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| 1 | KAI1/CD82 suppresses hepatocyte growth factorinduced migration of hepatoma cells via upregulationof Sprouty2显示文摘We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis.Hepatocyte growth factor(HGF)induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1(SphK1).Adenovirus-mediated gene transfer of KAI1(Ad-KAI1)downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells.Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level.Ablation of Sprouty2 with RNA interference can block the KAI1/CD82-induced suppression of hepatoma cell migration and downregulation of SphK1 expression.It is demonstrated that KAI1/CD82 suppresses HGF-induced migration of hepatoma cells via upregulation of Sprouty2. | MU ZhenBin1 ,3,WANG Hua 2,ZHANG Jing 2,LI QingFang 2,WANG LiSheng 2&GUO XiaoZhong 3 1State Key Laboratory of Cancer Biology and Institute of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,China 2Department of Experimental Hematology,Beijing Institute of Radiation Medicine,Beijing 100850,China 3Department of Gastroenterology,Shenyang General Hospital of PLA,Shenyang 110016,China | 2008 | Science China(Life Sciences)2008，51，7： | 7 |
| 2 | Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China显示文摘There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area(SLA) decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency(WUE) increased significantly. In addition, with the intensification of climatic drought stress, peroxidase(POD) and superoxide dismutase(SOD) activities in leaves increased sig- nificantly. As a result, the malondialdehyde(MDA) content increased while the oxygen free radical content decreased. Our results showed that most of the leaf ecological and physiological traits of the 12 Caragana species varied in ac- cordance with the climatic drought gradient in the Inner Mongolia region, which reflected the adaptation of the Cara- gana species to the local climate conditions. With relatively more active metabolism and faster growth, the Caragana species in the northeast had strong competitive abilities; on the other hand, with stronger resistance to climatic drought stress, the Caragana species in the southwest could survive in harsh environments. Based on our results, we con- cluded that both the environmental gradients and the adaptive responses of Caragana species to their environments played important roles in the formation of the Caragana species distribution pattern across the Inner Mongolia region. | LiNa XIE ChengCang MA HongYu GUO QingFang LI YuBao GAO | 2014 | Journal of Arid Land2014，6，3： | 5 |
| 3 | Establishment and evaluation of a peanut association panel and analysis of key nutritional traits显示文摘Breeding programs aim to improve the yield and quality of peanut(Arachis hypogaea L.); using association mapping to identify genetic markers linked to these quantitative traits could facilitate selection efficiency. A peanut association panel was established consisting of 268 lines with extensive phenotypic and genetic variation, meeting the requirements for association analysis. These lines were grown over 3 years and the key agronomic traits, including protein and oil content were examined. Population structure(Q) analysis showed two subpopulations and clustering analysis was consistent with Q-based membership assignment and closely related to botanical type. Relative Kinship(K) indicated that most of the panel members have no or weak familial relatedness, with 52.78% of lines showing K ? 0. Linkagedisequilibrium(LD) analysis showed a high level of LD occurs in the panel. Model comparisons indicated false positives can be effectively controlled by taking Q and K into consideration and more false positives were generated by K than Q. A preliminary association analysis using a Q t K model found markers significantly associated with oil, protein, oleic acid, and linoleic acid, and identified a set of alleles with positive and negative effects. These results show that this panel is suitable for association analysis,providing a resource for marker-assisted selection for peanut improvement. | Xiurong Zhang Suqing Zhu Kun Zhang Yongshan Wan Fengzhen Liu Qingfang Sun Yingjie Li | 2018 | Journal of Integrative Plant Biology2018，60，3： | 5 |
| 4 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 5 | Crystalline behaviors and phase transition during the manufacture of fine denier PA6 fibers显示文摘Recently we have successfully produced fine denier PA6 fibers by using additives containing lanthanide compounds.Meanwhile,crystallization and phase transition of PA6 fibers during spinning and drawing processes were investigated.During the spinning process,β phase crystal could be obtained in as-spun PA6 fibers which were produced with relatively high melt draw ratio,while γ phase crystal predominated when the melt draw ratio was relatively low.β phase crystal,whose behaviors are similar with those of γ phase by FT-IR and XRD characterization,could be transformed to α form easily when PA6 fibers are immersed in boiling water.However,γ phase crystal of PA6 remains unchanged in boiling water.Thus,β and γ phase crystals of PA6 can be differentiated by the crystalline behaviors of PA6 fibers after treatment in boiling water.Further experiments demonstrate that the β phase can also be produced during a drawing process where a phase transformation from γ to α occurs.In other words,β phase may act as an intermediate state during the phase transformation. | ZHANG ChengFeng LIU YuHai LIU ShaoXuan LI HuiZhen HUANG Kun PAN QingHua HUA XiaoHui HAO ChaoWei MA QingFang LV ChangYou LI WeiHong YANG ZhanLan ZHAO Ying WANG DuJin LAI GuoQiao JIANG JianXiong XU YiZhuang WU JinGuang | 2009 | Science China Chemistry2009，52，11： | 4 |
| 6 | Efficient CO_2 capture on low-cost silica gel modified by polyethyleneimine显示文摘In this work,a series of polyethyleneimine(PEI) functionalized commercial silica gel were prepared by wet impregnation method and used as CO 2 sorbent.The as-prepared sorbents were characterized by N 2 adsorption,FT-IR and SEM techniques.CO 2 capture was tested in a fixed bed reactor using a simulated flue gas containing 15.1% CO 2 in a temperature range of 25-100 C.The effects of sorption temperature and amine content on CO 2 uptake of the adsorbents were investigated.The silica gel with a 30 wt% PEI loading manifested the largest CO 2 uptake of 93.4 mg CO 2 /g adsorbent(equal to 311.3 mg CO 2 /g PEI) among the tested sorbents under the conditions of 15.1%(v/v) CO 2 in N 2 at 75 C and atmospheric pressure.Moreover,it was rather low-cost.In addition,the PEI-impregnated silica gel exhibited stable adsorption-desorption behavior during 5 consecutive test cycles.These results suggest that the PEI-impregnated silica gel is a promising and cost-effective sorbent for CO 2 capture from flue gas and other stationary sources with low CO 2 concentration. | Ke Wang Hongyan Shang Lin Li Xinlong Yan Zifeng Yan Chenguang Liu Qingfang Zha | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 4 |
| 7 | High starter phosphorus fertilization facilitates soil phosphorus turnover by promoting microbial functional interaction in an arable soil显示文摘Microbial phosphorus(P)turnover is critical in C utilization efficiency in agroecosystems.It is therefore necessary to understand the P mobilization processes occurring during P fertilization in order to ensure both crop yield and environmental quality.Here,we established a controlled pot experiment containing soil amended with three different levels of starter P fertilizer and collected soil samples after 30,60,and 90 days of incubation.Quantitative microbial element cycling(QMEC)smart chip technology and 16S rRNA gene sequencing were used to investigate functional gene structures involved in carbon,nitrogen and P cycling and the bacterial community composition of the collected samples.Although P fertilization did not significantly affect the structure of the soil microbial community,some rare microbiota were changed in particular phosphorus-solubilizing bacteria were enriched at the high P fertilization level,suggesting that the rare taxa make an important contribution to P turnover.P fertilization also altered the functional gene structure,and high P concentrations enhanced the functional gene diversity and abundance.Partial redundancy analysis further revealed that changes in rare taxa and functional genes of soil microorganisms drive the alteration of soil P pools.These findings extend our understanding of the microbial mechanisms of P turnover. | Hongzhe Li Qingfang Bi Kai Yang Simon bo Lasson Bangxiao Zheng Li Cui Yongguan Zhu Kai Ding | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 8 | Effects of rotational tillage practices on soil properties, winter wheat yields and water-use efficiency in semi-arid areas of north-west China显示文摘 | Xianqing Hou Rong Li Zhikuan Jia Qingfang Han Wei Wang Baoping Yang | 2012 | Field Crops Research2012，，： | 2 |
| 9 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 10 | Effects on soil temperature, moisture, and maize yield of cultivation with ridge and furrow mulching in the rainfed area of the Loess Plateau, China显示文摘 | Rong Li Xianqing Hou Zhikuan Jia Qingfang Han Xiaolong Ren Baoping Yang | 2013 | Agricultural Water Management2013，，： | 2 |
| 11 | GFTSM-based Model Predictive Torque Control for PMSM Drive System With Single Phase Current Sensor显示文摘 | Qingfang Teng Yuxing Jin Shuyuan Li Jianguo Zhu Youguang Guo | 2017 | 自动化学报2017，43，9： | 2 |
| 12 | 3 - 43 Effects on Seedling Growth and Antioxidant Enzymes Activity of Oil-sunflower Irradiated by Carbon Ion Beams显示文摘 | Liu Qingfang Li Wenjian Qu Ying Zhou Libin Yu Lixia Du Yan | 2010 | IMP & HIRFL Annual Report2010，，1： | 2 |
| 13 | Targeted therapy for head and neck cancer:signaling pathways and clinical studies显示文摘Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed. | Qingfang Li Yan Tie Aqu Alu Xuelei Ma Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 14 | Effect of Soil Drying Intensity During an Experimental Drying-Rewetting Event on Nutrient Transformation and Microbial Community Composition显示文摘Soil drying-rewetting(DRW) events affect nutrient transformation and microbial community composition; however, little is known about the influence of drying intensity during the DRW events. Therefore, we analyzed soil nutrient composition and microbial communities with exposure to various drying intensities during an experimental drying-rewetting event, using a silt loam from a grassland of northern China, where the semi-arid climate exposes soils to a wide range of moisture conditions, and grasslands account for over 40% of the nation's land area. We also conducted a sterilization experiment to examine the contribution of soil microbes to nutrient pulses. Soil drying-rewetting decreased carbon(C) mineralization by 9%–27%. Both monosaccharide and mineral nitrogen(N) contents increased with higher drying intensities(drying to ≤ 10% gravimetric water content), with the increases being 204% and 110% with the highest drying intensity(drying to 2% gravimetric water content), respectively, whereas labile phosphorus(P)only increased(by 105%) with the highest drying intensity. Moreover, levels of microbial biomass C and N and dissolved organic N decreased with increasing drying intensity and were correlated with increases in dissolved organic C and mineral N, respectively,whereas the increases in labile P were not consistent with reductions in microbial biomass P. The sterilization experiment results indicated that microbes were primarily responsible for the C and N pulses, whereas non-microbial factors were the main contributors to the labile P pulses. Phospholipid fatty acid analysis indicated that soil microbes were highly resistant to drying-rewetting events and that drought-resistant groups were probably responsible for nutrient transformation. Therefore, the present study demonstrated that moderate soil drying during drying-rewetting events could improve the mineralization of N, but not P, and that different mechanisms were responsible for the C, N, and P pulses observed during drying-rewetting events. | SUN Dashend BI Qingfang LI Kejie ZHU Jun ZHANG Qichun JIN Chongwei LU Lingli LIN Xianyong | 2018 | Pedosphere2018，28，4： | 2 |
| 15 | Modified Characteristics of Mesophase Pitch Prepared from Coal Tar Pitch by Adding Waste Polystyrene显示文摘 | CHENG Xianglin ZHA Qingfang LI Xueiun | 2008 | Fuel Processing Technology2008，89，： | 1 |
| 16 | Effects on soil temperature, moisture, and maize yield of cultivation with ridge and furrow mulching in the rainfed area of the Loess Plateau, China显示文摘 | Rong Li Xianqing Hou Zhikuan Jia Qingfang Han Xiaolong Ren Baoping Yang | 2013 | Agricultural Water Management2013，，： | 1 |
| 17 | Maximizing the number of oxygen-containing functional groups on activated carbon by using ammonium persulfate and improving the temperature-programmed desorption characterization of carbon surface chemistry显示文摘 | Na Li Xiaoliang Ma Qingfang Zha Kyungsoo Kim Yongsheng Chen Chunshan Song | 2011 | Carbon2011，，15： | 1 |
| 18 | Modified characteristics of mesophase pitch prepared from coal tar pitch by adding waste polystyrene显示文摘 | Xianglin Cheng Qingfang Zha Xuejun Li Xiaojun Yang | 2008 | Fuel Processing Technology2008，，12： | 1 |
| 19 | Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period显示文摘The present study analyzed data from 108 Cushing's disease patients,who underwent trans-sphenoidal surgery in one hospital between January 2003 and April 2010,to investigate the performance value of bilateral inferior petrosal sinus sampling (BIPSS).Of the 108 patients,52 underwent BIPSS prior to surgery and 56 did not.Results showed that BIPSS accuracy for the diagnosis of Cushing's disease was 86.5% (45/52),and accuracy for adenoma lateralization during surgery was 76.9% (40/52).In addition,early remission rate was significantly greater compared to patients without BIPSS.Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing's disease and helped to predict adenoma lateralization. | Changyan Fan Xiuhua Shi Qingfang Sun Liuguan Bian Weiguo Zhao Jiankang Shen Hua Zhang Tingwei Su Weiqing Wang Xiaoying Li Guang Ning Liang Kong Lingling Hu | 2011 | Neural Regeneration Research2011，6，28： | 1 |
| 20 | Study on Crustal Structure in Haiyuan Strong Earthquake Region显示文摘The crust/upper-mantle velocity structure and deep tectonic features are obtained in Haiyuan M = 8. 5 earthquake region from data processing of Xiji-Zhongwei deep seismic sounding (DSS) profile. The result shows that there is a great difference between the velocity structures on the two sides of the epicenter. The crust consists of alternative high and low velocity layers on the southern side while on the northern side it consists of a series of layers with positive velocity gradient. There exists a deep fault cutting Moho or an anomalous deep structural zone in the epicentral region. | Li Songlin,Zhang Xiankang,Zhang Chengke,Ren Qingfang,Shi Jinhu,Zhao Jinren,Fang Shengming,Liu Baofeng,Pan Suzhen, and Zhang Jianshi Research Center of Exploration Geophysics, CSB, Zhengzhou 450002 , China | 2001 | Earthquake Research in China2001，15，3： | 1 |
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