|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | VcFT-induced mobile florigenic signals in transgenic and transgrafted blueberries显示文摘FLOWERING LOCUS T(FT)can promote early flowering in annual species,but such role has not been well demonstrated in woody species.We produced self and reciprocal grafts involving non-transgenic blueberry(NT)and transgenic blueberry(T)carrying a 35S-driven blueberry FT(VcFT-OX).We demonstrated that the transgenic VcFT-OX rootstock promoted flowering of non-transgenic blueberry scions in the NT(scion):T(rootstock)grafts.We further analyzed RNASeq profiles and six groups of phytohormones in both NT:T and NT:NT plants.We observed content changes of several hormone metabolites,in a descending order,in the transgenic NT:T,non-transgenic NT:T,and non-transgenic NT:NT leaves.By comparing differential expression transcripts(DETs)of these tissues in relative to their control,we found that the non-transgenic NT:T leaves had many DETs shared with the transgenic NT:T leaves,but very few with the transgenic NT:T roots.Interestingly,a number of these shared DETs belong to hormone pathway genes,concurring with the content changes of hormone metabolites in both transgenic and non-transgenic leaves of the NT:T plants.These results suggest that phytohormones induced by VcFT-OX in the transgenic leaves might serve as part of the signals that resulted in early flowering in both transgenic plants and the non-transgenic NT:T scions. | Guo-qing Song Aaron Walworth Tianyi Lin Qiuxia Chen Xiumei Han LIrina Zaharia Gan-yuan Zhong | 2019 | Horticulture Research2019，6，1： | 3 |
| 2 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 3 | VcRR2 regulates chilling-mediated flowering through expression of hormone genes in a transgenic blueberry mutant显示文摘The molecular mechanism underlying dormancy release and the induction of flowering remains poorly understood in woody plants.Mu-legacy is a valuable blueberry mutant,in which a transgene insertion caused increased expression of a RESPONSE REGULATOR 2-like gene(VcRR2).Mu-legacy plants,compared with nontransgenic‘Legacy’plants,show dwarfing,promotion of flower bud formation,and can flower under nonchilling conditions.We conducted transcriptomic comparisons in leaves,chilled and nonchilled flowering buds,and late-pink buds,and analyzed a total of 41 metabolites of six groups of hormones in leaf tissues of both Mu-legacy and‘Legacy’plants.These analyses uncovered that increased VcRR2 expression promotes the expression of a homolog of Arabidopsis thaliana ENTCOPALYL DIPHOSPHATE SYNTHETASE 1(VcGA1),which induces new homeostasis of hormones,including increased gibberellin 4(GA4)levels in Mu-legacy leaves.Consequently,increased expression of VcRR2 and VcGA1,which function in cytokinin responses and gibberellin synthesis,respectively,initiated the reduction in plant height and the enhancement of flower bud formation of the Mu-legacy plants through interactions of multiple approaches.In nonchilled flower buds,29 differentially expressed transcripts of 17 genes of five groups of hormones were identified in transcriptome comparisons between Mu-legacy and‘Legacy’plants,of which 22 were chilling responsive.Thus,these analyses suggest that increased expression of VcRR2 was collectively responsible for promoting flower bud formation in highbush blueberry under nonchilling conditions.We report here for the first time the importance of VcRR2 to induce a suite of downstream hormones that promote flowering in woody plants. | Tianyi Lin Aaron Walworth Xiaojuan Zong Gharbia H.Danial Elise M.Tomaszewski Pete Callow Xiumei Han L.Irina Zaharia Patrick P.Edger Gan-yuan Zhong Guo-qing Song | 2019 | Horticulture Research2019，6，1： | 2 |
| 4 | Structure of KLa(WO4)2 with a novel isolated La polyhedron显示文摘 | Han Xiumei Lin Zhoubin Hu Zushu Wang Guofu | 2002 | Materials Research Innovations2002，6，： | 1 |
| 5 | Single-cell protein production from Jerusalem artichoke extract by a recently isolated marine yeast Cryptococcus aureus G7a and its nutritive analysis显示文摘 | Lingmei Gao Zhenming Chi Jun Sheng Xiumei Ni Lin Wang | 2007 | Applied Microbiology and Biotechnology2007，，4： | 1 |
| 6 | White up-conversion luminescence and highly-sensitive optical temperature sensing in Na_(3)La(VO_(4))_(2):Yb,Er,Tm,Ho phosphors显示文摘In this work,tunable white up-conversion luminescence was achieved in the Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) codoped Na_(3)La(VO_(4))_(2) phosphors under 980 nm excitation.The emissions of three primary colors are mainly attributed to the ~2H_(11/2)/~4S_(3/2)→~4I_(15/2) transitions of Er^(3+),~1G_(4)→~3H_6 transition of Tm^(3+),and_5F_5→~5I_8 transition of Ho^(3+).White luminescence characteristics and mechanisms of up-conversion system were investigated in detail.In addition,the temperature sensing behaviors of multiple levels emission combinations for Na_(3)La(VO_(4))_(2):Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) were analyzed by employing thermally coupled and non-thermally coupled energy levels.Based on the emissions of ~3F_(2,3)/~1G_(4) energy levels,the maximum relative and absolute sensitivities were obtained to be 2.20%/K and 0.279 K^(-1).The design of up-conversion luminescence materials with high-quality white luminescence and excellent sensitivity performance is critical in the field of optical applications. | Qi Xiao Xiumei Yin Lin Lv Xinyao Dong Na Zhou Kuichao Liu Xixian Luo | 2023 | Journal of Rare Earths2023，41，7： | 1 |
| 7 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 8 | Functionalized self-assembling peptide nanofiber hydrogels mimic stem cell niche to control human adipose stem cell behavior in vitro显示文摘 | Xi Liu Xiumei Wang Xiujuan Wang Hui Ren Jin He Lin Qiao Fu-Zhai Cui | 2013 | Acta Biomaterialia2013，，6： | 1 |
| 9 | Droplet size and stability of nano-emulsions produced by the temperature phase inversion method 显示文摘 | Sher Lin Ee Duan Xiumei | 2008 | Chemical Engineering Journal2008，140，： | 1 |
| 10 | Structure of KLa (WO4)2 with a novel isolated La polyhedron 显示文摘 | Han Xiumei Lin Zhoubin Hu Zhushu | 2002 | Material Research Innovation2002，17，6： | 1 |
| 11 | The impact of hepatitis B virus x protein and microRNAs in hepatocellular carcinoma: a comprehensive analysis显示文摘 | Li Lin Xiaomao Yin Xiumei Hu Qian Wang Lei Zheng | 2014 | Tumor Biology2014，，12： | 1 |
| 12 | Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell recruitment.However,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue repair.Consequently,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue repair.Vascular endothelial growth factor(VEGF)plays a significant role in wound healing by promoting angiogen-esis.The overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual functions.Prominin-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based bandages.The sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound site.Meanwhile,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the bandages.These dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment axis.Consequently,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen remodeling.Conclusively,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a promising avenue for scarless wound regeneration,which may also have implications for other tissue engineering disciplines. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 13 | YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma显示文摘Background:Y-box binding protein 1(YB1 or YBX1)plays a critical role in tumorigenesis and cancer progression.However,whether YB1 affects malignant transformation by modulating non-codingRNAs remains largely unknown.This study aimed to investigate the relationship between YB1 and microRNAs and reveal the underlying mechanism by which YB1 impacts on tumor malignancy via miRNAs-mediated regulatory network.Methods:The biological functions of YB1 in hepatocellular carcinoma(HCC)cells were investigated by cell proliferation,wound healing,and transwell invasion assays.The miRNAs dysregulated by YB1 were screened by microarray analysis in HCC cell lines.The regulation of YB1 on miR-205 and miR-200b was determined by quantitative real-time PCR,dual-luciferase reporter assay,RNA immunoprecipitation,and pull-down assay.The relationships of YB1,DGCR8,Dicer,TUT4,and TUT1 were identified by pull-down and coimmunoprecipitation experiments.The cellular co-localization of YB1,DGCR8,and Dicer were detected by immunofluorescent staining.The in vivo effect of YB1 on tumor metastasis was determined by injecting MHCC97H cells transduced with YB1 shRNA or shControl via the tail vein in nude BALB/c mice.The expression levels of epithelial tomesenchymal transition markerswere detected by immunoblotting and immunohistochemistry assays.Results:YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b‒ZEB1 axis partially in a Snail-independent manner.YB1 suppressedmiR-205 and miR-200b maturation by interacting with the microprocessors DGCR8 and Dicer as well as TUT4 and TUT1 via the conserved cold shock domain.Subsequently,the downregulation of miR-205 and miR-200b enhanced ZEB1 expression,thus leading to increased cell migration and invasion.Furthermore,statistical analyses on gene expression data from HCC and normal liver tissues showed that YB1 expression was positively associated with ZEB1 expression and remarkably correlated with clinical prognosis.Conclusion:This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b‒ZEB1 axis in HCC cells.Furthermore,these results highlight that YB1 may play biological functions via miRNAs-mediated gene regulation,and it can serve as a potential therapeutic target in human cancers. | Xiumei Liu Di Chen Huan Chen Wen Wang Yu Liu Yawei Wang Chao Duan Zhen Ning Xin Guo Wuxiyar Otkur Jing Liu Huan Qi Xiaolong Liu Aifu Lin Tian Xia Hong-xu Liu Hai-long Piao | 2021 | Cancer Communications2021，41，7： | 1 |
| 14 | Single-cell protein production from Jerusalem artichoke extract by a recently isolated marine yeast Cryptococcus aureus G7a and its nutritive analysis显示文摘 | Lingmei Gao Zhenming Chi Jun Sheng Xiumei Ni Lin Wang | 2007 | Applied Microbiology and Biotechnology2007，，4： | 1 |
| 15 | Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD–MS/MS显示文摘 | Lei Zhang Lin Zhu Yuefei Wang Zhenzuo Jiang Xin Chai Yan Zhu Xiumei Gao Aidi Qi | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，： | 1 |
| 16 | The DELLA-ABI4-HY5 module integrates light and gibberellin signals to regulate hypocotyl elongation显示文摘Plant growth is coordinately controlled by various environmental and hormonal signals,of which light and gibberellin(GA)signals are two critical factors with opposite effects on hypocotyl elongation.Although interactions between the light and GA signaling pathways have been studied extensively,the detailed regulatory mechanism of their direct crosstalk in hypocotyl elongation remains to be fully clarified.Previously,we reported that ABA INSENSITIVE 4(ABI4)controls hypocotyl elongation through its regulation of cellelongation-related genes,but whether it is also involved in GA signaling to promote hypocotyl elongation is unknown.In this study,we showthat promotion of hypocotyl elongation by GA is dependent on ABI4 activation.DELLAs interact directly with ABI4 and inhibit its DNA-binding activity.In turn,ABI4 combined with ELONGATED HYPOCOTYL 5(HY5),a key positive factor in light signaling,feedback regulates the expression of the GA2ox GA catabolism genes and thus modulates GA levels.Taken together,our results suggest that the DELLA-ABI4-HY5 module may serve as a molecular link that integrates GA and light signals to control hypocotyl elongation. | Haibo Xiong Dandan Lu Zhiyuan Li Jianghao Wu Xin Ning Weijun Lin Zechen Bai Canhui Zheng Yang Sun Wei Chi Lixin Zhang Xiumei Xu | 2023 | Plant Communications2023，4，5： | 0 |
| 17 | Morphological characteristics and DNA barcoding of Pampus echinogaster(Basilewsky, 1855)显示文摘The morphological similarities of Pampus fishes have led to considerable confusion in species-level identification,and no accurate information on neotype or DNA barcoding of Pampus echinogaster is available. Two hundred and seven specimens of P. echinogaster were collected from the coastal waters of Dandong, Dongying, Qingdao,Nantong, Zhoushan, Wenzhou, Changle, Taiwan, and Wakayama(Japan), from June 2010 to April 2013. The diagnostic characteristics of P. echinogaster are as follows: dorsal fin VIII-XI-43–51, anal fin V-VIII-43–49, pectoral fin 22–27, caudal fin 19–22, pelvic fin absent; first gill rakers sparse, slender(pointed), 3–4+12–16=15–20; vertebrae39–41; transverse occipital canal on top of head moderately small, wavy ridges not reaching upper origin of pectoral fin; ventral branch of lateral line canal spare, shorter than dorsal branch of lateral line canal. By combining congener sequences of the cytochrome oxidase I(COI) gene from Gen Bank, two absolute groups were detected among all specimens, which further indicated that two valid species were present based on genetic differences in amino acid sequences and the distance between the groups. The sequences of Group 1 can be regarded as DNA barcoding of P. echinogaster. The correct morphological redescription and DNA barcoding of P.echinogaster are presented here to provide a guarantee for efficient and accurate studies, a theoretical basis for classification, and enable appropriate fishery management and conservation strategies for the genus Pampus in the future. | LI Yuan ZHANG Yan GAO Tianxiang HAN Zhiqiang LIN Longshan ZHANG Xiumei | 2017 | Acta Oceanologica Sinica2017，36，12： | 0 |
| 18 | An Evaluation of the Coupling Coordination of Technological Innovation System in China’s Marine Biopharmaceutical Industry显示文摘The marine biopharmaceutical industry(MBI)has been considered as an important part of the blue economy.The high-quality development of this industry depends on the high-level coordinated development of technological innovation system(TIS).In the present study,the coupling mechanism of industrial innovation input subsystem and innovation output subsystem was analyzed for the first time.On this basis,the development level and coupling coordination level of TIS in China’s MBI during 2008-2018 were empirically evaluated with the capacity coupling coordination model.Then,the obstacle factors were diagnosed and recognized with the obstacle model.The results showed that the innovation input index fluctuated at a low level in China’s MBI.The innovation output index has basically maintained a growth trend,whereas the quality of development was not high.Although the coupling coordination level of TIS showed a positive change as mild disordered→primary coordinated→well-coordinated,the development type of innovation system has changed from the lagging output of innovation into the lagging input of innovation.Insufficient input of innovation factors remained the main obstacle to the improvement of coordination level.Based on the above analysis,suggestions were put forward from the perspectives of policy and fund guarantees to improve the coupling coordination level in China’s MBI. | FU Xiumei ZHENG Yangming LIN Chunyu WANG Ping WANG Changyun | 2023 | Journal of Ocean University of China2023，22，1： | 0 |
| 19 | Correction to:Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Correction to:Advanced Fiber Materials http://gffzzd3cc09b8251d45dfsqfnvoww6x05o6wvx.ffgz.tsg.suse.edu.cn/10.1007/s42765-022-00226-8 In this article the author name Muhammad Shafiq was incorrectly written as Shafiq Muhammad.The original article has been corrected. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 20 | enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model显示文摘Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which encodes the essential protein dystrophin.This genetic condition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the second or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarcolemma,which predisposes individuals to myonecrosis and activation of inflammatory signaling cascades.Unfortunately,there is currently no effective cure for DMD,and glucocorticoid steroids are commonly used in clinical settings to delay symptom development(Merlini et al.,2003). | Ming Jin Jiajia Lin Yu Zhang Qingquan Xiao Xiangfeng Kong Xiumei Zhang Zhurui Shao Yin Wang Yuyang Yu Jinjing Li Wan-Jin Chen Guoling Li Hui Yang Ning Wang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员