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| 1 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 2 | Influence of CeO2 loading on structure and catalytic activity for NH3-SCR over TiO2-supported CeO2显示文摘A series of supported CeO2/TiO2 catalysts were prepared to explore the influence of CeO2 loading on these catalysts for the selective catalytic reduction of NO3 by NH3(NH3-SCR).The catalysts were investigated in detail by means of XRD,Raman,H2-TPR,NH3-TPD,XPS,in situ DRIFTS,and NH3-SCR reaction.The activity of the catalyst is closely related to the content of CeO2.When the loading of CeO2 is near the dispersion capacity(1.16 mmol Ce4+/100 m^2 TiO2),the catalytic activity is better.This may be because that the dispersed CeO2 is the active species and the catalyst has appropriate redox property,along with the larger amounts of surface Ce content and surface adsorbed oxygen species.Finally,a possible reaction mechanism via the Langmuir-Hinshelwood(L-H)mechanism is tentatively proposed to further understand the NH3-SCR reaction. | Hongliang Zhang Long Ding Hongming Long Jiaxin Li Wei Tan Jiawei Ji Jingfang Sun Changjin Tang Lin Dong | 2020 | Journal of Rare Earths2020，38，8： | 5 |
| 3 | Structure and Function of the NS1 Protein of Influenza A Virus显示文摘当前在亚洲占优势的一个病毒在鸟和人中引起致命的肺病和多重机关失败的鸟的流行性感冒。尽管有集中的研究,流行性感冒的特征理解一个病毒决定它的毒力是不完全的。NS1Aprotein,流行性感冒的非结构的蛋白质一个病毒,被报导贡献它的致病力和毒力。NS1A 蛋白质是在抵抗主人起一个重要作用的多功能的蛋白质抗病毒的反应在流行性感冒感染期间。这评论简短在 NS1A 蛋白质的结构和功能上构画出当前的知识。 | Dongzi LIN Jingfang LAN Zhizhen ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 3 |
| 4 | Reinforcement learning based energy efficient robot relay for unmanned aerial vehicles against smart jamming显示文摘Unmanned aerial vehicles(UAVs)with limited energy resources,severe path loss,and shadowing to the ground base stations are vulnerable to smart jammers that aim to degrade the UAV communication performance and exhaust the UAV energy.The UAV anti-jamming communication performance,such as the outage probability,degrades if the robot relay is not aware of the jamming policies and the UAV network topology.In this paper,we propose a robot relay scheme for UAVs against smart jamming,which combines reinforcement learning with a function approximation approach named tile coding,to jointly optimize the robot moving distance and relay power with the unknown jamming channel states and locations.The robot mobility and relay policy are chosen based on the received jamming power,the robot received signal quality,location and energy consumption,and the bit error rate of the UAV messages.We also present a deep reinforcement learning version for the robot with sufficient computing resources.It uses three deep neural networks to choose the robot mobility and relay policy with reduced sample complexity,so as to avoid exploring dangerous policies that lead to the high outage probability of the UAV messages.The network architecture of the three networks is designed with fully connected layers instead of convolutional layers to reduce the computational complexity,which is analyzed by theoretical analyses.We provide the performance bound of the proposed schemes in terms of the bit error rate,robot energy consumption and utility based on a game-theoretic study.Simulation results show that the performance of our proposed relay schemes,including the bit error rate,the outage probability,and the robot energy consumption outperforms the existing schemes. | Xiaozhen LU Jingfang JIE Zihan LIN Liang XIAO Jin LI Yanyong ZHANG | 2022 | Science China(Information Sciences)2022，65，1： | 1 |
| 5 | Tetrahedron显示文摘Connecting a triangle base and an apex forms a simplest polyhedron-that is,a tetrahedron.On account of their structural simplicity and stability,two common classes of tetrahedra-namely,M4L4 and M4L6 (M indicates anions or metal cations,L indicates ligands with C3 symmetry for M4L4 and C2 symmetry for M4L6,respectively)-can be readily constructed from (i) six straight edges through an edge-bridged strategy or (ii) four triangle faces through a face-capped strategy,by means of supramolecular or coordination assembly.The intrinsic cavities inside tetrahedra enable them to act as versatile hosts for encapsulating a variety of guests,which leads to a wide range of applications including molecular recognition,catalysis,sensing and so on.In this review,we intend to summarize specifically the work carried out in the realm of porous tetrahedral cages.It includes representative synthetic strategies for the preparation of tetrahedra along with a general summary on their structural features.Thereafter,we will highlight the state-of-the-art progress in various functions of tetrahedra,in addition to presenting a full overview of applications wherein we aim to provide new insights into the design and preparation of new topological geometric structures and functional materials on the basis of the simplest polyhedron-tetrahedron. | Lin Wu Yusheng Chen Jingfang Pei Min Tang Shangshang Wang Zhichang Liu | 2019 | Chinese Journal of Chemistry2019，37，8： | 1 |
| 6 | Regeneration of deactivated CeCoxO2 catalyst by simple thermal treatment显示文摘Active species loss owing to reactant stream washing is a general problem which industrial catalysts suffer from.In case of catalysts synthesized by co-precipitation method,which have active species unused in bulk phase,can be regenerated by a simple thermal treatment that leads to active species in bulk phase migration to surface of the deactivated catalysts.In this work,the influence of regeneration temperature was investigated by employing ammonium hydroxide washing to simulate reactant stream washing of CeCoxO2 catalysts for NO+CO reaction.It is found that the deactivated catalyst can be regenerated by simple thermal treatment and increasing calcination temperature could accelerate the Co species migration from the bulk phase to surface of catalysts. | Yandi Cai Lihua Wang Shuohan Yu Jingfang Sun Baochun Liu Lin Dong | 2020 | Journal of Rare Earths2020，38，8： | 1 |
| 7 | Application of a nanoporous gold electrode for the sensitive detection of copper via mercury- free anodic stripping voltammetry显示文摘 | Huang Jingfang Lin B T | 2009 | Analyst2009，134，11： | 1 |
| 8 | Insight into the promotional mechanism of Cu modification towards wide-temperature NH3-SCR performance of NbCe catalyst显示文摘A simple strategy of Cu modification was proposed to broaden the operation temperature window for NbCe catalyst.The best catalyst Cu0.010/Nb1Ce3 presented over 90%NO conversion in a wide temperature range of 200-400℃and exhibited an excellent H_(2)O or/and SO_(2) resistance at 275℃.To understand the promotional mechanism of Cu modification,the correlation among the'activity-structure-property'were tried to establish systematically.Cu species highly dispersed on NbCe catalyst to serve as the active component.The strong interaction among Cu,Nb and Ce promoted the emergence of NbO4 and induced more Bronsted acid sites.And Cu modification obviously enhanced the redox behavior of the NbCe catalyst.Besides,EPR probed the Cu species exited in the form of monomeric and dimeric Cu^(2+),the isolated Cu^(2+)acted as catalytic active sites to promote the reaction:Cu^(2+)-NO_(3)^(-)+NO(g)→Cu^(2+)-NO_(2)^(-)+NO_(2)(g).Then the generated NO_(2) would accelerate the fast-SCR reaction process and thus facilitated the lowtemperature deNO_(x) efficiency.Moreover,surface nitrates became unstable and easy to decompose after Cu modification,thus providing additional adsorption and activation sites for NH3,and ensuring the improvement of catalytic activity at high temperature.Since the NH3-SCR reaction followed by E-R reaction pathway efficaciously over Cu_(0.010)/Nb_(1)Ce_(3) catalyst,the excellent H_(2)O and SO_(2) resistance was as expected. | Dongqi An Yuyao Yang Weixin Zou Yandi Cai Qing Tong Jingfang Sun Lin Dong | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 1 |
| 9 | Synergistic effects of CeO_(2)/Cu_(2)O on CO catalytic oxidation:Electronic interaction and oxygen defect显示文摘For CO catalytic oxidation,Cu and Ce species are of great importance,between which the synergistic effect is worth investigating.In this work,CeO_(2)/Cu_(2)O with Cu_(2)O {111} and {100} planes were comparatively explored on CO catalytic oxidation to reveal the effects of interfacial electronic interactions and oxygen defects.The activity result demonstrates that CeO_(2)/o-Cu_(2)O {111} has superior performance compared with CeO_(2)/c-Cu_(2)O {100}.Credit to the coordination unsaturated copper atoms(Cu_(CUS)) on oCu_(2)O {111} surface,the interfacial electronic interactions on CeO_(2)/o-Cu_(2)O {111} are more obvious than those on CeO_(2)/c-Cu_(2)O {100},leading to richer oxygen defect generation,better redox and activation abilities of CO and O_(2) reactants.Furthermore,the reaction mechanism of CeO_(2)/o-Cu_(2)O {111} on CO oxidation is revealed,i.e.,CO and O_(2) are adsorbed on the Cucus on Cu_(2)O {111} and oxygen defect of CeO_(2),respectively,and then synergistically promote the CO oxidation to CO_(2).The work sheds light on the designing optimized ceria and copper-based catalysts and the mechanism of CO oxidation. | Chengyan Ge Jingfang Sun Qing Tong Weixin Zou Lulu Li Lin Dong | 2022 | Journal of Rare Earths2022，40，8： | 1 |
| 10 | Effects of Molecular Crowding on G-Quadruplex-hemin Mediated Peroxidase Activity显示文摘The concentration of macromolecules in cells can reach up to 50-400 mg/mL.They occupy 40%(volume fraction)of the whole cellar space,known as molecular crowding.The diluted solution condition in vitro is different from the crowded physiological condition in vivo.Therefore,the simulation of the physiological condition is necessary for obtaining the reliable results.It has been reported that G-quadruplex can bind to hemin to enhance its catalytic function for generating oxygen radicals,which can oxidize the lipids,proteins and DNA,thus leading to the damage of cells and tissues.In this paper,we chose PEG400 as molecular crowding reagent to simulate the molecular crowding environment in vivo.The catalytic characteristics of G-quadruplex-hemin complex in H202-ABTS system have been investigated[ABTS=2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate)].The results showed that the binding affinity of G-quadruplex and hemin was decreased with the increasing of PEG400 concentration.They even lose their binding affinity in the presence of 40%PEG400.As a result,the peroxidase activity of G-quadruplex-hemin also reduced.Therefore,in physiological condition,hemin might not bind to G-quadruplex and it might not be the main reason to cause the damages of cells and tissues. | LIU Lu LIN Jingfang SONG Yanling YANG Chaoyong ZHU Zhi | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 11 | Outcomes of two-stage double-level rotational osteotomy in treating patients with congenital proximal radioulnar synostosis显示文摘Congenital proximal radioulnar synostosis(CPRUS)is a rare anomaly which is caused by abnormal fusion of the proximal radius and ulna during development.This is due to the failure of embryological separation,resulting in the fixed position of the forearm,from mild to severe pronation.1Mild deformity leads to slight disability because the shoulder and wrist can effectively compensate.2 Patients with bilateral cases and/or pronation defor-mity of>60°may be severely limited in daily activities.34 Most surgeons recommend surgical intervention when the loss of forearm rotation exceeds 60°,particularly when the forearm is fixed in pronation. | Hu Bo Jingfang Xu Jianlan Lin Weiwei Zhu Zhefeng Zhen Wensong Ye Wenhao Chen | 2023 | World Journal of Pediatric Surgery2023，6，2： | 0 |
| 12 | Triterpenols as Proxies for Tracking the Mangrove Evolution in China显示文摘Objective Located at the interface of terrestrial and marine ecosystems,mangroves are particularly sensitive to environmental changes.They provide a sedimentary sink for organic carbon,whereby core samples could provide detailed records of mangrove evolution.Human induced,rapid environmental changes in recent years require a better understanding of the mangrove ecosystems evolution in the past,by reconstructing the past | ZHANG Daolai LIU Na YIN Ping ZHU Zhigang LU Jingfang LIN Xuehui ZHANG Yuanyuan MENG Xianwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 0 |
| 13 | A new sesquiterpenoidal glucoside from the roots of Paeonia lactiflora显示文摘Objective:To study the chemical constituents of the roots of Paeonia lactiflora.Materials and methods:The isolation and purification were carried out by column chromatography on macroporous adsorbent resin,MCI gel,silica gel,and Sephadex LH-20,as well as semi-preparative RP-HPLC.The structures were elucidated on the basis of physicochemical properties and spectroscopic analysis,as well as the ECD quantum chemical computation methods.Results:A sesquiterpenoidal glucoside(1)along with two sesquiterpenoids(2-3)were isolated from the roots of Paeonia lactiflora,and their structures were identified as(+)-(1R,2R,4S,5S,10R)-2-α-D-glucopyranosyloxy-2-hydroxy-cadin-6,12-dien-15-oic acid(1),drim-7-en-3β,11,12-triol(2),and 3β-hydroxy-11,12-O-isopropylidenedrimene(3),respectively.Conclusion:Compound 1 was identified as a new sesquiterpenoidal glucoside. | Wanchao Zhong Guiyang Xia Huan Xia Jingfang Zhang Yanan Wang Sheng Lin | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 14 | Heterogenous glucose-stimulated insulin secretion at single islet level显示文摘Insulin secretion by pancreatic islets plays a vital role in regulating blood glucose levels.Nevertheless,the mech-anism responsible for this dynamic insulin secretion has not been completely understood,particularly at the single islet level.In this study,we have successfully developed an easy microfluidic platform that allows for the exploration of dynamic glucose-stimulated insulin secretion(GSIS)at the single islet level.With the utilization of this platform,we evaluated dynamic GSIS from single islets isolated from both normal and diabetic rats.Our results demonstrate that islets can be categorized into three types based on their dynamic GSIS:Type Ⅰ exhibits a biphasic GSIS profile with a fast first phase and flat second phase;Type Ⅱ also has a biphasic GSIS profile with a fast first phase but a slow increased second phase;Type Ⅲ displays only a slowly increased second phase and lacks a fast first phase.RNA sequencing analysis demonstrated that the cell type and exocytosis-specific genes are consistent with the proportion of cells and insulin release kinetics among the three types of islets,respectively.Moreover,our findings suggest that high expression of Atp5pb is anti-correlated with the first phase of insulin secretion.Furthermore,we revealed that diabetic islets exhibit only the type Ⅰ GSIS response,indicating a deliberate impairment of the second phase of insulin secretion.Together,this device serves as a crucial tool in the research field of islets and diabetes,allowing researchers to investigate islet functional heterogeneity and identity at the single islet level. | Jiaxiang Yin Hao Meng Haopeng Lin Meijun Mo Jingfang Lin Jingyi Chen Lihua Chen Xiaojun Xu Zonghong Li Wei Ji Tao Xu Huisheng Liu | 2023 | Engineered Regeneration2023，4，4： | 0 |
| 15 | Effect of CeO_(2) nanoparticle sizes on catalytic performances of sulfated CeO_(2)/Al_(2)O_(3) catalyst in NH_(3)-SCR reaction显示文摘The sulfated CeO_(2)/Al_(2)O_(3) catalysts with different sizes of CeO_(2)nanoparticles were prepared by using pure H_2O or acetic acid solution as impregnation solvent, and the influence of sizes of CeO_(2) nanoparticles on the catalytic performances of the sulfated CeO_(2)/Al_(2)O_(3) catalyst was studied. The catalytic performance tests show that the sulfated CeO_(2)/Al_(2)O_(3) catalyst using acetic acid solution as impregnation solvent has better catalytic activity and the resistance to K+poisoning than the sulfated CeO_(2)/Al_(2)O_(3) catalyst using pure H_(2)O as impregnation solvent. The excellent catalytic performances can be ascribed to the smaller sizes of CeO_(2) nanoparticles in CeO_(2)/Al_(2)O_(3) catalyst using acetic acid solution, which results in larger amount of adsorbed sulfate species, surface acid sites, surface active oxygen species and excellent redox property. These features are helpful for improving the catalytic performances of sulfated CeO_(2)/Al_(2)O_(3) catalyst using smaller amount of CeO_(2) to cut the costs. | Zhenghua Hu Dongqi An Lei Zhang Xuping Wang Siyong Fang Xinyun Tian Liu Qiu Jingfang Sun Tingzhen Li Lin Dong | 2024 | Journal of Rare Earths2024，42，3： | 0 |
| 16 | Solid-phase impregnation promotes Ce doping in TiO_(2) for boosted denitration of CeO_(2)/TiO_(2) catalysts显示文摘CeO_(2)/TiO_(2)(denoted as Ce Ti) catalysts obtained by solid-phase impregnation behaved better in lowtemperature selective catalytic reduction of NO_(x)with NH_(3)(NH_(3)-SCR) than that by conventional wet impregnation.To explore the main factors for activity distinction,the texture property,CeO_(2)dispersion and structure changes of TiO_(2)were comprehensively analyzed.It was found that surface changes of TiO_(2)had a significant impact on the improved activity.From results of inductively coupled plasma atomic emission spectrometer (ICP-AES),diffuse reflectance UV-vis spectroscopy (UV-vis-DRS) and Raman,it was inferred that Ce ions were partially incorporated into TiO_(2)lattice,accompanied with the formation of defects and vacancies during solid-phase impregnation.Accordingly,Ce Ti catalysts from solid-phase impregnation exhibited superiority in adsorption and activation of reactants.Further result from monitoring the preparation process indicated that the evolved NO played an important role in promoting Ce doping through depriving oxygen atoms on TiO_(2)surface.The interaction between Ce and Ti was enhanced.The catalyst performed better in NH_(3)-SCR,especially at low temperature,which testified the solid-phase impregnation could be an effective method to modulate interface structure for designing efficient catalyst. | Wang Song Jiawei Ji Kai Guo Xin Wang Xiaoqian Wei Yandi Cai Wei Tan Lulu Li Jingfang Sun Changjin Tang Lin Dong | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 17 | Promotion effect of bulk sulfates over CeO_(2)for selective catalytic reduction of NO by NH_(3)at high temperatures显示文摘Understanding the influence of sulfates over catalysts for selective catalytic reduction of NO with NH_(3)(NH_(3)-SCR)is crucial due to the universal presence of SO_(2)in exhaust gas.Depending on the degree of sulfation,there mainly exist surface and bulk sulfates and NH_(3)-SCR activity is generally considered to suffer more from bulk sulfates.Herein,the unique function of bulk sulfates over Ce O_(2)in promoting hightemperature SCR reaction is revealed.Notably,compared with CeO_(2)dominated with surface sulfates(S-CeO_(2)-4h)and commercial V_2O_5-WO_(3)/TiO_(2),CeO_(2)with bulk sulfates(S-Ce O_(2)-72h)exhibits admirable NO conversion at the temperature range of 400-550℃.Bulk sulfates provide more Br?nsted acid sites with stronger strength for NH_(3)adsorption.Moreover,the oxidation ability of Ce O_(2)is significantly inhibited due to electron-withdrawing effect from bulk sulfates,which alleviates NH_(3)oxidation at high temperatures.More NH_(3)adsorption with high stability and limited NH_(3)oxidation capacity ensure the excellent catalytic performance for S-CeO_(2)-72h in high-temperature denitration.This work provides new insight of bulk sulfates in promoting SCR activity and open a new avenue to design de NO_xcatalysts employed at high temperatures. | Jiawei Ji Li Han Wang Song Jingfang Sun Weixin Zou Changjin Tang Lin Dong | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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