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| 1 | Polyp Size and Advanced Histology in Patients Undergoing Colonoscopy Screening: Implications for CT Colonography显示文摘 | David Lieberman Matthew Moravec Jennifer Holub Leann Michaels Glenn Eisen | 2008 | Gastroenterology2008，，4： | 3 |
| 2 | Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression显示文摘Background: SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation;therefore, the importance of the ooplasmic SIRT1 pool for the further fate of mature oocytes has been strongly suggested. We hypothesised that SIRT1 plays the role of a signalling molecule in mature oocytes through selected epigenetic and non-epigenetic regulation.Results: We observed SIRT1 re-localisation in mature oocytes and its association with spindle microtubules.In mature oocytes, SIRT1 distribution shows a spindle-like pattern, and spindle-specific SIRT1 action decreasesα-tubulin acetylation. Based on the observation of the histone code in immature and mature oocytes, we suggest that SIRT1 is mostly predestined for an epigenetic mode of action in the germinal vesicles(GVs) of immature oocytes. Accordingly, BML-278-driven trimethylation of lysine K9 in histone H3 in mature oocytes is considered to be a result of GV epigenetic transformation.Conclusions: Taken together, our observations point out the dual spatiotemporal SIRT1 action in oocytes,which can be readily switched from the epigenetic to non-epigenetic mode of action depending on the progress of meiosis. | Jan Nevoral Lukas Landsmann Miriam Stiavnicka Petr Hosek Jiri Moravec Sarka Prokesova Hedvika Rimnacova Eliska Koutna Pavel Klein Kristyna Hoskova Tereza Zalmanova Tereza Fenclova Jaroslav Petr Milena Kralickova | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 3 | The gene expression fingerprint of human heart failure显示文摘 | Tan FL Moravec CS Li J | 2002 | Proc Natl Acad Sci U S A2002，99，11： | 2 |
| 4 | Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression显示文摘Pancreatic cancer(PC) is a leading cause of cancerrelated death worldwide. Clinical symptoms typically present late when treatment options are limited and survival expectancy is very short. Metastatic mutations are heterogeneous and can accumulate up to twenty years before PC diagnosis. Given such genetic diversity, detecting and managing the complex states of disease progression may be limited to imaging modalities and markers present in circulation. Recent developments in digital pathology imaging show potential for early PC detection, making a differential diagnosis, and predicting treatment sensitivity leading to long-term survival in advanced stage patients. Despite large research efforts, the only serum marker currently approved for clinical use is CA 19-9. Utility of CA 19-9 has been shown to improve when it is used in combination with PC-specific markers. Efforts are being made to develop early-screening assays that can detect tumor-derived material, present in circulation, before metastasis takes a significant course. Detection of markers that identify circulating tumor cells and tumor-derived extracellular vesicles(EVs) in biofluid samples offers a promising non-invasive method for this purpose. Circulating tumor cells exhibit varying expression of epithelial and mesenchymal markers depending on the state of tumor differentiation. This offers a possibility for monitoring disease progression using minimally invasive procedures. EVs also offer the benefit of detecting molecular cargo of tumor origin and add the potential to detect circulating vesicle markers from tumors that lack invasive properties. This review integrates recent genetic insights of PC progression with developments in digitalpathology and early detection of tumor-derived circulating material. | Radim Moravec Rao Divi Mukesh Verma | 2017 | World Journal of Gastrointestinal Oncology2017，9，6： | 2 |
| 5 | Electrical and luminescence properties of (CdZn)Te single crystals prepared by the vertical gradient freezing method 显示文摘 | HOSCHL P IVANOV Y M BELAS E FRANC J RILL R G HLIDEK P MORAVEC P ZVARA M SITTER H TOTH A L | 1998 | J Cryst Growth1998，，： | 1 |
| 6 | Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays 显示文摘 | Yang J Moravec CS Sussman MA | 2000 | Circulation2000，102，25： | 1 |
| 7 | Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin,and plating density in cell-based eytotoxieity assays 显示文摘 | Riss TL Moravec RA | 2004 | Assay Drug Dev Technol2004，2，1： | 1 |
| 8 | Terahertz imaging with compressed sensing and phase retrieval显示文摘 | W L Chan M Moravec R Baraniuk | 2008 | Optics Letters2008，33，9： | 1 |
| 9 | 显示文摘 | Franc J Moravec P Hlidek P | 2003 | J Electron Mater2003，32，7： | 1 |
| 10 | The gene expression fingerprint of human heart failure显示文摘 | Tan FL Moravec CS Li JB | 2002 | PNAS2002，99，11： | 1 |
| 11 | WordNet ontology based model for Web retrieval显示文摘 | Snasel V Moravec P Pokorny J | 2005 | IEEE2005，，： | 1 |
| 12 | Some nematodes of freshwaterfishers in Venezuela 显示文摘 | Moravec F Prouza A Royero R | 1997 | Folkt Parasitol (praha)1997，44，1： | 1 |
| 13 | Use of multiple assay endpoints to investigate the effects of incubation time,dose of toxin,and plating density in cell-based cytotox icity assays显示文摘 | Riss TL Moravec RA | 2004 | Assay Drug Dev Technol2004，2，1： | 1 |
| 14 | Chemical polishing of CdTe and CdZnTe in Iodine-methanol etching solutions 显示文摘 | Ivanits' ka V G Moravec P | 2006 | Journal of Electronic Materials2006，40，8： | 1 |
| 15 | Electron spectroscopy of ionbeam and hydrocarbon plasma generated diamondlike carbonfilms显示文摘 | MORAVEC T J ORENT T W | 1981 | Journal of Vacuum Science &Technology1981，18，2： | 1 |
| 16 | Some nematodes of freshwater fishers in Venezuela显示文摘 | MORAVEC F PROUZA A ROYERO R | 1997 | Folkt Parasitol1997，44，1： | 1 |
| 17 | Sensor fusion in certainty grids for mobile robots显示文摘 | Moravec H P | 1988 | AIMag1988，9，2： | 1 |
| 18 | Chemical etching of CdTe in aqueous solutions of H2 02-HI-citric acid 显示文摘 | Ivanits'ka V G Moravec P | 2007 | Journal of Electronic Materials2007，36，8： | 1 |
| 19 | The activated matrix metalloproteinase-9 in the failing human heart is suppressed by LVAD support 显示文摘 | McTieman CF Moravec CS | 1999 | Circulation1999，，： | 1 |
| 20 | The staford cart and the CMU rover显示文摘 | Moravec H P | 1983 | Proceedings of the IEEE1983，71，7： | 1 |
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