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| 1 | 新千年初的欧洲粉末冶金显示文摘本文回顾了欧洲粉末冶金协会 (EPMA)成立十年来的工作。这几年来EPMA组织并完成了两个主题网络 ,即粉末冶金过程模拟和金属注塑成型网络 ,建立了该协会的网站 ;评述了粉末冶金市场的发展 ,自 1 993年至 1 999年欧洲粉末冶金市场增长了 5 0 % ;强调了粉末冶金在汽车业应用的重要性 ;报道了欧洲粉末冶金发展动向 ,如温压汽车连杆已研制成功 。 | Lothar Albano-Müller 王崇琳 | 2001 | 粉末冶金工业2001，11，2： | 24 |
| 2 | DEVELOPMENT POTENTIALS AND RESEARCH NEEDS IN CIRCULATING FLUIDIZED BED COMBUSTION显示文摘First a report about present status of circulating fluidized bed reactors for coal and multi-fuel combustion in power plants is given. Thereafter the development potentials and research needs for further improvement of CFB com-bustors operating with finely grained bed materials are discussed and recommendations for direction of further research and development work are presented. | Lothar Reh | 2003 | China Particuology2003，1，5： | 11 |
| 3 | High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)显示文摘We developed a novel two-photon polymerization(2PP)configuration for fabrication of high-aspect three-dimensional(3D)structures,with an overall height larger than working distance of the microscope objective used for laser beam focusing into a photosensitive material.This method is based on a modified optical 2PP setup,where a microscope objective(1003 high N.A.),immersion oil and cover glass can be moved together into the photosensitive material,resulting in an effective higher and wider objective working range(WOW-2PP).The proposed technique enables the fabrication of high-aspect structures with sub-micrometer process resolution.3D structures with a height of 7 mm are demonstrated,which could hardly be built with the conventional 2PP set-up due to refractive index mismatch and laser beam disturbances. | Kotaro Obata Ayman El-Tamer Lothar Koch Ulf Hinze Boris N Chichkov | 2013 | Light(Science & Applications)2013，2，1： | 7 |
| 4 | p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a显示文摘 | Text Lei Duan Ricardo E. Perez Ling Chen Lothar A. Blatter Carl G. Maki | 2018 | Journal of Molecular Cell Biology2018，10，4： | 6 |
| 5 | The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants显示文摘到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因,知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度,重金属的压力,和 Botrytis cinerea 感染。抵抗的线, overexpressing 在不同层次的真菌的 chitinases,是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力,尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些,揭示经常的起来规定(至少双重) 10 ,在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。 | Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein Lothar Willmitzer Ilan Chet Ada Viterbo | 2012 | Molecular Plant2012，5，5： | 5 |
| 6 | 循环流化床能量最小多尺度作用模型显示文摘本文建立了完整的循环流化床流体动力学数学模型。内容包括顶部稀区和底部密区局部状态的模拟和径向分布的计算。并确定了两区共存和三种不同操作方式存在的条件。研究表明,能量最小在循环流化床的气固相互作用中起着重要的作用。顶部稀区和底部密区的气固相互作用机理完全不同。底部密区处于颗粒流体协调(FPC)状态,其稳定条件是悬浮输送能耗N_st等于最小值;而顶部稀区处于流体控制状态,其稳定条件是N_st=最大值或W_st=最小值。(W_st)_FPC=(W_st)_FD时,两区共存或过渡,系统处于饱和夹带状态。两个区域中的径向分布也都必须满足相应的整体稳定性条件。 | 李静海 郭慕孙 Lothar Reh | 1992 | 中国科学(B辑)1992，B，11： | 5 |
| 7 | 低成本β钛合金热处理后的显微组织变化和力学性能(英文)显示文摘研究了时效时间对低成本β(LCB)Ti-6.6Mo-4.5Fe-1.5Al钛合金的显微组织和力学性能的影响,以及显微组织与疲劳断裂裂纹的产生、延伸的联系。延长时效时间有助于二次α相和β晶粒体积分数的增多以及初始α相的部分球化。在500°C下热处理0.5h的合金得到的拉伸强度最大(1565MPa),疲劳极限最高(750MPa);而在500°C下热处理4h的合金得到的拉伸强度最小(1515MPa),疲劳极限最低(625MPa)。在500°C下热处理4h的合金的断裂模式为穿晶断裂,而在500°C下热处理0.5h的合金的断裂模式为穿晶断裂和沿晶断裂的混合。在疲劳样品的外表面形成的裂纹沿β晶界上初始α相延伸。 | Khaled M. IBRAHIM Mansour MHAEDE Lothar WAGNER | 2012 | Transactions of Nonferrous Metals Society of China2012，22，11： | 4 |
| 8 | 循证医学显示文摘前言:循证医学(EBM)是一个方法,用来解决病人诊治中如何评估检验结果的问题.实践中的EBM是使用有用的证据来确定病人健康状况.实践EBM的最好方法是形成、证实、和实施导则.导则是将医疗保健的研究和经验去改善病人诊治的过程.在检验诊断中,在流行高发条件时EBM对检验诊断具有最好的表现.因为在高发条件的病人数对发病率和治疗费用有着较大的影响. | Lothar Thomas Christian Thomas | 2002 | 上海医学检验杂志2002，17，1： | 4 |
| 9 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 10 | Process engineering in circular economy显示文摘Driven by increasing global population and by growing demand for individual wealth,the consumption of energy and raw materials as well as the steadily growing CO_2 concentration in atmosphere pose great challenges to process engineering.This complex multi-scale discipline deals with the transformation of mass by energy to manifold products in different industrial fields under economical and ecological sustainable conditions.In growing circular economy,process engineering increasingly plays an important role in recovering valuable components from very diffuse material flows leaving the user stocks following widely variable time periods of use.As well it is engaged in thermal recovery of energy therefrom and in environmentally safe disposal of residual solid wastes whose recovery economically is not feasible.An efficient recovery of materials and energy following the laws of entropy is a must.A complex network of mass,energy,transportation and information flows has to be regarded with growing traded quantities of used goods even on global level.Important constraints in time,however,exist for a necessary realization of innovative new processes and communal mobility and industrial infrastructure on medium and large scale.Based on reasonable long term and highly reliable statistics from industrial organizations representing steel and paper industry,some limits and trends of possible developments in processing of those industries with long recycling experience will be discussed. | Lothar Reh | 2013 | Particuology2013，11，2： | 3 |
| 11 | Laser-assisted bioprinting at different wavelengths and pulse durations with a metal dynamic release layer:A parametric study显示文摘For more than a decade,living cells and biomaterials(typically hydrogels)are printed via laser-assisted bioprinting.Often,a thin metal layer is applied as laser-absorbing material called dynamic release layer(DRL).This layer is vaporized by focused laser pulses generating vapor pressure that propels forward a coated biomaterial.Different lasers with laser wavelengths from 193 to 1064 nanometer have been used.As a metal DRL gold,silver,or titanium layers have been used.The applied laser pulse durations were usually in the nanosecond range from 1 to 30 ns.In addition,some studies with femtosecond lasers have been published.However,there are no studies on the effect of all these lasers parameters on bioprinting with a metal DRL,and on comparing different wavelengths and pulse durations–except one study comparing 500 femtosecond pulses with 15 ns pulses.In this paper,the effects of laser wavelength(355,532,and 1064 nm)and laser pulse duration(in the range of 8 to 200 ns)are investigated.Furthermore,the effects of laser pulse energy,intensity,and focal spot size are studied.The printed droplet volume,hydrogel jet velocity,and cell viability are analyzed. | Lothar Koch Ole Brandt Andrea Deiwick Boris Chichkov | 2017 | International Journal of Bioprinting2017，3，1： | 3 |
| 12 | Esther Jacobson-Tepfer,The Hunter,the Stag,and the Mother of Animals:Image,Monument,and Landscape in Ancient North Asia.Oxford:Oxford University Press,2015显示文摘One cannot help feeling envious of Esther Jacobson-Tepfer. Many times since the late1980s she has explored some of the most magnificently beautiful—and, for ordinary travelers, largely inaccessible—landscapes on earth:the Altai and Sayan mountain ranges with their surrounding woodlands and steppes. | Lothar von Falkenhausen | 2018 | 浙江大学艺术与考古研究2018，，1： | 3 |
| 13 | Mapping theArabidopsis Metabolic Landscape by Untargeted Metabolomics at Different Environmental Conditions显示文摘新陈代谢的染色体宽的协会研究(mGWAS ) ,因此,代谢物层次被认为是特点,帮助能解开新陈代谢的网络的基因基础。309 Arabidopsis 就职的一个总数在二个独立环境条件(控制和应力) 下面被种并且使遭到到介绍的 untargeted LC-MS-based metabolomic;获得的吸水的代谢物的层次在 GWAS 被使用。我们为超过 3000 半极的代谢物的 two-condition-based GWAS 导致了 123 高度解决的代谢物的察觉量的特点 loci ?(p 1.0E-08 ) 。有趣地,不同地,从在 Arabidopsis 主要代谢物,趋于被很多小效果的 loci 控制,的自然变化,我们在发现几个学生大效果的 loci 控制第二等的代谢物的变化的小效果的 loci 的一个广阔数字。two-condition-based GWAS 被集成用一个时间功课压力实验与导出网络的代谢物抄本关联跟随。通过这条综合途径,我们选择了在结构的基因和代谢物之间的 70 个关键候选人协会,并且试验性地验证了八个新奇协会,他们中的二个在二环境的出现微分基因规定学习了。我们表明联合有 time-course-derived 网络的基于 metabolomics 的 GWAS 两个都为识别代谢物基因协会在不同不能生活的环境下面执行了的大规模 untargeted 的力量,提供进 Arabidopsis 的新陈代谢的风景的新奇全球卓见。 | Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenboim Rik Kooke Michael Meret Joost B. Keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv Brotman | 2018 | Molecular Plant2018，11，1： | 3 |
| 14 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 15 | Phenolic profile and antioxidant activity of highbush blueberry ( Vaccinium corymbosum L.) during fruit maturation and ripening显示文摘 | Alejandro David Rodarte Castrejón Ines Eichholz Sascha Rohn Lothar W. Kroh Susanne Huyskens-Keil | 2008 | Food Chemistry2008，，3： | 2 |
| 16 | 肝特异性胰岛素样生长因子I基因缺失鼠原发性乳腺癌模型的建立显示文摘目的 在肝特异性胰岛素样生长因子Ⅰ (IGF Ⅰ )基因缺失鼠体内建立稳定的原发性乳腺癌模型 ,为进一步探讨血清中IGF Ⅰ水平对乳腺肿瘤的发生可能产生的影响建立研究平台。方法 实验中所用的肝脏特异性IGF Ⅰ基因缺失 (LID)小鼠 ,其循环中IGF Ⅰ水平仅为正常小鼠 (对照组小鼠 )的 2 5 %。用化学致癌剂 7,12 二甲基苯蒽(DMBA)诱导原发性乳腺肿瘤。结果 与对照组相比 ,LID鼠乳腺肿瘤的潜伏期均明显延长 ,LID小鼠可触及的乳腺肿瘤发病率明显下降 (2 6 3% /5 5 8% ) ,其肿瘤的出现也明显延迟 [(74 0± 1 2 )d/(5 9 5± 1 1)d]。对照组 6 0 %小鼠有 2个或者 2个以上肿瘤 ,而LID鼠仅 30 %有 1个以上肿瘤。结论 在致癌剂DMBA诱导的乳腺肿瘤模型中 ,IGF Ⅰ作为一种危险因子 。 | 吴毅平 Caren Cui Keiko Miyoshi Lothar Hennighausen Derek LeRoith Shoshana Yakar | 2004 | 华中科技大学学报(医学版)2004，33，2： | 2 |
| 17 | Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using ^13C-Stable Isotope Feeding and Coupled Mass Spectrometry显示文摘Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus (L.) G.Don is a rich source of plant-derived medicinal terpenoid indole alkaloids (TIAs),including the anti-hypertensive ajmalicine,the sedative compound serpentine,and the anticancer drugs vinblastine and vincristine.However,the latter two compounds are produced in C roseus plants only in very low amounts.Elicitors such as hormones (e.g.jasmonates or salicylic acid) activate plant natural defense responses,including increased secondary metabolite production (EI-Sayed and Verpoorte,2007;Lackman et al.,2011).There are two different metabolic pathways for the biosynthesis of terpenoids leading to the formation of the Cs central precursor isopentenyl diphosphate (IPP),namely the classical cytosolic mevalonate pathway and the mevalonate-independent plastidic 2-C-methyI-D-erythritol 4-phosphate (MEP) pathway. | Carla Antonio Natali R. Mustafa Sonia Osorio Takayuki Tohge Patrick Giavalbco Lothar Willmitzer Heiko Rischer Kirsi-Marj Oksman-Caldentey Robert Verpoorte Alisdair R. Fernie | 2013 | Molecular Plant2013，6，2： | 2 |
| 18 | GC–MS libraries for the rapid identification of metabolites in complex biological samples显示文摘 | Nicolas Schauer Dirk Steinhauser Sergej Strelkov Dietmar Schomburg Gordon Allison Thomas Moritz Krister Lundgren Ute Roessner-Tunali Megan G. Forbes Lothar Willmitzer Alisdair R. Fernie Joachim Kopka | 2005 | FEBS Letters2005，，6： | 2 |
| 19 | Modelling and simulation of fixtures during grinding显示文摘The complex workpiece-fixture behaviour during machining is an essential component of the fixture development process.In detail,the forces acting on fixture components have to be analysed.A method for the prediction of the reaction forces due to process and clamping loads is presented in this article.At the beginning,detailed information about the workpiece-fixture behaviour during the process is determined by a complex finite element model.Secondly,the reduction of the number of elements leads to a smaller model with less computation time,validated and used for the variation of process parameters.Finally,an analytical description is developed based on the combination of both results.With the help of the empiric equation it is possible to predict the reaction forces and the dependency on several process parameters.This method has been validated by modelling shape grinding of a nozzle guide vane. | Matthias KLAERNER Juergen LEOPOLD Lothar KROLL | 2009 | Science China(Technological Sciences)2009，52，7： | 2 |
| 20 | 德国160km/h货物列车显示文摘介绍了德国160km/h高速货物列车的研制与试运情况。该列车对制动的要求很高,需装用盘形制动(每轴装三个制动盘)、电控制动、防滑器等技术装置,并需在线路上配置ATC自动列车控制装置。 | Lothar Müller 郑权 | 1993 | 国外铁道车辆1993，30，1： | 2 |
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