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| 1 | Venous thrombosis and prothrombotic factors in inflammatory bowel disease显示文摘Patients with inflammatory bowel disease(IBD)may have an increased risk of venous thrombosis(VTE).PubMed,ISI Web of Knowledge and Scopus were searched to identify studies investigating the risk of VTE and the prevalence of acquired and genetic VTE risk factors and prothrombotic abnormalities in IBD.Overall,IBD patients have a two-to fourfold increased risk of VTE compared with healthy controls,with an overall incidence rate of 1%-8%.The majority of studies did not show significant differences in the risk of VTE between Crohn’s disease and ulcerative colitis.Several acquired factors are responsible for the increased risk of VTEin IBD:inflammatory activity,hospitalisation,surgery,pregnancy,disease phenotype(e.g.,fistulising disease,colonic involvement and extensive involvement)and drug therapy(mainly steroids).There is also convincing evidence from basic science and from clinical and epidemiological studies that IBD is associated with several prothrombotic abnormalities,including initiation of the coagulation system,downregulation of natural anticoagulant mechanisms,impairment of fibrinolysis,increased platelet count and reactivity and dysfunction of the endothelium.Classical genetic alterations are not generally found more often in IBD patients than in nonIBD patients,suggesting that genetics does not explain the greater risk of VTE in these patients.IBD VTE may have clinical specificities,namely an earlier first episode of VTE in life,high recurrence rate,decreased efficacy of some drugs in preventing further episodes and poor prognosis.Clinicians should be aware of these risks,and adequate prophylactic actions should be taken in patients who have disease activity,are hospitalised,are submitted to surgery or are undergoing treatment. | Fernando Magro Jo?o-Bruno Soares Dália Fernandes | 2014 | World Journal of Gastroenterology2014，20，17： | 27 |
| 2 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 3 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 4 | Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c - IAP2 is under NF-kappa B control 显示文摘 | Chu Z L Mckinsey T A Lia L Gentry J J Malim M H Ballard D W | 1997 | PNAS1997，94，10： | 1 |
| 5 | Tourism and Environment in Brazil 显示文摘 | Luchiari D P C^lia Serrano | 2008 | Tourism Geographies2008，3，2： | 1 |
| 6 | Photocatalytic degradation of gaseous toluene over bcc-In203 hollow microspheres显示文摘 | ZHANG Q Z LIA X Y ZHAO Q D etal | 2015 | Appl Surf Sci2015，337，： | 1 |
| 7 | A sampling artifact in the microdialysis study of changes in extracellularupon spinal cord injury 显示文摘 | Young J Robak G Lia D | 1997 | Anal Biochem1997，245，2： | 1 |
| 8 | Results of R0 surgery with D2 lymphadenectomy for the treatment of localised gastric cancer显示文摘 | Díaz de Liao A Yárnoz C Artieda C | | 0，，03： | 1 |
| 9 | Synthesis of Sm-doped BaTiO3 ceramics and characterization of a secondary phase 显示文摘 | Lia Z C Zhang H Zou X D | 2005 | Materials Science and Engineering B2005，116，： | 1 |
| 10 | Internet use and risk behaviours: an online survey of visitors to three gay websites in China显示文摘 | Zhang D Bi P Lia F etal | 2007 | Sex Transm Infect2007，83，7： | 1 |
| 11 | Effect of nano-micro TiN addition on the microstructure and mechanical properties of TiC based cermets显示文摘 | Liu N Xu Y D Lia H | 2002 | Journal of the European Ceramic Society2002，22，： | 1 |
| 12 | Heavy metal distribution in sediment profiles of the Pearl River estuary, South China显示文摘 | Li X D Onyx W H Wai Y S Lia Bma3- J Colesb Michael H Ramseyb Iain Thornton | 2000 | Applied Geochemistry2000，15，5： | 1 |
| 13 | A new method for deposition of cubic Ta diffusion barrier for Cu metallization显示文摘 | Yuan Z L Zhanga D H Lia C Y | 2003 | Thin Solid Films2003，434，： | 1 |
| 14 | A fast and efficient contact algorithm for fretting problems applied to fretting mode Ⅰ,Ⅱ and Ⅲ显示文摘 | Gallego L Nélias D Deyber S | | 0，，： | 1 |
| 15 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 16 | Thermal field characteristic analysis of steel box girder based on long- term measurement data 显示文摘 | Ding Y L Zhou G D LiA Q | 2012 | International Journal of Steel Structures2012，12，2： | 1 |
| 17 | Thelazia callipaeda (Spirurida, Thelaziidae) of carnivores and humans: morphological study by light and scanning electron microscopy 显示文摘 | Otranto D Lia RP Traversa D | 2003 | Parassitologia2003，45，34： | 1 |
| 18 | A Closer Examination of the Relationship Between Children’s Weight Status and the Food and Physical Activity Environment显示文摘 | Ohri-Vachaspati P Lloyd K De Lia D | 2013 | Preventive Medicine2013，57，3： | 1 |
| 19 | Perception of environmental obstacles to commuting physical activity in Brazilian elderly显示文摘 | Maruí W. Corseuil Ione Jayce C. Schneider Diego A. Santos Silva Filipe F. Costa Kelly S. Silva Lucélia J. Borges Eleonora d’Orsi | 2011 | Preventive Medicine2011，，4： | 1 |
| 20 | Determining the number of clusters using information entropy for mixed data显示文摘 | LIANGA J ZHAOA X W LIA D | 2012 | Pattern Recognition2012，45，6： | 1 |
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