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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 3 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 4 | Effect of acute and chronic arecoline treatment on cerebralmetabolism and blood flow in the conscious rat显示文摘 | MAIESE K HOLLOWAY H H LARSON D M | 1994 | Brain Res1994，641，1： | 1 |
| 5 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 6 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 7 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 8 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 9 | A novel biomechanical model assessing continuous orthodontic archwire activation显示文摘 | Canales C Larson M Grauer D | 2013 | Am J Orthod Dentofacial Orthop2013，143，2： | 1 |
| 10 | Precipitation and segregation in a2+ titanium aluminides 显示文摘 | Larson D J Miller M K | 1998 | Materials Science and Engineering1998，250，： | 1 |
| 11 | Long-term trends in the incidence of and survival with heart failure显示文摘 | LEVY D KENCHAIAH S LARSON M G | 2002 | N Engl J Med2002，347，18： | 1 |
| 12 | Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to longdistance transfers显示文摘 | Larson D M Duval S Sharkey S W | 2012 | Eur Heart J2012，33，10： | 1 |
| 13 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 14 | Most apparent distortion:full-reference image quality assessment and therole of strategy显示文摘 | Larson E C Chandler D M | 2010 | Journal of Electronic Imaging2010，19，1： | 1 |
| 15 | The natural history of borderline isolated systolic hypertension显示文摘 | SAGIE A LARSON M G LEVY D | 1993 | N Engl J Med1993，329，： | 1 |
| 16 | Asymptematic ventricular arrhythmias and mortality risk in subjects with left ventricular Hypertrophy显示文摘 | Bikkina M Larson MG Levy D | 1993 | J Am Collcardiol1993，22，4： | 1 |
| 17 | Changes in microrelief and their effects on infiltration and erosion during simulated rainfall显示文摘 | Magunda M Larson W Linden D | 1997 | Soil Technology1997，10，1： | 1 |
| 18 | Three dimensional atom probe investigation of vanadium nitride precipitates and the role of oxygen and boron in rapidly solidified 316 stainless steel 显示文摘 | Kelly T F Larson D J Miller M K | 1999 | Materials Science and Engineering1999，270，： | 1 |
| 19 | A controlled trial of an educational program to prevent low back injuries显示文摘 | DALTROY L H IVERSEN M D LARSON M G | 1997 | N Engl J Med1997，337，5： | 1 |
| 20 | Responding to emergencies: Lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
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