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| 1 | Association of the HLA-DRB1*0701 allele with perinuclear anti-neutrophil cytoplasmatic antibodies in Mexican patients with severe ulcerative colitis显示文摘瞄准:决定在 HLA-DRB1 等位基因和仙子之间的协会原子反嗜中性的 cytoplasmatic 抗体(p-ANCA ) 在有 ulcerative (UC ) 的墨西哥病人积极。方法:有 UC 的 90 个墨西哥混血儿病人(45 女性) ,由活体检视证实了,被学习。打字的高决定 HLA 被 PCR-SSO 反向的点污点和 PCR-SSP 执行。分子的打字技术被使用定义 HLA-DRB1 等位基因。连接酶的免疫吸着剂试金和免疫荧光技术被用来检测 p-ANCA。结果:48 (53%) UC 病人为由 ELISA 的 p-ANCA 是积极的并且如果。我们发现 p-ANCA-positive UC 病人与 p-ANCA-negative 控制相比有 HLA-DR7 的显著地增加的频率(22% 对 5.1% ;pC=0.02, OR=5.2, CI 95% :1.06-37.82 ) 。疾病活动在 20 个病人,作为严重被获得在 8 中等,在 14 并且不温和在留下的活动 38 个病人根据纯爱和 Witts 标准。亚群分析与 UC 和 p-ANCA 确实的严重活动在 20 个 UC 病人中的 15 个显示出 HLA-DRB1 *07 等位基因的显著地增加的频率[100% 对 0% ;pC=0.0000001;OR=35 ] 。没有有效差量在 p-ANCA 之间被发现象额外的肠的表明, proctocolectomy 和延期那样的积极病人, HLA 医生等位基因和另外的临床的特征。结论:HLA-DRB1 *07 与 p-ANCA 被联系积极 UC 墨西哥病人。 | Jesus K Yamamoto-Furusho Luis Uscanga-Domínguez Alondra Lopez-Martinez Julio Granados | 2006 | World Journal of Gastroenterology2006，12，10： | 8 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Hazardous elements and amorphous nanoparticles in historical estuary coal mining area显示文摘In Brazil, intense coal exploitation activities have led to environmental deterioration, including soil mortification, water contamination, loss of ecosystem, and atmospheric contamination. In addition,considerable quantities of sulfur-rich residues are left behind in the mining area; these residues pose grave environmental issues as they undergo sulfide oxidation reactions. When sulfur oxides come in contact with water, extreme acid leachate is produced with great proportions of sulfate, and hazardous elements(HEs), which are identified as coal drainage(CMD). CMD is an environmental pollution challenge, particularly in countries with historic or active coal mines. To prevent CMD formation or its migration, the source must be controlled; however, this may not be feasible at many locations. In such scenarios, the mine water should be collected, treated, and discharged. In this study, data from 2005 to2010 was gathered on the geochemistry of 11 CMD discharges from ten different mines. There are several concerns and questions on the formation of nanominerals in mine acid drainage and on their reactions and interfaces. The detailed mineralogical and geochemical data presented in this paper were derived from previous studies on the coal mine areas in Brazil. Oxyhydroxides, sulfates, and nanoparticles in these areas possibly go through structural transformations depending on their size and formation conditions. The geochemistry of Fe-precipitates(such as jarosite, goethite, and hematite) existent in the CMD-generating coal areas and those that could be considered as a potential source of hazardous elements(HEs)(e.g., Cr) were also studied because these precipitates are relatively stable in extremely low pH conditions. To simplify and improve poorly ordered iron, strontium, and aluminum phase characterization, field emission scanning electron microscopy(FE-SEM), high-resolution transmission electron microscopy(HR-TEM), micro-Raman spectroscopy, and X-ray diffraction(XRD) and sequential extraction(SE) studies were executed on a set CMD samples from the Brazilian mines. This study aimed to investigate the role of both nanomineral and amorphous phase distribution throughout the reactive coal cleaning rejects profile and HEs removal from the water mine to provide holistic insights on the ecological risks posed by HEs, nanominerals, amorphous phases, and to assess sediments in complex environments such as estuaries. | Ana L.Duarte Kátia DaBoit Marcos L.S.Oliveira Elba C.Teixeira Ismael L.Schneider Luis F.O.Silva | 2019 | Geoscience Frontiers2019，10，3： | 6 |
| 4 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 5 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 6 | Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: Experience in a Mexican institution显示文摘瞄准:在墨西哥 ulcerative (UC ) 的一件样品估计流行和 p-ANCA 的临床的价值病人。方法:在一个未来的、同意 IRB 的协议, p-ANCA 与 UC 在 80 个病人被决定(吝啬的年龄, 32 +/- 12.9 年) 。疾病的严厉和延期被临床的方法决定,寻找有 p-ANCA 地位的一个统计协会。结果:p-ANCA 在 41 被检测(51%) 病人。疾病的严厉是统计上与他们的存在联系的唯一的临床的变量(P <
0.0001;或 = 9;CI 95%= 3.2-24.7 ) 。结论:p-ANCA 的流行类似于在另外的国家报导了那。他们的存在被联系到 UC 严厉,但是比提供了没有更多的信息由临床的方法获得了。 | Jesus K Yamamoto-Furusho Takeshi Takahashi-Monroy Omar Vergara-Fernandez Edgardo Reyes Luis Uscanga | 2006 | World Journal of Gastroenterology2006，12，21： | 2 |
| 7 | Is artificial intelligence the final answer to missed polyps in colonoscopy?显示文摘Lesions missed by colonoscopy are one of the main reasons for post-colonoscopy colorectal cancer,which is usually associated with a worse prognosis.Because the adenoma miss rate could be as high as 26%,it has been noted that endoscopists with higher adenoma detection rates are usually associated with lower adenoma miss rates.Artificial intelligence(AI),particularly the deep learning model,is a promising innovation in colonoscopy.Recent studies have shown that AI is not only accurate in colorectal polyp detection but can also reduce the miss rate.Nevertheless,the application of AI in real-time detection has been hindered by heterogeneity of the AI models and study design as well as a lack of long-term outcomes.Herein,we discussed the principle of various AI models and systematically reviewed the current data on the use of AI on colorectal polyp detection and miss rates.The limitations and future prospects of AI on colorectal polyp detection are also discussed. | Thomas K L Lui Wai K Leung | 2020 | World Journal of Gastroenterology2020，26，35： | 2 |
| 8 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 9 | Prokineticin-1 (Prok-1) works coordinately with glial cell line derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells显示文摘 | Ngan E S Shum C K Poon H C Sham M H Garcia-Barcelo M M Lui V C | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 10 | Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women1显示文摘 | LIAN K LUI L ZMUDA J M | 2007 | Osteoarthrtis Cartilage2007，15，8： | 1 |
| 11 | AACVPR/ACC/AHA2007 performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services 显示文摘 | Thomas R J King M Lui K | 2007 | Circulation2007，116，14： | 1 |
| 12 | Coding-and interference-aware routing protocol in wireless networks显示文摘 | HOU R QU S LUI K S | 2013 | Computer Communica- tions2013，36，17： | 1 |
| 13 | On perimeter coverage in wireless sensor networks显示文摘 | Hung K S Lui K S | 2010 | IEEE Transactions on Wireless Communications2010，9，7： | 1 |
| 14 | Increased alpha-B-crystallin expression in mammary metaplastic carcinomas 显示文摘 | Chan S K Lui P C Tan P H | 2011 | Histopatholo- gy2011，59，2： | 1 |
| 15 | Finite element analysis of the influence of tool edge radius on size effect in orthogonal micro-cutting process 显示文摘 | Lui K Melkote S N | 2007 | Int J Mech Sci (S0020-7403)2007，49，5： | 1 |
| 16 | Longitudinal motor development of 'apparently normal' high-risk infants at 18 months,3 and 5 years显示文摘 | Goven TA Lui K | 2002 | Early Hum Dev2002，70，： | 1 |
| 17 | On the water impact of general two-dimensional sections 显示文摘 | Mei X Lui Y Yue D K P | 1999 | Applied Ocean Research1999，21，1： | 1 |
| 18 | The Complex Trial Protocol (CTP) : A new, countermeasure-resistant, accurate P300-based method for detection of concealed informa- tion 显示文摘 | Rosenfeld J P Labkovsky E Lui M A Winograd M Van- denboom C & Chedid K | 2008 | Psychophysiology2008，45，： | 1 |
| 19 | Patterns of Known and Novel Small RNAs in Human Cervical Cancer 显示文摘 | LUI W O POURMAND N PATYERSON B K | 2007 | Cancer Research2007，67，13： | 1 |
| 20 | Oxygen reduction reaction (ORR) catalyzed by carbon-supported cobalt polypyrrole (Co-PPy/C) electrocatalysts 显示文摘 | LEE K ZHANG L LUI H HUI R SHI Z ZHANG J | 2009 | Electrochim Acta2009，54，20： | 1 |
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