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| 1 | 一种基于高斯混合模型的轨迹预测算法显示文摘在智能交通控制系统、军事数字化战场、辅助驾驶系统中,实时、精确、可靠的移动对象不确定性轨迹预测具有极高的应用价值.智能轨迹预测不仅可以提供精准的基于位置的服务,而且可以提前监测和预判交通状况,进而推荐最佳路线,已经成为移动对象数据库研究的热点,亟需设计准确而高效的位置预测方法.针对现有方法的不足,提出了基于高斯混合模型的轨迹预测方法 GMTP,主要步骤包括:(1)针对复杂运动模式利用高斯混合模型建模;(2)利用高斯混合模型计算不同运动模式的概率分布,进而将轨迹数据划分为不同分量;(3)利用高斯过程回归预测移动对象最可能的运动轨迹.GMTP是高斯非线性概率统计模型,其优势在于:计算结果不仅是位置预测值,更是关于移动对象未来所有可能运动轨迹的概率分布,可以利用概率统计分布特性获得某种运动模式(如匀加速运动)下的位置预测.大量真实轨迹数据集上的实验结果表明:与相同参数设置下的高斯回归预测和卡尔曼滤波预测法相比,GMTP的预测准确性平均提高了22.2%和23.8%,预测时间平均缩减了92.7%和95.9%. | 乔少杰 金琨 韩楠 唐常杰 格桑多吉 Louis Alberto GUTIERREZ | 2015 | 软件学报2015，26，5： | 111 |
| 2 | 2007年世界卫生组织对于中枢神经系统肿瘤的分类显示文摘 | 占传家 朱文珍 王承缘 Louis DN | 2008 | 放射学实践2008，23，2： | 78 |
| 3 | GPC3在鉴别小肝癌与肝硬化、异型增生结节和局灶性结节性增生中的作用显示文摘 | Louis L Tamara S David C 潘敏鸿(摘译) 饶秋(摘译) 周晓军(审校) | 2006 | 临床与实验病理学杂志2006，22，6： | 44 |
| 4 | 复杂网络大数据中重叠社区检测算法显示文摘提出一种新的面向复杂网络大数据的重叠社区检测算法DOC(detecting overlapping communities over complex network big data),时间复杂度为O(nlog2(n)),算法基于模块度聚类和图计算思想,应用新的节点和边的更新方法,利用平衡二叉树对模块度增量建立索引,基于模块度最优的思想设计一种新的重叠社区检测算法.相对于传统的重叠节点检测算法,对每个节点分析的频率大为降低,可以在较低的算法运行时间下获得较高的识别准确率.复杂网络大数据集上的算法测试结果表明:DOC算法能够有效地检测出网络重叠社区,社区识别准确率较高,在大规模LFR基准数据集上其重叠社区检测标准化互信息指标NMI最高能达到0.97,重叠节点检测指标F-score的平均值在0.91以上,且复杂网络大数据下的运行时间明显优于传统算法. | 乔少杰 韩楠 张凯峰 邹磊 王宏志 Louis Alberto GUTIERREZ | 2017 | 软件学报2017，28，3： | 47 |
| 5 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 6 | Adipose-derived stromal cells: Their identity and uses in clinical trials, an update显示文摘In adults, adipose tissue is abundant and can be easily sampled using liposuction. Largely involved in obesity and associated metabolic disorders, it is now described as a reservoir of immature stromal cells. These cells, called adipose-derived stromal cells (ADSCs) must be distinguished from the crude stromal vascular fraction (SVF) obtained after digestion of adipose tissue. ADSCs share many features with mesenchymal stem cells derived from bone marrow, including paracrine activity, but they also display some specific features, including a greater angiogenic potential. Their angiogenic properties as well as their paracrine activity suggest a putative tumor-promoting role for ADSCs although contradictory data have been published on this issue. Both SVF cells and ADSCs are currently being investigated in clinical trials in several fields (chronic inflammation, ischemic diseases, etc. ). Apart from a phase Ⅲ trial on the treatment of fistula,most of these are in phaseⅠand use autologous cells. In the near future, the end results of these trials should provide a great deal of data on the safety of ADSC use. | Louis Casteilla Valérie Planat-Benard Patrick Laharrague Béatrice Cousin | 2011 | World Journal of Stem Cells2011，3，4： | 31 |
| 7 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 8 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 9 | 美国医疗系统的个案全程管理显示文摘如何在保证医疗质量的同时又有效地降低成本是每一个医疗系统管理者关注的重要问题。美国近20年来实施的“个案全程管理”的方法收到了较好的效果。本文简要介绍了这个方法的内容、起源、在医疗机构中的运用及其未来发展的前景。 | Louis Rubino Deborah Roberts 魏东海 | 2004 | 中国医院2004，8，12： | 25 |
| 10 | China’s Pattern of Growth: Moving to Sustainability and Reducing Inequality显示文摘This paper uses both macro level and sectoral data to study the sources and pattern of China’s impressive economic growth over the last 25 years. Extending the growth accounting framework, we show that widening inequality, rural poverty, and resource intensity are to a large extent rooted in China’s growth strategy, and resolving them requires a rebalancing of policies. We find that growth of investment in the industrial sector has been the single most important factor driving gross domestic product and overall labor productivity growth since the early 1990s. The shift of labor from low-productivity agriculture has been limited. The productivity gap between agriculture and the rest of the economy has continued to widen, leading to increased rural–urban income inequality. Continuing with the current growth pattern would further increase already high investment and saving needs to unsustainable levels, lower urban employment growth, and widen the rural–urban income gap. However, reducing subsidies to industry and investment, encouraging the development of the services industry, and reducing barriers to labor mobility would result in a more balanced growth and a substantial reduction in the income gap between rural and urban residents. | Louis Kuijs Tao Wang | 2006 | China & World Economy2006，14，1： | 24 |
| 11 | Hepatic progenitor cells in human liver tumor development显示文摘In recent years, the results of several studies suggest that human liver tumors can be derived from hepatic progenitor cells rather than from mature cell types. The available data indeed strongly suggest that most combined hepatocellular-cholangiocarcinomas arise from hepatic progenitor cells that retained their potential to differentiate into the hepatocytic and biliary lineages. Hepatic progenitor cells could also be the basis for some hepatocellular carcinomas and hepatocellular adenomas, although it is very difficult to determine the origin of an individual hepatocellular carcinoma. There is currently not enough data to make statements regarding a hepatic progenitor cell origin of cholangiocarcinoma. The presence of hepatic progenitor cell markers and the presence and extent of the cholangiocellular component are factors that are related to the prognosis of hepatocellular carcinomas and combined hepatocellular- cholangiocarcinomas, respectively. | Louis Libbrecht | 2006 | World Journal of Gastroenterology2006，12，39： | 24 |
| 12 | 用RAPD标记检测与杨树生长和物候期有关的QTLs显示文摘取美洲黑杨(母本)和青杨(父本)杂交获得的F2群体样本80株,应用RAPD标记检测与F2群体3个数量性状(苗高、地径和封顶期)有关的QTLs。在F2群体中,一年生苗高、地径和封顶期性状表现显著分离,基本符合正态分布。单因子方差分析检测出与苗高、地径和封顶期性状相关的7个、6个和3个标记座位,并计算了各标记对相关性状变异的贡献率。与数量性状相关的标记有不同的亲本来源。t检验结果表明,各标记显带型和不显带型组性状均值的差异显著或极显著(两个标记除外);与各性状相关标记的显带型或不显带型的频率,在各性状上的分布有异同。双因子方差分析结果表明,在与性状相关联的标记中,有两组QTLs互作组合与苗高性状相关联。 | 李金花 苏晓华 张绮纹 LOUIS ZSUFFA | 1999 | 林业科学研究1999，12，2： | 23 |
| 13 | Hypertension and renal disease显示文摘The relationship between chronic kidney disease(CKD)and hypertension remains enigmatic and a matter of considerable clinical and academic interest with evidence indicating that hypertension is both a cause and a consequence of kidney disease[1-2]. | Huang Chunfa Louis Stokes Cleveland Veteran Affairs Medical Center Division of Nephrology,Departments of Medicine,Case Western Reserve University and Rammelkamp Center for Research and Education,MetroHealth System Campus,Cleveland,Ohio 441061 | 2011 | 中华高血压杂志2011，19，12： | 23 |
| 14 | 施用生物炭和秸秆对石灰性褐土氮肥去向的影响显示文摘为明确秸秆直接还田和秸秆炭化为生物炭后施入土壤对氮肥转化(植株吸收、土壤残留及损失)的影响,采用大田微区试验,运用15N标记示踪技术,分析了石灰性褐土施用生物炭和秸秆后氮肥的去向,并阐明其影响机制。试验共设3个处理,单施化肥(NPK)、施化肥并施生物炭(NPK+B)以及施化肥并施秸秆(NPK+S)。结果表明:石灰性褐土上高粱植株当季的氮肥吸收率、土壤残留率和损失率分别是18.41%~24.94%、22.67%~35.47%和46.12%~52.40%;与NPK处理相比,NPK+B和NPK+S处理高粱植株的氮肥利用率分别降低2.20个百分点和6.53个百分点(P<0.05),土壤残留率分别增加5.58个百分点(P<0.05)和12.80个百分点(P<0.05),氮肥损失率分别降低3.40个百分点和6.28个百分点(P<0.05);施用秸秆显著提高了土壤活性有机碳含量、土壤微生物数量及代谢活性,增强了氮肥转化过程中土壤微生物对肥料氮的固定,从而减少氮肥损失。因此,与施用生物炭比较,秸秆直接还田是提高石灰性褐土氮肥有效性及秸秆资源合理利用的更有效途径。 | 武爱莲 王劲松 董二伟 王立革 郭珺 南江宽 韩雄 Louis McDonald 焦晓燕 | 2019 | 土壤学报2019，56，1： | 22 |
| 15 | 对气垫流浆箱自动调节系统的评估显示文摘本文建立了一个描述造纸机流浆箱的数学模型及其自动调节系统的计算机模拟系统。利用这个模型及模拟系统能对各种流浆箱自动调节系统进行动态模拟和质量评估。对气垫流浆箱的四种不同调节方案,进行模拟及其结果的比较和评估后发现:方案一(用总压控制进浆量,用浆位控制空气流出量)优于方案二(用总压控制空气流出量,而用浆位控制进浆量),方案三(在方案一基础上增加了内溢流)更好;在方案四中,由于加入了浆速一网速比的串级调节系统,能有效地克服网速干扰对浆速-网速比及纸页定量的影响。 | 刘焕彬 Louis L.Edwards | 1989 | 中国造纸1989，8，3： | 18 |
| 16 | 利用MODIS和ASAR资料估算青藏高原念青唐古拉山脉地区冰雪范围及厚度显示文摘利用可见光和微波卫星遥感资料分析了青藏高原念青唐古拉山脉地区冰雪范围和厚度的季节变化.结果表明:青藏高原念青唐古拉山脉地区冰雪范围的季节变化非常明显,2003年4月上旬、5月中旬、7月下旬和9月下旬的冰雪范围分别占选定研究区域的28.9%、69.9%、11.6%和14.7%.在选定的西布冰川区域,由微波遥感得到的冰雪厚度季节变化也非常明显,5月份厚度的数值最大,7月份最小.由于主动微波观测受地面高程、地形和夏季冰雪融化等因素的影响比较大,主动微波遥感在大面积估算冰雪厚度还有一定困难,有待将来作进一步的深入研究. | 文军 Dai Mo Deroin Jean-Paul 王致君 张堂堂 Humbert Louis | 2006 | 冰川冻土2006，28，1： | 17 |
| 17 | How tubular epithelial cells dictate the rate of renal fibrogenesis?显示文摘The main threat to a kidney injury,whatever its cause and regardless of whether it is acute or chronic,is the initiation of a process of renal fibrogenesis,since fibrosis can auto-perpetuate and is of high prognostic significance in individual patients.In the clinic,a decrease in glomerular filtration rate correlates better with tubulointerstitial damage than with glomerular injury.Accumulation of the extracellular matrix should not be isolated from other significant cellular changes occurring in the kidney,such as infiltration by inflammatory cells,proliferation of myofibroblasts,obliteration of peritubular capillaries and atrophy of tubules.The aim of this review is to focus on tubular epithelial cells(TEC),which,necessarily involved in the repair process,eventually contribute to accelerating fibrogenesis.In the context of injury,TEC rapidly exhibit phenotypic and functional changes that recall their mesenchymal origin,and produce several growth factors known to activate myofibroblasts.Because they are high-demanding energy cells,TEC will subsequently suffer from the local hypoxia that progressively arises in a microenvironment where the matrix increases and capillaries become rarified.The combination of hypoxia and metabolic acidosis may induce a vicious cycle of sustained inflammation,at the center of which TEC dictate the rate of renal fibrogenesis. | Kevin Louis Alexandre Hertig | 2015 | World Journal of Nephrology2015，4，3： | 16 |
| 18 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 19 | The discovery of artemisinin and the Nobel Prize in Physiology or Medicine显示文摘1 Summary The 2015 Nobel Prize in Physiology or Medicine was awarded to Professor Tu You You for her key contributions to the discovery of artemisinin.Artemisinin has saved millions of lives and represents one of the significant contributions of China to global health.Many scientists were in- | SU Xin-Zhuan MILLER Louis H. | 2015 | Science China(Life Sciences)2015，58，11： | 15 |
| 20 | Foreign object ingestion and esophageal food impaction:An update and review on endoscopic management显示文摘Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review. | Brian M Fung Seth Sweetser Louis M Wong Kee Song James H Tabibian | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 15 |
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