|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Effect of nitrogen limitation on antioxidant qualities is highly associated with genotypes of lettuce(Lactuca sativa L.)显示文摘Antioxidants are highly beneficial to human health, and their accumulation in lettuce, one of the most popular leafy vegetables, depends on both genetic and environmental factors. Nitrogen(N) availability plays an essential role in regulating antioxidant accumulation, but the influence of genotype × N interactions on the antioxidant qualities of lettuce is poorly understood. Therefore, the present study investigated the variation of growth and antioxidant qualities of 20 lettuce(Lactuca sativa L.) genotypes(10 green lettuce genotypes and 10 red lettuce genotypes) under limited N(low N, LN) conditions and standard N(high N, HN) conditions. For all 20 genotypes, LN conditions reduced shoot(i.e., leaf) growth, but increased plant concentrations of vitamin C,glutathione, and phenolic compounds, with the exception of carotenoids, compared with HN conditions. Because of reduced biomass under LN conditions, not all lettuce genotypes exhibited increased antioxidant yields or total antioxidant capacity yield. The variation in antioxidant quality was primarily genetically determined. Generally, the green lettuce genotypes exhibited more pronounced increases in antioxidant yields and total antioxidant capacity yield than the red lettuce genotypes under LN conditions. These results suggest that even though LN conditions generally tend to improve the antioxidant qualities of lettuce, the extent of this effect is highly dependent on genotype. Therefore, genotype should be given priority in future studies that aim to improve antioxidant qualities in lettuce through N management. | Weiwei ZHOU Ting LV Yan HU Wenjing LIU Qingfang BI Chongwei JIN Lingli LU Xianyong LIN | 2020 | Pedosphere2020，30，3： | 4 |
| 3 | An Experimental and Analytical Study on Cross-Laminated Bamboo Rocking Walls with Friction Dampers显示文摘Cross-laminated bamboo(CLB)have a high strength to weight ratio and stable bidirectional mechanical properties.Inspired by the investigation on cross-laminated timber(CLT)rocking walls,CLB rocking walls with conventional friction dampers(CFDs)are studied in this paper.To investigate the mechanical properties of the CLB rocking wall,seven tests are conducted under a cyclic loading scheme,and different test parameters,including the existence of the CFDs,the moment ratio,and the loading times,are discussed.The test results show a bilinear behavior of the CLB rocking wall.The small residual displacements of the CLB rocking wall demonstrate an idealized self-centering capacity.The cumulative energy dissipation curves indicate that the energy dissipation capacity of the CLB rocking wall can be greatly improved with CFDs.The limit states of the CLB rocking wall under a lateral force are proposed based on the strains,stress,and damage level of the CLB material and posttensioned rebar.In addition,an analytical model of the CLB rocking wall is developed based on the proposed limit states of the CLB rocking wall to evaluate the hysteretic response of the CLB rocking wall,and the model is validated by the experimental data.The comparison results show the potential value of the analytical model for engineering design. | Qingfang Lv Tongchen Han Ye Liu Yi Ding Yujie Lu | 2021 | Journal of Renewable Materials2021，9，10： | 2 |
| 4 | Effect of Soil Drying Intensity During an Experimental Drying-Rewetting Event on Nutrient Transformation and Microbial Community Composition显示文摘Soil drying-rewetting(DRW) events affect nutrient transformation and microbial community composition; however, little is known about the influence of drying intensity during the DRW events. Therefore, we analyzed soil nutrient composition and microbial communities with exposure to various drying intensities during an experimental drying-rewetting event, using a silt loam from a grassland of northern China, where the semi-arid climate exposes soils to a wide range of moisture conditions, and grasslands account for over 40% of the nation's land area. We also conducted a sterilization experiment to examine the contribution of soil microbes to nutrient pulses. Soil drying-rewetting decreased carbon(C) mineralization by 9%–27%. Both monosaccharide and mineral nitrogen(N) contents increased with higher drying intensities(drying to ≤ 10% gravimetric water content), with the increases being 204% and 110% with the highest drying intensity(drying to 2% gravimetric water content), respectively, whereas labile phosphorus(P)only increased(by 105%) with the highest drying intensity. Moreover, levels of microbial biomass C and N and dissolved organic N decreased with increasing drying intensity and were correlated with increases in dissolved organic C and mineral N, respectively,whereas the increases in labile P were not consistent with reductions in microbial biomass P. The sterilization experiment results indicated that microbes were primarily responsible for the C and N pulses, whereas non-microbial factors were the main contributors to the labile P pulses. Phospholipid fatty acid analysis indicated that soil microbes were highly resistant to drying-rewetting events and that drought-resistant groups were probably responsible for nutrient transformation. Therefore, the present study demonstrated that moderate soil drying during drying-rewetting events could improve the mineralization of N, but not P, and that different mechanisms were responsible for the C, N, and P pulses observed during drying-rewetting events. | SUN Dashend BI Qingfang LI Kejie ZHU Jun ZHANG Qichun JIN Chongwei LU Lingli LIN Xianyong | 2018 | Pedosphere2018，28，4： | 2 |
| 5 | Enhanced amplification of bacterial and fungal DNA using a new type ofDNA polymerase显示文摘 | LU Qingfang HU Hanqiao MO Junjie | 2012 | Australasian Plant Patholo~~2012，41，： | 1 |
| 6 | Durability zonation standard of concrete structural design显示文摘 | JIN Weiliang LU Qingfang | 2007 | Joumal of Southeast University2007，23，1： | 1 |
| 7 | Identification and cultivation of a wild mushroom from banana pseudo-stem显示文摘 | Liu Yuelian Lu Qingfang | 2011 | Sheath Scientia Horticulturae2011，129，4： | 1 |
| 8 | Enhanced amplification of bacterial and fungal DNA using a new type of DNA polymerase显示文摘 | Lu Qingfang Hu Hanqiao Mo Junjie | 2012 | Australasian Plant Pathol2012，，41： | 1 |
| 9 | Flexuralperformance of glued laminated bamboo beams显示文摘 | WEI Yang JIANG Shenxue LU Qingfang | 2011 | Adv MaterRes2011，1，： | 1 |
| 10 | Graphene/SiC-coated textiles with excellent electromagnetic interference shielding,Joule heating,high-temperature resistance,and pressure-sensing performances显示文摘Multifunctional,wearable,and durable textiles integrated with smart electronics have attracted tremendous attention.However,it remains a great challenge to balance new functionalities with high-temperature stability.Herein,textile-based pressure sensors with excellent electromagnetic interference(EMI)shielding,Joule heating,and high-temperature resistance were fabricated by constructing graphene/SiC(G/SiC)heterostructures on carbon cloth via laser chemical vapor deposition(LCVD).The resultant textiles exhibited excellent EMI efficiency of 74.2 dB with a thickness of 0.45 mm,Joule heating performance within a low working voltage(V)range of 1-3 V,and fast response time within 20 s.These properties arose from multiple reflections,interfacial polarization,and high conductivity due to the numerous amounts of nanoscale G/SiC heterostructures.More importantly,G/SiC/carbon fibers(CFs)demonstrated well high-temperature resistance with a heat resistance index(THri)of 380.2 C owing to the protection of a coating layer on the CFs upon oxidation.Meanwhile,the G/SiC/CFs presented good pressure-sensing performance with high sensitivity(S)of 52.93 kPal,fast response time of 85 ms,and a wide pressure range of up to 186 kPa.These features imply the potential of the G/SiC/CFs as efficient EMI shielding,electrical heater,and piezoresistive sensor textiles. | Chongjie Wang Qingfang Xu Jinrong Hu Pengjan Lu Han Wu Bingian Guo Rong Tu Kai Liu Meijun Yang Song Zhang Bao-Wen Li Chuanbin Wang Lianmeng Zhang | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
| 11 | ARTICLE OPEN Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection显示文摘Over 40% of the coronavirus disease 2019(COVID-19)COVID-19 patients were asymptomatically infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the immune responses of these asymptomatic individuals is a critical factor for developing the strategy to contain the COVID-19 pandemic.Here,we determined the viral dynamics and antibody responses among 143 asymptomatic individuals identified in a massive screening of more than 5 million people in eight districts of Wuhan in May 2020.Asymptomatic individuals were admitted to the government-designated centralized sites in accordance with policy.The incidence rate of asymptomatic infection is〜2.92/100,000.These individuals had low viral copy numbers(peaked at 315 copies/mL)and short-lived antibody responses with the estimated diminish time of 69 days.The antibody responses in individuals with persistent SARS-CoV-2 infection is much longer with the estimated diminish time of 257 days.These results imply that the immune responses in the asymptomatic individuals are not potent enough for preventing SARS-CoV-2 re-infection,which has recently been reported in recovered COVID-19 patients.This casts doubt on the efficacy of forming'herd-immunity'through natural SARS-CoV-2 infection and urges for the development of safe and effective vaccines. | Zhiwei Sui Xinhua Dai Qingbin Lu Yulan Zhang Min Huang Shufen Li Tao Peng Jie Xie Yongzhuo Zhang Chunchen Wu Jianbo Xia Lianhua Dong Jiayi Yang Wenfeng Huang Siyuan Liu Ziquan Wang Ke Li Qingfang Yang Xi Zhou Ying Wu Wei Liu Xiang Fang Ke Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 0 |
| 12 | Ultra-Lightweight Face Animation Method for Ultra-Low Bitrate Video Conferencing显示文摘Video conferencing systems face the dilemma between smooth streaming and decent visual quality because traditional video compression algorithms fail to produce bitstreams low enough for bandwidth-constrained networks.An ultra-lightweight face-animation-based method that enables better video conferencing experience is proposed in this paper.The proposed method compresses high-quality upperbody videos with ultra-low bitrates and runs efficiently on mobile devices without high-end graphics processing units(GPU).Moreover,a visual quality evaluation algorithm is used to avoid image degradation caused by extreme face poses and/or expressions,and a full resolution image composition algorithm to reduce unnaturalness,which guarantees the user experience.Experiments show that the proposed method is efficient and can generate high-quality videos at ultra-low bitrates. | LU Jianguo ZHENG Qingfang | 2023 | ZTE Communications2023，21，1： | 0 |
| 13 | Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer显示文摘Ovarian cancer is the tumor with the highest mortality among gynecological malig-nancies.Studies have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages(TAMs)in the microenvironment.Colony-stimu-lating factor 1(CSF-1)receptor(CSF-1R)plays a key role in regulating the number and differ-entiation of macrophages in certain solid tumors.There are few reports on the effects of targeted inhibition of CSF-1R in combination with chemotherapy on ovarian cancer and the tu-mor microenvironment.Here,we explored the antitumor efficacy and possible mechanisms of the CSF-1R inhibitor pexidartinib(PLX3397)when combined with the first-line chemothera-peutic agent paclitaxel in the treatment of ovarian cancer.We found that CSF-1R is highly ex-pressed in ovarian cancer cells and correlates with poor prognosis.Treatment by PLX3397 in combination with paclitaxel significantly inhibited the growth of ovarian cancer both in vitro and in vivo.Blockade of CSF-1R altered the macrophage phenotype and reprogrammed the immunosuppressive cell population in the tumor microenvironment. | Meijia Yu Yiming Wu Qingfang Li Weiqi Hong Yang Yang Xiaoyi Hu Yanfei Yang Tianqi Lu Xia Zhao Xiawei Wei | 2024 | Genes & Diseases2024，11，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员