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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 3 | The failure syndrome 显示文摘 | LARSON C M R C CLUTE | 1979 | American Journal of Small Business1979，4，2： | 1 |
| 4 | Modeling infiltration during a steady rain显示文摘 | Mein R G Larson C L | 1973 | Water Resources Research1973，9，2： | 1 |
| 5 | Locating discretionary service facility(Ⅱ):minimizing inconvenience显示文摘 | Berman O Bertismas K Larson R C | 1995 | Operations Research1995，43，4： | 1 |
| 6 | Aphroscopic management of femoroacetabular impinge- ment: early outcomes measures 显示文摘 | Larson C M Giveans M R | 2008 | Ar- throseopy2008，24，5： | 1 |
| 7 | Optimal location of discretionary service facilities显示文摘 | Berman O Fouska N Larson R C | 1992 | Transportation Science1992，26，3： | 1 |
| 8 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 9 | Effect of fibronectin on early embryo development in cow 显示文摘 | LARSON R C IGNOTZ G G CURRIE W B | 1992 | Reprood Fertil1992，96，1： | 1 |
| 10 | Optimal server location on a network operating as an M/G/1queue显示文摘 | Berman O Larson R C Chiu S S | 1985 | Oper Res1985，33，： | 1 |
| 11 | Worldwide correlation of Mesozoic magnetic anomalies, and its implications 显示文摘 | Larson R L Pitman W C I | 1972 | Geological Society of America Bulletin1972，83，： | 1 |
| 12 | Plate tectonic reconstructions of the Cretaceous and Cenozoic ocean basins显示文摘 | Scotese C R Gahagan L M Larson R L | 1988 | Tectonophysics1988，155，1234： | 1 |
| 13 | Magnetic lineations in the Pacific Jurassic quiet zone 显示文摘 | Cande S C Larson R L LaBrecque J L | 1978 | Earth and Planetary Science Letters1978，41，： | 1 |
| 14 | Responding to emergencies: Lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 15 | Optimal Location of Discretionary Service Facilities 显示文摘 | BERMAN O FOUSKA N LARSON R C | 1992 | Transportation Science1992，26，3： | 1 |
| 16 | Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence显示文摘 | Davidson R J Putnam K M Larson C L | | 0，，5479： | 1 |
| 17 | Plate tectonic reconstructions of the Cretaceous and Cenozoic ocean basins显示文摘 | Scotese C R Gahagan L M Larson R L | 1988 | Tectonophysics1988，155，： | 1 |
| 18 | Modeling infiltration during a steady rain 显示文摘 | Mein R G Larson C L | 1973 | Water Research1973，9，2： | 1 |
| 19 | Transforming growth factors and basic fibroblast growth factor synergistically promote early bovine embryo development during the fourth cill cycle显示文摘 | | 1992 | Mol Reprod Dev1992，23，： | 1 |
| 20 | Modeling infiltration during a steady rain显示文摘 | Mein R G C Larson L | 1973 | Water Resources Research1973，9，2： | 1 |
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