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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 3 | Time Temperature Relation for Rupture and Creep Stresses显示文摘 | Larson F R Miller J A | 1952 | Trans ASME1952，74，： | 1 |
| 4 | Serumuric acid and risk for cardiovascular disease and death: TheFramingham Heart Study显示文摘 | Culleton B F Larson M G Kannel W B | 1999 | Annals of Internal Medicine1999，131，01： | 1 |
| 5 | Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia显示文摘 | O'Brien S G Guilhot F Larson R A | | New England Journal of Medicine0，，： | 1 |
| 6 | How do trays and packings stack up显示文摘 | Kister H Z Larson K F Yanagi T | 1994 | Chem Eng Prog1994，90，2： | 1 |
| 7 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 8 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses显示文摘 | WEIGHT C J LARSON B T FERGANY A F | 2010 | J Urol2010，183，4： | 1 |
| 9 | Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the Fram- ingham Study显示文摘 | Keaney J F Jr Larson M G Vasan R S | 2003 | Aeterioscler Thromb Vasc Biol2003，23，3： | 1 |
| 10 | Coalition Structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M Shehory O Tohme F | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 11 | Potential Added value of psychological capital in predicting work attitudes 显示文摘 | Larson M Luthans F | 2006 | Journal of Leadership & Organizational Studies2006，13，： | 1 |
| 12 | Impact of reduced heart rate variability on risk for cardiac events: the Framingham Heart Study 显示文摘 | Tsuji H Larson M G Venditti F J | 1996 | Circulation1996，94，： | 1 |
| 13 | Imatinib compared with interferon and low-dose eytarabine for newly diagnosed chronic-phase chronic myeloid leukemia 显示文摘 | O'Brien SG Guilhot F Larson RA | 2003 | N Engl J Med2003，348，11： | 1 |
| 14 | Potential Added Value of Psychological Capital in Predicting Work Attitudes显示文摘 | Larson M Luthans F | 2006 | Journal of Leadership & Organiza- tional Studies2006，13，2： | 1 |
| 15 | Three dimensional atom probe investigation of vanadium nitride precipitates and the role of oxygen and boron in rapidly solidified 316 stainless steel 显示文摘 | Kelly T F Larson D J Miller M K | 1999 | Materials Science and Engineering1999，270，： | 1 |
| 16 | Imatinib Pharmaeokineties and Its Correlation with Response and Safety in Chronic-phase Chronic Myeloid Leukemia: a Subanalysis of the IRIS Study显示文摘 | Larson RA Druker B J Guilhot F | 2008 | Blood2008，111，8： | 1 |
| 17 | Biomechanics of lumbar pedicle screw/plate fixation in trauma 显示文摘 | Yoganandan N Larson SJ Pintar F | 1990 | Neurosurgery1990，27，6： | 1 |
| 18 | Responding to emergencies: Lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 19 | Potential Added Value of Psychological Capital in Predicting Work Attitudes显示文摘 | Larson M D Luthans F | 2006 | Journal of Leadership & Organizational Studies2006，13，2： | 1 |
| 20 | Reduced fertility associated with low progesterone postbreeding and increased milk urea nitrogen in lactating cows显示文摘 | LARSON S F BUTLER W R CURRIE W B | 1997 | Journal of Dairy Science1997，80，： | 1 |
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