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| 1 | Investigation of confocal microscopy for differentiation of renal cell carcinoma versus benign tissue.Can an optical biopsy be performed?显示文摘Objective:Novel optical imaging modalities are under development with the goal of obtaining an“optical biopsy”to efficiently provide pathologic details.One such modality is confocal microscopy which allows in situ visualization of cells within a layer of tissue and imaging of cellular-level structures.The goal of this study is to validate the ability of confocal microscopy to quickly and accurately differentiate between normal renal tissue and cancer.Methods:Specimens were obtained from patients who underwent robotic partial nephrectomy for renal mass.Samples of suspected normal and tumor tissue were extracted from the excised portion of the kidney and stained with acridine orange.The stained samples were imaged on a Nikon E600 C1 Confocal Microscope.The samples were then submitted for hematoxylin and eosin processing and read by an expert pathologist to provide a gold-standard diagnosis that can later be compared to the confocal images.Results:This study included 11 patients,17 tissue samples,and 118 confocal images.Of the 17 tissue samples,10 had a gold-standard diagnosis of cancer and seven were benign.Of 118 confocal images,66 had a gold-standard diagnosis of cancer and 52 were benign.Six confocal images were used as a training set to train eight observers.The observers were asked to rate the test images on a six point scale and the results were analyzed using a web based receiver operating characteristic curve calculator.The average accuracy,sensitivity,specificity,and area under the empirical receiver operating characteristic curve for this study were 91%,98%,81%,and 0.94 respectively.Conclusion:This preliminary study suggest that confocal microscopy can be used to distinguish cancer from normal tissue with high sensitivity and specificity.The observers in this study were trained quickly and on only six images.We expect even higher performance as observers become more familiar with the confocal images. | Michael C.Phung Andrew R.Rouse Jayce Pangilinan Robert C.Bell Erika R.Bracamonte Sharfuddeen Mashi Arthur F.Gmitro Benjamin R.Lee | 2020 | Asian Journal of Urology2020，7，4： | 2 |
| 2 | Perception of environmental obstacles to commuting physical activity in Brazilian elderly显示文摘 | Maruí W. Corseuil Ione Jayce C. Schneider Diego A. Santos Silva Filipe F. Costa Kelly S. Silva Lucélia J. Borges Eleonora d’Orsi | 2011 | Preventive Medicine2011，，4： | 1 |
| 3 | MicroRNAprofileanalysisofhumanprostatecancers 显示文摘 | TongA W FulghamP JayC etal | 2009 | CancerGeneTher2009，16，： | 1 |
| 4 | Dy- namics of nutrients and phytoplankton biomass in the Pearl River estuary and adjacent waters of Hong Kong during summer: Preliminary evidence for phosphorus and silicon limitation 显示文摘 | YIN Kedong QIAN Peiyuan CHEN Jayc | 2000 | Marine Ecology Progress Se- ries2000，194，： | 1 |
| 5 | Evolutionofextendedspectrum betalactam resistance(SHV-8)inastrainofEscherichiacoliduringmultipleepisodesofbacteremia显示文摘 | RasheedJK JayC MetchockB etal | 1997 | AntimicrobAgentsChemother1997，41，3： | 1 |
| 6 | ZnO Nanowire Arrays for Enhanced Photocurrent in PbS Quantum Dot Solar Cells显示文摘 | Joel Jean Sehoon Chang Patrick R. Brown Jayce J. Cheng Paul H. Rekemeyer Moungi G. Bawendi Silvija Grade?ak Vladimir Bulovi? | 2013 | Adv. Mater2013，，20： | 1 |
| 7 | Random sequence oligonucleotide primers detect polymorphic DNA products which segregate in inbred strains of mice显示文摘 | Scott R. Woodward Jayce Sudweeks Cory Teuscher | 1992 | Mammalian Genome1992，，2： | 1 |
| 8 | A refined Poisson summation formula for certain Braverman-Kazhdan spaces显示文摘Braverman and Kazhdan(2000)introduced influential conjectures aimed at generalizing the Fourier transform and the Poisson summation formula.Their conjectures should imply that quite general Langlands L-functions have meromorphic continuations and functional equations as predicted by Langlands'functoriality conjecture.As an evidence for their conjectures,Braverman and Kazhdan(2002)considered a setting related to the so-called doubling method in a later paper and proved the corresponding Poisson summation formula under restrictive assumptions on the functions involved.The connection between the two papers is made explicit in the work of Li(2018).In this paper,we consider a special case of the setting in Braverman and Kazhdan's later paper and prove a refined Poisson summation formula that eliminates the restrictive assumptions of that paper.Along the way we provide analytic control on the Schwartz space we construct;this analytic control was conjectured to hold(in a slightly different setting)in the work of Braverman and Kazhdan(2002). | Jayce Robert Getz Baiying Liu | 2021 | Science China Mathematics2021，64，6： | 0 |
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