|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microstructure Evolution and Mechanical Behavior of Laser Melting Deposited TA15 Alloy at 500℃ under In-Situ Tension in SEM显示文摘TA15 alloy fabricated by laser melting deposition was investigated at 500℃ under tensile deformation. The damage behavior of microstructure was analyzed by the real time observation of the microstructure evolution, microcracks initiation and propagation using in-situ tensile equipment fitted in the SEM chamber. Finally, the mechanism of fracture was discussed. The result showed anisotropic mechanical properties in X-and Z-direction. The existence of columnar β grains and its orientation to the tensile direction were the major factors inducing the anisotropic mechanical properties. As compared to Z-direction specimen, high tensile strength was observed in X-direction specimen due to the resistance in slips propagation provided by the prior-β grain boundaries( β GBs). Accumulation of the cracks at prior β GB caused the shear fracture. In case of Z-direction specimen, parallel orientation of prior β GB and GB α with the tensile direction resulted in a homogeneous deformation. The high reduction of cross section showed the enhanced ductile characteristics at high temperature. | Muhammad Rizwan Junxia Lu Fei Chen Ruxia Chai Rafi Ullah Yuefei Zhang Ze Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 2 |
| 2 | Col10a1 gene expression and chondrocyte hypertrophy during skeletal development and disease显示文摘类型 X 骨胶原基因, COL10A1,被 hypertrophic chondrocytes 明确地在 endochondral 期间表示骨化。Endochondral 骨化是包含软骨中介并且在 skeletogenesis 期间在脊椎动物导致大多数骨骼的形成的一个协调得好的过程。Chondrocyte 肥大是连接骨头和软骨开发的 endochondral 骨化的一个批评阶段。与 chondrocyte 肥大给它的特定的协会,在 endochondral 的类型 X 骨胶原戏必需品角色骨化。当变化和人的 COL10A1 的反常表示引起反常 chondrocyte 在许多骨胳的混乱被看见了的肥大时,有变异的类型 X 骨胶原的转基因的鼠标开发显示有缺点的 endochondral 骨化的可变骨骼造血的畸形,这以前被显示出当变化和人的 COL10A1 的反常表示引起反常 chondrocyte 在许多骨胳的混乱被看见了的肥大时。在这评论,我们与显示出生长板缺点的 COL10A1 基因变化总结了骨胳的 chondrodysplasia。我们也考察了相关的最近的研究有骨关节炎的类型 X 骨胶原基因表示和 chondrocyte 肥大。由于它的重要临床的关联,类型 X 骨胶原基因规定广泛地在过去的二十年被学习了。这里,我们集中于描绘 cis 提高元素和他们有约束力的因素的最近的进步一起授与 hypertrophic chondrocyte 特定的鼠科的类型 X 骨胶原基因(Col10a1 ) 表示。基于文学评论和我们的自己的研究,我们推测有多重因素,贡献 hypertrophic chondrocyte 特定的 Col10a1 表示。这些因素包括两 transactivators (例如 Runx2, MEF2C 等等) 并且抑压者(例如 AP1, NFATc1, Sox9 等等) ,当 Col10a1 表示的另外的余因子或 epigenetic 控制不能被排除时。 | Yaojuan LU Longwei QIAO Guanghua LEI Ranim R. MIRA Junxia GU Qiping ZHENG | 2014 | Frontiers in Biology2014，9，3： | 2 |
| 3 | An Expedient Method for Regioselective Methylation of Catechol Coumarins显示文摘 | LU Junxia WANG Ping HOU Jie ZOU Liwei CUI Pan YANG Ling GE Guangbo GONG Xiaojie | 2016 | Chemical Research in Chinese Universities2016，32，5： | 1 |
| 4 | Preparation and characterization of some surface negatively charged residue mutants of cytochrome b_5显示文摘Site-directed mutagenesis was used to obtain seven variants of tryptic fragment of bovine liver cytochrome bs (cyt bs), in which the negatively charged residues around the heme exposed edge of cyt bs were replaced by hydropho-bic amino acid alanine. Double-site mutants, triple-site mutants and even quadruple-site mutants were obtained. DNA sequencing and molecular weight measurements of the mutant proteins both confirmed that these site-directed muta-genesises were successfully performed. Spectroelectrochem-istry of these mutant proteins revealed that the apparent redox potentials of these mutant proteins caused a positive shift of 2-10 mV. The global structure of these mutant proteins did not show much difference from that of the wild type cyt bs, providing a solid base for the further study on the roles of the proteins’ surface charges. | WANG Yunhua, WANG Wenhu, LU Junxia, REN Yi, GU Shaohua, XIE Yi & HUANG Zhongxian1. Chemical Biology Lab, Department of Chemistry, Fudan University, Shanghai 200433, China 2. Genetic Institute, School of Life, Fudan University, Shanghai 200433, China | 2001 | Chinese Science Bulletin2001，46，7： | 1 |
| 5 | Studies on the roles of vanadyl sulfate and sodium nitrite in catalytic oxidation of benzyl alcohol with molecular oxygen显示文摘An efficient catalytic system consisting of vanadyl sulfate/sodium nitrite was disclosed previously for the oxidation of benzylic alcohols into aldehydes with molecular oxygen.However,the roles of catalyst components were not investigated.In this paper,we examined catalytic oxidation of benzyl alcohol as a model reaction,especially by infrared spectroscopy.The role of each component is discussed including nitrite,vanadyl,sulphate,and water.Sodium nitrite could be converted into nitrate and nitric acid.The vanadium(IV)could be smoothly oxidized into vanadium(V)under mild and acidic conditions without any organic ligands.The transformation of sulfate and bisulfate,the cessation of an induction period,and the oxidation of benzyl alcohol were closely interrelated.The multiple roles of water are discussed,including reduction of the induction period,participation in redox cycles of nitric compounds,deactivation of vanadium,and as a byproduct of oxidation.This study contributes to further development of aerobic oxidation using vanadium based catalysts. | Zhongtian Du Junxia Liu Tianliang Lu Yangyang Ma Jie Xu | 2015 | Science China Chemistry2015，58，1： | 1 |
| 6 | CO2 Emission Calculation and Reduction Options in Ceramic Tile Manufacture-The Foshan Case显示文摘 | Junxia Peng Yubo Zhao Lihua Jiao Weimin Zheng Lu Zeng | 2012 | Energy Procedia2012，，： | 1 |
| 7 | Sub-tropic degraded red soil restoration: Is soil organic carbon build-up limited by nutrients supply显示文摘 | Xia Gong Yuanqiu Liu Qinglin Li Xiaohua Wei Xiaomin Guo Dekui Niu Wenyuan Zhang Junxia Zhang Lu Zhang | 2013 | Forest Ecology and Management2013，，： | 1 |
| 8 | Monitoring the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)during high-temperature solid state synthesis via in situ SEM显示文摘The particle morphology determined by the sintering process is the director factor affecting the electrochemical performance of Ni-rich NMC cathode materials.To prepare the ideal NMC particles,it is of great significance to understand the morphological changes during sintering process.In this work,the morphology evolution of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)synthesis at temperature ranging from 300–1080℃were observed by in situ SEM.The uniform mixture of spherical Ni_(0.8)Mn_(0.1)Co_(0.1)(OH)_(2)precursor and lithium sources(LiOH)was employed by high temperature solid-state process inside the SEM,which enables us to observe morphology changes in real time.The results show that synthetic reaction of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)usually includes three processes:the raw materials’dehydration,oxidation,and combination,accompanied by a significant reduction in particle size,which is important reference to control the synthesis temperature.As heating temperature rise,the morphology of mixture also changed from flake to brick-shaped.However,Ni nanoparticle formation is apparent at higher temperature~1000℃,suggesting a structural transformation from a layered to a rock-salt-like structure.Combining the in-situ observed changes in size and morphology,and with the premise of ensuring the morphology change from flakes to bricks,reducing the sintering temperature as much as possible to prevent excessive reduction in particle size and layered to a rock-salt structure transformation is recommended for prepare ideal NMC particles. | Liang Tang Xiaopeng Cheng Rui Wu Tianci Cao Junxia Lu Yuefei Zhang Ze Zhang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 9 | Up regulated expression of peroxisome proliferator activated receptor γ in the hypothalamic-pituitary adrenal axis of weaned pigs after Eseherichia eoli lipopolysaecharide ehallenge显示文摘 | Liu Yulan Shi Junxia Lu Jing | 2010 | The Veterinary Journal2010，184，2： | 1 |
| 10 | Roles of Phe58 residue in stabilizing structure of cytochrome b_5显示文摘To understand effect of π-stacking interactions between the side chain of aromatic amino acids and the por-phyrin ring on structures and properties in cytochrome b5 (cyt b5), the Phe58 residue was mutated to tyrosine and tryptophan, respectively by site-directed mutagenesis. The denaturation of cyt bs F58W and F58Y toward guanidine hydrochloride was examined by UV-visible and fluorescence spectroscopy. The kinetics of heme transfer reactions between apo-myoglobin and the mutants were studied. The results indicated that the mutation of F58 residue for Y58 or W58 reduced the interaction between of peptide and the heme group, resulting in decrease of the Tm and Cm values of the proteins, increase of the heme transfer reaction rate, and shifts of the redox potential. | WANG Yunhua, LU Junxia, WANG Wenhu, REN Yi, XIE Yi & HUANG ZhongxianDepartment of Chemistry, Fudan University, Shanghai 200433, China | 2002 | Chinese Science Bulletin2002，47，24： | 1 |
| 11 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 12 | Study on the mechanical properties and service life of H13 mandrels显示文摘The microstructures and mechanical properties of H13 mandrels made by Baosteel and foreign companies were investigated in this study.Based on the comparison research,the processes were optimized,such as steelmaking,heat treatment and multiple forging processes.The quality of Baosteel mandrels was greatly improved by increasing the homogenizing of an annealing temperature and refining processes.The results of the pilot trial showed that the average number of piercing steel tubes for Baosteel mandrels was over 3000,which reached the level of imported mandrels. | TIAN Yuxin LU Minghe CAI Haman ZHANG Jinghai GUO Junxia | 2011 | Baosteel Technical Research2011，5，2： | 0 |
| 13 | Toward better understanding of the status of mercury in the environment in China and its contribution to the global mercury cycle显示文摘 | Julia LU Xinbin FENG Qi WAN Yongqing JIN Xiaojuan WANG Junxia WANG Xinjie SONG Tangdong YAO Chengxiao ZHANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 14 | Total gaseous mercury (TGM) in the atmosphere of southern Tibetan Plateau, China显示文摘 | Junxia WANG Tandong YAO Julia LU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 15 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 16 | HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation显示文摘Ultra-stable fibrous structure is a hallmark of amyloids.In contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed‘functional amyloids’,contribute to signal transduction as temporal signaling hubs in humans.However,it is unclear how these functional amyloids are effectively disassembled to terminate signal transduction.RHIM motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian cells.Here,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as‘amyloidase’—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and mice.Different from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X_(1))φ(X_(3)).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional monomers.Notably,HSPA8’s amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone system.Using this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis activation.The discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo. | Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun | 2023 | Cell Research2023，33，11： | 0 |
| 17 | Advances in the treatment of IgA nephropathy with biological agents显示文摘Immunoglobulin A nephropathy(IgAN)is the most common primary glomerular disease,and the“four-hit”theory represents its currently accepted pathogenic mechanism.Mucosal immunity triggered by infections in the respiratory tract,intestines,or other areas leads to antigen presentation,T cell stimulation,B cell maturation,and the production of IgA-producing plasma cells.The proteins B-lymphocyte stimulator(BLyS)and a proliferation-inducing ligand(APRIL)are involved in this process,and alternative complement and lectin pathway activation are also part of the pathogenic mechanism.Kidney Disease Improving Global Outcomes guidelines indicate that a specific effective treatment for IgAN is lacking,with renin-angiotensin-aldosterone system inhibitors being the primary therapy.Recent research shows that biological agents can significantly reduce proteinuria,stabilize the estimated glomerular filtration rate,and reverse some pathological changes,such as endocapillary proliferation and crescent formation.There are four main categories of biological agents used to treat IgA nephropathy,specifically anti-CD20 monoclonal antibodies,anti-BLyS or APRIL monoclonal antibodies,monoclonal antibodies targeting both BLyS and APRIL(telitacicept and atacicept),and monoclonal antibodies inhibiting complement system activation(narsoplimab and eculizumab).However,further research on the dosages,treatment duration,long-term efficacy,and safety of these biological agents is required. | Yongze Zhuang Hailing Lu Junxia Li | 2024 | Chronic Diseases and Translational Medicine2024，10，1： | 0 |
| 18 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 19 | Allele frequency of somatic mutations in individuals reveals signatures of cancer-related genes显示文摘在过去的十年,全面定序努力揭示了癌症相关的基因的签名,例如司机和旅客基因, oncogenes,和肿瘤 suppressor 基因(TSG )[1 ] 。这些签名提供在分子的水平定义癌症的一个工具并且增加我们癌症的理解。然而,揭示这些签名的当前的方法总是在一张大癌症人口探索变异的基因的复发,消费样品收集上的很多时间和钱,定序并且确认,进一步产生大量数据分析[2 ] 。我们想知道这些签名是否能从另外的方面被恢复。由于一系列变化从对恶意的损害良性,广泛的基因变化在单个肿瘤以内存在。在这个过程期间,司机基因提供一个选择生长优点给他们居住在的房间。因此,在一个个人的体的变化的等位基因频率,测量变化居住在的细胞的比例,能反映两个选择生长优点和变化的按年代先后的顺序。这里,我们作了一个努力在个人用体的变化的等位基因频率揭示癌症相关的基因的签名。 | Xingyu Lu Qian Xu Junxia Wang Jie Bi Zhen Wang Yixue Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员