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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | 查看详情显示文摘 | Louis B Ocampo F Yun H S Twssonnier J P Pereira M M | | 0，，： | 1 |
| 3 | Otoplasty:anterior scraping technique and results in 500 cases显示文摘 | Louise CL Nicolas G Patrieia B | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 4 | Life cycle assessment of mine tailings management in Canada显示文摘 | Catherine Reid Valérie Bécaert Michel Aubertin Ralph K. Rosenbaum Louise Deschênes | 2008 | Journal of Cleaner Production2008，，4： | 1 |
| 5 | High-risk sexual behaviors in a context of substance abuse a focus group approach显示文摘 | Louise N Manon T Colette B | 2000 | J Subst Abuse Treat2000，19，4： | 1 |
| 6 | The potential use of cereal(1→3,1→4)-β-D-glucans as functional food ingredients显示文摘 | CHARLES S B LOUISE J C | 2005 | Journal of Cereal Science2005，42，： | 1 |
| 7 | Effects of gas flow rate and inlet concentration on xylene vapors biofiltration performance 显示文摘 | Hasna J Louise B Guy V | 2000 | J Chem Engine2000，76，3： | 1 |
| 8 | A new design approach for fiber DFB lasers with improved efficiency 显示文摘 | Kuthan Yelen Louise M B Hickey Mikhail N Zervas | 2004 | IEEE J Quant Electron2004，40，6： | 1 |
| 9 | The pyrolysis of tobacco ingre-dients 显示文摘 | RICHARD R B LOUISE J B | 2004 | Journal of Analytical and Applied Pyrolysis2004，71，1： | 1 |
| 10 | Effects of two proteinase inhibitors on the digestive enzymes and survival of honey bees (Apis mellifera L)显示文摘 | ELISABETH P J B LOUISE A M JOHN T | 1996 | Journal of Insect Physiology1996，9，42： | 1 |
| 11 | Cloning and characterization of Aplysia neutral endopeptidase,a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica显示文摘 | Jacques P Z Louise W Wafa B | 1999 | The Journal of Neuroscience1999，19，11： | 1 |
| 12 | A DNA vaccine encoding a peptide mimic of Streptococcus pneumoniae serotype 4 capsular polysaccharide induces specific anti-carbohydrate antibodies in Balb/c mice显示文摘 | LESINSKIS Gregory B SMITHSON S Louise SRIVGSTAVA Neeti | 2001 | Vaccine2001，19，1314： | 1 |
| 13 | Contribution of High Plasma Triglycerides and Low High-Density Lipoprotein Cholesterol to Residual Risk of Coronary Heart Disease After Establishment of Low-Density Lipoprotein Cholesterol Control 显示文摘 | Vincent JCarey Louise B Nancy L | 2010 | Am J Cardiol2010，106，6： | 1 |
| 14 | Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation 显示文摘 | Mark A B Louise H Health E | 2006 | Cell Sci2006，117，92： | 1 |
| 15 | Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations显示文摘 | Merchant K A Best R B Louis J M Gopich I V Eaton W A | | 0，，： | 1 |
| 16 | Efficacy and safety of angiotensin- converting enzyme inhibitors in patients with left ventricular systolic dysfunction and hyponatremia显示文摘 | Louise B Lars K Morten S | 2013 | J Card Fail2013，19，11： | 1 |
| 17 | Synthesis of ZSM-5 coatings on stainless steel grids and their catalytic performance for partial oxidation of benzene by N2O显示文摘 | LOUIS B RESUE P KIWI-MINSKER L | | 0，，： | 1 |
| 18 | Plant defense responses: What have we learnt from Arabidopsis?显示文摘 | LOUISE F T Jonathan P A Karam B S | 2005 | Functional Plant Bi- ology2005，32，1： | 1 |
| 19 | A new design approach for fiber DFB lasers with improved efficiency显示文摘 | Kuthan Y Louise M B H Mikhail N Z | 2004 | IEEE Journal of Quantum Electrics2004，40，6： | 1 |
| 20 | Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa:Comparison of Native and Antibiotic-Bound Forms显示文摘 | SARAH S LOUISE B VINCENZO R | 2011 | J Mol Biol2011，405，1： | 1 |
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