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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Preparation and characterization of a pan nanofibre containing ag nanoparticles via electrospinning 显示文摘 | YANG Q B LID M HONG Y L | 2003 | Synthetic Metals2003，，137： | 1 |
| 3 | On similarity preserving feature selection显示文摘 | ZHAO Z WANG L LID H | 2013 | IEEE Transactions on Knowledge and Data Engineering2013，25，3： | 1 |
| 4 | Diode-end-pumped electro-optically Q-switched Nd : YVO4 slab laser and its second-harmonic generation显示文摘 | ZHANG H L SHI P LID J | 2003 | Applied Optics2003，42，9： | 1 |
| 5 | Effects of Chinese herbal polysaccharidds on the immunity and growth performance of young broilers显示文摘 | CHEN H L LID F CHANG B Y | 2003 | Poult Sci2003，82，3： | 1 |
| 6 | Giant magnetostriction on FeSSGalS stacked ribbon samples 显示文摘 | LID G D LID L B LID Z H ZHANG M CHEN J L LI J Q WU G H | 2004 | Applied Physics Letters2004，84，12： | 1 |
| 7 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 8 | Effect of solid lubricants on tribologieal behavior of glass fiber reinforced polyamide 6 显示文摘 | YOU Y L LID X DENG X | 2013 | Polymer Composites2013，34，11： | 1 |
| 9 | Spark Discharge and High-speed Impact Treatment of Turbostratic CNx Powder 显示文摘 | LID C YU D L HE J L | 2003 | Mate- rials Science and Engineering A2003，350，： | 1 |
| 10 | Microstructural Models of Dynamic Recrystallization in Hot-Deformed Inconel 625 Superalloy 显示文摘 | GUO Q M LID F GUO S L | 2012 | Materials and Manufacturing Processes2012，9，27： | 1 |
| 11 | Discrete filled function method for discrete global optimization 显示文摘 | NG C ZHANG L S LID | 2005 | Computational Optimization and Applications2005，31，： | 1 |
| 12 | Bubble formation in an annular granularJet dispersed by a central air roundJet显示文摘 | LU H LID H F LI W F XUJ L | 2013 | AIChEJ2013，59，6： | 1 |
| 13 | In vitro induction of benzo(a)pyrene diol epoxide- DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer显示文摘 | LID H WANG M Y CHENG L | 1996 | Cancer Res1996，56，： | 1 |
| 14 | Sequential S02/C02 capture of calcium-based solid waste from paper industry in the calcium looping process显示文摘 | LI YJ LID C T SUN R Y LID H L WU S M LU C M | 2012 | Ind Eng Chern Res2012，51，16： | 1 |
| 15 | Dietary supplementation with zinc oxide increases IGF- I and IGF- I receptor gene expression in the small intestine of weanling piglets 显示文摘 | LI X L YIN J D LID F | 2006 | The Journal of Nutrition2006，136，7： | 1 |
| 16 | Transient hy persensitivity to soybean meal in the early weaned pig显示文摘 | LID F Nelssen J L Reddy P G | 1990 | Journal of Animal Science1990，，68： | 1 |
| 17 | The influence of fast-setting/early-strength agent on high phosphorous slag content cement显示文摘 | LID X SHEN J L CHEN L | 2001 | Cement and Concrete Research2001，31，： | 1 |
| 18 | Compatibilizing effect of mal- eated polypropylene on the mechanical properties of injection molded polypropylene/polyamide 6/functionalized-TiO2nano- composites 显示文摘 | OU B L LID X LIU Y J | 2009 | Compos Sci Technol2009，69，34： | 1 |
| 19 | Regioselective synthesis of 6-trifluoromethyl-1,4,5,6-tetrahydropyrazolo pyran derivatives 显示文摘 | LID M SONG L P SONG S D | 2007 | J Fluorine Chem2007，128，： | 1 |
| 20 | A Convexification Methods for a Class of Global Optimization Problem with Application to Reliability Optimization显示文摘 | SUN X L MCKINNON K LID | 2001 | Journal of Global Optimization2001，21，： | 1 |
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