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| 1 | Maize ZmFDR3 localized in chloroplasts is involved in iron transport显示文摘Iron is an essential nutrient for plant metabolism such that Fe-limited plants display chlorosis and suffer from reduced photosynthetic efficiency. Differential display previously identified genes whose expression was elevated in Fe-deficient maize roots. Here,we describe the functional characterization of one of the genes identified in the screen,ZmFDR3 (Zea maize Fe-deficiency-related). Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport. ZmFDR3 contains a domain found in FliN-proteins of the type III secretion system and is predicted to localize to the thylakoid of plastids. Fluorescence immunocytochemistry showed that ZmFDR3 is localized in the plastids of roots,stems and leaves,with high expression found in guard cell chloroplasts. Transgenic tobacco expressing a 35S-ZmFDR3 construct contains elevated iron content,displays well arranged thylakoid membranes and has photosynthetic indices that are higher than those of the wild type. Together,these results suggest that ZmFDR3 functions in chloroplast iron transport. | HAN JianHui1,SONG XiuFang1,LI Peng1,YANG HuiJun2 & YIN LiPing1 1 College of Life Science,Capital Normal University,Beijing 100048,China 2 Department of Biological Sciences,University of South Carolina,Columbia,SC 29208,USA | 2009 | Science China(Life Sciences)2009，52，9： | 7 |
| 2 | Discovery of virus pathogen from soft-shelled turtle Trionyx sinesis显示文摘THE soft-shelled turtle Trionyx sinesis, because of its nutritional and medicinal values, | Zhang, QY Li, ZQ Jiang, YL Liang, SC Gui, JF | 1997 | Chinese Science Bulletin1997，42，6： | 3 |
| 3 | Prevention of stroke in urban China-a community-based intervention trial 显示文摘 | Fang XH Kronmal RA Li SC | 1999 | Stroke1999，30，： | 1 |
| 4 | Inactivation of MYC reverses tumorigenesis显示文摘 | Li Y Casey SC Felsher DW | 2014 | J Intem Med2014，276，1： | 1 |
| 5 | Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease显示文摘BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-219 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11.8%(13/110), 45.5%(40/88), χ2=8.2, P < 0.01]. The TT allele frequency of the Alzheimer disease group was significantly higher than that in the control group [76% (42/55), 48% (21/44)], while GT+GG allele frequency was remarkably lower than that in the control group [24%(13/55), 52%(23/44), χ2=8.7, P < 0.01]. ②Total cholesterol level: The level of the TT genotype patients in the Alzheimer group was obviously higher than that in GT+GG genotype patients (t =2.46, P < 0.05); the cholesterol level in the two genotypes of the control group was similar (P > 0.05). CONCLUSION: TT genotype and allele T in the APOE promoter-219 polymorphisms are the sensitive gene, and genotype TT has a relationship with the increase of total cholesterol level. | Fang Liu1,2, Xiao Sun1, Jing Wang1, Yan Kong1, Li Cui1, Xiangdang Shi2 1Department of Neurology, Fengtian Hospital, Shenyang Medical College, Shenyang 110024, Liaoning Province, China 2Medical University of South Carolina, SC, U.S.A | 2006 | Neural Regeneration Research2006，1，9： | 1 |
| 6 | Antidiabetic therapies affect risk of pancreatic cancer显示文摘 | Li D Yeung SC Hassan MM | 2009 | Gastroenterology2009，137，2： | 1 |
| 7 | Drought tolerance through over-expression of expansin gene TaEXPB23 in transgenic tobacco 显示文摘 | Li F Xing SC Guo QF | 2011 | Plant Physiol2011，168，： | 1 |
| 8 | Inactivation oI MYC rever- ses tumorigenesis显示文摘 | Li Y Casey SC Felsher DW | 2014 | J Intern Med2014，276，1： | 1 |
| 9 | Cerebrovascular disease in the People′s Republic of China:epidemiologic and clinical features显示文摘 | Li SC Schoenberg BS Wang CC | 1985 | Neurology1985，35，12： | 1 |
| 10 | 显示文摘 | Liu L Zhang T Li SC | 2009 | Mater Lett2009，63，23： | 1 |
| 11 | Clinical significance of regulatory T cells and CD8+effector populations in patients with human endometrial carcinoma显示文摘 | Chang WC Li CH Huang SC | 2010 | Cancer2010，116，24： | 1 |
| 12 | Enriched meshless manifold method for two-dimensional crack modeling 显示文摘 | Li SC Li SC Cheng YM | 2005 | Theoretical and Applied Fracture Mechanics2005，44，： | 1 |
| 13 | Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid显示文摘 | Pflugfelder SC Liu ZG Monoroy M Li DQ Caruijal ME Price-Schiavi SA | 2000 | Invest Ophthalmol Vis Sci2000，41，6： | 1 |
| 14 | Effects of fatty liver and related factors on the efficacy of combination antiviral therapy in patients with chronic hepatitis C显示文摘 | Yu JW Li SC Wang GQ | | 0，，： | 1 |
| 15 | Effects of hydroxyapatite ultrafine powder or colony formation and cytoskeletones of MGC80-3 cell显示文摘 | Li SP Zhang SC Chen WJ | 1998 | Bioceramics1998，9，2： | 1 |
| 16 | Meaning of Health-related quality of life among children and adolescents in an Asian country:A focus group approach显示文摘 | Wee HL Chua HX Li SC | 2006 | Qual Life Res2006，15，5： | 1 |
| 17 | Contralateral haematoma secondary to decompressive craniectomy performed for severe head trauma: a descriptive study of 15 cases显示文摘 | Wen L Li QC Wang SC | 2013 | Brain Inj2013，27，3： | 1 |
| 18 | Antidiabetic therapies affect risk of pancreatic cancer 显示文摘 | Li DH Yeung SC Hassan MM | 2009 | Gastroenterology2009，137，2： | 1 |
| 19 | Dual-tasking postur- al control: Aging and the effects of cognitive demand in con- junction with focus of attention显示文摘 | Huxhold O Li SC Schmiedek F | 2006 | Brain Research Bulletin2006，69，： | 1 |
| 20 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population 显示文摘 | LI Y CHANG SC GOLDSTEIN BY | 2011 | Cancer Epidemiol2011，35，4： | 1 |
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