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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | Processing aspects of the space shuttle orbiter's ceramic reusable surface insu- lation显示文摘 | Banas R P Gzowski E R Larson W L | 1983 | Ceram Eng Sci Proc1983，4，78： | 1 |
| 4 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008，63，6： | 1 |
| 5 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 6 | Anterior eruciate ligament in- sertions on the tibia and femur and their relationships to critical bony landmarks using high - resolution volumne - rendering compu- ted tomography 显示文摘 | Pumell ML Larson AI Clancy W | 2008 | Am J Sports Med2008，36，11： | 1 |
| 7 | The natural history of left ventricular geometry in the community:clinical correlates and prognostic significance of change in LV geometric pattern显示文摘 | Lieb W Gona P Larson MG | 2014 | JACC Cardiovasc Imaging2014，7，9： | 1 |
| 8 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 9 | Serumuric acid and risk for cardiovascular disease and death: TheFramingham Heart Study显示文摘 | Culleton B F Larson M G Kannel W B | 1999 | Annals of Internal Medicine1999，131，01： | 1 |
| 10 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 11 | A visibility matching tone reproduction operator for high dynamic range scenes显示文摘 | Rushmeier H Larson G W Piatko C | 1997 | IEEE Transactions on Visualization and Computer Graphics1997，3，4： | 1 |
| 12 | -2-floro-deoxy-d-dlucose positron emissiontomography localizes residual thyroid cancer in patients with negative diagnostic ^131Ⅰ whole body scans elevated serum thyroglobulin levels显示文摘 | Wang W Macapinlae H Larson Sm | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
| 13 | Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to longdistance transfers显示文摘 | Larson D M Duval S Sharkey S W | 2012 | Eur Heart J2012，33，10： | 1 |
| 14 | Elastic waves interacting with buried land mines: A study using the FDTD method显示文摘 | Scott W Jr Larson G D | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，： | 1 |
| 15 | Effect of fibronectin on early embryo development in cow 显示文摘 | LARSON R C IGNOTZ G G CURRIE W B | 1992 | Reprood Fertil1992，96，1： | 1 |
| 16 | Relationships between spa- tial environmental heterogeneity and plant species diversity on a limestone pavement 显示文摘 | LUNDHOLM J T LARSON D W | 2003 | Ecography2003，26，6： | 1 |
| 17 | Worldwide correlation of Mesozoic magnetic anomalies, and its implications 显示文摘 | Larson R L Pitman W C I | 1972 | Geological Society of America Bulletin1972，83，： | 1 |
| 18 | Coalition Structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M Shehory O Tohme F | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 19 | Potassium deficien- cy induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana 显示文摘 | Troufflard S Mullen W Larson T | 2010 | BMC Plant Biology2010，10，： | 1 |
| 20 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
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