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94篇 您的检索式：作者名="Lauer D"

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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	Capillary electrophoresis of proteins in un treated fused silica tubing显示文摘	Lauer H H McManigill D	1986	Anal Chem1986，58，：	1
3	Dynamic site index equation for thinned stands of even-aged natural longleaf pine 显示文摘	Lauer D K Kush J S	2010	Southern Journal of Applied Forestry2010，34，1：	1
4	Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regu- lation of tissue inhibitor of matrix metalloproteinase 1/matrix metaUopro- teinase 9 axis and transforming growth factor betal in the rat heart显示文摘	Lauer D Slavic S Sommerfeld M	2014	Hypertension2014，63，3：	1
5	Pathopbysiological role of platelets and platelet system in acute panereatitis显示文摘	Uhlmann D Lauer H Serr F	2008	Microvaseular Research2008，76，2：	1
6	Complement factor Hbinds malondialdehyde epitopes and protects from oxidative stress显示文摘	Weismann D Hartvigsen K Lauer N	2011	Nature2011，478，7367：	1
7	Is there a relationship between exercise systolic blood pressure response and left ventricular mass? The Framingham Heart Study显示文摘	Lauer MS Levy D Anderson KM	1992	Ann Intern Med1992，116，3：	1
8	Modulation of growth factor binding properties of alpha2-macroglobulin by enzyme therapy 显示文摘	Lauer D Mailer R Cott C	2001	Cancer Chemother Pharmacol2001，，：	1
9	Hepatitis C virus infection显示文摘	Lauer G M Walker B D	2001	New England Journal of Medicine2001，345，1：	1
10	Separate and joint influences of obesity and mild hypertension on left ventricular mass and geome?try: the Framingham Heart Study显示文摘	Lauer MS Anderson KM Levy D	1992	JAm Coll Cardiol1992，，：	1
11	Mossbauer studiesof FeCu thin films 显示文摘	KEUNE W LAUER J WILLIAMSON D L	1974	Journal de Physique1974，35，47：	1
12	Plate osteosynthesis of the mandibuar condyle 显示文摘	Lauer G Haim D Proff P	2007	Ann Anat2007，2，：	1
13	Angiotensin type 2 re- ceptor stimulation ameliorates left ventricular fibrosis and dys- function via regulation of tissue inhibitor of matrix metallopro- teinase 1/matrix metalloproteinase 9 axis andtransforming growth factor β1 in the rat heart显示文摘	Lauer D Slavic S Sommerfeld M	2014	Hypertension2014，63，3：	1
14	Capillary zone electrophoresis of proteins in untreated fused silica tubing 显示文摘	Lauer H H McManigill D	1986	Anal Chem1986，58，：	1
15	The redox state of cerium in basaltic magmas:An experimental study of iron-cerium interaction in silicate melts显示文摘	Schreiber H D Lauer H V Thanyasir T	1980	Geochimica Cosmochimica Acta1980，44，：	1
16	Mobile-phase transport properties of liquefied gases in near critical and supercritical fluid chroma-tography 显示文摘	Lauer H H McManigill D	1983	Analytical Chemistry1983，55，8：	1
17	Plate osteosynthesis of the mandibu- lar condyle显示文摘	Lauer G Haim D Proff P	2007	Ann Anat2007，221，：	1
18	Needlescopic ablation of small adrenal masses显示文摘	Lauer E Del P J Raman J D	2009	Curr Urol Rep2009，10，1：	1
19	Pathophysiological role of plate- lets and platelet system in acute pancreatitis显示文摘	Uhlmann D Lauer H Serr F	2008	Micrevascular Re- search2008，76，2：	1
20	The redox state of cerium in basaltic magmas: An experimental study of iron-cerium interaction in silicate melts显示文摘	Schreiber H D Lauer H Vand Thanyasir T	1980	Geochimica et Cosmoehimica Acta1980，44，：	1

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