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| 1 | Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations显示文摘Pancreatic neuroendocrine tumors(PNETs)are known to be the second most common epithelial malignancy of the pancreas.PNETs can be listed among the slowest growing as well as the fastest growing human cancers.The prevalence of PNETs is deceptively low;however,its incidence has significantly increased over the past decades.According to the American Cancer Society’s estimate,about 4032(>7%of all pancreatic malignancies)individuals will be diagnosed with PNETs in 2020.PNETs often cause severe morbidity due to excessive secretion of hormones(such as serotonin)and/or overall tumor mass.Patients can live for many years(except for those patients with poorly differentiated G3 neuroendocrine tumors);thus,the prevalence of the tumors that is the number of patients actually dealing with the disease at any given time is fairly high because the survival is much longer than pancreatic ductal adenocarcinoma.Due to significant heterogeneity,the management of PNETs is very complex and remains an unmet clinical challenge.In terms of research studies,modest improvements have been made over the past decades in the identification of potential oncogenic drivers in order to enhance the quality of life and increase survival for this growing population of patients.Unfortunately,the majority of systematic therapies approved for the management of advanced stage PNETs lack objective response or at most result in modest benefits in survival.In this review,we aim to discuss the broad challenges associated with the management and the study of PNETs. | Gabriel Benyomo Mpilla Philip Agop Philip Bassel El-Rayes Asfar Sohail Azmi | 2020 | World Journal of Gastroenterology2020，26，28： | 4 |
| 2 | CFD modeling to study the effect of particle size on dispersion in 20l explosion chamber: An overview显示文摘Mine disasters occur predominantly due to methane or coal dust explosion or a combination of both.Among the top ten worst coal mine disasters in India, nine are due to coal dust explosion. The current paper describes a general overview of the parameters causing dispersion leading to coal dust explosion,and computational fluid dynamics(CFD) simulation study to observe the effects of particle size on dispersion in Indian coal mines. Turbulent kinetic energy(TKE) and velocity vector path of dust-air mixture and dust-free air were simulated to understand their effects on coal dust dispersion. The TKE contours and velocity vector paths for dust-free air were uniform and symmetrical due to resistance-free path available. The TKE contours and velocity vector paths for dust-air mixture shows the asymmetrical distribution of contours, due to entrainment of air with dust particles. Vortices were observed in velocity vector paths which gradually diminish on increment of time sequence. These vortices are dead centres where velocity and coal dust particles concentration are both zero. | Santosh Kumar Ray Niroj Kumar Mohalik Asfar Mobin Khan Debashish Mishra Nikhil Kumar Varma Jai Krishna Pandey Pradeep Kumar Singh | 2020 | International Journal of Mining Science and Technology2020，30，3： | 3 |
| 3 | Review of preventive and constructive measures for coal mine explosions:An Indian perspective显示文摘Firedamp and coal dust explosion constitute a lion’s share in mine accidents in a global mining scenario.This paper reports a list of mine explosion disasters since last two decades,a critical review of the different prevention and constructive measures,and its recent development to avoid firedamp and coal dust explosion.Preventive legislation in core coal-producing countries,viz.China,USA,Australia,South Africa,and India related to firedamp and coal dust explosion are critically analysed.Accidents occurred due to explosion after Nationalisation of Coal Mines(1973)in India are listed.Prevention and constructive measures adopted in India are critically analysed with respect to the global mining scenario.Measures like methane credit concept,classification of mines/seams with respect to explosion risk zone,deflagration index;installation of automatic fire warning devices,canopy air curtain technology,explosion-prevention measures,such as fire-retardant materials,inhibitors,extinguishing agent,dust suppressor,and active explosion barrier are discussed in detail to avoid explosion and thereby adhering to zero accident policy due to coal mine explosion. | Santosh Kumar Ray Asfar Mobin Khan Niroj Kumar Mohalik Debashish Mishra Somu Mandal Jai Krishna Pandey | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 4 | TGA/DSC study to characterise and classify coal seams conforming to susceptibility towards spontaneous combustion显示文摘Thermogravimetric analysis/differential scanning calorimeter(TGA/DSC)technique along with basic coal characteristics study is carried out for eighty coal samples of Indian coalfields,to determine spontaneous combustion propensity behaviour of coal.TGA study of coal samples indicates that there is an increase in the mass of coal samples in the temperature range 150-350℃,which may be due to oxygen adsorption and absorption.The correlation and principal component analysis states that the component of proximate analysis(M_(ad),VM_(d),FR,and VR)have an acceptable correlation with the TGA experiments results i.e.,Tgsh and Tgign.Multiple fixed nonlinear regression analysis shows that thermogravimetry(TG)experiment results Tgign may be the best index to categorise/classify the coal as per their susceptibility towards spontaneous combustion.The authors proposed four groups of classification as per their propensity towards spontaneous combustion depending upon the moisture(M_(ad)),volatile matter(VM_(d)),and TG ignition temperature from differential thermogravimetric(DTG)curve(Tgign)using hierarchal clustering analysis.The coal samples of different seams from Indian coalfield may be classified into four different clusters,viz.very highly/extremely susceptible(Tgign<260℃),highly susceptible(260℃≤Tgign<290℃),moderately susceptible(290℃≤Tgign≤320℃),and poorly susceptible(Tgign>320℃).The field observations and TGA/DSC experiment results with the following statistical analysis substantiate a similar assessment. | Niroj Kumar Mohalik Somu Mandal Santosh Kumar Ray Asfar Mobin Khan Debashish Mishra Jai Krishna Pandey | 2022 | International Journal of Mining Science and Technology2022，32，1： | 2 |
| 5 | Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance显示文摘 | Zhiwei Wang Yiwei Li Aamir Ahmad Asfar S. Azmi Dejuan Kong Sanjeev Banerjee Fazlul H. Sarkar | 2010 | Drug Resistance Updates2010，，4： | 2 |
| 6 | Over‐expression of FoxM1 leads to epithelial–mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Sanjeev Banerjee Aamir Ahmad Yiwei Li Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | J Cell Biochem2011，，9： | 2 |
| 7 | Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy显示文摘 | Delabranche X Boisrame-Helms J Asfar P | 2013 | Intensive Care Med2013，39，10： | 1 |
| 8 | Biliazy reconstruction without T tubes or stents in liver transplantation:report of 502 concecutire cases显示文摘 | Verran DJ Asfar SK Ohent CN | 1997 | Liver Transpl Surg1997，3，4： | 1 |
| 9 | Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review显示文摘 | Asfar S. Azmi Bin Bao Fazlul H. Sarkar | 2013 | Cancer and Metastasis Reviews . 2013 (3-4)2013，，3： | 1 |
| 10 | Hemorrhoidectomy and sphincterotomy:a prospective study comparing the effectiveness of anal stretch and sphincterotomy in reducing pain after hemorrhoidectomy显示文摘 | Asfar SK Juma TH Ala-Edeen T | 1988 | Dis Colon Rectum1988，31，3： | 1 |
| 11 | Cerebral arterial gas embolism- a race against timel 显示文摘 | Souday V Radermacher P Asfar P | 2013 | Crit Care Med2013，41，7： | 1 |
| 12 | Recurrent brain hematomas in MELAS associated with an ND5 gene mitochondrial mutatiaon显示文摘 | Penisson-Besnier I Reynier P Asfar P | 2000 | Neurology2000，55，： | 1 |
| 13 | Effect of green tea in the prevention and reversal of fasting-induced in testinal mucosal damage显示文摘 | ABDEEN S DASHTI H | 2003 | Nutrition2003，19，6： | 1 |
| 14 | Would measurement of Creactive protein reduce the rate of negative exploration for acute appendicitis?显示文摘 | Asfar S Safar H Khoursheed M | 2000 | J R Coil Surg Edinb2000，45，1： | 1 |
| 15 | Systemic microvas- cular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary by- pass显示文摘 | Koning NJ Simon LE Asfar P | 2014 | Am J Physiol Heart Circ Physiol2014，307，7： | 1 |
| 16 | Cerebral arterial gas emlxllism- a race against timel 显示文摘 | Souday V Radermacher P Asfar P | 2013 | Crit Care Med2013，41，7： | 1 |
| 17 | Activated K‐Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype显示文摘 | Zhiwei Wang Shadan Ali Sanjeev Banerjee Bin Bao Yiwei Li Asfar S. Azmi Murray Korc Fazlul H. Sarkar | 2012 | J. Cell. Physiol2012，，3： | 1 |
| 18 | Bench-to-bedside review : Hy- drogen sulfide-the third gasenous transmitter:applications for criti- cal care显示文摘 | Wagner F Asfar P Calzia E | 2009 | Crit Care2009，13，3： | 1 |
| 19 | Mechanisms of induction of renal allograft tolerance in CD45RB-treated mice显示文摘 | Lazarovits A I Visser L Asfar S | 1999 | Kidney Int1999，55，4： | 1 |
| 20 | High versus low bloodpressure target in patients with septic shock显示文摘 | Asfar P Meziani F Hamel JF | 2014 | N Engl J Med2014，370，17： | 1 |
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