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| 1 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 2 | Functional traits of tree species with phylogenetic signal co-vary with environmental niches in two large forest dynamics plots显示文摘Aims While using phylogenetic and functional approaches to test the mechanisms of community assembly,functional traits often act as the proxy of niches.However,there is little detailed knowledge regarding the correlation between functional traits of tree species and their niches in local communities.We suggest that the co-varying correlation between functional traits and niches should be the premise for using phylogenetic and functional approaches to test mechanisms of community assembly.Using functional traits,phylogenetic and environmental data,this study aims to answer the questions:(i)within local communities,do functional traits of co-occurring species covary with their environmental niches at the species level?and(ii)what is the key ecological process underlying community assembly in Xishuangbanna and Ailaoshan forest dynamic plots(FDPs)?Methods We measured seven functional traits of 229 and 36 common species in Xishuangbanna and Ailaoshan FDPs in tropical and subtropical China,respectively.We also quantified the environmental niches for these species based on conditional probability.We then analyzed the correlations between functional traits and environmental niches using phylogenetic independent contrasts.After examining phylogenetic signals of functional traits using Pagel’sλ,we quantified the phylogenetic and functional dispersion along environmental gradients within local tree communities.Important Findings For target species,functional traits do co-vary with environmental niches at the species level in both of the FDPs,supporting that functional traits can be used as a proxy for local-scale environmental niches.Functional traits show significant phylogenetic signals in both of the FDPs.We found that the phylogenetic and functional dispersion were significantly clustered along topographical gradients in the Ailaoshan FDP but overdispersion in the Xishuangbanna FDP.These patterns of phylogenetic and functional dispersion suggest that environmental filtering plays a key role in structuring local tree assemblages in Ailaoshan FDP,while competition exclusion plays a key role in Xishuangbanna FDP. | Jie Yang Xiuqin Ci Mengmeng Lu Guocheng Zhang Min Cao Jie Li Luxiang Lin | 2014 | Journal of Plant Ecology2014，7，2： | 16 |
| 3 | Walnut-inspired microsized porous silicon/graphene core-shell composites for high-performance lithium-ion battery anodes显示文摘 | Wei Zhai Qing Ai Lina Chen Shiyuan Wei Deping Li Lin Zhang Pengchao Si Jinkui Feng Lijie Ci | 2017 | Nano Research2017，10，12： | 12 |
| 4 | Topology-aware virtual network embedding based on closeness centrality显示文摘 | Zihou WANG Yanni HAN Tao LIN Yuemei XU Song CI Hui TANG | 2013 | Frontiers of Computer Science2013，7，3： | 5 |
| 5 | Contrasting effects of space and environment on functional and phylogenetic dissimilarity in a tropical forest显示文摘Aims The evolutionary history and functional traits of species can illumi-nate ecological processes supporting coexistence in diverse forest communities.However,little has been done in decoupling the rela-tive importance of these mechanisms on the turnover of phylogenetic and functional characteristics across life stages and spatial scales.Therefore,this study aims to estimate the contribution of environment and dispersal on the turnover of phylogenetic and functional diversity across life stages and spatial scales,in order to build a coherent pic-ture of the processes responsible for species coexistence.Methods We conducted the study in Xishuangbanna Forest Dynamics Plot in Yunnan Province,southwest China.We used four different spatial point process models to estimate the relative importance of disper-sal limitation and environmental filtering.The functional traits and phylogenetic relationships of all individual trees were incorporated in the analyses to generate measures of dissimilarity in terms of pair-wise and nearest-neighbor phylogenetic and functional characteris-tics across life stages and spatial scales.Important Findings We found non-random patterns of phylogenetic and functional turnover across life stages and spatial scales.Environmental filtering structured pairwise phylogenetic and functional beta diversity across spatial scales,while dispersal limitation alone,and in combination with environment filtering,shaped nearest neighbor phylogenetic and functional beta diversity.The relative importance of dispersal limitation and environmental filtering appeared to change with life stage but not with spatial scale.Our findings suggest that phylogenetic and functional beta diversity help to reveal the ecological processes responsible for evolu-tionary and functional assembly and highlight the importance of using a range of different metrics to gain full insights into these processes. | Mengesha Asefa Calum Brown Min Cao Guocheng Zhang Xiuqin Ci Liqing Sha Jie Li Luxiang Lin Jie Yang | 2019 | Journal of Plant Ecology2019，12，2： | 3 |
| 6 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 7 | Fip-vvo,a new fungal immunomodu-latory protein isolated from Volvariella volvacea显示文摘 | Hsu HC Hsu CI Lin RH | 1997 | Biochemical Jour-nal1997，323，2： | 1 |
| 8 | Calcium overload and cardiac function显示文摘 | Vassalle M Lin CI | 2004 | Biomed Sci2004，11，5： | 1 |
| 9 | Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells显示文摘 | Wu WT Chen CN Lin CI | 2005 | Endocrinology2005，146，8： | 1 |
| 10 | Lysophospholipids increases ICAM-1 expression in HUVEC through a Gi-and NF-kappaB-dependent mechanism显示文摘 | Lee H Lin CI Liao JJ | 2004 | Am J Physiol Cell Physiol2004，287，6： | 1 |
| 11 | Lysophosphatidic acid regulates inflammation-related genes in human endotheli-al cells through LPA1and LPA3显示文摘 | Lin CI Chen CN Lin PW | 2007 | Biochem Biophys Res Commun2007，363，4： | 1 |
| 12 | A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina ve- lutipes and its complete amino acid sequence 显示文摘 | Ko JL Hsu CI Lin RH | 1995 | Eur J Biochem1995，228，2： | 1 |
| 13 | Treatment of spinal cord ependymom as by surgery with or without postoperative radio therapy显示文摘 | Lin YH Huang CI Wong TT | 2005 | J Neurooncol2005，71，2： | 1 |
| 14 | Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow显示文摘 | Lee DY Lee CI Lin TE | | 0，，： | 1 |
| 15 | TM4SFI: a newvascular therapeutic target in cancer 显示文摘 | LIN CI MERLEY A SCIUTO TE | 2014 | Angiogenesis2014，17，4： | 1 |
| 16 | Wideband shorted annular stacked patch antenna for global navigation satellite systcm application with compact size and broad beamwidth characteristics显示文摘 | Xi Li Lin Yang Min Wang Yi Wang Xi Chen and Juan1 ci | 2013 | Progrcss In Electromagnetics Research C2013，，35： | 1 |
| 17 | Intrauterine diagnosis of heterotaxy syndrome显示文摘 | Lin JH Chang CI Wang JK | | 0，，06： | 1 |
| 18 | Diet, vegetarian tood and prostate carcinoma among men in Taiwan显示文摘 | Chen YC Chiang CI Lin RS | 2005 | Br J Cancer2005，93，9： | 1 |
| 19 | Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18显示文摘 | Lin CI Orlov I Ruggiero AM | 2001 | Nature2001，410，6824： | 1 |
| 20 | Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer显示文摘 | Lin CI Du J Shen WT | 2011 | J Clin Endocrinol Metab2011，96，3： | 1 |
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