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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 3 | Tumor suppressor p53 is a regulator of bcl - 2 and bax geue expression in vitro and in vivo 显示文摘 | Wang HG Lin HK Liebennann DA | 1994 | Oncogene1994，9，6： | 1 |
| 4 | Combination of quercetin with ra- diotherapy enhances tumor radiosensitivity in vitro and in vivo 显示文摘 | Lin C Yu Y Zhao HG | 2011 | Radiother Oncol2011，104，3： | 1 |
| 5 | The prevalence and control of schistosomiasis in Poyang Lake region, China 显示文摘 | Chen HG Lin DD | 2004 | Parasitol Int2004，53，2： | 1 |
| 6 | Potential value of vertebral proton MR spectroscopy in determining bone weakness 显示文摘 | Schellinger D Lin CS Hatipoglu HG | 2001 | AJNR2001，22，： | 1 |
| 7 | Laparoscopic versus open myomectomy- A meta - analysis of randomized controlled tri- Ms 显示文摘 | ChuJin YH Xia - chart Chen FZ Feng Lin HG | 2009 | European Journal of Obstetrics & Gy- necology and Reproductive Biology2009，145，： | 1 |
| 8 | Coronal and root caries in southern Chinese adults显示文摘 | Lin HC Wong MC Zhang HG | 2001 | J Dent Res2001，80，5： | 1 |
| 9 | A1, Bcl-2 family member, prolongs cell survival and permits myeloid differentiation显示文摘 | Lin EY Orlofrky A Wang HG | 1996 | Blood1996，87，3： | 1 |
| 10 | Sensitive quantitation of minimal residual disease in chronic myeloid leukemia tzsing nanofluidic digital polymerase chain reaction assay 显示文摘 | Goh HG Lin M Fukushima T | 2011 | Leuk Lymphoma2011，52，5： | 1 |
| 11 | Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells显示文摘 | Loong CC Lin CY | 2002 | Cytokine2002，19，4： | 1 |
| 12 | Potential value of vertebral MR spectroscopy in determining bone weakness 显示文摘 | Schellinger D Lin CS Hatipoulu HG | 2001 | AJNR2001，22，： | 1 |
| 13 | Combination of quercetin with radio- therapy enhances tumor radiosensitivity in vitro and in vivo 显示文摘 | Lin C Yu Y Zhao HG | 2012 | Ra- diother Oncol2012，104，3： | 1 |
| 14 | Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells 显示文摘 | Heieh HG Loong CC Lin CY | 2002 | Cytokine2002，19，4： | 1 |
| 15 | Effectiveness of intratympanic dexam-ethasone injection in sudden-deafness patients as salvage treatment显示文摘 | Ho HG Lin HC Shu MT | 2004 | Laryngoscope2004，114，7： | 1 |
| 16 | Effectiveness of intratypanic dexamethasone injection in sudden-deafness patients as a salvage treatment显示文摘 | Ho HG Lin HC Shu MT | 2004 | Laryngoscope2004，114，7： | 1 |
| 17 | Laparoscopy-assisted versusopen gastrectomy with D2 lymph node dissection for advanced gas-tric cancer: a meta-analysis 显示文摘 | Huang YL Lin HG Yang JW | 2014 | Int J Clin Exp Med2014，7，6： | 1 |
| 18 | Laparoscopic versus open myomectomy-A meta-analysis of randomized controlled trials显示文摘 | ChuJin YH Xia-chan Chen FZ Feng Lin HG | 2009 | European Journal of Obstetrics & Gynecology and Reproductive Biology2009，145，： | 1 |
| 19 | Laparoscopy-assisted versus open gastrectomy with D2 lymph node dissection for advanced gastric cancer: a meta-analysis 显示文摘 | Huang YL Lin HG Yang JW | 2014 | Int J Clin Exp Med2014，7，6： | 1 |
| 20 | Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations显示文摘 | Lin MW Sham P Hwu HG | 1997 | Hum Genet1997，99，3： | 1 |
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