU停留时间为4(2~9)天,完成了356份睡眠自评报告。自我感知的睡眠质量为46(26~65)mm。睡眠的患者自评和护士评估之间存在中度相关(Spearman等级相关系数为0.39~0.50;P<0.001)。经患者认可的改善睡眠的对策包括适当的止痛和镇静药物,平和舒适的环境,以及集群护理、耳塞等物理措施。结论:患者在ICU期间,完成睡眠自评的中位数为2(1~3)日,表明常规使用自评是可行的。自评报告显示患者的睡眠质量低。在患者自评的多种辅助或妨碍睡眠的因素中,环境因素和影响患者舒适度的因素是最常见的。应实施针对这些因素的干预,以改善患者睡眠状况。 | Leanne M.Aitken Rosalind Elliott Marion Mitchell Chelsea Davis Bonnie Macfarlane Amanda Ullman Krista Wetzig Ashika Datt Sharon McKinley | 2017 | 中国护理管理2017，17，4： | 3 |
| 8 | Polyp Size and Advanced Histology in Patients Undergoing Colonoscopy Screening: Implications for CT Colonography显示文摘 | David Lieberman Matthew Moravec Jennifer Holub Leann Michaels Glenn Eisen | 2008 | Gastroenterology2008，，4： | 3 |
| 9 | 微囊藻毒素-LR的特征红外光谱显示文摘利用傅里叶变换红外(FTIR)光谱仪研究了微囊藻毒素-LR在扫描范围4000-600cm^-1的红外吸收光谱图,微囊藻毒素-LR分子构成中的主要官能团,如带有单一取代基的苯环、胍基、γ-羧基等特征红外吸收带在谱图上均得到了确认。 | 赵亮 Gayle Newcombe Leanne Britcher | 2006 | 光谱学与光谱分析2006，26，6： | 3 |
| 10 | Clinical disease registries in acute myocardial infarction显示文摘Disease registries,containing systematic records of cases,have for nearly 100 years been valuable in exploring and understanding various aspects of cardiology. This is particularly true for myocardial infarction,where such registries have provided both epidemiological and clinical information that was not readily available from randomised controlled trials in highlyselected populations. Registries,whether mandated or voluntary,prospective or retrospective in their analysis,have at their core a common study population and common data definitions. In this review we highlight how registries have diversified to offer information on epidemiology,risk modelling,quality assurance/improvement and original research-through data mining,transnational comparisons and the facilitation of enrolment in,and follow-up during registry-based randomised clinical trials. | Reza Ashrafi Hussain Hussain Robert Brisk Leanne Boardman Clive Weston | 2014 | World Journal of Cardiology2014，6，6： | 2 |
| 11 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 12 | 种植者日记——洋桔梗的实用栽培技术和采后处理技巧显示文摘洋桔梗Eustoma grandiflorm(Raf.)Shnn,为龙胆科之宿根性草本花卉,又名丽钵花、土耳其桔梗、德州蓝铃.原产美国中南部内布拉斯加至德州一带,一般多利用为一、二年生草花栽培.日本在1935年引进洋桔梗,并开始少量栽培.1 975年后育种快速发展,每年均有许多新品种问世,至1992年8月共有206个品种,其中有158个品种较为常见. | Leanne Pundt 李志 | 2004 | 农村实用工程技术(温室园艺)2004，，3： | 2 |
| 13 | Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog显示文摘 | Michael Rera Sepehr Bahadorani Jaehyoung Cho Christopher L. Koehler Matthew Ulgherait Jae H. Hur William S. Ansari Thomas Lo D. Leanne Jones David W. Walker | 2011 | Cell Metabolism2011，，5： | 2 |
| 14 | Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice显示文摘Dentin matrix protein 1(DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protein that promotes hydroxyapatite formation and activates intracellular signaling pathway via interacting with avb3 integrin. Recent in vitro studies suggested that DMP1 might also act as a transcription factor. In this study, we examined whether full-length DMP1 could function as a transcription factor in the nucleus and regulate odontogenesis in vivo. We first demonstrated that a patient with the DMP1M1 V mutation, which presumably causes a loss of the secretory DMP1 but does not affect the nuclear translocation of DMP1, shows a typical rachitic tooth defect. Furthermore, we generated transgenic mice expressingNLSDMP1, in which the endoplasmic reticulum(ER) entry signal sequence of DMP1 was replaced by a nuclear localization signal(NLS) sequence, under the control of a 3.6 kb rat type I collagen promoter plus a 1.6 kb intron 1. We then crossbred theNLSDMP1 transgenic mice with Dmp1 null mice to express the NLSDMP1 in Dmp1-deficient genetic background. Although immunohistochemistry demonstrated thatNLSDMP1 was localized in the nuclei of the preodontoblasts and odontoblasts, the histological, morphological and biochemical analyses showed that it failed to rescue the dental and periodontal defects as well as the delayed tooth eruption in Dmp1 null mice. These data suggest that the full-length DMP1 plays no apparent role in the nucleus during odontogenesis. | Shu-Xian Lin Qi Zhang Hua Zhang Kevin Yan Leanne Ward Yong-Bo Lu Jian-Quan Feng | 2014 | International Journal of Oral Science2014，6，3： | 2 |
| 15 | The Effects of Nurses’ Job Satisfaction on Retention: An Australian Perspective显示文摘 | Leanne Cowin | 2002 | JONA: The Journal of Nursing Administration2002，，5： | 2 |
| 16 | Transanal Endoscopic Microsurgery: A Systematic Review显示文摘 | Philippa F. Middleton M.P.H. Leanne M. Sutherland Ph.D. Guy J. Maddern F.R.A.C.S. Ph.D | 2005 | Diseases of the Colon & Rectum2005，，2： | 2 |
| 17 | FAMILY ENVIRONMENTAL FACTORS INFLUENCING THE DEVELOPING BEHAVIORAL CONTROLS OF FOOD INTAKE AND CHILDHOOD OVERWEIGHT显示文摘 | Leann Lipps Birch Kirsten Krahnstoever Davison | 2001 | The Pediatric Clinics of North America2001，，4： | 2 |
| 18 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 2 |
| 19 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | 2011 (9785)2011，，9785： | 2 |
| 20 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
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