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| 1 | Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent:In-vitro and ex-vivo investigations显示文摘Gatifloxacin eye drops are frequently used in eye infections.However such formulations have a major drawback i.e.short duration of action and usually require 4e6 times installations daily.A chitosan coated niosomal formulation of gatifloxain was purposed to show a longer retention time on eyes and subsequent reduction in dosing frequency.Vesicles were prepared by solvent injection method using cholesterol and Span-60.An extensive optimization of formulation was done using different ratios of cholesterol,Span-60 and drug,revealed NS60-5(cholesterol:span-6050:50 and drug content of 20 mg)to be the optimized niosome formulation.NS60-5 had shown a highest entrapment efficiency of 64.9±0.66%with particle size 213.2±1.5 nm and zeta potential34.7±2.2 mV.Optimized niosomes were also coated with different concentrations of chitosan and evaluated.Permeation studies had revealed that optimized niosomes(86.77±1.31%)had increased the transcorneal permeation of Gatifloxacin more than two fold than simple drug solution(37.19±1.1%).Longer retention potential of the coated niosomes was further verified by fluorescence microscopy.Study revealed that simple dye solution got easily washed out with in 6 h.The uncoated niosomes(NS60-5)showed a longer retention(more than 6 h),which was further enhanced in case of coated niosomes i.e.CNS60-1(more than 12 h).Antimicrobial studies had shown the better efficacy of CNS60-1(zone of inhibition)when compared to marketed formulation.The final chitosan formulation was found to have shown better ocular tolerability as demonstrated by corneal hydration test histopathology investigations. | Yahaya Zubairu Lalit Mohan Negi Zeenat Iqbal Sushama Talegaonkar | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 4 |
| 2 | Effect of various pretreatment methods on anaerobic mixed microflora to enhance biohydrogen production utilizing dairy wastewater as substrate显示文摘 | S Venkata Mohan V Lalit Babu P N Sarma | 2008 | Bioresource Technology2008，99，1： | 1 |
| 3 | Influence of recirculation on the performance of anaerobic sequencing batch biofilm reactor (AnSBBR) treating hypersaline composite chemical wastewater显示文摘 | Mohan S V Lalit B V Vijaya B Y | 2007 | Bioresour Technol2007，98，7： | 1 |
| 4 | Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction显示文摘BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac biomarkers.Rapid restoration of brisk flow in the coronary vasculature is critical in reducing mortality and morbidity.In patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective option.AIM To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after thrombolysis.METHODS This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary arteries.Patients received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another group.The primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the procedure.The secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 d.RESULTS The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,respectively.Smoking rate was 54.6%and 55.8%in the routine and delayed groups,respectively.Thrombolysis was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,respectively.No significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reported MACCE in the two groups did not demonstrate any significant correlation.Secondary endpoints such as angina,dyspnea,and major bleeding were non-significantly different between the two groups.CONCLUSION Delayed PCI pharmacoinvasive strategy in a critical diseased but not completely occluded artery beyond 24 h in patients who have been timely thrombolyzed seems a reasonable strategy. | Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi | 2023 | World Journal of Cardiology2023，15，1： | 1 |
| 5 | Short wave infrared(SWIR)hyperspectral imaging technique for examination of aflatoxin B1(AFB1)on corn kernels显示文摘 | Lalit Mohan Kandpal Sangdae Lee Moon S Kim | 2015 | Food Control2015，51，： | 1 |
| 6 | Phylogenetic reconstruction using secondary structures and sequence motifs of ITS2 rDNA of Paragonimus westermani (Kerbert, 1878) Braun, 1899 (Digenea: Paragonimidae) and related species显示文摘 | Prasad Pramod Kumar Tandon Veena Biswal Devendra Kumar Goswami Lalit Mohan Chatterjee Anupam | 2010 | BMC Genomics2010，10，3： | 1 |
| 7 | Anaerobic bio-hydrogen production from dairy wastewater treatment insequencing batch reactor (AnSBR) : Effect of organic loading rate 显示文摘 | Venkata Mohan S Lalit Babu V Sarma P N | 2007 | Enzyme and Microbial Technology2007，41，： | 1 |
| 8 | Effect of various pretreatment methods on anaerobic mixed microflora to enhance biohydrogen production utilizing dairy wastewater as substrate显示文摘 | Venkata Mohan S Lalit Babu V Sanna P N | 2008 | Bioresource Technology2008，99，： | 1 |
| 9 | Anti-juvenile activity of Azadirachta indica extract on the development and morphometry of filaria vector, Culex quinquefasciatus (Diptera: Culicidae) Say显示文摘 | Preeti Sharma Lalit Mohan Chand N. Srivastava | 2009 | Parasitology Research2009，，5： | 1 |
| 10 | Electricity price forecasting in deregulated markets: A review and evaluation显示文摘 | Sanjeev Kumar Aggarwal Lalit Mohan Saini Ashwani Kumar | 2008 | International Journal of Electrical Power and Energy Systems2008，，1： | 1 |
| 11 | Influ-ence of recireulation on the performance of anaerobic se- quencing batch biofilm reactor (AnSBBR) treating hy- persaline composite chemical wastewater 显示文摘 | Mohan S V Lalit Babu V Vijaya Bhaskar Y | 2007 | Bioresour Technol2007，98，7： | 1 |
| 12 | Anaerobic biohydrogen production from dairy wastewater treatment in sequencing batch reactor (AnSBR): Effect of organic loading rate 显示文摘 | S Venkata Mohan V Lalit Babu P N Sarma | 2007 | Enzyme and Microbial Technology2007，41，： | 1 |
| 13 | Effect of various pretreatment methods on anaerobic mixed micro- flora to enhance biohydrogen production utilizing dairy wastewater as substrate 显示文摘 | Venkata Mohan S Lalit Babu V Sarna P N | 2008 | Bioresource Technology2008，99，： | 1 |
| 14 | AI Fairness-From Machine Learning to Federated Learning显示文摘This article reviews the theory of fairness in AI-frommachine learning to federated learning,where the constraints on precision AI fairness and perspective solutions are also discussed.For a reliable and quantitative evaluation of AI fairness,many associated concepts have been proposed,formulated and classified.However,the inexplicability of machine learning systems makes it almost impossible to include all necessary details in the modelling stage to ensure fairness.The privacy worries induce the data unfairness and hence,the biases in the datasets for evaluating AI fairness are unavoidable.The imbalance between algorithms’utility and humanization has further reinforced suchworries.Even for federated learning systems,these constraints on precision AI fairness still exist.Aperspective solution is to reconcile the federated learning processes and reduce biases and imbalances accordingly. | Lalit Mohan Patnaik Wenfeng Wang | 2024 | Computer Modeling in Engineering & Sciences2024，139，5： | 0 |
| 15 | Science Letters:Demonstration of a new biosensing concept for immunodiagnostic applications based on change in surface conductance of antibodies after biomolecular interactions显示文摘We report an important observation that the surface conductivity of antibody layer immobilized on polylysine-coated glass substrate decreases upon the formation of complex with their specific antigens. This change in conductivity has been ob- served for both monoclonal and polyclonal antibodies. The conductance of monoclonal mouse IgG immobilized on polylysine-coated glass substrate changed from 1.02×10?8 ??1 to 1.41×10?11 ??1 at 10 V when complex is formed due to the specific biomolecular interactions with rabbit anti-mouse IgG F(ab′)2. Similar behavior was observed when the same set up was tested in two clinical assays: (1) anti-Leishmania antigen polyclonal antibodies taken from Kala Azar positive patient serum interacting with Leishmania promastigote antigen, and (2) anti-p21 polyclonal antibodies interacting with p21 antigen. The pro- posed concept can represent a new immunodiagnostic technique and may have wide ranging applications in biosensors and nanobiotechnology too. | VASHIST Sandeep Kumar KAUR Inderpreet BAJPAI Ram Prakash BHARADWAJ Lalit Mohan TEWARI Rupinder RAITERI Roberto | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，9： | 0 |
| 16 | Swarm-LSTM: Condition Monitoring of Gearbox Fault Diagnosis Based on Hybrid LSTM Deep Neural Network Optimized by Swarm Intelligence Algorithms显示文摘Nowadays,renewable energy has been emerging as the major source of energy and is driven by its aggressive expansion and falling costs.Most of the renewable energy sources involve turbines and their operation and maintenance are vital and a difficult task.Condition monitoring and fault diagnosis have seen remarkable and revolutionary up-gradation in approaches,practices and technology during the last decade.Turbines mostly do use a rotating type of machinery and analysis of those signals has been challenging to localize the defect.This paper proposes a new hybrid model wherein multiple swarm intelligence models have been evaluated to optimize the conventional Long Short-Term Memory(LSTM)model in classifying the faults from the vibration signals data acquired from the gearbox.This helps to analyze the performance and behavioral patterns of the system more effectively and efficiently which helps to suggest for replacement of the unit with higher precision.The results have demonstrated that the proposed hybrid modeling approach is effective in classifying the faults of the gearbox from the time series data and achieve higher diagnostic accuracy in comparison to the conventional LSTM methods. | Gopi Krishna Durbhaka Barani Selvaraj Mamta Mittal Tanzila Saba Amjad Rehman Lalit Mohan Goyal | 2021 | Computers, Materials & Continua2021，，2： | 0 |
| 17 | Formulation,in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method显示文摘Introduction:Griseofulvin is an antifungal drug belonging to Biopharmaceutical Classification System(BCS class II)having low solubility.Objectives:To formulate,evaluate and enhance the dissolution of poorly water soluble drug Griseofulvin by using solid dispersion method.Methods:Six formulations were prepared by solid dispersion method using Polyethylene Glycol(PEG 6000)125 mg,0 mg,62.5 mg,100 mg,25 mg,150 mg and superdisintegrants Crospovidone 0 mg,125 mg,62.5 mg,100 mg,25 mg,150 mg in all batches respectively.Findings:Satisfactory results were obtained from evaluation of physical characteristics of Griseofulvin tablets including:carr’s compressibility index(17.5±0.19%to 11.76±0.67%),Hausner ratio(1.21±0.01 to 1.13±0.02)and post compression parameters including:thickness(5.16±0.02 mm to 4.57±0.19 mm),friability(0.024%to 0.322%),hardness(4±0.28 kg/cm^(2)to 5±0.57 kg/cm^(2)),disintegration time(14-870 seconds).Conclusions:F3 was best formulation among all formulated batches with in-vitro drug release 30.05%in 10 minutes,69.21%in 30 minutes and 97.11%in 45 minutes.This indicated that formulation F3 batch with PEG 6000 of 62.5 mg and crospovidone 62.5 mg showed increased dissolution. | Gopal Pokhrel Bikash Dani Srijana Shrestha Rakshya Chaudhary Ramesh Dhami Barnabas Sunuwar Sharad Pudasaini Vijay Yadav Lalit Mohan Pant Rajan Ghimire | 2022 | Journal of Pharmacy and Pharmacology2022，10，4： | 0 |
| 18 | MCBC-SMOTE:A Majority Clustering Model for Classification of Imbalanced Data显示文摘Datasets with the imbalanced class distribution are difficult to handle with the standard classification algorithms.In supervised learning,dealing with the problem of class imbalance is still considered to be a challenging research problem.Various machine learning techniques are designed to operate on balanced datasets;therefore,the state of the art,different undersampling,over-sampling and hybrid strategies have been proposed to deal with the problem of imbalanced datasets,but highly skewed datasets still pose the problem of generalization and noise generation during resampling.To overcome these problems,this paper proposes amajority clusteringmodel for classification of imbalanced datasets known as MCBC-SMOTE(Majority Clustering for balanced Classification-SMOTE).The model provides a method to convert the problem of binary classification into a multi-class problem.In the proposed algorithm,the number of clusters for themajority class is calculated using the elbow method and the minority class is over-sampled as an average of clustered majority classes to generate a symmetrical class distribution.The proposed technique is cost-effective,reduces the problem of noise generation and successfully disables the imbalances present in between and within classes.The results of the evaluations on diverse real datasets proved to provide better classification results as compared to state of the art existing methodologies based on several performance metrics. | Jyoti Arora Meena Tushir Keshav Sharma Lalit Mohan Aman Singh Abdullah Alharbi Wael Alosaimi | 2022 | Computers, Materials & Continua2022，，12： | 0 |
| 19 | Status of carbohydrate,protein and lipid profile in the mosquito larvae treated with certain phytoextracts显示文摘Objective:To investigate the impact of the most potent petroleum ether extract of Artemisia annua(A.annua) and Azadirachta indica(Az.indica) on total carbohydrate,lipid and protein level of Anopheles stephensi and Culex quinquefasciatus larvae.Methods:Mosquito larvae were exposed to the extracts selected as per standard WHO procedure.Carbohydrate(glucose),total lipid and protein were estimated by the methods as Nelson,Bragdon and Lowry described, respectively.Results:The glucose levels were increased to 27.87%and 46.8%,respectively in anopheline larval tissues after treatment with petroleum ether extract of A.annua and methanolic extract of Az.indica.In culicine larvae,glucose levels were reduced to 58.96%and 24.65%, respectively.After treatment with A.annua extract,lipid contents in anopheline and culicine larvae decreased by 28.57%and 25.0%,respectively and increased by 14.29%and 50.00%in the Anopheles and Culex larvae,respectively after treatment with methanolic extract of Az. indica.Total protein levels were reduced to 63.13%and 92.62%in anopheline and to 32.39%and 48.12%in culicine larvae after treatment with A.annua and Az.Indica extracts,respectively. Conclusions:Two extracts produce significant alterations in the biochemical pr of iles of anopheline and culicine larvae.Further,the impacting factors of extracts on carbohydrate,lipid and protein contents of larvae are species and specific extraction.It indicates the disturbed metabolic activity of the larvae. | Preeti Sharma Lalit Mohan Kamal Kumar Dua Chand Narayan Srivastava | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，4： | 0 |
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