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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Capillary electrophoresis of proteins in un treated fused silica tubing显示文摘 | Lauer H H McManigill D | 1986 | Anal Chem1986，58，： | 1 |
| 3 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral arterial bypass assistance显示文摘 | Thiele H Lauer B Hambrecht R | 2001 | Circulation2001，104，： | 1 |
| 4 | Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septicrats显示文摘 | Lauer S Freise H Westphal M | 2009 | CritCare2009，13，4： | 1 |
| 5 | Pathopbysiological role of platelets and platelet system in acute panereatitis显示文摘 | Uhlmann D Lauer H Serr F | 2008 | Microvaseular Research2008，76，2： | 1 |
| 6 | Fracture characteristics of carbon fibre, ceramic and non-palladium endodontic post systems at monotonously increasing loads显示文摘 | Ottl P Hahn L Lauer H | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 7 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral arterial bypass assistance显示文摘 | Thiele H Lauer B Hambrecht R | | 0，，： | 1 |
| 8 | Fracture characteristics of carbon fibre, ceramic and non - palladium endodontic post systems at monotonously increasing loads显示文摘 | Ottl P Hahn L Lauer H C H | 2002 | Journal of oral rehabilitation2002，29，2： | 1 |
| 9 | Random Survival Forests 显示文摘 | Ishwaran H Kogalur U B Blackstone E H Lauer M S | 2008 | The Annals of Applied Statis- tics2008，2，3： | 1 |
| 10 | Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration:Engineering cell-invasion characteristics显示文摘 | LUTOLF M P LAUER J L SCHMOEKEL H G | 2003 | Proc Natl Acad Sc USA2003，100，9： | 1 |
| 11 | RF artifacts caused by metallic implants or instruments which get more prominent at 3 T: an in vitro study显示文摘 | Graf H Lauer UA Berger A | 2005 | Magn Reson lmag2005，23，3： | 1 |
| 12 | The role of thoracic epidural analgesia in receptor-dependent and receptor-independent pulmonary vasoconstriction in experimental pancreatitis 显示文摘 | Lauer S Freise H Fischer LG | 2007 | Anesth Analg2007，105，2： | 1 |
| 13 | Thoracic epidural analgesia with low concentration of bupivacaine induces thoracic and lumbar sympathetic block: a randomized, double blind clinical trial 显示文摘 | Freise H Meissner A Lauer S | 2008 | Anesthesiology2008，109，6： | 1 |
| 14 | Capillary zone electrophoresis of proteins in untreated fused silica tubing 显示文摘 | Lauer H H McManigill D | 1986 | Anal Chem1986，58，： | 1 |
| 15 | The redox state of cerium in basaltic magmas:An experimental study of iron-cerium interaction in silicate melts显示文摘 | Schreiber H D Lauer H V Thanyasir T | 1980 | Geochimica Cosmochimica Acta1980，44，： | 1 |
| 16 | Reversal of cardiogenic shock by percutaneous left atrial-to-femoral atrial bypass assistance显示文摘 | Thiele H Lauer B Hambreeht R | 2001 | Circulation2001，104，： | 1 |
| 17 | Mobile-phase transport properties of liquefied gases in near critical and supercritical fluid chroma-tography 显示文摘 | Lauer H H McManigill D | 1983 | Analytical Chemistry1983，55，8： | 1 |
| 18 | Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins显示文摘 | Hailer A A Lauer G M King T H | 2007 | Vaccine2007，25，8： | 1 |
| 19 | Production of a single-chain variable fragment antibody against fumonisin B1显示文摘 | Lauer B Ottleben I Jacobsen H J | 2005 | Journal of agricultural and food chemistry2005，53，4： | 1 |
| 20 | Characteristics and outcome of congenital left ventricular aneurysm and diverticulum : analysis of 809 cases published since 1816显示文摘 | Ohlow MA von Korn H Lauer B | 2015 | Int J Cardio12015，185，1： | 1 |
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