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| 1 | Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing,China显示文摘背景中国是 Mycobacterium 的高负担国家之一肺结核(TB ) 感染全球性,与高发生和死亡。我们学习了 rifampin ( RIF )和抵抗 Mycobacterium 肺结核从中国北京拉紧的异菸肼( INH )的分子的特征,四十 pansusceptible 和 Mycobacterium 肺结核的 81 抵抗紧张从北京孤立以便为特定的药 resistance.Methods 的快速的察觉发现基因标记,中国在 2002-2005 期间被分析。修改 rifampin oligonucleotide (RIFO ) 试金基于反向的线污点杂交被用来在 rpoB 基因的 81 bp 热点区域检测变化,它与 RIF 抵抗被联系。INH 抵抗联系了基因,规章的区域 mab-inhA (-15C/T) 和结构的基因 katG S315T 被反向的线污点杂交和 PCR 限制碎片长度多型性(RFLP ) 检测方法分别地。所有紧张被 spoligotying 打,北京遗传型被 NTF 地点分析进一步细分。药抵抗的分发在上述基因联系了变化在这些 groups.Results 被比较 65 (91.5%) 抵抗的 71 RIF 并且 52 (92.9%) 56 multidrug 抵抗(MDR,对至少 RIF 和 INH 抵抗的 .e ) 紧张被发现在 rpoB 热点区域怀有变化。没有变化在 RIF 敏感紧张被检测。修改 RIFO 试金的特性和敏感是 100% 并且 91.5% 分别地。katG315 AGCACC 和 inhA-15CT 变化在 40 被发现(60.6%) 并且 10 (15.2%) 66 NH 抵抗紧张,分别地; 7.6%INH 抵抗的紧张在这两基因有变化。因此, katG315 和 inhA-15 的联合使用识别了 68.2%INH 抵抗的紧张。北京遗传型说明了 91.7% 全部的紧张并且进一步被细分进“现代”(76.6%) 并且“祖先”(23.4%) 组。在药的 prevaiance 的“祖先”、“现代”的组之间没有重要差别联系抵抗的基因 mutations.Conclusions rpoB 基因的热点区域能为 RIF 抵抗紧张的察觉被用作基因标记;katG315 和 inhA-15 的联合使用能改进 INH 抵抗紧张的察觉率;北京遗传型在中国北京是流行的;修改 RIFO 试金能是为抵抗的 RIF 的快速的察觉的一个实际工具, MDR 在平淡的诊断工作孤立。 | JIAO Wei-wei Mokrousov Igor SUN Gui-zhi LI Mo LIU Jia-wen Narvskaya Olga SHEN A-dong | 2007 | Chinese Medical Journal2007，，9： | 39 |
| 2 | Immunohistochemical study on p53,H-rasp21,c-erbB-2 protein and PCNA expression in HCC tissues of Hart and minority ethnic patients显示文摘AIM To find out the difference of humanprimary liver carcinogenesis between Han andminority ethnic patients in Xinjiang.METHODS Expression of p53,c-erbB-2,H-rasp21 protein and proliferating cell nuclearantigen(PCNA)in tumor tissues of 50 patients(Han 38,minority 12)with primary hepaticcarcinoma was detected byimmunohistochemistry(LSAB).RESULTS The positive frequency of p53,c-erbB-2,H-rasp21 and PCNA expression was46.0%(23/50),70.0%(35/50),68.0%(34/50)and 82.0%(41/50)in tumor tissues;4.0%(2/50),22.0%(11/50),64.0%(32/50)and 52.0%(26/ 50)in peritumors respectively and asignificant difference,except for H-rasp21,ofoncogene alteration was found(P<0.05)between tumor and non-tumorous tissues.Combined the three oncogenes alteration,26%(13/50)tumor tissues had positiveimmunoreactivity,but in peritumor and normallivers it was negative.The positive rate of p53,c-erbB-2 and H-rasp21 protein expression was39.5%(15/38),60.5%(23/38)and 39.5%(15/38)in tumors of Han patients;66.7%(8/12),100%(12/12)and 75.0%(9/12)in minoritiesrespectively,with statistical difference (P<0.05).CONCLUSION Overexpression of p53,c-erbB-2and H-rasp21 in human primary liver carcinoma isan important biomarker of genetic alteration.The different frequency of these oncogeneticchanges may reflect some environmental or/andethnic hereditary factors affecting the livercarcinogenesis.The special life style of Han,Uygur,Kazak and Mongolia nationalities inXinjiang may also be related to theetiopathogenesis of this disease. | Guo Yue Lin Zhao Lun Chen Cai Mo Lu Ying Li Xiao Jia Ping Rong Huang Department of Laboratory Medicine,Chinese PLA 474 Hospital,Urumqi 830011,Xinjiang Uygur Autonomic Region,China Department of Pathology,the 1st Teaching Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomic Region,China | 2000 | World Journal of Gastroenterology2000，6，2： | 40 |
| 3 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 4 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 5 | Indosinian isotope ages of plutons and deposits in southwestern Miaoershan-Yuechengling,northeastern Guangxi and implications on Indosinian mineralization in South China显示文摘The Miaoershan-Yuechengling complex pluton is the largest granitoid complex in the western Nanling metallogenic belt with a surface exposure of >3000 km2.The complex pluton is composed of an early stage granitoid batholith and late stage small intrusions.The early stage batholith contains mainly medium-grained porphyritic mica granite and porphyritic monzonite granite,whereas the late stage intrusions are composed of muscovite granite porphyry and muscovite monzonitic granite.There are many W-Sn-Mo-Pb-Zn-Cu ores in the contact zone between the batholith and strata,forming an ore-rich belt around the batholith.Based on zircon LA-ICP-MS U-Pb ages,the southwestern part of the early stage batholith formed at 228.7 ± 4.1 Ma(MSWD = 2.49),with slightly earlier magmatic activity at 243.0 ± 5.8 Ma(MSWD = 2.62).The Yuntoujie muscovite granite was associated with W-Mo mineralization and has a zircon LA-ICP-MS U-Pb age of 216.8 ± 4.9 Ma(MSWD = 1.44).The Re-Os isochron age of molybdenite from the Yuntoujie W-Mo ore was 216.8 ± 7.5 Ma(MSWD = 11.3).Our new isotope data suggest that the late stage intrusive stocks from the southwestern Miaoershan-Yuechengling batholith were closely associated with W-Mo mineralization from the Indosinian period.These new results together with previous isotope data,suggest that South China underwent not only the well-known Yanshanian mineralization event,but also a widespread Indosinian metallogenic event during the Mesozoic period.Therefore,South China has a greater potential for Indosinian mineralization than previously thought such that more attention should be given to the Indosinian ore prospecting in South China. | WU Jing LIANG HuaYing HUANG WenTing WANG ChunLong SUN WeiDong SUN YaLi LI Jing MO JiHai WANG XiuZhang | 2012 | Chinese Science Bulletin2012，57，9： | 28 |
| 6 | Asymptotically Optimal Scenario Analysis and Wait-and-See Model for Optimal Power Flow With Wind Power显示文摘精确模拟风功率分布的场景,有效求解反映风电随机性的最优潮流模型,对大规模风电并网的经济调度、质量控制及安全运行均具有重要意义。引入风电随机变量,建立最优潮流的"wait-and-see"(WS-OPF)模型;采用优于其他指标的瓦瑟斯坦(Wasserstein)距离为衡量指标,形成与风功率概率分布最优近似的场景模型,生成渐近最优场景,获得潮流分布及机组最优出力等指导调度安全经济运行的重要信息。最后,以IEEE 30和IEEE 300系统为例,对比各种距离指标的模拟精度,验证Wasserstein距离的优良性;同时,与不考虑风电随机性的模型相比,WS-OPF模型能更好地模拟风功率随机特性,提供与实际发生的风功率相近的调度方案,从而合理地规避风电接入电网的风险,提高风电的消纳能力。 | LI Jinghua WEI Hua MO Dong | 2012 | 中国电机工程学报2012，32，22： | 27 |
| 7 | The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China显示文摘Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous. | Li Jinyi, He Zhengjun, Mo Shenguo and (Institute of Geology, CAGS, Beijing 100037, China) Zheng Qingdao (Heilongjiang Bureau of Exploration and Exploitation of Geology and M ineral Resources, Ha’erbin 150036, China) | 1999 | Global Geology1999，4，2： | 26 |
| 8 | Influence of moderate pre-oxidation treatment on the physical, chemical and phosphate adsorption properties of iron-containing activated carbon显示文摘A novel adsorbent based on iron oxide dispersed over activated carbon(AC) were prepared, and used for phosphate removal from aqueous solutions. The influence of pre-oxidation treatment on the physical, chemical and phosphate adsorption properties of iron-containing AC were determined. Two series of ACs, non-oxidized and oxidized carbon modified by iron(denoted as AC-Fe and AC/OFe), resulted in a maximum impregnated iron of 4.03% and 7.56%, respectively. AC/O-Fe showed 34.0%–46.6% higher phosphate removal efficiency than the AC-Fe did. This was first attributed to the moderate pre-oxidation of raw AC by nitric acid, achieved by dosing Fe(II) after a pre-oxidation, to obtain higher iron loading, which is favorable for phosphate adsorption. Additionally, the in-situ formed active site on the surface of carbon, which was derived from the oxidation of Fe(II) by nitric acid dominated the remarkably high efficiency with respect to the removal of phosphate. The activation energy for adsorption was calculated to be 10.53 and 18.88 kJ/mol for AC-Fe and AC/OFe, respectively. The results showed that the surface mass transfer and intra-particle diffusion were simultaneously occurring during the process and contribute to the adsorption mechanism. | Zhengfang Wang Mo Shi Jihua Li Zheng Zheng | 2014 | Journal of Environmental Sciences2014，26，3： | 24 |
| 9 | Regulatory T cells as a new therapeutic target for atherosclerosis显示文摘动脉粥样硬化是贡献 T 和 B 房间免疫者回答的过多的激活的 self-self-antigens 和 non-self-antigens 引起的自体免疫的疾病。这些回答进一步加重脉管的 infiammation 并且经由释放 pro-infiammatory cytokines 支持到匾的动脉粥样硬化和危险的前进。特别地,规章的 T 房间( Tregs )由压制象 T 和 B 房间,生来的杀手( NK )房间,单核白血球,和树枝状的房间( DC )那样的各种各样的房间的有免疫力的回答作为主要 immunoregulatory 房间导致并且维持有免疫力的动态平衡和忍耐,象由 secreting 一样处于生理、病理学的状态的禁止的 cytokines interleukin ( IL )-10, IL-35 和抄写生长因素(TGF-)。众多的证据证明 Treg 的减少的数字和机能障碍可以是在动脉粥样硬化致病的 involveved。增加或恢复并且改进 Tregs 的抑制免疫力的能力数字可以用作基本免疫疗法对待动脉粥样硬化患者心血管的疾病。在这篇文章,我们 briefiy 介绍 Treg 子集的当前的知识,总结在 Tregs 和动脉粥样硬化开发之间的关系,并且讨论调整为动脉粥样硬化致病和匾稳定性的改进的预防的 Tregs 的可能性。尽管对动脉粥样硬化的调停 Treg 的保护的准确分子的机制尚待被阐明,为指向 Tregs 的规定的策略可以为动脉粥样硬化患者的预防和治疗提供特定、重要的途径心血管的疾病。 | Han-xiao OU Bing-bing GUO Qi LIU Yu-kun LI Zhen YANG Wen-jie FENG Zhong-cheng MO | 2018 | Acta Pharmacologica Sinica2018，39，8： | 24 |
| 10 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 11 | Effect of Simulated N Deposition on Soil Exchangeable Cations in Three Forest Types of Subtropical China显示文摘The effects of simulated nitrogen(N)deposition on soil exchangeable cations were studied in three forest types of subtropical China.Four N treatments with three replications were designed for the monsoon evergreen broadleaf forest (mature forest):control(0 kg N ha-1 year-1),low N(50 kg N ha-1 year-1),medium N(100 kg N ha-1 year-1)and high N(150 kg N ha-1 year-1),and only three treatments(i.e.,control,low N,medium N)were established for the pine and mixed forests.Nitrogen had been applied continuously for 26 months before the measurement.The mature forest responded more rapidly and intensively to N additions than the pine and mixed forests,and exhibited some significant negative symptoms,e.g.,soil acidification,Al mobilization and leaching of base cations from soil.The pine and mixed forests responded slowly to N additions and exhibited no significant response of soil cations.Response of soil exchangeable cations to N deposition varied in the forests of subtropical China,depending on soil N status and land-use history. | LU Xian-Kai MO Jiang-Ming P.GUNDERSERN ZHU Wei-Xing ZHOU Guo-Yi LI De-Jun ZHANGXu | 2009 | Pedosphere2009，19，2： | 21 |
| 12 | Diagnostic value of magnetic resonance cholangiopancreatography in choledocholithiasis显示文摘AIM:To evaluate the diagnostic accuracy of magnetic resonance cholangiopancreatography(MRCP) in patients with choledocholithiasis.METHODS:We systematically searched MEDLINE,EMBASE,Web of Science,and Cochrane databases for studies reporting on the sensitivity,specificity and other accuracy measures of diagnostic effectiveness of MRCP for detection of common bile duct(CBD) stones.Pooled analysis was performed using random effects models,and receiver operating characteristic curves were generated to summarize overall test performance.Two reviewers independently assessed the methodological quality of studies using standards for reporting diagnostic accuracy and quality assessment for studies of diagnostic accuracy tools.RESULTS:A total of 25 studies involving 2310 patients with suspected choledocholithiasis and 738 patients with CBD stones met the inclusion criteria.The average inter-rater agreement on the methodological quality checklists was 0.96.Pooled analysis of the ability of MRCP to detect CBD stones showed the following effect estimates:sensitivity,0.90(95%CI:0.88-0.92,χ2 = 65.80; P < 0.001); specificity,0.95(95%CI:0.93-1.0,χ2 = 110.51; P < 0.001); positive likelihood ratio,13.28(95%CI:8.85-19.94,χ2 = 78.95; P < 0.001); negative likelihood ratio,0.13(95%CI:0.09-0.18,χ2 = 6.27; P < 0.001); and diagnostic odds ratio,143.82(95%CI:82.42-250.95,χ2 = 44.19; P < 0.001).The area under the receiver operating characteristic curve was 0.97.Significant publication bias was not detected(P = 0.266).CONCLUSION:MRCP has high diagnostic accuracy for the detection of choledocholithiasis.MRCP should be the method of choice for suspected cases of CBD stones. | Wen Chen Jing-Jia Mo Li Lin Chao-Qun Li Jian-Feng Zhang | 2015 | World Journal of Gastroenterology2015，21，11： | 21 |
| 13 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 14 | Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the health | ZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian | 2017 | Biomedical and Environmental Sciences2017，30，8： | 20 |
| 15 | Use of a disposable circumcision suture device versus conventional circumcision: a systematic review and meta-analysis显示文摘这系统的评论在冗余的包皮和 phimosis 的治疗估计了可处理的割礼缝术设备(DCSD ) 和常规割礼(CC ) 的安全和功效。二个独立评论家在中国和国外为冗余的包皮或 phimosis 的处理用 DCSD 和 CC 为使随机化的控制试用(RCT ) 进行了文学搜索。九 RCT (1898 个盒子) 被包括。与 CC 组相比, DCSD 组有一更短的起作用的时间(标准化吝啬的差别[SMD ]= 21.44;95% 信心间隔[95% CI ][25.08, 17.79 ] ;P < 0.00001 ) ,更短的创伤愈合时间(SMD = 3.66;95% CI [5.46, 1.85 ] ;P < 0.0001 ) ,更少的 intraoperative 血损失(SMD = 9.64;95% CI [11.37, 7.90 ] ;P < 0.00001 ) ,更好化妆的阴茎外观(机会比率[或]=8.77;95% CI [5.90, 13.02 ] ;P < 0.00001 ) ,更低的 intraoperative 疼痛分数,更低的 24-h 手术后的疼痛分数,感染的更低的发生,更少的切口浮肿,和更少不利事件。在裂开,或 hematoma 的发生的 CC 和 DCSD 组之间没有差别。这元分析的结果显示 DCSD 看起来比 CC 更安全、更有效。然而,有更大的学习人口的另外的高质量的 RCT 被需要。 | Zhong-Chao Huo Gang Liu Xiao-Yan Li Fei Liu Wen-Ju Fan Ru-Hua Guan Pei-Feng Li De-Yang Mo Yong-Zhi He | 2017 | Asian Journal of Andrology2017，19，3： | 19 |
| 16 | Biomimeitc Design of a Stubble-Cutting Disc Using Finite Element Analysis显示文摘 | Mo Li | 2013 | Journal of Bionic Engineering2013，10，1： | 17 |
| 17 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 18 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 19 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 20 | Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use显示文摘 | Li Mo Ding Ding Shi-Yun Pu Qin-Hui Liu Hong Li Bi-Rong Dong Xiao-Yan Yang Jin-Han He | 2016 | Chinese Medical Journal2016，，1： | 16 |
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