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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Fracture characteristics of carbonfiber,ceramic and non-palladium endodontic post systems atmonotonously increasing loads显示文摘 | Ottl P Hahn L Lauer HCh | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 3 | Fracture characteristics of carbon fiber,ceramic and non-palladium endodontic post systems at monotonously increasimg loads显示文摘 | OttL P Hahn L lauer HCH | 2002 | Oral Rehabil2002，29，2： | 1 |
| 4 | Hepatitis B virus transactivator HBX uses a tumour promoter signalling pathway显示文摘 | Kekulé AS Lauer U Weiss L | 1993 | Nature1993，361，6414： | 1 |
| 5 | Fracture characteristics of carbon fibre, ceramic and non-palladium endodontic post systems at monotonously increasing loads显示文摘 | Ottl P Hahn L Lauer H | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 6 | Fracture characteristics of car- bon fiber ceramic and non - palladium endodontie post systems at monotonously increasing loads显示文摘 | Ottl P Hahn L Lauer HCH | 2002 | Oral Rchabil2002，29，2： | 1 |
| 7 | Fracture characteristics of carbon fibre, ceramic and non - palladium endodontic post systems at monotonously increasing loads显示文摘 | Ottl P Hahn L Lauer H C H | 2002 | Journal of oral rehabilitation2002，29，2： | 1 |
| 8 | Fracture characteristics of carbon fibre ceramic and non-palladium endodontic post systems at monotonously in- creasing loads显示文摘 | Ottl P Hahn L Lauer HCH | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 9 | Fracture characteristics of carbon fiber, ceramic and non-palladium endodontie post systems at monotonously increasing loads 显示文摘 | OTTL P HAHN L LAUER HCH | 2002 | J Oral Rehabil2002，29，： | 1 |
| 10 | Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration:Engineering cell-invasion characteristics显示文摘 | LUTOLF M P LAUER J L SCHMOEKEL H G | 2003 | Proc Natl Acad Sc USA2003，100，9： | 1 |
| 11 | Mossbauer studiesof FeCu thin films 显示文摘 | KEUNE W LAUER J WILLIAMSON D L | 1974 | Journal de Physique1974，35，47： | 1 |
| 12 | Fracture characteristics of carbon fiber, ceramic and non-palladium endodontic post systems at monotonously increasing loads 显示文摘 | Ottl P Hahn L Lauer HCh | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 13 | Hepatitis B virus transactivator HBx uses a tumor promoter signaling pathway显示文摘 | Kekule AS Lauer U Weiss L | 1993 | Nature1993，361，6414： | 1 |
| 14 | A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy显示文摘 | Hakim SG Kosmehl H Lauer l | 2005 | Cancer Res2005，65，10： | 1 |
| 15 | Epithelioid sarcoma-like(pseudomyogenic)hemangioendothelioma, clinically mimicking dermatofibroma, diagnosed by skin biopsy in a 30-year-old man 显示文摘 | Stuart L N Gardner J M Lauer S R | 2013 | J Cutan Pathol2013，40，10： | 1 |
| 16 | 查看详情显示文摘 | Tremaine S Gebhardt K Bender R Bower G Dressier A Faber S M Filippenko A V Green R Grillmair G Ho L C Kormendy J Lauer T R Magorrian J Pinkney J Richstone D | | 0，，： | 1 |
| 17 | Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice显示文摘 | MITCHELL L A LAUER F T BURCHIEL S W | 2009 | Nat Nanotechnol2009，4，： | 1 |
| 18 | PDMS Device for Patterned Application of Microfluids to Neuronal Cells Arranged by Microcontact Printing显示文摘 | Thiebaud P Lauer L Knoll W | 2002 | Biosens Bioelectron2002，17，12： | 1 |
| 19 | Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8^+ T cells显示文摘 | Lucas M Vargas-Cuero A L Lauer G M | 2004 | J Immunol2004，172，： | 1 |
| 20 | Fracture Characteristics of Carbon Fiber, Ceramic and Non-palladium Endodontic Post Systems at Monotonously Increasing Loads显示文摘 | Ottl P Hahn L Lauer H C H | 2002 | J Oral Rehabil2002，29，2： | 1 |
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