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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Autoimmune thrombocytopenia associated with hepatitis C virus infection 显示文摘 | Blanquer A Linares M | 1998 | Acta Haematologica1998，99，4： | 1 |
| 3 | Manipulating protein acetyla- tion in breast cancer:a promising approach in combination with hormo- nal therapies? 显示文摘 | Linares A Dalenc F Balaguer P | 2011 | J Biomed Biotechnol2011，2011，85： | 1 |
| 4 | Modified bentonite with Na2CO3 as possible antacid medicament显示文摘 | LINARES C F TORRES A | 2005 | Studies in Surface Sci- ence and Catalysis2005，158，： | 1 |
| 5 | K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells显示文摘 | LINARES J F DURAN A YAJIMA T | 2013 | Molecular Cell2013，51，3： | 1 |
| 6 | Risk factors for pulmonary Aspergillus terreus infection in patients with positive culture for filamentous fungi显示文摘 | Castón JJ Linares MJ Gallego C Rivero A Font P Solís F | | 0，，： | 1 |
| 7 | Antioxidantand neuroprotective activity of the extract from theseaweed,Halimeda incrassata(Ellis)Lamouroux,againstin vitro and in vivo toxicity induced by methyl-mercury显示文摘 | LINARES A F LOIKKANEN J JORGE M F | 2004 | Vet Hum Toxicol2004，46，1： | 1 |
| 8 | Autoimmune Thrombocytopenia Associated with Hepatitis C Virus Infection显示文摘 | Blanquer A Linares M | 1998 | Acta Haematol1998，99，： | 1 |
| 9 | Synthesis, Biological Activity, and Quantitative Structure-Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives显示文摘 | Bra(n) M.F Gradillas A Gómez A Acero N Linares F Mu(n)oz-Mingarro D.M Abradelo C Rey-Stolle F Yuste M Campos J Gallo M Espinosa A | | 0，，9： | 1 |
| 10 | p62 is a key regulator of nutrient sensing in the mTORC1 pathway显示文摘 | Duran A Amanchy R Linares J F Joshi J Abu-Baker S Porollo A Hansen M Moscat J Di | | 0，，01： | 1 |
| 11 | The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis显示文摘 | Duran A Linares J F Galvez A S Wikenheiser K Flores J M DiazMeco M T Moscat J | | 0，，04： | 1 |
| 12 | Overexpression of the multidrug efflux pumps Mex CD-Opr J and Mex EF-OprN is associated with a reduction of type Ⅲ secretion in Pseuddomonss aeruginosa显示文摘 | Linares J F Lopez J A Camafeita E | 2005 | J Bacteriol2005，187，4： | 1 |
| 13 | Autoimmune thrombo-cytopenic associated with hepatitis C virus infection显示文摘 | Blanquer A Linares M | 1998 | Acta Haematol1998，99，4： | 1 |
| 14 | The signaling adaptor p62 is an important NF - kappaB mediator in tumorigenesis 显示文摘 | DURAN A LINARES J F GALVEZ A S | 2008 | Cancer Cell2008，13，4： | 1 |
| 15 | The effect of oxygen surface groups of the support on platinum dispersion in Pt/carbon catalysts 显示文摘 | Prado Burguete C Linares Solano A Rodriguez-Reinoso F | 1989 | J Catal1989，115，： | 1 |
| 16 | Autoimmune Thrombocytopenia Associated with Hepatitis C Virus Infection显示文摘 | Blanquer A Linares M | 1998 | Acta Haematol1998，99，： | 1 |
| 17 | 查看详情显示文摘 | Linares A V Vandevelde F Pantigny J Falcimaigne-Cordin A Haupt K | | 0，，： | 1 |
| 18 | Benthic nitrogen fluxes along a depth gradient in a microtidal fjord: the role of denitrificafion and microphytobenthos显示文摘 | Sundback K Linares F Larson F Wulff A | 2004 | Limnology and Oceanography2004，49，： | 1 |
| 19 | Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF- OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa显示文摘 | Linares J F Lopez J A Camafeita E | 2005 | J Bacteriol2005，187，4： | 1 |
| 20 | Nitrogen dynamics in nontidal littoral sediments:role of microphytobenthos and denitrification显示文摘 | SUNDBACK K MILES A LINARES F | 2006 | Estuaries and Coasts2006，29，6： | 1 |
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