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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Impacts of the European Emission Trading Scheme Directive and Permit Assignment Methods on the Spanish Electricity Sector显示文摘 | LINARES P SANTOS F J VENTOSA M LAPIEDRA L | 2006 | Energy Journal2006，27，1： | 1 |
| 3 | Infection-related mortality in a large cohort of renal transplant recipients显示文摘 | Linares L Cofdn F Cervera C | 2007 | Transplant Proc2007，39，7： | 1 |
| 4 | Autoimmune thrombocytopenia associated with hepatitis C virus infection 显示文摘 | Blanquer A Linares M | 1998 | Acta Haematologica1998，99，4： | 1 |
| 5 | Manipulating protein acetyla- tion in breast cancer:a promising approach in combination with hormo- nal therapies? 显示文摘 | Linares A Dalenc F Balaguer P | 2011 | J Biomed Biotechnol2011，2011，85： | 1 |
| 6 | Study of the susceptibility of yeast isolates of clinical interest to five antifungal agents using the E- test 显示文摘 | Linares M J Manoz J F Solis F | 1998 | Rev Esp Quimioter1998，11，3： | 1 |
| 7 | Modified bentonite with Na2CO3 as possible antacid medicament显示文摘 | LINARES C F TORRES A | 2005 | Studies in Surface Sci- ence and Catalysis2005，158，： | 1 |
| 8 | Rearing of Octopus vulgaris paralarvae:present status,bottlenecks and trends显示文摘 | Iglesias J Sanchez F J Bersano J G F Carrasco J F Dhont J Fuentes L Linares F Munoz J L | | 0，，： | 1 |
| 9 | Antibiotics as inmrmicrobial signaling agents instead of weapons显示文摘 | LINARES J F GUSTAFSSON I BAQUERO F | 2006 | Procnatl Acad Sci USA2006，103，19： | 1 |
| 10 | Well posedness for the 1D Zakharov-Rubenchik system显示文摘 | Linares F Matheus C | 2009 | Advances in Differential Equations2009，14，34： | 1 |
| 11 | K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells显示文摘 | LINARES J F DURAN A YAJIMA T | 2013 | Molecular Cell2013，51，3： | 1 |
| 12 | Scaling,stability and singularities for nonlinear dispersive wave equations: the crital case 显示文摘 | ANGULO J BONA J LINARES F | 2002 | Nonlinearity2002，15，： | 1 |
| 13 | In vitro activity of linezolid and 11 other antimicrobials against 566 clinical isolates and comparison between NCCLS microdilution and Etest methods 显示文摘 | Tubau F Fernandez-Roblas R Linares J | 2001 | J Antimicrob Chemother2001，47，5： | 1 |
| 14 | Risk factors for pulmonary Aspergillus terreus infection in patients with positive culture for filamentous fungi显示文摘 | Castón JJ Linares MJ Gallego C Rivero A Font P Solís F | | 0，，： | 1 |
| 15 | Antioxidantand neuroprotective activity of the extract from theseaweed,Halimeda incrassata(Ellis)Lamouroux,againstin vitro and in vivo toxicity induced by methyl-mercury显示文摘 | LINARES A F LOIKKANEN J JORGE M F | 2004 | Vet Hum Toxicol2004，46，1： | 1 |
| 16 | Some ImProvements of Traditional Lifting Line Theory for Ship propellers显示文摘 | Gomez G P Linares F G Briones I B | | 0，，04： | 1 |
| 17 | Dual effect of organic acids as a function of external pH in Oenococcus oeni显示文摘 | AUGAGNEUR Y RITT J F LINARES D M | 2007 | Arch Microbiol2007，188，2： | 1 |
| 18 | Autoimmune Thrombocytopenia Associated with Hepatitis C Virus Infection显示文摘 | Blanquer A Linares M | 1998 | Acta Haematol1998，99，： | 1 |
| 19 | Synthesis, Biological Activity, and Quantitative Structure-Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives显示文摘 | Bra(n) M.F Gradillas A Gómez A Acero N Linares F Mu(n)oz-Mingarro D.M Abradelo C Rey-Stolle F Yuste M Campos J Gallo M Espinosa A | | 0，，9： | 1 |
| 20 | Antibiotics as intermicrobial signaling agents instead of weapons显示文摘 | Linares J F Gustafsson I Baquero F et ol | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，19： | 1 |
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