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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Preparation and characterization of a pan nanofibre containing ag nanoparticles via electrospinning 显示文摘 | YANG Q B LID M HONG Y L | 2003 | Synthetic Metals2003，，137： | 1 |
| 3 | Osteonecrosis of the fem- oral head:a prospective study with MRI 显示文摘 | Sakamoto M Shimizu K Lid S | 1997 | J Bone Joint Surg Br1997，79，3： | 1 |
| 4 | Two new cucurbitane- type glycosides obtained from roots of Siraitia grosvenori SWINGLE 显示文摘 | LID P EL-AASR M IKEDA T et 01 | 2009 | Chemical and Pharmaceutical Bulletin2009，57，8： | 1 |
| 5 | A functional bone morphogenetic protein system in the ovary 显示文摘 | SHIMASAKI S ZACHOW R J LID M | 1999 | PNAS1999，96，13： | 1 |
| 6 | The influence of different doping elements on microstructure, piezoelectric coefficient and resistivity of sputtered ZnO film 显示文摘 | WANG X B SONG C LID M | 2006 | Applied Surface Science2006，253，： | 1 |
| 7 | Giant magnetostriction on FeSSGalS stacked ribbon samples 显示文摘 | LID G D LID L B LID Z H ZHANG M CHEN J L LI J Q WU G H | 2004 | Applied Physics Letters2004，84，12： | 1 |
| 8 | A new smoothed particle hydrodynamics non-Newtonian model for fric-tion stir welding: process modeling and simulation of microstruc- ture evolution in a magnesium alloy显示文摘 | PAN W X LID X TARTAKOVSKY A M | 2013 | International Journal of Plasticity2013，48，： | 1 |
| 9 | Concept of virtual electric/magnetic walls and its realization with artificial magnetic conductor technique显示文摘 | LID C BOONE F BOZZI M | 2008 | IEEE Microwave and Wireless Components Letters2008，18，11： | 1 |
| 10 | Financial constraint R&D investment and stock returns 显示文摘 | LID M | 2015 | The Review of Financial Studies2015，28，3： | 1 |
| 11 | Epitaxial BiFe03 multiferroic thin film heterostructures 显示文摘 | WANG J NEATON J B ZHENG H NAGARAJAN V OGALE S B LID B VIEHLAND D VAITHYANAATHAN V SCHLOM D G WAGHMARE U V SPALDIN N A RABE K M WUTTIG M RAMESH R | 2003 | Science2003，299，： | 1 |
| 12 | Microstructural Models of Dynamic Recrystallization in Hot-Deformed Inconel 625 Superalloy 显示文摘 | GUO Q M LID F GUO S L | 2012 | Materials and Manufacturing Processes2012，9，27： | 1 |
| 13 | Combined Effects of Two Environental Endocrine Disruptors Nonylphenol and di-n butyl Phthalate on Rat Sertoli Cells in Vitro 显示文摘 | LID M HU Y SHEN X H | 2010 | Reproductive Toxicology2010，30，3： | 1 |
| 14 | An epidemiological study of rosacea显示文摘 | Berg M Lid~n S | 1989 | Acta Derm Venereo11989，69，： | 1 |
| 15 | Tensile deformation behavior of aluminum alloys at warm forming temperatures显示文摘 | LID M GHOSH A | 2003 | Materials Science and Engineering2003，352，： | 1 |
| 16 | Comparison of outcomes among patients randomized to warfarin therapy according to anti- coagulant control: results from SPORTIF Ill and V 显示文摘 | White liD Gruber M Feyzi J | 2007 | Arch In- tern Med2007，167，： | 1 |
| 17 | Modeling simultaneous glucose and xylose uptake in Saccharomyces cerevisiae from kinetics and gene expression of sugar transporters显示文摘 | Bertilsson M Andersson J Lidén G | 2008 | Bioprocess&Biosystems Engineering2008，31，4： | 1 |
| 18 | Heat transfer for water flow in trapezoidal silicon microchannels 显示文摘 | QU W MALA G M LID | 2000 | Int J Heat and Mass Transfer2000，43，21： | 1 |
| 19 | Determination and quality evaluation of green tea extracts through qualita- tive and quantitative analysis of multi-components by single marker ( QAMS ) 显示文摘 | LID W ZHU M SHAO Y D | 2016 | Food Chemistry2016，197，： | 1 |
| 20 | Biaxial warm forming behavior of aluminum sheet alloys 显示文摘 | LID M GHOSH A K | 2004 | Journal of Materials Processing Technology2004，145，： | 1 |
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