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| 1 | The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province,a non HCC prevalent area in China显示文摘AIM:In hepatocellular carcinoma(HCC)prevalent areas of China,the point mutation of p53 exon7 is highly correlated with hepatitis B virus(HBV)infection and aflatoxin B intake While in non-HCC_prevalent areas of China,these factors are not so important in the etiology of HCC.Therefore,the point mutation of p53 exon7 may also be different than that in HCC-pervalent areas of China.The aim of this study is to investigate the status and carcinogenic role of the point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province,a non-HCC-prevalent area in China.METHODS:RCR,PCR-SSCP and PCR-RFLP were applied to analyze the homozygous deletion and point mutation of p53 exon7 in HCC samples from Anhui,which were confimed by DNA sequencing and Genbak comparison.RESULTS:In the 38 samples of hepatocellular carcinoma,no homozygous deletion of p53 exon7 was detected and point mutations of p53 exon7 were found in 4 cases,which were found to be heterozygous mutation of codon 249 with a mutation rate of 10.53%(4/38).The third base mutation(G→T)of p53 codon 249 was found by DNA sequencing and Genbank comparison.CONCLUSION:The incidence of point mutation of p53 codon 249 is lower in hepatocellular carcinoma and the heterozygous mutation of p53 exon7 found in these patients only indicate that they have genetic susceptibility to HCC p53 codon 249 is a hotspot of p53 exon7 point mutation suggesting that the point mutation of p53 exon 7 may not play a majuor role in the carcinogenesis of HCC in Anhui Province,a non-HCC-prevalent area in China. | LiuH WangY 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 13 |
| 2 | Pollution characteristics of the recent sediments in the Hangzhou section of the Grand Canal,China显示文摘Spatial distribution of heavy metals, arsenic and organic matter in recent sediments in the Hangzhou section of the Grand Canal and their relationships were analyzed. The results showed that the concentrations of heavy metals and organic matters varied widely along the canal, and the average geological accumulation factors decreased in the following orders: organic carbon(2.6), zinc(2.1), cadmium(2.0), copper(1.5), lead(1.1), nitrogen(0.9), mercury (0.8), phosphorus(0.4), arsenic(0.2) and chromium(0). Content of heavy metals and organic carbon in the top 10 cm layer were lower than that of lower layers, except for mercury and organic carbon in the S9 section. Contents of organic carbon in the top 50 cm layer of the mud sediments are significantly higher than those underneath. In the bottom mud layer, there is a concentration peak of the pollutants. In the mud sediments of the canal, cadmium mainly occurred in the Fe and Mn oxide fraction, copper in the organic fraction, lead in the Fe and Mn oxide fraction, and zinc in the carbonate and the Fe and Mn oxide fraction. | CHENYing-xu LIUHe ZHUGuang-wei CHENHua-lin TIANGuang-min | 2004 | Journal of Environmental Sciences2004，16，1： | 3 |
| 3 | Synthesis of hexagonal and triangular Fe3O4 nanosheets via seed-mediated solvothermal growth显示文摘 | Chunhui Li Ruixue Wei Yanmin Xu Ailing Sun Liuhe Wei | 2014 | Nano Research2014，7，4： | 2 |
| 4 | Record of Tethyan oceanclosure and Indosinian collision along the Ailaoshan suture zone(SW China)显示文摘 | LiuH C Wang Y J Cawood P A | 2015 | Gondwana Research2015，27，3： | 1 |
| 5 | Comparativestudyofdifferentproce-duresfortheseparationofperipheralbloodmononuclearcellsincytokine-inducedkillercellimmunotherapyforhepatocarcinoma显示文摘 | LiuH LiJ WangF etal | 2015 | TumourBiol2015，36，4： | 1 |
| 6 | A correlation of radiographic and functional measurements in adult degenerative scoliosis显示文摘 | PloumisA LiuH MehbodAA | 2009 | Spine(Phila Pa 1976)2009，34，15： | 1 |
| 7 | Mechanism of meehanieal property enhancement in nitrogen and titanium implanted 321 stainless steel 显示文摘 | Xu Ming Li Liuhe Liu Youming | 2006 | Materials Science and Engineering A2006，425，： | 1 |
| 8 | Associationofasymptomatico-ralcandidalcarriage,oralcandidiasisandCD4+ lymphocytecountinHIV-positivepatientsinChina显示文摘 | LiuX LiuH GuoZ etal | 2006 | OralDis2006，12，1： | 1 |
| 9 | CarbazolealkaloidsfromthestemsofClausenalansium显示文摘 | LIUH LICJ YANGJZ etal | 2012 | JNatProd2012，75，4： | 1 |
| 10 | Electrochemically assisted mi- crobial production of hydrogen from acetate 显示文摘 | LiuH Grot S Logan B E | 2005 | Environ Sci Technol2005，39，11： | 1 |
| 11 | Resveratrol neuroprotective effects duringfocal cerebral ischemia injury via nitric oxide mecha-nism in rats显示文摘 | Tsai S K Hung L M Fu Y T Cheng H Nien M W LiuH Y | 2007 | J Vase Surg2007，46，： | 1 |
| 12 | Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia inhibition of FoxOl-dependent expression of key autophagy genes by insulin显示文摘 | LiuH Y Han J M Cao S Y | 2009 | The Journal of Biological Chemistry2009，284，31： | 1 |
| 13 | The role of nm23-H1 in the progression of transitional cellbladder cancer显示文摘 | Chow NH LiuHS Chan SH | 2000 | Clin Cancer Res2000，6，9： | 1 |
| 14 | Synthesis of TS-1 using amorphous SiO2 and its catalytic properties for hydroxylation of phenol in fixed-bed reactor 显示文摘 | LIUH LUGZ GUOYL etal | 2005 | Applied Catalysis A: General2005，293，： | 1 |
| 15 | Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots显示文摘It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots(CDs) and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H condition.With the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging. | Yangyang He Zhanxian Li Qingyan Jia Bingjie Shi Hongyan Zhang Liuhe Wei Mingming Yu | 2017 | Chinese Chemical Letters2017，28，10： | 1 |
| 16 | Increasedc-Fosexpressioninthemedialpartofthelateralhabenuladuringcue-evokedheroin-see-kinginrats显示文摘 | ZhangF ZhouW LiuH etal | 2005 | NeurosciLett2005，386，2： | 1 |
| 17 | ThermalexpansionbehaviorandcrystalstructureofCuSb2Ti5 显示文摘 | WeiXZ LiuH R He W | 2008 | MatLet2008，62，45： | 1 |
| 18 | Intraoperativereal-timequer-yingofwhitemattertractsduringframelessstereotacticneuronaviga-tion显示文摘 | ElhawaryH LiuH PatelP | | 0，，02： | 1 |
| 19 | Loss of nm23 expression predicts distal metastasis and poor survival for breast cancer 显示文摘 | MAOHS LIUH FUX L | 2001 | Int J Ooncol2001，18，3： | 1 |
| 20 | Distinct functions oferythropoietin and stem cell factor are linked to activation ofmTOR kinase signaling pathway in human erythroid progenitors显示文摘 | GESLAIN R UDDINS LIUH | 2013 | Cytokine2013，61，1： | 1 |
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