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| 1 | Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3显示文摘为药抵抗的肿瘤的发展的一个新兴的模型利用作为癌症干细胞(CSC ) 或开始癌症的房间(用户信息控制系统) 知道的自我更新的恶意的祖先的一个水池。这研究的目的是从卵巢的癌症房间线 SKOV3 宣传如此的用户信息控制系统。SKOV3 范围房间在与表皮的生长因素补充的没有浆液的文化系统用 40.0 mol/l cisplatin 和 10.0 mol/l paclitaxel 被选择,基本成纤维细胞生长因素,白血病禁止的因素或标准包含浆液的系统。这些房间在药选择(cisplatin 和 paclitaxel ) 和没有浆液的文化系统下面形成了非支持者范围。选择范围房间对 cisplatin, paclitaxel, adriamycin,和 methotrexate 更抵抗。重要地,范围房间有自强的性质,与干细胞基因 Nanog, Oct4, sox2, nestin, ABCG2, CD133,和干细胞因素受体的高表示 CD117 (c 工具包) 。一致地,流动 cytometric 分析表明范围房间比区分的房间(33%) 有 CD133+/CD117+-positive 房间(71%) 的一个高得多的百分比。而且, SKOV3 范围房间是更多的 tumorigenic。而且, cDNA microarray 和随后的本体论的分析表明分类基因的一个大比例与 angiogenesis,细胞外的矩阵,调停 integrin 的发信号小径,房间粘附,和房间增长有关。从在这个文化系统下面的 SKOV3 房间线的 subpopulation 隔离出现一在为以他们的幸存,自强,和 chemoresistance 学习卵巢的 CSC,并且为开发明确地防碍卵巢的 CSC 的治疗学的药的 vitro 模型合适。 | Li Ma Dongmei Lai Te Liu Weiwei Cheng Lihe Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 18 |
| 2 | Effect of platinum on the photocatalytic degradation of chlorinated organic compound显示文摘TiO 2 nanoparticles, doped with different Pt contents, were prepared by a modified photodeposition method using Degussa P-25 TiO 2 , H 2 PtCl 6 ·6H 2 O and methanol as the solvents. The physicochemical properties of Pt/TiO 2 were investigated by the nitrogen adsorption and desorption isotherm measurement technique, X-ray diffraction analysis and photoluminescence spectra, respectively. Reaction rates from photocatalytic removal of dichloromethane over Degussa P-25 TiO 2 and Pt/TiO 2 were evaluated. The average diameter and BET surface area of the TiO 2 catalyst particles were 300 nm and 50 m 2 /g, respectively. The degradation efficiency was 99.0%, 82.7%, 55.2%, and 57.9% with TiO 2 at inlet concentrations of 50, 100, 200, and 300 ppm, respectively. And the degradation efficiency was 99.3%, 79.7%, 76.5%, and 73.4% with a 0.005 wt.% Pt/TiO 2 at inlet concentrations of 50, 100, 200, and 300 ppm, respectively. In addition, we found that the photoluminescence emission peak intensities decreased with increases in the doping amount of Pt, which indicates that the irradiative recombination was weakened. Furthermore, the results showed that the UV/0.005 wt.% Pt/TiO 2 process was capable of efficiently decomposing gaseous DCM in air. | Chih Ming Ma Ya Wen Lee Gui Bing Hong Te Li Su Je Lueng Shie Chang Tang Chang | 2011 | Journal of Environmental Sciences2011，23，4： | 5 |
| 3 | Axiomatic design method to design a screw drive in-pipe robot passing through varied curved pipes显示文摘A screw drive in-pipe robot is promising inspection equipment for small pipes. However, most of the existing screw drive in-pipe robots have problems of motion interference and slipping inside curved or irregular pipes. These problems result from the coupled relations among the steering motion, the motion speed and the load ability of the robot. In order to deal with the problems, the axiomatic design(AD) theory is applied to evaluate and analyze the existing designs. Then an uncoupled concept design based on the AD theory is proposed and the complete AD decomposition process is presented. After that, the proposed robot based on a tri-axial differential angle modulation mechanism is designed to realize the uncoupled concept. Finally, the uncoupled property is verified in a dynamics simulation system. The simulation results indicate that the motion speed, load ability and steering motion of the proposed robot can be adjusted individually compared with the robots that have inclining-angle-fixed rollers. Owing to the uncoupled design, the proposed robot can mechanically adapt to straight pipes and curved pipes with less roller slipping. | LI Te MA ShuGen LI Bin WANG MingHui WANG YueChao | 2016 | Science China(Technological Sciences)2016，59，2： | 5 |
| 4 | Design and optimization of DBR in 980 nm bottom-emitting VCSEL显示文摘According to the theory of DBR,with the P-type DBR as an example,the electrical characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded region are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consists of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabricated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concen-tration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. According to the theory of DBR,with the P-type DBR as an example,the electri-cal characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded re-gion are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed,with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consist of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabri-cated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concentration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. | LI Te NING YongQiang HAO ErJuan CUI JinJiang ZHANG Yan LIU GuangYu QIN Li LIU Yun WANG LiJun CUI DaFu XU ZuYan | 2009 | Science in China(Series F)2009，52，7： | 4 |
| 5 | Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications显示文摘Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to strict glycemic control,a number of therapeutics have been used to slow down the progression of diabetic complications. However,a majority of current therapies for most diabetic complications have shown disappointing results in clinical trials.Because these complications arise from a number of pathological processes,targets for early interventions that could lead to effective treatments are largely unknown. | Fan Yu Song Guo Te Li Jie Ran Wei Zhao Dengwen Li Min Liu Xiumin Yan Xiaoyong Yang Xueliang Zhu Jun Zhou | 2019 | Cell Research2019，29，2： | 3 |
| 6 | Terahertz time-domain spectroscopy of some pentoses显示文摘The well-resolved absorption spectra of D-xylose, D-ribose, D-arabinose, D-lyxose and other related substances in the spectral region between 0.3 and 2.0 THz are measured using tera- hertz time-domain spectroscopy (THz-TDS) at 295 K. Comparing the absorption spectra of different chemicals, we can distinguish the samples easily. Thus THz-TDS is demonstrated to be a power and characteristic spectral tool, which is highly sensitive to the minor changes of the molecular structures and can be applied to detect and analyze similar materials. | GE Min ZHAO Hongwei JI Te YU Xiaohan WANG Wenfeng LI Wenxin | 2006 | Science China Chemistry2006，49，3： | 3 |
| 7 | Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus显示文摘Infection by foot-and-mouth disease virus(FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease(FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of viral resistance to acid-induced disassembly and improve the acid stability of FMDV. Sequencing of capsid-coding regions revealed four amino acid replacements(VP1 N17D, VP2 H145Y, VP2 G192D, and VP3 K153E) in the viral population of the acid-selected 10th passage. We performed single or combined mutagenesis using a reverse genetic system, and our results provide direct experimental evidence that VP2 H145Y or VP1 N17D substitution confers an acid-resistant phenotype to type Asia1 FMDV. | Haiwei Wang Shanshan Song Jianxiong Zeng Guohui Zhou Decheng Yang Te Liang Li Yu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 8 | Fuzzy Theory Based Control Method for an In-pipe Robot to Move in Variable Resistance Environment显示文摘Most of the existing screw drive in-pipe robots cannot actively adjust the maximum traction capacity, which limits the adaptability to the wide range of variable environment resistance, especially in curved pipes. In order to solve this problem, a screw drive in-pipe robot based on adaptive linkage mechanism is proposed. The differential property of the adaptive linkage mechanism allows the robot to move without motion interference in the straight and varied curved pipes by adjusting inclining angles of rollers self-adaptively. The maximum traction capacity of the robot can be changed by actively adjusting the inclining angles of rollers. In order to improve the adaptability to the variable resistance, a torque control method based on the fuzzy controller is proposed. For the variable environment resistance, the proposed control method can not only ensure enough traction force, but also limit the output torque in a feasible region. In the simulations, the robot with the proposed control method is compared to the robot with fixed inclining angles of rollers. The results show that the combination of the torque control method and the proposed robot achieves the better adaptability to the variable resistance in the straight and curved pipes. | LI Te MA Shugen LI Bin WANG Minghui WANG Yuechao | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 2 |
| 9 | Safety of yttrium-90 ibritumomab tiuxetan radioimmunotherapy for relapsed low-grade,follicular,or transformed non-Hodgkin's lymphoma显示文摘 | Witzig TE White CA Gordon LI | 2003 | J Clin Oncol2003，21，7： | 1 |
| 10 | Arsenic trioxide causes redistribution of cell cycle,caspase activation,and GADD expression in human colonic,breast,and pancreatic cancer cells显示文摘 | Li X Ding X Adrian TE | 2004 | Cancer Invest2004，22，3： | 1 |
| 11 | Treatment with ibritumomab tiuxetan radioimmunotherapy in patients with rituximab-refractory follicular non-Hodgkin's lymphoma显示文摘 | Witzig TE Flinn IW Gordon LI | 2002 | J Clin Oncol2002，20，15： | 1 |
| 12 | p53 alterations and protein accumulation in benign breast tissue and breast cantor risk: a cohort study 显示文摘 | Rohan TE Li SQ Hartwick R el al | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，7： | 1 |
| 13 | Distribution of DDT in a Typical DDT Waste Contaminated Site显示文摘 | Wenbin Liu Changliang Li Minghui Zheng Li Wang Sumei Li Te Ba Guijin Su Lirong Gao Lifei Zhang | 2008 | Bulletin of Environmental Contamination and Toxicology2008，，3： | 1 |
| 14 | The basic helix loop helix transcription factor Twistl is a novel regulator of ATF4 in osteoblasts显示文摘 | Danciu TE Li Y Koh A | 2012 | J Cell Biochem2012，113，1： | 1 |
| 15 | The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair显示文摘 | Li B Castano AP Hudson TE | 2010 | FASEB J2010，24，12： | 1 |
| 16 | One step memory of group reputation is optimal to promote cooperation in public goods games显示文摘 | Aming Li Te Wu Rui Cong Long Wang | 2013 | EPL (Europhysics Letters)2013，，3： | 1 |
| 17 | Single-frequency Laser at 473 nm by Use of Twisted-mode Technique显示文摘 | HAO Er-juan TAN Hui-ming LI Te | 2007 | Optics communication2007，270，： | 1 |
| 18 | Mobilized human hematopoieticstem/ progenitor cells promote kidney repair after ischemia/reperfusioninjury显示文摘 | Li B Cohen A Hudson TE | 2010 | Circulation2010，121，20： | 1 |
| 19 | Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury显示文摘 | Li B Cohen A Hudson TE | | 0，，： | 1 |
| 20 | The coevolutionary ultimatum game显示文摘 | Jia Gao Zhi Li Te Wu Long Wang | 2011 | EPL (Europhysics Letters)2011，，4： | 1 |
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