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| 1 | Microstructure and mechanical properties of Al-Mg-Mn alloy with erbium显示文摘The effect of trace element Er on the microstructure and properties of Al-6Mg-0.7Mn-0.1Cr-0.15Ti alloy was investigated. The results show that the ultimate room-temperature and high-temperature strength sof the alloy have not increased obviously with the addition of erbium, but the uniform elongation of alloys decreases from 9% and 27.5% to 5.5% and 22.5%, respectively. The reason is that the addition of Er will first react with Ti, Cr to form Al20Ti2Er, Al8Cr4Er phases. The precipitation strengthening makes up the weakening of grain refinement strengthening. During deformation, the primary Al(TiCr)Er and Al3Er particles fracture first and act as the microcrack sources because of the stress concentration. | Wang, Xudong Lin, Shuangping Yang, Junjun Tang, Zhenlei Nie, Zuoren | 2012 | Rare Metals2012，31，3： | 6 |
| 2 | The Oncoprotein HBXIP Uses Two Pathways to Up-regulate S100A4 in Promotion of Growth and Migration of Breast Cancer Cells显示文摘 | Shuangping Liu Leilei Li Yingyi Zhang Yiwen Zhang Yu Zhao Xiaona You Zhenhua Lin Xiaodong Zhang Lihong Ye | 2012 | Journal of Biological Chemistry2012，，36： | 3 |
| 3 | Annealing behavior of a modified 5083 aluminum alloy显示文摘 | Shuangping Lin Zuoren Nie Hui Huang Bolong Li | 2009 | Materials and Design2009，，3： | 2 |
| 4 | Annealing behavior of a modified 5083 aluminum alloy显示文摘 | Shuangping Lin Zuoren Nie Hui Huang Bolong Li | 2009 | Materials and Design2009，，3： | 1 |
| 5 | Annealing be- havior ofamodified 5083 aluminum alloy显示文摘 | Lin Shuangping Nie Zuoren Huang Hui | 2010 | Materials&Design2010，31，： | 1 |
| 6 | Delayed fracture resistance of 30MnSi high strength steel显示文摘 | LIN Shuangping ZHANG Yan FAN Meiguang etal | 2012 | Applied Mechanics and Materials2012，，174177： | 1 |
| 7 | Mater Des显示文摘 | Lin Shuangping Nie Zuoren Huang Hui | 2010 | 31:16072010，31，： | 1 |
| 8 | Binary Program Vulnerability Mining Based on Neural Network显示文摘Software security analysts typically only have access to the executable program and cannot directly access the source code of the program.This poses significant challenges to security analysis.While it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining methods.However,these tools suffer from some shortcomings.In terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search space.Additionally,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information loss.In this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation techniques.By leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion method.This combination allows for the unified handling of binary programs across various architectures,compilers,and compilation options.Subsequently,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)network.Finally,the graph embedding network is utilized to evaluate the similarity of program functionalities.Based on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target function.The solved content serves as the initial seed for targeted fuzzing.The binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity scores.This approach facilitates cross-architecture analysis of executable programs without their source codes and concurrently reduces the risk of symbolic execution path explosion. | Zhenhui Li Shuangping Xing Lin Yu Huiping Li Fan Zhou Guangqiang Yin Xikai Tang Zhiguo Wang | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 9 | PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism显示文摘Metabolic reprogramming is a hallmark of cancer,including lung cancer.However,the exact underlying mechanism and therapeutic potential are largely unknown.Here we report that protein arginine methyltransferase 6(PRMT6)is highly expressed in lung cancer and is required for cell metabolism,tumorigenicity,and cisplatin response of lung cancer.PRMT6 regulated the oxidative pentose phosphate pathway(PPP)flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phosphogluconate dehydrogenase(6PGD)and a-enolase(ENO1).Furthermore,PRMT6 methylated R324 of 6PGD to enhancing its activity;while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate(2-PG)binding to ENO1,respectively.Lastly,targeting PRMT6 blocked the oxidative PPP flux,glycolysis pathway,and tumor growth,as well as enhanced the antitumor effects of cisplatin in lung cancer.Together,this study demonstrates that PRMT6 acts as a posttranslational modification(PTM)regulator of glucose metabolism,which leads to the pathogenesis of lung cancer.It was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy. | Mingming Sun Leilei Li Yujia Niu Yingzhi Wang Qi Yan Fei Xie Yaya Qiao Jiaqi Song Huanran Sun Zhen Li Sizhen Lai Hongkai Chang Han Zhang Jiyan Wang Chenxin Yang Huifang Zhao Junzhen Tan Yanping Li Shuangping Liu Bin Lu Min Liu Guangyao Kong Yujun Zhao Chunze Zhang Shu-Hai Lin Cheng Luo Shuai Zhang Changliang Shan | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
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