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| 1 | Trends in Temperature and Precipitation Extremes over Circum-Bohai-Sea Region,China显示文摘Trends in temperature and precipitation extremes from 1961 to 2008 have been investigated over Circum-Bohai-Sea region,China using daily temperature and precipitation data of 63 meteorological stations.The re-sults show that at most stations,there is a significant increase in the annual frequency of warm days and warm nights,as well as a significant decrease in the annual frequency of cold days,cold nights,frost days,and annual diurnal temperature range(DTR).Their regional averaged changes are 2.06 d/10yr,3.95 d/10yr,-1.88 d/10yr,-4.27 d/10yr,-4.21 d/10yr and-0.20℃/10yr,respectively.Seasonal changes display similar patterns to the annual results,but there is a large seasonal difference.A significant warming trend is detected at both annual and seasonal scales,which is more contributed by changes of indices defined by daily minimum temperature than those defined by daily maximum tem-perature.For precipitation indices,the regional annual extreme precipitation displays a weak decrease in terms of magnitude and frequency,i.e.extreme precipitation days(RD95p),intensity(RINTEN),proportion(RPROP) and maximum consecutive wet days(CWD),but a slight increase in the maximum consecutive dry days(CDD),which are consistent with changes of annual total precipitation(PRCPTOT).Seasonally,PRCPTOT and RD95p both exhibit an increase in spring and a decrease in other seasons with the largest decrease in summer,but generally not significant.In summary,this study shows a pronounced warming tendency at the less rainy period over Circum-Bohai-Sea region,which may affect regional economic development and ecological protection to some extent. | JIANG Dejuan LI Zhi WANG Qiuxian | 2012 | Chinese Geographical Science2012，22，1： | 7 |
| 2 | LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase显示文摘Limb and CNS expressed 1 like(LIX1L) is over-expressed in several types of tumors.However,the function of LIX1L in glucose metabolism and hepatocellular carcinoma(HCC) progression remains elusive.Here we report that LIX1L is over-expressed in human HCC tissues,which predicts unfavorable prognosis.LIX1L deficiency in vivo significantly attenuated liver cancer initiation in mice.Functional studies indicated that LIX1L overexpression elevated proliferation,migratory,invasive capacities of HCC cells in vitro,and promoted liver cancer growth and metastasis in vivo.LIX1L knockdown up-regulated fructose-1,6-bisphosphatase(FBP1) expression to reduce glucose consumption as well as lactate production.Mechanistically,LIX1L increased miR-21-3p expression,which targeted and suppressed FBP1,thereby promoting HCC growth and metastasis.MiR-21-3p inhibitor could abrogate LIX1L induced enhancement of cell migration,invasion,and glucose metabolism.Inhibition of miR-21-3p suppressed tumor growth in an orthotopic tumor model.Our results establish LIX1L as a critical driver of hepatocarcinogenesis and HCC progression,with implications for prognosis and treatment. | Jie Zou Xiaoyun Zhu Dejuan Xiang Yanqiu Zhang Jie Li Zhigui Su Lingyi Kong Hao Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 3 | Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling,Anticipation,and Reward显示文摘The olfactory bulb(OB) is the first relay station in the olfactory system.In the OB,mitral/tufted cells(M/Ts),which are the main output neurons,play important roles in the processing and representation of odor information.Recent studies focusing on the function of M/Ts at the single-cell level in awake behaving mice have demonstrated that odor-evoked firing of single M/Ts displays transient/long-term plasticity during learning.Here,we tested whether the neural activity of M/Ts and sniffing patterns are dependent on anticipation and reward in awake behaving mice.We used an odor discrimination task combined with in vivo electrophysiological recordings in awake,head-fixed mice,and found that,while learning induced plasticity of spikes and beta oscillations during odor sampling,we also found plasticity of spikes,beta oscillation,sniffing pattern,and coherence between sniffing and theta oscillations during the periods of anticipation and/or reward.These results indicate that the activity of M/Ts plays important roles not only in odor representation but also in salience-related events such as anticipation and reward. | Penglai Liu Tiantian Cao Jinshan Xu Xingfeng Mao Dejuan Wang Anan Li | 2020 | Neuroscience Bulletin2020，36，6： | 2 |
| 4 | FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors显示文摘 | Aamir Ahmad Zhiwei Wang Dejuan Kong Shadan Ali Yiwei Li Sanjeev Banerjee Raza Ali Fazlul H. Sarkar | 2010 | Breast Cancer Research and Treatment2010，，2： | 2 |
| 5 | The complexities of obesity and diabetes with the development and progression of pancreatic cancer显示文摘 | Bin Bao Zhiwei Wang Yiwei Li Dejuan Kong Shadan Ali Sanjeev Banerjee Aamir Ahmad Fazlul H. Sarkar | 2010 | BBA - Reviews on Cancer2010，，2： | 2 |
| 6 | Pancreatic cancer stem cells: Emerging target for designing novel therapy显示文摘 | Yiwei Li Dejuan Kong Aamir Ahmad Bin Bao Fazlul H. Sarkar | 2012 | Cancer Letters2012，，： | 2 |
| 7 | Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance显示文摘 | Zhiwei Wang Yiwei Li Aamir Ahmad Asfar S. Azmi Dejuan Kong Sanjeev Banerjee Fazlul H. Sarkar | 2010 | Drug Resistance Updates2010，，4： | 2 |
| 8 | Over‐expression of FoxM1 leads to epithelial–mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Sanjeev Banerjee Aamir Ahmad Yiwei Li Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | J Cell Biochem2011，，9： | 2 |
| 9 | Long-term trend analysis of seasonal precipitation for Beijing China显示文摘 | Li Miao Xia Jun Meng Dejuan | | 0，，01： | 1 |
| 10 | Experimental investigation on gas–liquid flow, heat and mass transfer characteristics in a dual-contact-flow absorption tower显示文摘 | Dejuan Kong Yafei Zhang Na Li Qulan Zhou Rui Luo Tongmo Xu | 2013 | Chemical Engineering Research and Design2013，，： | 1 |
| 11 | The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness显示文摘 | Bin Bao Asfar S. Azmi Shadan Ali Aamir Ahmad Yiwei Li Sanjeev Banerjee Dejuan Kong Fazlul H. Sarkar | 2012 | BBA - Reviews on Cancer2012，，2： | 1 |
| 12 | Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Yiwei Li Aamir Ahmad Sanjeev Banerjee Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | Cancer Letters2011，，1： | 1 |
| 13 | Forkhead box M1 transcription factor: A novel target for cancer therapy显示文摘 | Zhiwei Wang Aamir Ahmad Yiwei Li Sanjeev Banerjee Dejuan Kong Fazlul H. Sarkar | 2009 | Cancer Treatment Reviews2009，，2： | 1 |
| 14 | Mass Transfer Characteristics in Double-Contact-Flow Absorber With Liquid Column/Screen Flow Type: Modeling and Ex- periment 显示文摘 | LI Na ZHOU Qulan KONG Dejuan | 2010 | Chemical Engineering Science2010，65，8： | 1 |
| 15 | The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness显示文摘 | Bin Bao Asfar S. Azmi Shadan Ali Aamir Ahmad Yiwei Li Sanjeev Banerjee Dejuan Kong Fazlul H. Sarkar | 2012 | BBA - Reviews on Cancer2012，，2： | 1 |
| 16 | PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids显示文摘To the Editor:Proteolysis Targeting Chimera(PROTAC)is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome.Since PROTACs can degrade target proteins without high affinity,it is natural to speculate that this technology can be used to identify the targets of natural products。Although a recent study reported the employment of PROTACs to explore the unknown non-kinase target of a multi-kinase inhibitor sorafenib,whether PROTACs can be used to find the potential targets of natural products remains unexplored. | Yanli Wu Yueying Yang Wang Wang Dejuan Sun Jing Liang Man Zhu Hua Li Lixia Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 17 | Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research显示文摘 | Yiwei Li Dejuan Kong Zhiwei Wang Fazlul H. Sarkar | 2010 | Pharmaceutical Research2010，，6： | 1 |
| 18 | The flexible interrelation between AOX respiratory pathway and photosynthesis in rice leaves显示文摘 | Hanqing Feng Hongyu Li Xin Li Jiangong Duan Houguo Liang Dejuan Zhi Jun Ma | 2007 | Plant Physiology and Biochemistry2007，，3： | 1 |
| 19 | The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer显示文摘 | Fazlul H. Sarkar Yiwei Li Zhiwei Wang Dejuan Kong | 2010 | Cancer and Metastasis Reviews2010，，3： | 1 |
| 20 | Nonisothermal Cocuring Behavior and Kinetics of Epoxy Resin/3-Glycidy- loxypropyl-POSS with MeTHPA显示文摘 | Gao Jungang Kong Dejuan Li Shurong | 2010 | Polymer Composites2010，31，1： | 1 |
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