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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Improved catalytic activi-ty and stability of mesostructured sulfated zirconia by Al promoter显示文摘 | YIN Y S LINA Y SHENG Q M | 2004 | Applied Catalysis A: General2004，268，15： | 1 |
| 3 | Development of new features of ant colony optimization for flowshop scheduling显示文摘 | LUB C Y SHYUC S J | 2008 | International Journal of Production Economics2008，112，2： | 1 |
| 4 | Attenuation relations of Arias intensity based on the Chi-Chi Taiwan earthquake data 显示文摘 | HWANGA H LINA C K YEHB Y T CHENGB S N CHENC K C | 2004 | Soil Dynamics and Earthquake Engineering2004，24，7： | 1 |
| 5 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 6 | Surgical treatment of mitral valve regurgitation indilated cardiomyopathy显示文摘 | Calaf iore AM M au roMD Gal lina S | 2004 | Heart Su rg Forum2004，7，： | 1 |
| 7 | Innovative initiatives dupporting inclusive innovation in India:social business incubation and micro venture capital显示文摘 | LINA S | 2012 | Technological Forecasting and Social Change2012，79，4： | 1 |
| 8 | Nanosized ALPO4-5 molecular sieves and ultrathin films prepared by microwave synthesis 显示文摘 | Mintova S Bein T Lina L | 1998 | Chemistry of Materials1998，10，： | 1 |
| 9 | D -Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain显示文摘 | Antoni Bayes-Genis Jose Mateo Miquel Santaló Artur Oliver Josep Guindo Lina Badimon Antoni Mart??nez-Rubio Jordi Fontcuberta Robert S. Schwartz Antoni Bayés de Luna | 2000 | American Heart Journal2000，，3： | 1 |
| 10 | Improved catalytic activity and stability of meso structured sulfated zirconia by Al promoter显示文摘 | Yin y S Lina Y Sheng Q M | 2004 | Applied Catalysis A:General2004，268，： | 1 |
| 11 | Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults显示文摘 | Guixiang Zhao Earl S Ford Chaoyang Li Penny M Kris-Etherton Terry D Etherton Lina S Balluz | 2010 | Journal of Hypertension2010，，9： | 1 |
| 12 | Biomarkers for Severity of Neonatal Hypoxic-Ischemic Encephalopathy and Outcomes in Newborns Receiving Hypothermia Therapy显示文摘 | Lina F Chalak Pablo J Sánchez Beverley Adams-Huet | 2014 | The Journal of Pediatrics2014，164，3： | 1 |
| 13 | Diabetes mellitus and health-related quality of life among older adults Findings from the behavioral risk factor surveillance system (BRFSS)显示文摘 | David W Browna Lina S Balluza Wayne H Giles b | 2004 | Diabetes Res Clinl Prac2004，，65： | 1 |
| 14 | Regulation of connexin36 gap junction channels by n ‐alkanols and arachidonic acid显示文摘 | Alina Marandykina Nicolás Palacios‐Prado Lina Rimkut? Vytenis A. Skeberdis Feliksas F. Bukauskas | 2013 | The Journal of Physiology2013，，8： | 1 |
| 15 | Compu- tation of minimal event bases that ensure diagnosability显示文摘 | BASILIO J C LINA S T S LAFORTUNE S etal | 2012 | Discrete Event Dynamic Synst2012，，： | 1 |
| 16 | Resistance to fas-induced apoptosis in hepatocyte cultures:Role of GSH depletion by cell isolation and culture显示文摘 | Lina Musallam Chantal Ethier Pierre S Haddad1 | 2002 | Am J Physiol Gastrointest Liver Physiol2002，283，3： | 1 |
| 17 | Effect of Various Organic Precursors on the Performance of LiFePO4 / C Composite Cathode by Coprecipitation Method显示文摘 | Onga C W Lina Y K Chen J S | 2007 | Journal of The Electrochemical Society2007，154，： | 1 |
| 18 | Drying kinetics of whole durum wheat pasta according to temperature and relative humidity显示文摘 | Villeneuve S G?linas P | 2007 | Swiss Society of Food Science and Technology2007，40，： | 1 |
| 19 | Flow injection spectrophotometric determination of free and total sulfite in wines based on the induced oxidation of manganese(II)显示文摘 | Lina R Silva G N P Silva C S | 1998 | Anal Lett1998，31，13： | 1 |
| 20 | Vitamin and mineral supplement use in the United States: results from the third National Health and Nutrition Examination Survey 显示文摘 | Lina S Stephane M Rossanne M | 2000 | Arch Faro Med2000，9，12： | 1 |
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