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| 1 | Prognostic value of systemic immune.inflammation index in patients with gastric cancer显示文摘Background:Inflammation-based indexes have been used to predict survival and recurrence in cancer patients.Systemic immune-inflammation index(Sll) was reported to be associated with prognosis in some malignant tumors.In the present study,we aimed to explore the association between Sll and the prognosis of patients with gastric cancer.Methods:We retrospectively analyzed data from 444 gastric cancer patients who underwent gastrectomy at the First Affiliated Hospital of Sun Yat-sen University between January 1994 and December 2005.Preoperative Sll was calculated.The Chi square test or Fisher's exact test was used to determine the relationship between preoperative Sll and clinicopathologic characteristics.Overall survival(OS) rates were estimated using the Kaplan-Meier method,and the effect of Sll on OS was analyzed using the Cox proportional hazards model.Receiver operating characteristic(ROC)curves were used to compare the predictive ability of Sll,NLR,and PLR.Results:Sll equal to or higher than 660 was significantly associated with old age,large tumor size,unfavorable Borrmann classification,advanced tumor invasion,lymph node metastasis,distant metastasis,advanced TNM stage,and high carcino-embryonic antigen level,high neutrophil-lymphocyte ratio,and high platelet-lymphocyte ratio(all P<0.05).High Sll was significantly associated with unfavorable prognosis(P<0.001) and Sll was an independent predictor for OS(P=0.015).Subgroups analysis further showed significant associations between high Sll and short OS in stage Ⅰ,Ⅱ,Ⅲ subgroups(all P<0.05).Sll was superior to NLR and PLR for predicting OS in patients with gastric cancer.Conclusion:Preoperative Sll level is an independent prognostic factor for OS in patients with gastric cancer. | Kang Wang Feiyu Diao Zhijun Ye Xinhua Zhang Ertao Zhai Hui Ren Tong Li Hui Wu Yulong He Shirong Cai Jianhui Chen | 2017 | Chinese Journal of Cancer2017，36，9： | 30 |
| 2 | Prostate cancer identification: quantitative analysis of T2-weighted MR images based on a back propagation artificial neural network model显示文摘Computer-aided diagnosis(CAD) systems have been proposed to assist radiologists in making diagnostic decisions by providing helpful information. As one of the most important sequences in prostate magnetic resonance imaging(MRI), image features from T2-weighted images(T2WI) were extracted and evaluated for the diagnostic performances by using CAD. We extracted 12 quantitative image features from prostate T2-weighted MR images. The importance of each feature in cancer identification was compared in the peripheral zone(PZ) and central gland(CG), respectively. The performance of the computer-aided diagnosis system supported by an artificial neural network was tested. With computer-aided analysis of T2-weighted images, many characteristic features with different diagnostic capabilities can be extracted. We discovered most of the features(10/12) had significant difference(P<0.01) between PCa and non-PCa in the PZ, while only five features(sum average, minimum value, standard deviation, 10 th percentile, and entropy) had significant difference in CG. CAD prediction by features from T2 w images can reach high accuracy and specificity while maintaining acceptable sensitivity. The outcome is convictive and helpful in medical diagnosis. | ZHAO Kai WANG ChengYan HU Juan YANG XueDong WANG He LI FeiYu ZHANG XiaoDong ZHANG Jue WANG XiaoYing | 2015 | Science China(Life Sciences)2015，58，7： | 16 |
| 3 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 4 | Three-dimensional porous graphene sponges assembled with the combination of surfactant and freeze-drying显示文摘与表面活化剂和 freeze-drying 的联合,我们开发了二种 graphene 多孔的结构。在一方面,把肥皂水泡的泡沫用作模板,有富有的层次毛孔的三维的多孔的 graphene 海绵被综合了。材料的毛孔包含长度规模的三个层次,包括毫米,测微计和纳米。结构能被改变结冰媒介调节,调整激动人心的率或增加功能的添加剂。由 graphene 氧化物 / 表面活化剂暂停的直接 freeze-drying,在另一方面,有方向性地排列的毛孔的一个多孔的框架被准备。表面活化剂给 graphene 氧化物表的更好的分散,导致一个高特定的表面区域。两个获得的材料展出优秀吸收能力和好压缩性能,提供大量可能的应用程序,例如吸收剂,存储媒介,和搬运人。 | Rujing Zhang Yachang Cao Peixu Li Xiaobei Zang Pengzhan Sun Kunlin wang Minlin Zhong Jinquan Wei Dehai Wu Feiyu Kang Hongwei Zhu | 2014 | Nano Research2014，7，10： | 10 |
| 5 | Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer显示文摘Background:Accurate evaluation of lymph node metastasis in bladder cancer(BCa)is important for disease staging,treatment selection,and prognosis prediction.In this study,we aimed to evaluate the diagnostic accuracy of com-puted tomography(CT)and magnetic resonance imaging(MRI)for metastatic lymph nodes in BCa and establish criteria of imaging diagnosis.Methods:We retrospectively assessed the imaging characteristics of 191 BCa patients who underwent radical cys-tectomy.The data regarding size,shape,density,and diffusion of the lymph nodes on CT and/or MRI were obtained and analyzed using Kruskal-Wallis test and χ^(2) test.The optimal cutoff value for the size of metastatic node was deter-mined using the receiver operating characteristic(ROC)curve analysis.Results:A total of 184 out of 3317 resected lymph nodes were diagnosed as metastatic lymph nodes.Among 82 imaging-detectable lymph nodes,51 were confirmed to be positive for metastasis.The detection rate of metastatic nodes increased along with more advanced tumor stage(P<0.001).Once the ratio of short-to long-axis diameter≤0.4 or fatty hilum was observed in lymph nodes on imaging,it indicated non-metastases.Besides,lymph nodes with spiculate or obscure margin or necrosis indicated metastases.Furthermore,the short diameter of 6.8 mm was the optimal threshold to diagnose metastatic lymph node,with the area under ROC curve of 0.815.Conclusions:The probability of metastatic nodes significantly increased with more advanced T stages.Once lymph nodes are detected on imaging,the characteristic signs should be paid attention to.The short diameter>6.8 mm may indicate metastatic lymph nodes in BCa. | Yong Li Feiyu Diao Siya Shi Kaiwen Li Wangshu Zhu Shaoxu Wu Tianxin Lin | 2018 | Cancer Communications2018，38，1： | 7 |
| 6 | Quantitative nanoscale mapping of three-phase thermal conductivities in filled skutterudites via scanning thermal microscopy显示文摘In the last two decades, a nano structuring paradigm has been successfully applied in a wide range of thermoelectric materials, resulting in significant reduction in thermal conductivity and superior thermoelectric performance. These advances, however, have been accomplished without directly investigating the local thermoelectric properties, even though local electric current can be mapped with high spatial resolution. In fact, there still lacks an effective method that links the macroscopic thermoelectric performance to the local micro structures and properties. Here, we show that local thermal conductivity can be mapped quantitatively with good accuracy, nanometer resolution and one-to-one correspondence to the micro structure using a three-phase skutterudite as a model system. Scanning thermal microscopy combined with finite element simulations demonstrate close correlation between sample conductivity and probe resistance,enabling us to distinguish thermal conductivities spanning orders of magnitude, yet resolving thermal variation across a phase interface with small contrast. The technique thus provides a powerful tool to correlate local thermal conductivities, micro structures and macroscopic properties for nano structured materials in general and nano structured thermo electrics in particular. | ehsan nasr esfahani feiyue ma shanyu wang yun ou jihui yang jiangyu li | 2018 | National Science Review2018，5，1： | 6 |
| 7 | Relationship between Framingham risk score and subclinical atherosclerosis in carotid plaques: an in vivo study using multi-contrast MRI显示文摘The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease(CVD).In this study,we used multi-contrast magnetic resonance imaging(MRI) to investigate the carotid plaque feature in asymptomatic,at-risk subjects;we also evaluated the correlation between MRI findings and Framingham risk score(FRS).One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI.After the arterial morphology and plaque components were outlined,the differences in carotid plaque burden among the various risk categories were analyzed.The FRS analysis showed that high-risk individuals had thicker vessel wall and higher plaque lipid content than did low risk participants.A substantial proportion of advanced carotid plaques occurred in low and intermediate-risk groups.Multi-contrast MRI may provide incremental value to the FRS in managing asymptomatic at-risk population. | Feiyu Li Xiaoying Wang | 2017 | Science China(Life Sciences)2017，60，1： | 5 |
| 8 | Ultrabroad band microwave absorption from hierarchical MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)Tx hybrids via annealing treatment显示文摘Two-dimensional(2D)transition metal carbide MXene-based materials hold great potentials applied for new electromagnetic wave(EMW)absorbers.However,the application of MXenes in the field of electromagnetic wave absorption(EMA)is limited by the disadvantages of poor impedance matching,single loss mechanism,and easy oxidation.In this work,MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids were prepared by the annealing-treated Mo_(2)TiC_(2)T_(x)MXene and uniform MoO_(3)and TiO_(2)oxides in-situ grew on Mo_(2)TiC_(2)T_(x)layers.At the annealing temperature of 300℃,the minimum reflection loss(RLmin)value of MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)reaches-30.76 dB(2.3 mm)at 10.18 GHz with a significantly broadening effective absorption bandwidth(EAB)of 8.6 GHz(1.8 mm).The in-situ generated oxides creating numerous defects and heterogeneous interfaces enhance dipolar and interfacial polarizations and optimize the impedance matching of Mo_(2)TiC_(2)T_(x).Considering the excellent overall performance,the MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids can be a promising candidate for EMA. | Feiyue HU Fan ZHANG Xiaohan WANG Yaya LI Hailong WANG Rui ZHANG Hongxia LI Bingbing FAN | 2022 | Journal of Advanced Ceramics2022，11，9： | 5 |
| 9 | Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon显示文摘Research on CRISPR-Cas(clustered regularly interspaced short palindromic repeats-CRISPR associated protein) systems has led to the revolutionary CRISPR/Cas9 genome editing technique. However, for most archaea and half of bacteria, exploitation of their native CRISPR-Cas machineries may be more straightforward and convenient. In this study, we harnessed the native type I-B CRISPR-Cas system for precise genome editing in the polyploid haloarchaeon Haloarcula hispanica. After testing different designs, the editing tool was optimized to be a single plasmid that carries both the self-targeting miniCRISPR and a 600-800 bp donor. Significantly, chromosomal modifications, such as gene deletion, gene tagging or single nucleotide substitution, were precisely introduced into the vast majority of the transformants. Moreover, we showed that simultaneous editing of two genomic loci could also be readily achieved by one step. In summary, our data demonstrate that the haloarchaeal CRISPR-Cas system can be harnessed for genome editing in this polyploid archaeon, and highlight the convenience and efficiency of the native CRISPR-based genome editing strategy. | Feiyue Cheng Luyao Gong Dahe Zhao Haibo Yang Jian Zhou Ming Li Hua Xiang | 2017 | Journal of Genetics and Genomics2017，44，11： | 5 |
| 10 | Group VB transition metal dichalcogenides for oxygen reduction reaction and strain-enhanced activity governed by p-orbital electrons of chalcogen显示文摘Developi ng alter native oxyge n reducti on reactio n (ORR) catalysts to replace precious Pt-based metals with abundant materials is the key challe nge of commercial application of fuel cells. Owing to their various compositi ons and tun able electronic properties, transition metal dichalcogenides (TMDs) have the great potential to realize high-efficiency catalysts for ORR. Here, various 3R-phase dichalcogenides of group VB and VIB transition metals (MX2, M = Nb, Ta, Mo, W;X = S, Se, Te) are investigated for ORR catalysts by using density functional theory calculations. The computed over-potentials of group VB TMDs are much less than those of group VIB TMDs. For group VB TMDs, a volcano-type plot of ORR catalytic activity is established on the adsorption energies of *OH, and NbS2 and TaTe2 exhibit best ORR activity with an oveepotential of 0.54 V. To achieve even better activity, strain engineering is performed to tune ORR catalytic activity, and the minimum over-potential of 0.43 V can be realized. We further dem on strate that the shift of p orbital center of surface chalcoge n elements under strain is responsible for tuning the catalytic activity of TMDs. | Shuyang Zhao Ke Wang Xiaolong Zou Lin Gan Hongda Du Chengjun Xu Feiyu Kang Wenhui Duan Jia Li | 2019 | Nano Research2019，12，4： | 4 |
| 11 | Advances in Understanding Materials for Rechargeable Lithium Batteries by Atomic Force Microscopy显示文摘The development of advanced lithium batteries represents a major technological challenge for the new century.Understanding the fundamental electrode degradation mechanisms is important for battery performance improvements.The complex electrochemical processes inside a working battery are being explored to a limited extent.Various advanced material characterization techniques have been used to monitor dynamic conditions for optimizing battery materials.State-of-the-art atomic force microscopy methods have been applied to energy storage systems,specifically lithium-ion batteries.Atomic force microscopy is an ideal tool to provide localized morphological,chemical,and physical information at nanoscale for the in-depth understanding of the electrochemical processes,reaction mechanisms,and degradation of battery materials.Here,we review recent progress in the development and application of atomic force microscopy for high-performance lithium-ion batteries.We discuss atomic force microscopy as an analytical tool to help researchers understand graphite,silicon,layered metal oxides,and other representative electrode materials.We summarize the importance of atomic force microscopy technique in studying the next-generation Li–S and Li–O 2 batteries.We also highlight some of the remaining challenges and possible solutions for future development. | Shuwei Wang Qi Liu Chenglong Zhao Fengzheng Lv Xianying Qin Hongda Du Feiyu Kang Baohua Li | 2018 | Energy & Environmental Materials2018，1，1： | 4 |
| 12 | Solid-state lithium batteries: Safety and prospects显示文摘Solid-state lithium batteries are flourishing due to their excellent potential energy density.Substantial efforts have been made to improve their electrochemical performance by increasing the conductivity of solid-state electrolytes(SEs)and designing a compatible battery configuration.The safety of a solid lithium battery has generally been taken for granted due to the nonflammability and strength of SEs.However,recent results have shown the release of dangerous gases and intense heat due to the formation of lithium dendrites,indicating the safety of solid-state lithium batteries may have been overestimated.In this review,we introduce a safety evaluation methodology,then focus on the garnet Li_(7)La_(3)Zr_(2)O_(12)(LLZO)and sulfide-based SEs,summarizing their structure,conductivity,compatibility with a lithium metal anode,electrochemical/chemical stability,and mechanical/thermal stability,which correlate closely with battery safety.We also evaluate the safety of all-solid-state lithium batteries,then conclude by discussing future avenues for improving the safety of SE-based batteries. | Yong Guo Shichao Wu Yan-Bing He Feiyu Kang Liquan Chen Hong Li Quan-Hong Yang | 2022 | eScience2022，2，2： | 4 |
| 13 | On the Unusual Holocene Carbonate Sediment in Lake Nam Co,Central Tibet显示文摘In lacustrine sediments,aragonite is a widespread mineral,whereas monohydrocalcite is a rare carbonate mineral. In the cold and high-attitude Xizang (Tibetan) Plateau,where aragonite has been commonly found in lacustrine sediments,there is no aragonite,but low-Mg calcite,monohydrocalcite and trace dolomite. The lake receives solutes primarily from surface runoffs and remains fairly constant water chemistry for a long time. The total CaCO3 percentage in sediments could be controlled by evaporation and inflow of detrital materials. The absence of aragonite is unusual when compared to other lacustrine sediments from the Tibetan Plateau. This could be due to low Ca/Mg ratio,low salinity,low Mg and Ca concentration. Monohydrocalcite might precipitate from the lake water mediated by biological activities. Low-Mg calcite originated from minor ostracoda shell and the precipitation of lake water with biological activities. | LI Minghui KANG Shichang ZHU Liping WANG Feiyue WANG Junbo YI Chaolu FANG Xiaomin XIE Manping | 2009 | Journal of Mountain Science2009，6，4： | 3 |
| 14 | Progress and perspective of the cathode/electrolyte interface construction in all-solid-state lithium batteries显示文摘Security risks of flammability and explosion represent major problems with the use of conventional lithium rechargeable batteries using a liquid electrolyte.The application of solid-state electrolytes could effectively help to avoid these safety concerns.However,integrating the solid-state electrolytes into the all-solid-state lithium batteries is still a huge challenge mainly due to the high interfacial resistance present in the entire battery,especially at the interface between the cathode and the solid-state electrolyte pellet and the interfaces inside the cathode.Herein,recent progress made from investigations of cathode/solid-state electrolyte interfacial behaviors including the contact problem,the interlayer diffusion issue,the space-charge layer effect,and electrochemical compatibility is presented according to the classification of oxide-,sulfide-,and polymer-based solid-state electrolytes.We also propose strategies for the construction of ideal next-generation cathode/solid-state electrolyte interfaces with high room-temperature ionic conductivity,stable interfacial contact during long cycling,free formation of the space-charge region,and good compatibility with high-voltage cathodes. | Shiming Su Jiabin Ma Liang Zhao Kui Lin Qidong Li Shasha Lv Feiyu Kang Yan-Bing He | 2021 | Carbon Energy2021，3，6： | 3 |
| 15 | Nanostructured Anode Materials for Non-aqueous Lithium Ion Hybrid Capacitors显示文摘The rapid advancement in electronic devices,electric vehicles,and grid storage stations have lead to a high demand for energy storage devices with enhanced power and energy densities as well as extended lifespans.Lithium ion hybrid capacitors are constructed with battery-type anodes and capacitor-type cathodes,which enables the direct integration of the high energy from lithium ion batteries and high power and long lifetime from supercapacitors,making lithium ion hybrid capacitor one of the most promising energy storage devices.In the past two decades,tremendous efforts have been put into the search for suitable battery-type anode materials with improved Faradaic reaction kinetics so that it can match with the fast non-Faradaic charging rate of the capacitive cathodes.This review aims to provide an up-to-date and comprehensive summary of the battery-type anode materials for high-performance lithium ion hybrid capacitors.To date,a large variety of battery-type anode materials have been explored with smart material design strategies,such as carbonaceous materials,metal oxides,alloys,sulfides,nitirdes,and Mxenes,etc.,which will be discussed in detail.A perspective to the challenges and future developing trends of lithium ion hybrid capacitors is proposed to close. | Cuiping Han Hongfei Li Ruiying Shi Lei Xu Junqin Li Feiyu Kang Baohua Li | 2018 | Energy & Environmental Materials2018，1，2： | 3 |
| 16 | Sieving carbons promise practical anodes with extensible low-potential plateaus for sodium batteries显示文摘Non-graphitic carbons are promising anode candidates for sodium-ion batteries,while their variable and complicated microstructure severely limits the rational design of high-energy carbon anodes that could accelerate the commercialization of sodium-ion batteries,as is the case for graphite in lithium-ion batteries.Here,we propose sieving carbons,featuring highly tunable nanopores with tightened pore entrances,as high-energy anodes with extensible and reversible low-potential plateaus(<0.1 V).It is shown that the tightened pore entrance blocks the formation of the solid electrolyte interphase inside the nanopores and enables sodium clustering to produce the plateau.Theoretical and spectroscopic studies also show that creating a larger area of sodiophilic pore surface leads to an almost linearly increased number of sodium clusters,and controlling the pore body diameter guarantees the reversibility of sodium cluster formation,producing a sieving carbon anode with a record-high plateau capacity of 400 mAh g.More excitingly,this approach to preparing sieving carbons has the potential to be scalable for modifying different commercial porous carbons. | Qi Li Xiangsi Liu Ying Tao Jianxing Huang Jun Zhang Chunpeng Yang Yibo Zhang Siwei Zhang Yiran Jia Qiaowei Lin Yuxuan Xiang Jun Cheng Wei Lv Feiyu Kang Yong Yang Quan-Hong Yang | 2022 | National Science Review2022，9，8： | 3 |
| 17 | Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression显示文摘 | Chi Han Li Feiyue Xu Sheungching Chow Lu Feng Deling Yin Tzi Bun Ng Yangchao Chen | 2014 | European Journal of Cancer2014，，15： | 2 |
| 18 | Electrochemical properties of nanosized hydrous manganese dioxide synthesized by a self-reacting microemulsion method显示文摘 | Chengjun Xu Baohua Li Hongda Du Feiyu Kang Yuqun Zeng | 2008 | Journal of Power Sources2008，，： | 2 |
| 19 | General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics显示文摘最近,增加注意作为 theranostic 平台被付了到结合磁电机的聚合物核心壳 nanoparticles (NP ) 。然而,表面活化剂的利用和有在合成的潜在的毒性的额外的氧化剂,为磁性的 NP ( MNP )@的各种各样的类型的控制合成的一般方法的缺乏结合了聚合物 NP ,并且获得平衡磁电机光的性质的困难极大地在 theranostics 限制了结合磁电机的聚合物的应用。我们发展了一在里面没有额外的表面活化剂和氧化剂的 situ 表面聚合方法综合有平衡、突出的磁电机光的性质的 MNP@polypyrrole (PPy ) NP。有一种可调节的尺寸,不同形状,和控制的壳厚度的 MNP@PPy NP 用这个方法被获得。方法被扩大综合另外的结合 MNP 的聚合物核心壳 NP,例如 MNP@polyaniline 并且 MNP@poly (3,4-ethylenedioxythiophene ): poly (4-styrenesulfonate )(PEDOT : PSS ) 。我们根据我们的试验性的结果讨论建议方法的形成机制。最后,使用光并且获得的 MNP@PEDOT 的磁性: PSS NP,在 vivo,多模式的指导成像的过高热在老鼠被导致,完成优秀肿瘤脱离治疗学的效果。我们的工作为在生物医学的域里扩大结合 MNP 的聚合物核心壳 NP 的应用程序是有益的。 | Hao Yan Lingyun Zhao Wenting Shang Zhongqun Liu Wensheng Xie Cai Qiang Zhiyuan Xiong Ranran Zhang Baohua Li Xiaodan Sun Feiyu Kang | 2017 | Nano Research2017，10，2： | 2 |
| 20 | Flexible supercapacitors显示文摘Flexible supercapacitors show a great potential for applications in wearable,miniaturized,portable,largescale transparent and flexible consumer electronics due to their significant,inherent advantages,such as being flexible,lightweight,low cost and environmentally friendly in comparison with the current energy storage devices.In this report,recent progress on flexible supercapacitors,flexible electrodes and electrolytes is reviewed.In addition,the future challenges and opportunities are discussed. | Shan Shi Chengjun Xu Cheng Yang Jia Li Hongda Du Baohua Li Feiyu Kang | 2013 | Particuology2013，11，4： | 2 |
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