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| 1 | Bimetallic Ru-Ni/TiO2 catalysts for hydrogenation of N-ethylcarbazole:Role of TiO2 crystal structure显示文摘Hydrogenation of N-ethylcarbazole(NEC),the hydrogen lean form of a liquid organic hydrogen carrier,on TiO2 supported Ru-Ni bimetallic catalysts is investigated.Crystal structure of TiO2 plays a critical role on the hydrogenation activity and selectivity towards fully hydrogenated product.Ru/anatase catalyst exhibits higher selectivity but lower reactivity compared to Ru/rutile catalyst.Ni addition significantly promotes the performance of Ru/anatase catalyst while causes severe performance deterioration of Ru/rutile catalyst.Commercial P25,a mixture of anatase and rutile phases in approximate ratio A/R1/4,is found to be the best TiO2 support for NEC hydrogenation.Ru/P25 catalyst outperforms both Ru/rutile and Ru/anatase and its activity can be further slightly improved by Ni addition.The unexpected synergism between the two different TiO2 phases for Ru based NEC hydrogenation catalysts is related to metal-support interaction and Ru-Ni interaction. | Hongen Yu Xue Yang Yong Wu Yanru Guo Shuan Li Wei Lin Xingguo Li Jie Zheng | 2020 | Journal of Energy Chemistry2020，29，1： | 7 |
| 2 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 3 | Pulping performance of transgenic poplar with depressed Caffeoyl-CoA O-methyltransferase显示文摘This paper evaluated pulping performance of 3-year-old field-grown transgenic poplar (Populus tremula × Populus alba). The transgenic poplar with anti-sense CCoAOMT had an about 13% decreased lignin content, in which a slight increment was found in S/G ratio. Chemical analysis showed that the transgenic poplar had significantly less benezene-ethanol extractive than that of control wood, but no significant differences were found in contents of ash, cold water extractive, hot water extractive, 1% NaOH extractive, holocellulose, pentosans and cellulose. Fiber assay demonstrated that down-regulation of CCoAOMT expression improved the fiber quality in transgenic poplar. Kraft pulping showed that lower lignin in transgenic poplar led to remarkable improved pulp quality and increased pulp yield. | WEI JianHua WANG YanZhen WANG HongZhi LI RuiFen LIN Nan MA RongCai QU LeQing SONG YanRu | 2008 | Chinese Science Bulletin2008，53，22： | 5 |
| 4 | Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘H3K9me2 和 H3K27me2 是与抄写压抑联系的重要 epigenetic 标记,当 H3K4me3 与抄写激活被联系时。活跃、压抑的 histone methylations 以一种互相独占的方式散布,这被显示出,但是内在的机制糟糕被理解。这里,我们识别了 ceKDM7A,一个哲学博士(植物 homeodomain )- 并且 JmjC 包含域的蛋白质,为 H3K9me2 和 H3K27me2 特定的 histone demethylase。我们进一步证明 ceKDM7A 的 PHD 领域在染色体宽的水平绑了 H3K4me3 和与 ceKDM7A co 局部性的 H3K4me3。到 H3K4me3 的 PHD 域绑定的混乱在 vivo 减少了 demethylase 活动,并且 ceKDM7A 的损失减少了它的联系目标基因的表达式。这些结果显示 ceKDM7A 被招募到倡导者到 demethylate H3K9me2 和 H3K27me2 并且通过 PHD 领域的绑定激活基因表示到 H3K4me3。因此,我们的学习识别双特性的 histone demethylase 并且提供新奇卓见进 histone methylation 的规定。 | Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen | 2010 | Cell Research2010，20，8： | 2 |
| 5 | Preparation and properties of a new porous ceramic material used in clean energy field显示文摘At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean energy applications. In this work, a reticulated porous ceria ceramic material with interconnected porous structure was prepared by the impregnation technique using organic polyurethane sponges as template. The influences of pretreated sponge, dipping time length, pore size and sintering temperature on the porosity and strength of the porous ceria ceramics were system atically studied. With the increasing sintering temperature, the glass phase occurred and led to an increase in strength, but an decrease in porosity. Eventually, we analyzed the relationships betw een porosity and strength of these porous materials, aiming to provide theoretical and practical references for its application in clean-energy field. | Shuming Wang Xiaofang Zhang Fenghua Kuang Jiangshan Li Yanxin Wang Ruiping Wang Yanru Wang Xin Lin Jianming Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 2 |
| 6 | Simultaneous improvement in cold tolerance and yield of temperate japonica rice ( O ryza sativa L .) by introgression breeding显示文摘 | Lijun Meng Xiuyun Lin Jinming Wang Kai Chen Yanru Cui Jianlong Xu Zhikang Li | 2013 | Plant Breed2013，，6： | 1 |
| 7 | Deposition of uniform mc-Si : H layers on plasma etched vertical ZnO nanowires显示文摘 | LIN Yanru CHANG Chiwei CHEN Yihua | 2010 | Cryst Eng Comm2010，12，： | 1 |
| 8 | Minimizing upper boundof ruin probability under discrete risk model with Markovchain interest rate 显示文摘 | Xu Lin Zhu Dongjin Zhou Yanru | 2014 | Communication in Statistics -Theoryand Methods2014，44，： | 1 |
| 9 | Minimizing upper Bound of ruin probability under discrete risk model with markov chain interest rate显示文摘 | Xu Lin Zhu Dongjin Zhou Yanru | 2015 | Communications in Statistics-Theory and Methods2015，44，81： | 1 |
| 10 | Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy显示文摘Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment. | Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin | 2023 | Cancer Biology & Medicine2023，20，4： | 0 |
| 11 | POSSIBLE HIGH A1 SUBSTITUTION IN THE T1-Ba-Ca-Cu-O SUPERCONDUCTING SYSTEM显示文摘The A1 substitution in the T1-Ba-Ca-Cu-O superconducting system was studied.Up to 70%of Tl can be substituted by Al,without significant reduction of Tc.X-ray diffraction indicates partial A1 substitution does not alter the crystal structure of the 2223 phase.Excessive A1 formed Al-Cu alloy and unidentified phases,which gradually destroyed the superconductivity. | MENG Xianren LIN Mingzhu TANG Weihua REN Yanru LIN Zhenjin TU Qingyun SANG Lihua LIU Zhenxing | 1990 | Chinese Physics Letters1990，7，3： | 0 |
| 12 | Preparation and laser performances of Nd3+:GSGG ceramic powder raw materials显示文摘This paper explores a new laser working material: gallium scandium gadolinium(GSGG), which was successfully prepared by one step co-precipitation method, and the potential properties of this Nd^3+ doped laser ceramic raw materials were proposed. The size of the prepared powder was uniform and mainly about 65 nm. The GSGG phase could be obtained after a heat-treatment of 1000℃ for 4h, and the characterized fluorescence decay curves showed that about 1 at.% concentration of Nd^3+in Nd^3+:GSGG precursor presented optimum fluorescence intensity at 1.06μm waveband. | Shuming Wang Xin Lin Qing Ye Jiangshan Li Xiaofang Zhang Ruiping Wang Yanru Wang | 2019 | Journal of Materials Science & Technology2019，35，5： | 0 |
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