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    题名 作者 年代 出处 被引量
1产后出血的预防和处理指南显示文摘目的:为产后出血(PPH)的预防和临床处理作一综述,为临床医师提供预防和处理产后出血的指南。涉及方面:预防、适当干预、使其影响最小化的方法。结果:建立常规,便于临床医师鉴别可能的高危人群,一旦发生产后过多出血,可指导临床如何迅速处理。证据:遵循加拿大定期健康检查办公室制定的证据等级。评估:由产科专家完善。利弊和成本:评估子宫收缩药和其他积极处理措施的方便性、正确性、有效性和安全性。建议:根据证据的等级,本指南分等级列出了12条建议。确认:按照MeSH词表推荐的postpartum haemorrhage在medline上查询相关文献,在Cochrane图书馆查找相关研究文献,并参考the ALARMcourse Manual。发起人:由产科临床实践委员会制定和综述,并由SOGC(加拿大妇产科协会)委员会批准。Nan Schuurmans MD FRCSC, Edmonton AB Catherine MacKinnon MD FRCSC, Brantford ON Carolyn Lane MD CCFP Calgary AB Duncan Etches MD CCFP Vancouver BC 刘铭(译) 段涛(译) 2007现代妇产科进展2007,16,3:152
2Current concepts on osteonecrosis of the femoral head显示文摘It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.Joaquin Moya-Angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane 2015World Journal of Orthopedics2015,6,8:94
3Seasonal water storage change of the Yangtze River basin detected by GRACE显示文摘US-Germany co-sponsered satellite gravimetry mission GRACE (Gravity Recovery And Climate Experiment), launched in March 2002, has been producing monthly time series of Earth gravity models up to degree and order of 120. The GRACE mission consists of two identical satellites flying on an almost polar orbit with an altitude of about 300-500 km and satelite-to-satellite ranging of about 220 km. Thanks to the payloads of space-borne GPS receivers, accelerometers and high-precision K-band satelite-to-satellite ranging mesurements, GRACE gravity models are expected to achieve more than one order of magnitude of improvement over previous models at spatial scales of a few hundred kilometers or larger. Recovery of surface mass re-distribution based on GRACE’s time-varying gravity models is applied to studies in solid Earth geophysics, oceanography, climatology and geodesy. At secular time scales, GRACE is expected to provide valuable information on global ice changes, whose variations have profound influences on global climate, and in particular, on sea level changes. At seasonal time scales, GRACE is expected to reveal surface water changes with an ac- curacy of less than 1 cm, or ocean bottom pressure changes with an accuracy of less than 1 mbar (1 mbar =102 Pa). These surface mass redistribution measurements would impove our understanding of the global and regional mass and energy cycles that are critical to human life. Using 15 GRACE monthly gravity models covering the period from April 2002 to December 2003, this study compares seasonal water storage changes recovered from GRACE data and hydrology models at global and regional scales, with particular focus on the Yangtze River basin of China. Annual amplitude of 3.4 cm of equivalent water height change is found for the Yangtze River basin with maximum in Spring and Autumn, agreeing with two state-of-the-art hydrology models. The differences between GRACE re- sults and model predictions are less than 1-2 cm. We conclude that satellite gravimetry has huge potentials in monitering water storage changes in large river basins such as Yangtze.HU Xiaogong1, CHEN Jianli1,2, ZHOU Yonghong1, HUANG Cheng1 & LIAO Xinhao1 1. Center for Astro-geodynamics Research, Shanghai Astronomical Observatory, National Astronomical Observatories, Shanghai 200030, China 2. Center for Space Research, University of Texas at Austin, 3925 W. Braker Lane, Suite 200, Austin, TX78750, USA 2006Science China Earth Sciences2006,49,5:29
4患者赋权问题及其解决思路——国外患者赋权理论文献综述显示文摘从患者赋权的界定,到患者赋权的表现形式及实现方法,再到当前各国患者赋权的不同侧重点等方面均已表明患者赋权是一个争议颇多的概念。从患者赋权的定义出发,国外学界大体上将患者赋权分为患者支持、患者激活、患者承诺与患者参与四种既相对独立又互有补充的类型,在此基础上,国外学界架构起颇具特色的实现患者赋权的方法,这为研究患者赋权问题提供了广阔的理论视角。通过探讨国外患者赋权的理论与实践经验,以期能为我国如何更好地看待和解决这一社会转型期所产生的问题提供良好的经验借鉴。焦剑 Lane Timothy 2019医学与哲学2019,40,6:16
5有效的继续医学教育活动:提高医生实践水平改善患者临床疗效显示文摘政府、公众和医疗机构都认为,医疗卫生人员有义务和责任保持自己的医疗水平,提高患者的医疗保健服务质量。美国国家医学研究所(the Institute of Medicine)、美国毕业后医学教育认证委员会(the Accreditation Council for Graduate Medical Education)和美国医学专科委员会(the American Board of Medical Specialties)规定了医疗卫生人员的必备技能,如患者诊疗、医学知识、以实践为基础的学习、改善人际交往和沟通能力、专业性和以系统为基础的实践等。并建议各医学院校的教学课程、医院的住院医师培训项目以及继续医学教育活动都应围绕医疗卫生人员的这些必备技能来设计教学内容。Regnier K Kopelow M Lane D Alden E 2012中国继续医学教育2012,4,2:15
6Upland rice and lowland rice exhibited different P/P expression under water deficit and ABA treatment显示文摘Aquaporins 玩在植物水关系的一个重要角色。为了进一步在水下面在植物理解 aquaporin 功能,强调, aquaporins 的亚群的表示,血浆膜内在的蛋白质(果仁) ,在高地米饭在蛋白质和 mRNA 水平被学习(Oryza sativa L。cv。Zhonghan 3 ) 并且低地米饭(Oryza sativa L。cv。Xiushui 63 ) 他们什么时候是水,与 20% 聚乙烯乙二醇(木钉) 由处理强调了。植物对 20% 木钉处理不同地作出回应。高地米饭叶子的叶水内容很快被减少。果仁蛋白质水平在木钉处理的 10 h 以后在两种类型的根,但是仅仅在高地米饭的叶子显著地增加了。在 mRNA 水平, OsPIP1; 2, OsPIP1; 3, OsPIP2; 1 并且 OsPIP2; 5 在象 OsPIP1 一样的根; 2 并且 OsPIP1; 3 在高地米饭在叶子是显著地起来调整的,而相应基因仍然保持在低地米饭未改变或下面调整。同时,我们在内长的 abscisic 酸(骆驼毛的织物) 观察了重要增加在高地米饭然而并非在在水赤字下面的低地米饭的水平。有 60 microM 骆驼毛的织物的处理提高了 OsPIP1 的表示; 2, OsPIP2; 5 并且 OsPIP2; 6 在根和 OsPIP1; 2, OsPIP2; 4 并且 OsPIP2; 6 在高地米饭的叶子。到水应力和骆驼毛的织物的果仁基因的应答的海角是不同的,暗示果仁基因的规定包含在水赤字期间的骆驼毛的织物依赖者和骆驼毛的织物无关的发信号小径。Hong-Li Lian Xin Yu David Lane Wei-Ning Sun Zhang-Cheng Tang Wei-Ai Su 2006Cell Research2006,16,7:14
7Male obesity and subfertility, is it really about increased adiposity?显示文摘在繁殖的人的过重和肥胖的流行全球正在增加,与 > 70% 人 >作为在一些西方的国家超重或肥胖分类的 18 年。男肥胖与男 subfertility 被联系,损害性荷尔蒙,减少精子计数,增加氧化精子 DNA 损坏并且改变精子的 epigenetic 地位。精子的这些变化由于肥胖工作,进一步在人与损害胚胎开发,减少的实时出生率和增加的流产率被联系。动物模型建议了这些不利繁殖效果能被传给后代;在概念建议那人的健康可以影响他们的孩子的健康。除了更高的脂肪过多,男肥胖与 comorbidities 被联系,包括新陈代谢的症候群,血胆脂醇过多, hyperleptinemia 和一个支持 inflammatory 州,独立地与男 subfertility 被连接了的所有。一起拿,这些调查结果建议生育力上的男肥胖的效果是可能的 multifactorial 与也影响精子的联系 comorbidities,怀孕和随后的孩子健康。Nicole O McPherson 2015Asian Journal of Andrology2015,17,3:10
8美国大学国际化教育发展钩沉与启示显示文摘大学国际化教育本质是教育资源的国际流动与有效利用。美国大学国际化教育发展呈现出区别于传统教育的商业性、跨界跨文化性以及教育语境的对立统一性等鲜明特征。国家、学术、社会以及大学自身四个关键教育生态元素是美国大学国际化教育发展力量的主要来源。以美为鉴,创建以国家领导、学术创新、社会认同和大学治理为核心的中国大学国际化教育的发展动力系统对于中国'双一流'战略的实现具有现实意义。赵富春 倪亚红 Jason Lane Vivien Ng 2018江苏高教2018,0,3:10
9Multi-scale phylogenetic structure in coastal dune plant communities across the globe显示文摘Aims Studies integrating phylogenetic history and large-scale community assembly are few,and many questions remain unanswered.Here,we use a global coastal dune plant data set to uncover the important factors in community assembly across scales from the local filtering processes to the global long-term diversification and dispersal dynamics.Coastal dune plant communities occur worldwide under a wide range of climatic and geologic conditions as well as in all biogeographic regions.However,global patterns in the phylogenetic composition of coastal dune plant communities have not previously been studied.Methods The data set comprised vegetation data from 18463 plots in New Zealand,South Africa,South America,North America and Europe.The phylogenetic tree comprised 2241 plant species from 149 families.We calculated phylogenetic clustering(Net Relatedness Index,NRI,and Nearest Taxon Index,NTI)of regional dune floras to estimate the amount of in situ diversification relative to the global dune species pool and evaluated the relative importance of land and climate barriers for these diversification patterns by geographic analyses of phylogenetic similarity.We then tested whether dune plant communities exhibit similar patterns of phylogenetic structure within regions.Finally,we calculated NRI for local communities relative to the regional species pool and tested for an association with functional traits(plant height and seed mass)thought to vary along sea–inland gradients.Important Findings Regional species pools were phylogenetically clustered relative to the global pool,indicating regional diversification.NTI showed stronger clustering than NRI pointing to the importance of especially recent diversifications within regions.The species pools grouped phylogenetically into two clusters on either side of the tropics suggesting greater dispersal rates within hemispheres than between hemispheres.Local NRI plot values confirmed that most communities were also phylogenetically clustered within regions.NRI values decreased with increasing plant height and seed mass,indicating greater phylogenetic clustering in communities with short maximum height and good dispersers prone to wind and tidal disturbance as well as salt spray,consistent with environmental filtering along sea–inland gradients.Height and seed mass both showed significant phylogenetic signal,and NRI tended to correlate negatively with both at the plot level.Low NRI plots tended to represent coastal scrub and forest,whereas high NRI plots tended to represent herb-dominated vegetation.We conclude that regional diversification processes play a role in dune plant community assembly,with convergence in local phylogenetic community structure and local variation in community structure probably reflecting consistent coastal-inland gradients.Our study contributes to a better understanding of the globally distributed dynamic coastal ecosystems and the structuring factors working on dune plant communities across spatial scales and regions.Ane Kirstine Brunbjerg Jeannine Cavender-Bares Wolf L.Eiserhardt Rasmus Ejrnæs Lonnie W.Aarssen Hannah L.Buckley Estelle Forey Florian Jansen Jens Kattge Cynthia Lane Roy A.Lubke Angela T.Moles Ana Laura Monserrat Robert K.Peet Julissa Roncal Louise Wootton Jens-Christian Svenning 2014Journal of Plant Ecology2014,7,2:9
10Lower serum folate is associated with development and invasiveness of gastric cancer显示文摘AIM: To evaluate the associations of serum folate levelwith development, invasiveness and patient survival of gastric cancer. METHODS: In this nested case-control study, patients with newly diagnosed gastric cancer undergoing gastrectomy were enrolled, and patients receiving chemotherapy prior to surgery, with other concurrent malignancy, or of the aboriginal and alien populations were excluded. In total, 155 gastric cancer patients and 149 healthy controls were enrolled for determination of serum folate levels and their correlation with gastric cancer. Using the median value of serum folate computed among the overall population as the cutoff value, the associations between serum folate and gastric cancer in all cases and different age and gender subgroups were analyzed by multivariate logistic regression analysis. In the patient cohort of gastric cancer, receiver-operating characteristic analyses were performed to calculate the best cutoff values of serum folate, and the associations between serum folate levels and clinicopathological features were further analyzed by multivariate regression analysis. Survival analyses were conducted using the Cox proportional hazards model.RESULTS: The mean serum folate level was significantly lower in gastric cancer patients than that in controls(3.71 ± 0.30 ng/mL vs 8.00 ± 0.54 ng/mL, P < 0.01), and folate levels were consistently lower in gastric cancer patients regardless of age and gender(all P < 0.01). Using the median serum folate value as the cutoff value, low serum folate was significantly associated with gastric cancer risk in the whole population(OR = 19.77, 95%CI: 10.54-37.06, P < 0.001) and all strata(age < 60 years OR = 17.39, 95%CI: 7.28-41.54, age ≥ 60 years(OR = 21.67, 95%CI: 8.27-56.80), males(OR = 17.95, 95%CI: 7.93-40.62), and females(OR = 20.95, 95%CI: 7.66-57.31); all P < 0.001. In the patient cohort of gastric cancer, the respective cutoff values showed that low serum folate levels were significantly associated with serosal invasion(OR = 2.54, 95%CI: 1.23-5.23), lymphatic invasion(OR = 2.23, 95%CI: 1.17-4.26), and liver metastasis(OR =6.67, 95%CI: 1.28-34.91) of gastric cancer(all P < 0.05). Serum folate level below 1.90 ng/mL was associated with poor patient survival(HR = 1.84, 95%CI: 1.04-3.27, P < 0.05) in univariate analysis.CONCLUSION: Lower serum folate levels were significantly associated with gastric cancer development and invasive phenotypes. The role of folate depletion in gastric cancer invasion warrants further study.Teng-Yu Lee En-Pei Chiang Yin-Ting Shih Hsien-Yuan Lane Jaw-Town Lin Chun-Ying Wu 2014World Journal of Gastroenterology2014,20,32:9
11Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng 2013Cell Research2013,23,5:8
12以专业为导向的工科英语教学模式设计与实践显示文摘目前,工科院校专业英语不受重视,与用人单位对专业技术人才专业英语应用能力要求高形成矛盾。培养既懂专业又懂英语的人才是发展方向,以专业导向进行英语教学是培养国际化的第六代工程师的重要手段之一。根据对企业、学生、教师的调查,设计了贯穿大学四年的递进型专业导向性英语教育体系以促进学生在大学期间完成由综合英语向专业英语的转变。实践证明,该教学模式可行,效果良好。唐阳 冯鉴 Thomas Lane 2014高等工程教育研究2014,62,4:8
13Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices.Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros 2008World Journal of Gastroenterology2008,14,28:7
14Robotic surgery in pediatric urology显示文摘While robotic surgery has shown clear utility and advantages in the adult population,its role in pediatrics remains controversial.Pediatric-sized robotic instruments and equipment are not readily available yet,so certain modifications can be made in order to make robotic surgery successful in children.While the cost of robotic surgery remains high compared to open procedures,patients experience greater satisfaction and quality of life with robotic surgery.Robotic pyeloplasty is a standard of care in older children,and has even been performed in infants and re-do surgery.Other robotic procedures performed in children include heminephroureterectomy,ureteroureterostomy,ureteral reimplantation,urachal cyst excision,bladder diverticulectomy,and bladder reconstructive procedures such as augmentation,appendicovesicostomy,antegrade continence enema,bladder neck reconstruction and sling,as well as other procedures.Robotic surgery has also been used in oncologic cases such as partial nephrectomy and retroperitoneal lymph node dissection.Future improvements in technology with production of pediatric-sized robotic instruments,along with increases in robotictrained pediatric urologists and surgeon experience along each’s learning curve,will help to further advance the field of robotic surgery in pediatric urology.Adam Howe Zachary Kozel Lane Palmer 2017Asian Journal of Urology2017,4,1:6
15Comparison of 1,800 Laparoscopic and Open Partial Nephrectomies for Single Renal Tumors显示文摘Inderbir S. Gill Louis R. Kavoussi Brian R. Lane Michael L. Blute Denise Babineau J. Roberto Colombo Igor Frank Sompol Permpongkosol Christopher J. Weight Jihad H. Kaouk Michael W. Kattan Andrew C. Novick 2007The Journal of Urology2007,,1:5
16Brands and Branding: Research Findings and Future Priorities显示文摘Kevin Lane Keller Donald R. Lehmann 2006Marketing Science2006,,6:4
17p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen 2015Cell Research2015,25,3:4
18Comparison of Cold and Warm Ischemia During Partial Nephrectomy in 660 Solitary Kidneys Reveals Predominant Role of Nonmodifiable Factors in Determining Ultimate Renal Function显示文摘Brian R. Lane Paul Russo Robert G. Uzzo Adrian V. Hernandez Stephen A. Boorjian R. Houston Thompson Amr F. Fergany Thomas E. Love Steven C. Campbell 2011The Journal of Urology2011,,2:3
19奥马佐单抗治疗顽固性特应性皮炎显示文摘Atopic dermatitis is a common diagnosis that presents a therapeutic challenge. Although multiple therapeutic modalities exist, there is no single monotherapy that has proven exceptional in ameliorating the symptoms of this disease. Current topical and systemic therapeutic options offer benefit but carry varying degrees of adverse effects that often limit their application. We present 3 patients with severe, recalcitrant atopic dermatitis successfully treated with omalizumab.Lane J.E. Cheyney J.M. Lane T.N. 李晓莉 2006世界核心医学期刊文摘(皮肤病学分册)2006,0,4:3
20Every Minute Counts When the Renal Hilum Is Clamped During Partial Nephrectomy 显示文摘R. Houston Thompson Brian R. Lane Christine M. Lohse Bradley C. Leibovich Amr Fergany Igor Frank Inderbir S. Gill Michael L. Blute Steven C. Campbell 2010European Urology2010,,:3
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