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| 1 | Necroptosis in inflammatory bowel disease and other intestinal diseases显示文摘For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease(IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD. | Sha Li Long-Gui Ning Xin-He Lou Guo-Qiang Xu | 2018 | World Journal of Clinical Cases2018，6，14： | 7 |
| 2 | Anisotropic surface roughness and shear behaviors of rough-walled plaster joints under constant normal load and constant normal stiffness conditions显示文摘In this context,we experimentally studied the anisotropic mechanical behaviors of rough-walled plaster joints using a servo-controlled direct shear apparatus under both constant normal load(CNL)and constant normal stiffness(CNS)conditions.The shear-induced variations in the normal displacement,shear stress,normal stress and sheared-off asperity mass are analyzed and correlated with the inclination angle of the critical waviness of joint surfaces.The results show that CNS condition gives rise to a smaller normal displacement due to the larger normal stress during shearing,compared with CNL condition.Under CNL conditions,there is one peak shear stress during shearing,whereas there are no peak shear stress for some cases and two peaks for other cases under CNS conditions depending on the geometry of joint surfaces.The inclination angle of the critical waviness has been verified to be capable of describing the joint surface roughness and anisotropy.The joint surface is more significantly damaged under CNS conditions than that under CNL conditions.With increment of the inclination angle of the critical waviness,both the normal displaceme nt and shea red-off asperity mass increase,following power law functions;yet the coefficient of deternination under CNL conditions is larger than that under CNS conditions.This is because the CNS condition significantly decreases the inclination angle of the critical waviness during shearing due to the larger degree of asperity degradation. | Richeng Liu Sha Lou Xiaojing Li Guansheng Han Yujing Jiang | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，2： | 5 |
| 3 | Rapid Detection of Sildenafil Drugs in Liquid Nutraceuticals Based on Surface-Enhanced Raman Spectroscopy Technology显示文摘在这研究,提高表面的拉曼光谱学(重量的单位) 技术被用来很快检测非法增加的 sildenafil 药。由密度的详细归属分析功能的理论(DFT ) 被用来指导特定的实验。拉曼信号从银胶体(Ag 关口) 被获得底层,和他们面对矿物质盐增加了,钾碘化物(KI ) 。这些方法在象 1 獳? 敷椠汬獵牴瑡 ? 桴 ? 潰整瑮慩?景琠敨渠睥栠略楲瑳捩猠档浥 e 一样低的水的答案检测了 | Hang Zhao Wuliji Hasi Lin Bao Siqingaowa Han Xuanyu Sha Jia Sun Xiutao Lou Dianyang Lin Zhiwei Lv | 2017 | Chinese Journal of Chemistry2017，35，10： | 3 |
| 4 | A 3-D DDA damage analysis of brick masonry buildings under the impact of boulders in mountainous areas显示文摘In mountainous areas, geological disasters carrying large boulders can cause severe damage to the widely used masonry buildings due to the high impact forces. To better understand the damage of brick masonry buildings under the impact of boulders, a 'block-joint' model is developed using threedimensional discontinuous deformation analysis(3-D DDA) to simulate the behaviour of the 'brick-mortar' structure. The 'block-joint' model is used to capture not only the large displacement and deformation of individual bricks but also the large-scale sliding and opening along the mortar between the bricks. The linear elastic constitutive model is applied to account for the non-plastic deformation behaviour of brick materials. Furthermore, the mechanical characteristics of the mortar are represented using the Mohr-Coulomb and Drucker-Prager criteria. To propose safe structural design schemes and effective reinforcement for brick masonry buildings, seven construction techniques are considered, includingdifferent grades of brick and mortar, effective shear areas and reinforced members. The proposed 3-D DDA model is used to analyse the velocity distribution and the key point displacements of the brick masonry building under the impact of boulders. The results show that upgrading the brick and mortar, increasing the wall thickness, making full use of the wall thickness, and adding a circular beam and structural column are very effective approaches for improving the impact resistance of brick masonry buildings. | LIU Shu-guang LI Zhu-jun ZHANG Hong WU Wei ZHONG Gui-hui LOU Sha | 2018 | Journal of Mountain Science2018，15，3： | 3 |
| 5 | Water quality assessment by pollution-index method in the coastal waters of Hebei Province in western Bohai Sea, China显示文摘 | Shuguang Liu Sha Lou Cuiping Kuang Wenrui Huang Wujun Chen Jianle Zhang Guihui Zhong | 2011 | Marine Pollution Bulletin2011，，10： | 2 |
| 6 | Degradation mechanism analysis of LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) single crystal cathode materials through machine learning显示文摘LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)has become one of the most popular cathode materials for current lithium-ion batteries due to its high-energy density and cost performance.However,the rapid capacity fading of NCM severely hinders its development and applications.Here,the single crystal NCM523 materials under different degradation states are characterized using scanning transmission electron microscopy(STEM).Then we developed a neural network model with a two-sequential attention block to recognize the crystal structure and locate defects in STEM images.The number of point defects in NCM523 is observed to experience a trend of increasing first and then decreasing in the degradation process.The space between the transition metal columns shrinks obviously,inducing dramatic capacity decay.This analysis sheds light on the defect evolution and chemical transformation correlated with layered material degradation.It also provides interesting hints for researchers to regenerate the electrochemical capacity and design better battery materials with longer life. | Wuxin Sha Yaqing Guo Danpeng Cheng Qigao Han Ping Lou Minyuan Guan Shun Tang Xinfang Zhang Songfeng Lu Shijie Cheng Yuan-Cheng Cao | 2022 | npj Computational Materials2022，，1： | 1 |
| 7 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 8 | Hydrothermal synthesis of nitrogen-containing carbon nanodots as the high-efficient sensor for copper(II) ions显示文摘 | Yunfei Sha Jiaying Lou Shizhe Bai Da Wu Baizhan Liu Yun Ling | 2012 | Materials Research Bulletin2012，，： | 1 |
| 9 | IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance显示文摘 | Xueyan Zhang Jiayuan Sun Huimin Wang Yuqing Lou Yanwei Zhang Huifang Sha Jiuxian Feng Baohui Han | 2014 | Tumor Biology2014，，1： | 1 |
| 10 | IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance显示文摘 | Xueyan Zhang Jiayuan Sun Huimin Wang Yuqing Lou Yanwei Zhang Huifang Sha Jiuxian Feng Baohui Han | 2014 | Tumor Biology2014，，： | 1 |
| 11 | Microwave Assisted Hydrothermal Way Towards Highly Crystalized N-Doped Carbon Quantum Dots and Their Oxygen Reduction Performance显示文摘We proposed a green microwave-assisted hydrothermal way to synthesize highly crystalized N-doped carbon quantum dots(N-CQDs).The N-CQDs obtained by this microwave method have good crystalline degree(ID/IG=0.6)and a high molar ratio of N/C(11.1%)comparing with those obtained from traditional top-down method.The experimental results show that glycerine plays a key role ill the fonnation of highly crystalized N-CQDs.The as-prepared N-CQDs have good luminescent property and may be utilized as fluorescent probe to detect ions or mark cells.As the majority of N atoms in the N-CQDs were pyridinic type(64.8%),the as-prepared N-CQDs were used as a catalyst for the oxygen reduction reaction(ORR)electrocatalysis in the anode of the fuel cell(the onset potential is-0.121V),which was a 4e-transfer procedure and the catalyst showed good stability after 100 cycles. | HUANG He LIANG Chen SHA Haoyan YU Ying LOU Yue CHEN Cailing LI Chunguang CHEN Xiaobo SHI Zhan FENG Shouhua | 2019 | Chemical Research in Chinese Universities2019，35，2： | 1 |
| 12 | A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue显示文摘Due to the abuse of antibiotics,antibiotic residues can be detected in both natural environment and various industrial products,posing threat to the environment and human health.Here we describe the design and implementation of an engineered Escherichia coli capable of degrading tetracycline(Tc)-one of the commonly used antibiotics once on humans and now on poultry,cattle and fisheries.A Tcdegrading enzyme,TetX,from the obligate anaerobe Bacteroides fragilis was cloned and recombinantly expressed in E.coli and fully characterized,including its Km and kcat value.We quantitatively evaluated its activity both in vitro and in vivo by UVeVis spectrometer and LC-MS.Moreover,we used a tetracycline inducible amplification circuit including T7 RNA polymerase and its specific promoter PT7 to enhance the expression level of TetX,and studied the dose-response of TetX under different inducer concentrations.Since the deployment of genetically modified organisms(GMOs)outside laboratory brings about safety concerns,it is necessary to explore the possibility of integrating a kill-switch.Toxin-Antitoxin(TA)systems were used to construct a mutually dependent host-plasmid platform and biocontainment systems in various academic and industrious situations.We selected nine TA systems from various bacteria strains and measured the toxicity of toxins(T)and the detoxifying activity of cognate antitoxins(A)to validate their potential to be used to build a kill-switch.These results prove the possibility of using engineered microorganisms to tackle antibiotic residues in environment efficiently and safely. | Zepeng Mu Zhuoning Zou Ye Yang Wenbo Wang Yue Xu Jianyi Huang Ruiling Cai Ye Liu Yajin Mo Boyi Wang Yiqun Dang Yongming Li Yushan Liu Yueren Jiang Qingyang Tan Xiaohong Liu Cheng Hu Hua Li Sha Wei Chunbo Lou Yang Yu Jiangyun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 0 |
| 13 | Direct identification of total and missing OH reactivities from light-duty gasoline vehicle exhaust in China based on LP-LIF measurement显示文摘Considerable efforts have been devoted to characterising the chemical components of vehicle exhaust.However,these components may not accurately reflect the contribution of vehicle exhaust to atmospheric reactivity because of the presence of species not accounted for(“missing species”)given the limitations of analytical instruments.In this study,we improved the laser photolysis–laser-induced fluorescence(LP-LIF)technique and applied it to directly measure the total OH reactivity(TOR)in exhaust gas from light-duty gasoline vehicles in China.The TOR for China Ⅰ to Ⅵ-a vehicles was 15.6,16.3,8.4,2.6,1.5,and 1.6×10^(4) sec^(-1),respectively,reflecting a notable drop as emission standards were upgraded.The TOR was comparable between cold and warm starts.The missing OH reactivity(MOR)values for China Ⅰ to Ⅳ vehicles were close to zero with a cold start but were much higher with a warm start.The variations in oxygenated volatile organic compounds(OVOCs)under different emission standards and for the two start conditions were similar to those of the MOR,indicating that OVOCs and the missing species may have similar production processes.Online measurement revealed that the duration of the stable driving stage was the primary factor leading to the production of OVOCs and missing species.Our findings underscore the importance of direct measurement of TOR from vehicle exhaust and highlight the necessity of adding OVOCs and other organic reactive gases in future upgrades of emission standards,such that the vehicular contribution to atmospheric reactivity can be more effectively controlled. | Xuehui Liu Zibing Yuan Qing’e Sha Shengrong Lou Hongli Wang Xin Li Junyu Zheng Bin Yuan Min Shao | 2023 | Journal of Environmental Sciences2023，，11： | 0 |
| 14 | Hurricane impacts on turbidity and sediment in the Rookery Bay National Estuarine Research Reserve, Florida, USA显示文摘The resuspension and transportation of sediments affect the nutrient or contaminants cycles in water column.Therefore,hurricane-induced sediment resuspension in coastal waters may cause environment impacts on coastal ecosystems.In this study,field observed data during a hurricane event from the Rookery Bay National Estuarine Research Reserve(Rookery Bay NERR),Florida,were studied.Based on the relationship between sediment and turbidity,variations of turbidity in the Rookery Bay NERR were discussed in this paper under the impact of the Hurricane Isaac in 2012.Time series analysis indicates that Hurricane Isaac causes the substantial increase of turbidity.Traditional direct regression analysis with raw data was found to result in poor correlation(R^2 < 0.41) between wind speed and turbidity due to the impacts of multi-factors in coastal waters of study region during hurricane.Then Hanning Filter was used to remove tidal effect,which shows some improvement of correlations(R2 > 0.6) between wind speed and turbidity.Further improvement was made by introducing a phase factor to account for the lag time between the peak turbidity and peak wind speed,which lead to further improvement of the regression equation between wind speed and turbidity.By using Hanning Filter and phase factor,the regression equation between turbidity and wind speed fits well with observations(R2 > 0.96).Different lag time between wind speed and turbidity at different locations illustrated that wind had different effects on turbidity due to the locations and water depth.Based on the approximate empirical relationship between turbidity and sediment concentration,a regression equation between wind speed and sediment concentration was derived approximately.The equation could be applied to approximately estimate the sediment concentration using wind speed during hurricane,especially with the strong wind speed above 4 m/s.It can be used to provide technical supports for sediment assessment and coastal zone research under extreme clime in the study region. | Sha Lou Wenrui Huang Shuguang Liu Guihui Zhong Elijah Johnson | 2016 | International Journal of Sediment Research2016，31，4： | 0 |
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